Phosphatidylinositol-4,5-bisphosphate
A phosphoinositide present in all eukaryotic cells, particularly in the plasma membrane.
General
Type : Phospholipid
Chemical_Nomenclature : [(2R)-3-[hydroxy-[(1R,2R,3S,4R,5R,6S)-2,3,6-trihydroxy-4,5-diphosphonooxycyclohexyl]oxyphosphoryl]oxy-2-[(Z)-octadec-9-enoyl]oxypropyl] (Z)-octadec-9-enoate
Canonical SMILES : CCCCCCCC\/C=CCCCCCCCC(=O)OC[C@H](COP(=O)(O)O[C@@H]1[C@@H]([C@@H]([C@H]([C@@H]([C@H]1O)OP(=O)(O)O)OP(=O)(O)O)O)O)OC(=O)CCCCCCC\/C=CCCCCCCCC
InChI : InChI=1S\/C45H85O19P3\/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(46)59-35-37(61-39(47)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2)36-60-67(57,58)64-43-40(48)41(49)44(62-65(51,52)53)45(42(43)50)63-66(54,55)56\/h17-20,37,40-45,48-50H,3-16,21-36H2,1-2H3,(H,57,58)(H2,51,52,53)(H2,54,55,56)\/b19-17-,20-18-\/t37-,40-,41+,42+,43-,44-,45-\/m1\/s1
InChIKey : IGQSAMXNWMLOOS-GGDMTQDZSA-N
Other name(s) : PIP2 || Phosphatidylinositol-4,5-bisphosphate || CHEBI:18348 || 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate || Phosphatidylinositol Phosphate, PtdIns(4,5)P2 || PtdIns(4,5)P2 || PIPP || PtsIns-4,5-P2 || RefChem:929165 || Phosphatidyl-myo-inositol 4,5-bisphosphate || PtdInsP2 || SCHEMBL29352241
MW : 1023.1
Formula : C45H85O19P3
CAS_number :
PubChem : 5311358\
UniChem : IGQSAMXNWMLOOS-GGDMTQDZSA-N
Target
Structures : No structure
Families : Duf_7379
References (1)
| Title : A Legionella pneumophila T4SS effector protein (Ravl) triggers mitochondrial fragmentation through phosphoinositide phosphatase activity - Zhang_2025_Int.J.Biol.Macromol_332_148613 |
| Author(s) : Zhang R , Zhang M , Li X , Lu Z , Song C , Du Y , Chesterman C , van Staalduinen L , Wang Y , Pei H , Jia Z , Zheng J |
| Ref : Int J Biol Macromol , 332 :148613 , 2025 |
| Abstract : |
| PubMedSearch : Zhang_2025_Int.J.Biol.Macromol_332_148613 |
| PubMedID: 41167367 |
| Gene_locus related to this paper: legph-RavL |