Radicicol
Radicicol is a macrocyclic antifungal antibiotic that inhibits signal-dependent transcriptional activation and induces differentiation in leukemia. It inhibits protein tyrosine kinase and heat shock protein 90 (Hsp90)
General
Type : Natural, Toxin, Macrolide, Polyketide, Mycotoxin-metabolite, Organochlorine
Chemical_Nomenclature : (4R,6R,8R,9Z,11E)-16-chloro-17,19-dihydroxy-4-methyl-3,7-dioxatricyclo[13.4.0.06,8]nonadeca-1(15),9,11,16,18-pentaene-2,13-dione
Canonical SMILES : C[C@@H]1C[C@@H]2[C@H](O2)\/C=CC=CC(=O)CC3=C(C(=CC(=C3Cl)O)O)C(=O)O1
InChI : InChI=1S\/C18H17ClO6\/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19\/h2-5,8-9,14-15,21-22H,6-7H2,1H3\/b4-2+,5-3-\/t9-,14-,15-\/m1\/s1
InChIKey : WYZWZEOGROVVHK-GTMNPGAYSA-N
Other name(s) : Monorden || Monorden A || (+)-Monorden A || I60EH8GECX || CHEMBL414883 || CHEBI:556075 || LSM-6548 || NS00073687 || Q7280510 || Q27167070
MW : 364.8
Formula : C18H17ClO6
CAS_number : 12772-57-5
PubChem : 6323491
UniChem : WYZWZEOGROVVHK-GTMNPGAYSA-N
Target
Structures : No structure
Families : Zearalenone-hydrolase-fam2
References (3)
| Title : Enzymatic Hydrolysis of Resorcylic Acid Lactones by an Aeromicrobium sp - Hoogstra_2024_Toxins.(Basel)_16_404 |
| Author(s) : Hoogstra SJ , Hendricks KN , McMullin DR , Renaud JB , Bora J , Sumarah MW , Garnham CP |
| Ref : Toxins (Basel) , 16 :404 , 2024 |
| Abstract : |
| PubMedSearch : Hoogstra_2024_Toxins.(Basel)_16_404 |
| PubMedID: 39330862 |
| Gene_locus related to this paper: 9actn-RALH |
| Title : Enzymatic Hydrolysis of Resorcylic Acid Lactones by an Aeromicrobium sp - Hoogstra_2024_Toxins.(Basel)_16_404 |
| Author(s) : Hoogstra SJ , Hendricks KN , McMullin DR , Renaud JB , Bora J , Sumarah MW , Garnham CP |
| Ref : Toxins (Basel) , 16 :404 , 2024 |
| Abstract : |
| PubMedSearch : Hoogstra_2024_Toxins.(Basel)_16_404 |
| PubMedID: 39330862 |
| Gene_locus related to this paper: 9actn-RALH |
| Title : Enzymatic Hydrolysis of Resorcylic Acid Lactones by an Aeromicrobium sp - Hoogstra_2024_Toxins.(Basel)_16_404 |
| Author(s) : Hoogstra SJ , Hendricks KN , McMullin DR , Renaud JB , Bora J , Sumarah MW , Garnham CP |
| Ref : Toxins (Basel) , 16 :404 , 2024 |
| Abstract : |
| PubMedSearch : Hoogstra_2024_Toxins.(Basel)_16_404 |
| PubMedID: 39330862 |
| Gene_locus related to this paper: 9actn-RALH |