legph-RavL
Legionella pneumophila T4SS effector protein RavL
Comment
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 \/ ATCC 33152 \/ DSM 7513) || Upon ingestion by macrophages, Legionella pneumophila hijacks host membrane trafficking by decorating Legionella-containing vacuoles (LCV), thereby escaping lysosomal degradation. L. pneumophila is dependent on the T4SS effector protein RavL to recruit mitochondria or promote mitochondria association with the LCV, which induces mitochondrial fragmentation and ultimately alters mitochondrial metabolism. RavL is a phosphatidylinositol polyphosphate 5-phosphatase that specifically hydrolyzes the D5 phosphate of PtdIns(4)P
Relationship
Family : Duf_7379
Block : X
Position in NCBI Life Tree : Legionella pneumophila
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Bacteria N E > Proteobacteria N E > Gammaproteobacteria N E > Legionellales N E > Legionellaceae N E > Legionella N E > Legionella pneumophila N EMolecular evidence
Sequence
Peptide
MLKRVLNTAK AKQPISTTGI FAHTYYWLTS PAGDQSYQNP NYKNEEDNNT GTAIYFIHGT ADQPAAFKRV AERLIDTGLP DEICSLNLLA FDQRYQGKSI KFFAEQLKNK IKVNQHQRVI LMAHSRGGLV ASYFAEFLAK EASIDVPLVI TMGTPFNGSY LAVKPLSWFS DSIREMEINS EFLAQLKQEI VEHSVSAYHF FIAKEDAIVP GESGYIKDYV DKYPESLHIL DRHGHLSIMS SHRLVSHISS LLHDYIDDYQ NDTEEVKISK LGELTLIEDY YPVKSEPDSL FNP
References (1)
| Title : A Legionella pneumophila T4SS effector protein (Ravl) triggers mitochondrial fragmentation through phosphoinositide phosphatase activity - Zhang_2025_Int.J.Biol.Macromol_332_148613 |
| Author(s) : Zhang R , Zhang M , Li X , Lu Z , Song C , Du Y , Chesterman C , van Staalduinen L , Wang Y , Pei H , Jia Z , Zheng J |
| Ref : Int J Biol Macromol , 332 :148613 , 2025 |
| Abstract : |
| PubMedSearch : Zhang_2025_Int.J.Biol.Macromol_332_148613 |
| PubMedID: 41167367 |
| Gene_locus related to this paper: legph-RavL |