human-PNLIPRP2

Homo sapiens (Human) pancreatic lipase related protein 2 PLRP2

Comment

human-PNLIPRP2 adopt in solution an open lid conformation which creates a large cavity capable of accommodating the galactose polar head of galactolipids (Eydoux 2008). q5jyh9 (old) protein (fragment) a dead processed gene (incomplete) nothing close in the genome to complete, RP6149D17.1-001, ENSG00000189372

Relationship

Family : Pancreatic_lipase

Block : L

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Database

Sequence

Peptide

MLPPWTLGLL LLATVRGKEV CYGQLGCFSD EKPWAGTLQR PVKLLPWSPE DIDTRFLLYT NENPNNFQLI TGTEPDTIEA SNFQLDRKTR FIIHGFLDKA EDSWPSDMCK KMFEVEKVNC ICVDWRHGSR AMYTQAVQNI RVVGAETAFL IQALSTQLGY SLEDVHVIGH SLGAHTAAEA GRRLGGRVGR ITGLDPAGPC FQDEPEEVRL DPSDAVFVDV IHTDSSPIVP SLGFGMSQKV GHLDFFPNGG KEMPGCKKNV LSTITDIDGI WEGIGGFVSC NHLRSFEYYS SSVLNPDGFL GYPCASYDEF QESKCFPCPA EGCPKMGHYA DQFKGKTSAV EQTFFLNTGE SGNFTSWRYK VSVTLSGKEK VNGYIRIALY GSNENSKQYE IFKGSLKPDA SHTCAIDVDF NVGKIQKVKF LWNKRGINLS EPKLGASQIT VQSGEDGTEY NFCSSDTVEE NVLQSLYPC

References (19)

Title : Interfacial adsorption and activity of pancreatic lipase-related protein 2 onto heterogeneous plant lipid model membrane - Kergomard_2023_Biochimie__
Author(s) : Kergomard J , Carriere F , Paboeuf G , Chonchon L , Barouh N , Vie V , Bourlieu C
Ref : Biochimie , : , 2023
PubMedID: 37062468
Gene_locus related to this paper: human-PNLIPRP2

Title : Structure and Function of Pancreatic Lipase-Related Protein 2 and Its Relationship With Pathological States - Zhu_2021_Front.Genet_12_693538
Author(s) : Zhu G , Fang Q , Zhu F , Huang D , Yang C
Ref : Front Genet , 12 :693538 , 2021
PubMedID: 34290745
Gene_locus related to this paper: human-PNLIPRP2

Title : The beta5-Loop and Lid Domain Contribute to the Substrate Specificity of Pancreatic Lipase-related Protein 2 (PNLIPRP2) - Xiao_2015_J.Biol.Chem_290_28847
Author(s) : Xiao X , Lowe ME
Ref : Journal of Biological Chemistry , 290 :28847 , 2015
PubMedID: 26494624
Gene_locus related to this paper: human-PNLIP , human-PNLIPRP2

Title : In vitro digestion of the self-emulsifying lipid excipient Labrasol() by gastrointestinal lipases and influence of its colloidal structure on lipolysis rate - Fernandez_2013_Pharm.Res_30_3077
Author(s) : Fernandez S , Jannin V , Chevrier S , Chavant Y , Demarne F , Carriere F
Ref : Pharm Res , 30 :3077 , 2013
PubMedID: 23636839
Gene_locus related to this paper: human-PNLIPRP2

Title : Partial deletion of beta9 loop in pancreatic lipase-related protein 2 reduces enzyme activity with a larger effect on long acyl chain substrates - Dridi_2013_Biochim.Biophys.Acta_1831_1293
Author(s) : Dridi K , Amara S , Bezzine S , Rodriguez JA , Carriere F , Gaussier H
Ref : Biochimica & Biophysica Acta , 1831 :1293 , 2013
PubMedID: 24046870
Gene_locus related to this paper: human-PNLIPRP2

Title : Inhibition of phospholipase A1, lipase and galactolipase activities of pancreatic lipase-related protein 2 by methyl arachidonyl fluorophosphonate (MAFP) - Amara_2012_Biochim.Biophys.Acta_1821_1379
Author(s) : Amara S , Delorme V , Record M , Carriere F
Ref : Biochimica & Biophysica Acta , 1821 :1379 , 2012
PubMedID: 22835523
Gene_locus related to this paper: human-PNLIPRP2

Title : Analysis of the discriminative inhibition of mammalian digestive lipases by 3-phenyl substituted 1,3,4-oxadiazol-2(3H)-ones. - Point_2012_Eur.J.Med.Chem_58_452
Author(s) : Point V , Pavan Kumar KV , Marc S , Delorme V , Parsiegla G , Amara S , Carriere F , Buono G , Fotiadu F , Canaan S , Leclaire J , Cavalier JF
Ref : Eur Journal of Medicinal Chemistry , 58 :452 , 2012
PubMedID: 23153815
Gene_locus related to this paper: canfa-1lipg , cavpo-2plrp , human-CEL , human-PNLIP , human-PNLIPRP2 , pig-1plip

Title : Kinetic properties of mouse pancreatic lipase-related protein-2 suggest the mouse may not model human fat digestion - Xiao_2011_J.Lipid.Res_52_982
Author(s) : Xiao X , Ross LE , Miller RA , Lowe ME
Ref : J Lipid Res , 52 :982 , 2011
PubMedID: 21382969
Gene_locus related to this paper: human-PNLIPRP2 , human-PNLIPRP3 , mouse-1plip , mouse-LIPR2

Title : Lipolysis of natural long chain and synthetic medium chain galactolipids by pancreatic lipase-related protein 2 - Amara_2010_Biochim.Biophys.Acta_1801_508
Author(s) : Amara S , Barouh N , Lecomte J , Lafont D , Robert S , Villeneuve P , de Caro A , Carriere F
Ref : Biochimica & Biophysica Acta , 1801 :508 , 2010
PubMedID: 20083229
Gene_locus related to this paper: human-PNLIPRP2

Title : Continuous measurement of galactolipid hydrolysis by pancreatic lipolytic enzymes using the pH-stat technique and a medium chain monogalactosyl diglyceride as substrate - Amara_2009_Biochim.Biophys.Acta_1791_983
Author(s) : Amara S , Lafont D , Fiorentino B , Boullanger P , Carriere F , de Caro A
Ref : Biochimica & Biophysica Acta , 1791 :983 , 2009
PubMedID: 19447192
Gene_locus related to this paper: cavpo-2plrp , human-PNLIPRP2

Title : Structure of human pancreatic lipase-related protein 2 with the lid in an open conformation - Eydoux_2008_Biochemistry_47_9553
Author(s) : Eydoux C , Spinelli S , Davis TL , Walker JR , Seitova A , Dhe-Paganon S , de Caro A , Cambillau C , Carriere F
Ref : Biochemistry , 47 :9553 , 2008
PubMedID: 18702514
Gene_locus related to this paper: human-PNLIPRP2

Title : Further biochemical characterization of human pancreatic lipase-related protein 2 expressed in yeast cells - Eydoux_2007_J.Lipid.Res_48_1539
Author(s) : Eydoux C , De Caro J , Ferrato F , Boullanger P , Lafont D , Laugier R , Carriere F , de Caro A
Ref : J Lipid Res , 48 :1539 , 2007
PubMedID: 17401110
Gene_locus related to this paper: human-PNLIPRP2

Title : Pancreatic lipase and pancreatic lipase-related protein 2, but not pancreatic lipase-related protein 1, hydrolyze retinyl palmitate in physiological conditions - Reboul_2006_Biochim.Biophys.Acta_1761_4
Author(s) : Reboul E , Berton A , Moussa M , Kreuzer C , Crenon I , Borel P
Ref : Biochimica & Biophysica Acta , 1761 :4 , 2006
PubMedID: 16497549
Gene_locus related to this paper: human-PNLIP , human-PNLIPRP2

Title : Human pancreatic lipase-related protein 2: tissular localization along the digestive tract and quantification in pancreatic juice using a specific ELISA - Eydoux_2006_Biochim.Biophys.Acta_1760_1497
Author(s) : Eydoux C , Aloulou A , De Caro J , Grandval P , Laugier R , Carriere F , de Caro A
Ref : Biochimica & Biophysica Acta , 1760 :1497 , 2006
PubMedID: 16887271
Gene_locus related to this paper: human-PNLIPRP2

Title : High-level expression of nonglycosylated human pancreatic lipase-related protein 2 in Pichia pastoris - Sebban-Kreuzer_2006_Protein.Expr.Purif_49_284
Author(s) : Sebban-Kreuzer C , Deprez-Beauclair P , Berton A , Crenon I
Ref : Protein Expr Purif , 49 :284 , 2006
PubMedID: 16861001
Gene_locus related to this paper: human-PNLIPRP2

Title : Human pancreatic lipase-related protein 2 is a galactolipase - Sias_2004_Biochemistry_43_10138
Author(s) : Sias B , Ferrato F , Grandval P , Lafont D , Boullanger P , de Caro A , Leboeuf B , Verger R , Carriere F
Ref : Biochemistry , 43 :10138 , 2004
PubMedID: 15287741
Gene_locus related to this paper: human-PNLIPRP2

Title : Characterization of pancreatic lipase-related protein 2 isolated from human pancreatic juice - De Caro_2004_Biochim.Biophys.Acta_1701_89
Author(s) : De Caro J , Sias B , Grandval P , Ferrato F , Halimi H , Carriere F , de Caro A
Ref : Biochimica & Biophysica Acta , 1701 :89 , 2004
PubMedID: 15450178
Gene_locus related to this paper: human-PNLIPRP2

Title : The DNA sequence and comparative analysis of human chromosome 10 - Deloukas_2004_Nature_429_375
Author(s) : Deloukas P , Earthrowl ME , Grafham DV , Rubenfield M , French L , Steward CA , Sims SK , Jones MC , Searle S , Scott C , Howe K , Hunt SE , Andrews TD , Gilbert JG , Swarbreck D , Ashurst JL , Taylor A , Battles J , Bird CP , Ainscough R , Almeida JP , Ashwell RI , Ambrose KD , Babbage AK , Bagguley CL , Bailey J , Banerjee R , Bates K , Beasley H , Bray-Allen S , Brown AJ , Brown JY , Burford DC , Burrill W , Burton J , Cahill P , Camire D , Carter NP , Chapman JC , Clark SY , Clarke G , Clee CM , Clegg S , Corby N , Coulson A , Dhami P , Dutta I , Dunn M , Faulkner L , Frankish A , Frankland JA , Garner P , Garnett J , Gribble S , Griffiths C , Grocock R , Gustafson E , Hammond S , Harley JL , Hart E , Heath PD , Ho TP , Hopkins B , Horne J , Howden PJ , Huckle E , Hynds C , Johnson C , Johnson D , Kana A , Kay M , Kimberley AM , Kershaw JK , Kokkinaki M , Laird GK , Lawlor S , Lee HM , Leongamornlert DA , Laird G , Lloyd C , Lloyd DM , Loveland J , Lovell J , Mclaren S , McLay KE , McMurray A , Mashreghi-Mohammadi M , Matthews L , Milne S , Nickerson T , Nguyen M , Overton-Larty E , Palmer SA , Pearce AV , Peck AI , Pelan S , Phillimore B , Porter K , Rice CM , Rogosin A , Ross MT , Sarafidou T , Sehra HK , Shownkeen R , Skuce CD , Smith M , Standring L , Sycamore N , Tester J , Thorpe A , Torcasso W , Tracey A , Tromans A , Tsolas J , Wall M , Walsh J , Wang H , Weinstock K , West AP , Willey DL , Whitehead SL , Wilming L , Wray PW , Young L , Chen Y , Lovering RC , Moschonas NK , Siebert R , Fechtel K , Bentley D , Durbin R , Hubbard T , Doucette-Stamm L , Beck S , Smith DR , Rogers J
Ref : Nature , 429 :375 , 2004
PubMedID: 15164054
Gene_locus related to this paper: human-LIPA , human-LIPK , human-PNLIPRP1 , human-PNLIPRP2 , human-PNLIPRP3

Title : Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity - Giller_1992_J.Biol.Chem_267_16509
Author(s) : Giller T , Buchwald P , Blum-Kaelin D , Hunziker W
Ref : Journal of Biological Chemistry , 267 :16509 , 1992
PubMedID: 1379598
Gene_locus related to this paper: human-LPL , human-PNLIPRP1 , human-PNLIPRP2