human-PNLIPRP2
Homo sapiens (Human) pancreatic lipase related protein 2 PLRP2
Comment
human-PNLIPRP2 adopt in solution an open lid conformation which creates a large cavity capable of accommodating the galactose polar head of galactolipids (Eydoux 2008). q5jyh9 (old) protein (fragment) a dead processed gene (incomplete) nothing close in the genome to complete, RP6149D17.1-001, ENSG00000189372
Relationship
Family : Pancreatic_lipase
Block : L
Position in NCBI Life Tree : Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N EMolecular evidence
No mutation
No disease
Sequence
Peptide
MLPPWTLGLL LLATVRGKEV CYGQLGCFSD EKPWAGTLQR PVKLLPWSPE DIDTRFLLYT NENPNNFQLI TGTEPDTIEA SNFQLDRKTR FIIHGFLDKA EDSWPSDMCK KMFEVEKVNC ICVDWRHGSR AMYTQAVQNI RVVGAETAFL IQALSTQLGY SLEDVHVIGH SLGAHTAAEA GRRLGGRVGR ITGLDPAGPC FQDEPEEVRL DPSDAVFVDV IHTDSSPIVP SLGFGMSQKV GHLDFFPNGG KEMPGCKKNV LSTITDIDGI WEGIGGFVSC NHLRSFEYYS SSVLNPDGFL GYPCASYDEF QESKCFPCPA EGCPKMGHYA DQFKGKTSAV EQTFFLNTGE SGNFTSWRYK VSVTLSGKEK VNGYIRIALY GSNENSKQYE IFKGSLKPDA SHTCAIDVDF NVGKIQKVKF LWNKRGINLS EPKLGASQIT VQSGEDGTEY NFCSSDTVEE NVLQSLYPC
References (19)
| Title : Interfacial adsorption and activity of pancreatic lipase-related protein 2 onto heterogeneous plant lipid model membrane - Kergomard_2023_Biochimie__ |
| Author(s) : Kergomard J , Carriere F , Paboeuf G , Chonchon L , Barouh N , Vie V , Bourlieu C |
| Ref : Biochimie , : , 2023 |
| Abstract : |
| PubMedSearch : Kergomard_2023_Biochimie__ |
| PubMedID: 37062468 |
| Gene_locus related to this paper: cavpo-2plrp , human-PNLIPRP2 |
| Title : Structure and Function of Pancreatic Lipase-Related Protein 2 and Its Relationship With Pathological States - Zhu_2021_Front.Genet_12_693538 |
| Author(s) : Zhu G , Fang Q , Zhu F , Huang D , Yang C |
| Ref : Front Genet , 12 :693538 , 2021 |
| Abstract : |
| PubMedSearch : Zhu_2021_Front.Genet_12_693538 |
| PubMedID: 34290745 |
| Gene_locus related to this paper: human-PNLIPRP2 |
| Title : The beta5-Loop and Lid Domain Contribute to the Substrate Specificity of Pancreatic Lipase-related Protein 2 (PNLIPRP2) - Xiao_2015_J.Biol.Chem_290_28847 |
| Author(s) : Xiao X , Lowe ME |
| Ref : Journal of Biological Chemistry , 290 :28847 , 2015 |
| Abstract : |
| PubMedSearch : Xiao_2015_J.Biol.Chem_290_28847 |
| PubMedID: 26494624 |
| Gene_locus related to this paper: human-PNLIP , human-PNLIPRP2 |
| Title : In vitro digestion of the self-emulsifying lipid excipient Labrasol() by gastrointestinal lipases and influence of its colloidal structure on lipolysis rate - Fernandez_2013_Pharm.Res_30_3077 |
| Author(s) : Fernandez S , Jannin V , Chevrier S , Chavant Y , Demarne F , Carriere F |
| Ref : Pharm Res , 30 :3077 , 2013 |
| Abstract : |
| PubMedSearch : Fernandez_2013_Pharm.Res_30_3077 |
| PubMedID: 23636839 |
| Gene_locus related to this paper: human-PNLIPRP2 |
| Title : Partial deletion of beta9 loop in pancreatic lipase-related protein 2 reduces enzyme activity with a larger effect on long acyl chain substrates - Dridi_2013_Biochim.Biophys.Acta_1831_1293 |
| Author(s) : Dridi K , Amara S , Bezzine S , Rodriguez JA , Carriere F , Gaussier H |
| Ref : Biochimica & Biophysica Acta , 1831 :1293 , 2013 |
| Abstract : |
| PubMedSearch : Dridi_2013_Biochim.Biophys.Acta_1831_1293 |
| PubMedID: 24046870 |
| Gene_locus related to this paper: human-PNLIPRP2 |
| Title : Analysis of the discriminative inhibition of mammalian digestive lipases by 3-phenyl substituted 1,3,4-oxadiazol-2(3H)-ones. - Point_2012_Eur.J.Med.Chem_58_452 |
| Author(s) : Point V , Pavan Kumar KV , Marc S , Delorme V , Parsiegla G , Amara S , Carriere F , Buono G , Fotiadu F , Canaan S , Leclaire J , Cavalier JF |
| Ref : Eur Journal of Medicinal Chemistry , 58 :452 , 2012 |
| Abstract : |
| PubMedSearch : Point_2012_Eur.J.Med.Chem_58_452 |
| PubMedID: 23153815 |
| Gene_locus related to this paper: canfa-1lipg , cavpo-2plrp , human-CEL , human-PNLIP , human-PNLIPRP2 , pig-1plip |
| Title : Inhibition of phospholipase A1, lipase and galactolipase activities of pancreatic lipase-related protein 2 by methyl arachidonyl fluorophosphonate (MAFP) - Amara_2012_Biochim.Biophys.Acta_1821_1379 |
| Author(s) : Amara S , Delorme V , Record M , Carriere F |
| Ref : Biochimica & Biophysica Acta , 1821 :1379 , 2012 |
| Abstract : |
| PubMedSearch : Amara_2012_Biochim.Biophys.Acta_1821_1379 |
| PubMedID: 22835523 |
| Gene_locus related to this paper: human-PNLIPRP2 |
| Title : Kinetic properties of mouse pancreatic lipase-related protein-2 suggest the mouse may not model human fat digestion - Xiao_2011_J.Lipid.Res_52_982 |
| Author(s) : Xiao X , Ross LE , Miller RA , Lowe ME |
| Ref : J Lipid Res , 52 :982 , 2011 |
| Abstract : |
| PubMedSearch : Xiao_2011_J.Lipid.Res_52_982 |
| PubMedID: 21382969 |
| Gene_locus related to this paper: human-PNLIPRP2 , human-PNLIPRP3 , mouse-1plip , mouse-LIPR2 |
| Title : Lipolysis of natural long chain and synthetic medium chain galactolipids by pancreatic lipase-related protein 2 - Amara_2010_Biochim.Biophys.Acta_1801_508 |
| Author(s) : Amara S , Barouh N , Lecomte J , Lafont D , Robert S , Villeneuve P , de Caro A , Carriere F |
| Ref : Biochimica & Biophysica Acta , 1801 :508 , 2010 |
| Abstract : |
| PubMedSearch : Amara_2010_Biochim.Biophys.Acta_1801_508 |
| PubMedID: 20083229 |
| Gene_locus related to this paper: human-PNLIPRP2 |
| Title : Continuous measurement of galactolipid hydrolysis by pancreatic lipolytic enzymes using the pH-stat technique and a medium chain monogalactosyl diglyceride as substrate - Amara_2009_Biochim.Biophys.Acta_1791_983 |
| Author(s) : Amara S , Lafont D , Fiorentino B , Boullanger P , Carriere F , de Caro A |
| Ref : Biochimica & Biophysica Acta , 1791 :983 , 2009 |
| Abstract : |
| PubMedSearch : Amara_2009_Biochim.Biophys.Acta_1791_983 |
| PubMedID: 19447192 |
| Gene_locus related to this paper: cavpo-2plrp , human-PNLIPRP2 |
| Title : Structure of human pancreatic lipase-related protein 2 with the lid in an open conformation - Eydoux_2008_Biochemistry_47_9553 |
| Author(s) : Eydoux C , Spinelli S , Davis TL , Walker JR , Seitova A , Dhe-Paganon S , de Caro A , Cambillau C , Carriere F |
| Ref : Biochemistry , 47 :9553 , 2008 |
| Abstract : |
| PubMedSearch : Eydoux_2008_Biochemistry_47_9553 |
| PubMedID: 18702514 |
| Gene_locus related to this paper: human-PNLIPRP2 |
| Title : Further biochemical characterization of human pancreatic lipase-related protein 2 expressed in yeast cells - Eydoux_2007_J.Lipid.Res_48_1539 |
| Author(s) : Eydoux C , De Caro J , Ferrato F , Boullanger P , Lafont D , Laugier R , Carriere F , de Caro A |
| Ref : J Lipid Res , 48 :1539 , 2007 |
| Abstract : |
| PubMedSearch : Eydoux_2007_J.Lipid.Res_48_1539 |
| PubMedID: 17401110 |
| Gene_locus related to this paper: human-PNLIPRP2 |
| Title : Pancreatic lipase and pancreatic lipase-related protein 2, but not pancreatic lipase-related protein 1, hydrolyze retinyl palmitate in physiological conditions - Reboul_2006_Biochim.Biophys.Acta_1761_4 |
| Author(s) : Reboul E , Berton A , Moussa M , Kreuzer C , Crenon I , Borel P |
| Ref : Biochimica & Biophysica Acta , 1761 :4 , 2006 |
| Abstract : |
| PubMedSearch : Reboul_2006_Biochim.Biophys.Acta_1761_4 |
| PubMedID: 16497549 |
| Gene_locus related to this paper: human-PNLIP , human-PNLIPRP2 |
| Title : Human pancreatic lipase-related protein 2: tissular localization along the digestive tract and quantification in pancreatic juice using a specific ELISA - Eydoux_2006_Biochim.Biophys.Acta_1760_1497 |
| Author(s) : Eydoux C , Aloulou A , De Caro J , Grandval P , Laugier R , Carriere F , de Caro A |
| Ref : Biochimica & Biophysica Acta , 1760 :1497 , 2006 |
| Abstract : |
| PubMedSearch : Eydoux_2006_Biochim.Biophys.Acta_1760_1497 |
| PubMedID: 16887271 |
| Gene_locus related to this paper: human-PNLIPRP2 |
| Title : High-level expression of nonglycosylated human pancreatic lipase-related protein 2 in Pichia pastoris - Sebban-Kreuzer_2006_Protein.Expr.Purif_49_284 |
| Author(s) : Sebban-Kreuzer C , Deprez-Beauclair P , Berton A , Crenon I |
| Ref : Protein Expr Purif , 49 :284 , 2006 |
| Abstract : |
| PubMedSearch : Sebban-Kreuzer_2006_Protein.Expr.Purif_49_284 |
| PubMedID: 16861001 |
| Gene_locus related to this paper: human-PNLIPRP2 |
| Title : Human pancreatic lipase-related protein 2 is a galactolipase - Sias_2004_Biochemistry_43_10138 |
| Author(s) : Sias B , Ferrato F , Grandval P , Lafont D , Boullanger P , de Caro A , Leboeuf B , Verger R , Carriere F |
| Ref : Biochemistry , 43 :10138 , 2004 |
| Abstract : |
| PubMedSearch : Sias_2004_Biochemistry_43_10138 |
| PubMedID: 15287741 |
| Gene_locus related to this paper: human-PNLIPRP2 |
| Title : Characterization of pancreatic lipase-related protein 2 isolated from human pancreatic juice - De Caro_2004_Biochim.Biophys.Acta_1701_89 |
| Author(s) : De Caro J , Sias B , Grandval P , Ferrato F , Halimi H , Carriere F , de Caro A |
| Ref : Biochimica & Biophysica Acta , 1701 :89 , 2004 |
| Abstract : |
| PubMedSearch : De Caro_2004_Biochim.Biophys.Acta_1701_89 |
| PubMedID: 15450178 |
| Gene_locus related to this paper: human-PNLIPRP2 |
| Title : Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity - Giller_1992_J.Biol.Chem_267_16509 |
| Author(s) : Giller T , Buchwald P , Blum-Kaelin D , Hunziker W |
| Ref : Journal of Biological Chemistry , 267 :16509 , 1992 |
| Abstract : |
| PubMedSearch : Giller_1992_J.Biol.Chem_267_16509 |
| PubMedID: 1379598 |
| Gene_locus related to this paper: human-LPL , human-PNLIPRP1 , human-PNLIPRP2 |