1. Home
  2. Type Substrate
  3. Natural

Natural

Substrates or inhibitors found in nature. Toxins are harmful substances produced within living cells or organisms
Substrate Main targeted enzyme families Type Structure
BrefeldinA Hormone-sensitive_lipase_like Natural Antibiotic Macrocycle Toxin
Prostaglandin-D2-Glyceryl-Ester Carb_B_Chordata Prostaglandin Acyl-Glycerol Cannabinoid-Receptor-ligand Natural
Model-condensed-tannin Tannase Tannase_Bact Chromen Derivative of Gallate Natural Polyphenol
Cy3(sin)(sin)diG5G LYsophospholipase_carboxylesterase Anthocyanin Flavonoid Glycoside Natural Hydroxycinnamic-ester Sinapyl
Cy3(sin)diG5G-1 LYsophospholipase_carboxylesterase Anthocyanin Flavonoid Glycoside Natural Hydroxycinnamic-ester Sinapyl
Cy3(caf)diG5G LYsophospholipase_carboxylesterase Anthocyanin Flavonoid Glycoside Natural Hydroxycinnamic-ester
Perillyl-octanoate Canar_LipB Natural_modified Terpenoid Alkyl ester Octanoate
Verbascoside Natural Hydroxycinnamic-ester Alkaloid Glycoside
Octadecaneuropeptide S9N_PPCE_Peptidase_S9 Peptide Natural
C55-P-beta-D-Glucose 6_AlphaBeta_hydrolase Natural Carbohydrate
Capsaicin Canar_LipB Fatty acid ester Natural Not AlphaBeta Hydrolase target
Anandamide Acyl-Glycerol Natural Arachidonate Not AlphaBeta Hydrolase target
Arecoline Carb_B_Chordata Muscarinic agonist Nicotinic agonist Pyridine Natural
Methyl-protocatechuate Tannase Derivative of Gallate Benzoate Natural
Bn-MeGlcA3Xyl3 Glucuronoyl_esterase Glycoside Natural Glucuronoyl Carbohydrate
Zearalanone Zearalenone-hydrolase-fam2 Zearalenone-hydrolase Natural Toxin Macrolide Polyketide Mycotoxin-metabolite
Homocysteine-thiolactone Valacyclovir-hydrolase Carb_B_Chordata BCHE Natural Sulfur Compound Not AlphaBeta Hydrolase target Thiophen
Rhodomycin-D Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Tylosin Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Tilmicosin Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Tildipirosin Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Leucomycin-a5 Aclacinomycin-methylesterase_RdmC Macrolide Polyketide Natural Antibiotic
Adipic-acid Canar_LipB Natural Fatty acid Adipate
Hexanoic-acid CarbLipBact_2 Fungal_carboxylesterase_lipase Lipase_2 Bacterial_lip_FamI.5 Canar_LipB Natural Fatty acid
Sapienic-acid Bacterial_lip_FamI.6 Fatty acid Natural
Ochratoxin-A 6_AlphaBeta_hydrolase Natural Antibiotic Peptide Propionate Toxin Chromen
Sorbitol Natural Buffer Component
Dihydroprecondylocarpine-acetate Plant_carboxylesterase Indole Alkaloid Natural
Voacangine Hydroxynitrile_lyase Alkaloid Indole Natural
Dehydrosecodine Plant_carboxylesterase Alkaloid Indole Natural
Butyl-gallate Carboxylesterase Carb_B_Chordata Derivative of Gallate Natural
Gallotannin Tannase_Bact Tannase Derivative of Gallate Natural Polyphenol
P(3HB-co-4HB) PHA_synth_I Polyhydroxyalkanoate Natural Polymer
P(3HB-co-3HHx) PHA_synth_I PHA_synth_II Polyhydroxyalkanoate Natural Polymer Hexanoate
3-Hydroxydecanoyl-3-hydroxydecanoic-acid HAA-synthase-thioesterase-RhlA-PhaG Natural Fatty acid
3-hydroxydecanoic-acid PHA_synth_II HAA-synthase-thioesterase-RhlA-PhaG Natural Fatty acid
Sinapinic-acid Esterase_phb Tannase Lipase_3 Natural Acrylate Hydroxycinnamic-ester Sinapyl
Lecanoric-acid Thioesterase BD-FAE Natural
Orsellinate Thioesterase BD-FAE Natural
Everninic-acid Natural
Evernic-acid Natural
Tiancimycin-B Tiancimycin-TnmK-Tripeptidase-HIP Natural Antibiotic Polyketide Alkyne
PHB-Dimer 6_AlphaBeta_hydrolase Natural Polymer Polyhydroxyalkanoate
Menthol Hormone-sensitive_lipase_like Fungal_carboxylesterase_lipase Natural Flavor
Thiostrepton 6_AlphaBeta_hydrolase Natural Peptide Antibiotic Macrocycle Quinoline
Gossypol Carb_B_Arthropoda Natural Insecticide Polyphenol
P(3HO) 5_AlphaBeta_hydrolase PHAZ7_phb_depolymerase Extracel-MCL-phaZ Polyhydroxyalkanoate Polymer Natural
P(6HO) 5_AlphaBeta_hydrolase Polyhydroxyalkanoate Polymer Natural
1,3,6-Trigalloylglucose Tannase Tannase_Bact Derivative of Gallate Natural Polyphenol
Benzyl-butyl-phthalate Fungal_carboxylesterase_lipase Cutinase Phthalate Natural
Tiancimycin-H Tiancimycin-TnmK-Tripeptidase-HIP Natural Antibiotic Polyketide Alkyne
Coumarin-3-carboxylic-acid FAE-Bacterial-promiscuous Natural Coumarin Chromen
Cinnamic-acid FAE-Bacterial-promiscuous Canar_LipB Lipase_3 Natural
3-Phenylpropionic-acid Canar_LipB Natural Propionate
Ethyl-cinnamate FAE-Bacterial-promiscuous Lipase_3 Natural
Omphalotin-A S9N_PPCE_Peptidase_S9 Peptide Natural Macrolide Polyketide Antibiotic
Mycotoxin-T-2 Carb_B_Chordata Hormone-sensitive_lipase_like Natural Toxin Mycotoxin-metabolite Epoxide
Skyllamycin-A Thioesterase Peptide Natural Macrolide Polyketide Antibiotic Azabicyclo
Skyllamycin-like-precursor Thioesterase Peptide Natural Polyketide Macrolide Antibiotic
6-Tuliposide-B Plant_carboxylesterase Natural Carbohydrate
6-Tuliposide-A Plant_carboxylesterase Natural Carbohydrate
MeGlcA2 Glucuronoyl_esterase Natural Glucuronoyl Carbohydrate
MeGlcA Glucuronoyl_esterase Natural Glucuronoyl Carbohydrate
Pimaricin Thioesterase Natural Macrolide Polyketide Antibiotic
Rosmarinic-acid Hormone-sensitive_lipase_like Natural Hydroxycinnamic-ester
delta-octalactone Lactone Natural
delta-hexadecalactone Canar_LipB Lactone Natural Pheromone Hexadecanoate Palmitate
Caffeoylshikimate Monoglyceridelipase_lysophospholip Natural
Mycophenolic-acid-CoA MpaH CoA Natural Benzofuran Aminopurin Purine
Retinol-palmitate Pancreatic_lipase Carb_B_Chordata Fungal_carboxylesterase_lipase Cholesterol_esterase Acidic_Lipase Natural Retinol ester Hexadecanoate Palmitate
Retinol-oleate Pancreatic_lipase Cholesterol_esterase Retinol ester Natural Oleate
Retinol-acetate Retinol ester Natural Acetate
ORFZ-Substrate Duf_1100-S Mycotoxin-metabolite Natural Toxin
PyiE-Substrate Duf_1100-S Mycotoxin-metabolite Natural Toxin
CurDD BCHE CMBL Carb_B_Chordata Drug Pro-Drug Natural_modified
Rifampicin Arylacetamide_deacetylase Drug Not AlphaBeta Hydrolase target Acetate Natural Antibiotic
Epicatechin-gallate AlphaBeta_hydrolase Plant_carboxylesterase Derivative of Gallate Natural Polyphenol Benzoate Chromen
Epigallocatechin-gallate AlphaBeta_hydrolase Plant_carboxylesterase Tannase_Bact Derivative of Gallate Benzoate Natural Polyphenol
Pentagalloylglucose Plant_carboxylesterase Derivative of Gallate Natural Polyphenol
DHDMP MpaH Natural Benzofuran
15-Hete-G Acyl-Glycerol Cannabinoid-Receptor-ligand Natural
PGE2-glyceryl-ester Monoglyceridelipase_lysophospholip ABHD6-Lip ABHD12-PHARC Carb_B_Chordata Prostaglandin Acyl-Glycerol Cannabinoid-Receptor-ligand Natural
1,5-Seco-vibralactone Hormone-sensitive_lipase_like Natural Lactone
Chlorogenic-acid Fungal_carboxylesterase_lipase AlphaBeta_hydrolase Tannase FaeC Hormone-sensitive_lipase_like Plant_carboxylesterase Monoglyceridelipase_lysophospholip Natural Antioxidant Hydroxycinnamic-ester
Propyl-gallate Plant_carboxylesterase Derivative of Gallate Natural Polyphenol Benzoate
Beta-Glucogallin Plant_carboxylesterase Tannase_Bact Derivative of Gallate Natural Polyphenol Benzoate
N-acetylserotonin Arylacetamide_deacetylase Derivative of Tryptamine Indole Not AlphaBeta Hydrolase target Natural
Z-3-Hexenyl-acetate Plant_carboxylesterase Carb_B_Arthropoda Acetate Plant volatile Natural Odorant Flavor
E-2-hexenyl-acetate Plant_carboxylesterase Carb_B_Arthropoda Acetate Plant volatile Natural Flavor
2-Heptylquinolin-4(1H)-one HOD-cofactorfree-dioxygenase Quinoline Natural
2-Heptyl-3-hydroxy-4-quinolone HOD-cofactorfree-dioxygenase Quinoline Natural
Methyl-farnesoate Juvenile_hormone_esterase Carb_B_Arthropoda Natural
2-Monoolein abh_upf0017 Natural Acyl-Glycerol
1-Oleoyl-2-arachidonoyl-sn-glycerol Lipase_3 Natural Acyl-Glycerol
1-Stearoyl-2-arachidonoylglycerol Lipase_3 Natural Acyl-Glycerol
O-palmitoleoyl-L-serine Pectinacetylesterase-Notum Natural Acyl peptide
Radicicol Zearalenone-hydrolase-fam2 Natural Toxin Macrolide Polyketide Mycotoxin-metabolite
Zearalenone Carbon-carbon_bond_hydrolase Zearalenone-hydrolase Zearalenone-hydrolase-fam2 6_AlphaBeta_hydrolase Natural Toxin Macrolide Polyketide Mycotoxin-metabolite
N-acetylanthranilate Hormone-sensitive_lipase_like HOD-cofactorfree-dioxygenase Natural Benzoate
DSHA Carbon-carbon_bond_hydrolase Natural Inden
Gibberellin-A3 Plant_carboxylesterase Natural Plant hormone
Gibberellin-A4 Plant_carboxylesterase Natural Plant hormone
Hepoxilin-A3 Epoxide_hydrolase Natural Epoxide Fatty acid
Hepoxilin-B3 Epoxide_hydrolase Natural Epoxide Fatty acid
Beta-zearalenol Zearalenone-hydrolase Mycotoxin-metabolite Polyketide Macrolide Natural Toxin
Alpha-zearalenol Zearalenone-hydrolase Mycotoxin-metabolite Polyketide Macrolide Natural Toxin
3-hydroxyoctanoate Hydroxynitrile_lyase Fatty acid Natural
3-Oxoheptanoic-acid Hydroxynitrile_lyase Natural Fatty acid
Undecanoic-acid ABHD6-Lip Natural Fatty acid
Stearic-acid Natural Fatty acid
Myristic-acid Pectinacetylesterase-Notum Natural Fatty acid Tetradecanoate
Alpha-amanitin-proprotein S9N_PPCE_Peptidase_S9 Natural Toxin Macrocycle Peptide
Polyneuridine-aldehyde Hydroxynitrile_lyase Alkaloid Natural
Suberin Cutinase Polymer Natural
Cutin Cutinase Acetylxylan_esterase Polyesterase-lipase-cutinase Polymer Natural
7-Aminocephalosporanic-acid Acetyl-esterase_deacetylase BD-FAE Natural Antibiotic Azabicyclo
Methyl-salicylate Hydroxynitrile_lyase 6_AlphaBeta_hydrolase Plant hormone Natural Aryl ester Salicylic Benzoate
Karrikin-4 RsbQ-like Plant hormone Karrikin Butenolide Natural Strigolactone receptors ligand
Karrikin-3 RsbQ-like Plant hormone Karrikin Butenolide Natural Strigolactone receptors ligand
Karrikin-2 RsbQ-like Plant hormone Karrikin Butenolide desmethyl Strigolactone receptors ligand Strigolactone receptors ligand Natural
Karrikin-1 RsbQ-like Plant hormone Karrikin Butenolide Natural Strigolactone receptors ligand
5-Deoxystrigol RsbQ-like Plant_carboxylesterase Plant hormone Strigolactone Strigolactone receptors ligand Natural Inden
Orobanchol RsbQ-like Plant_carboxylesterase Plant hormone Strigolactone Strigolactone receptors ligand Natural
4-Deoxyorobanchol RsbQ-like Plant hormone Strigolactone Strigolactone receptors ligand Natural Inden
Sorgolactone RsbQ-like Plant hormone Strigolactone Strigolactone receptors ligand Natural Inden
Strigol RsbQ-like Plant hormone Strigolactone Strigolactone receptors ligand Natural Inden
SCHEMBL4804016 Plant_carboxylesterase Natural Flavonoid Chromen
Cephalosporin-C Homoserine_transacetylase Acetyl-esterase_deacetylase BD-FAE Natural Antibiotic Azabicyclo
PHB Esterase_phb Esterase_phb_PHAZ PHAZ7_phb_depolymerase PolyAspartate-hydrolase PHB_depolymerase_PhaZ PHA_synth_I OHBut_olig_hydro_put Natural Polymer Polyhydroxyalkanoate
PHBV Esterase_phb Bacterial_lip_FamI.5 Extracel-MCL-phaZ Natural Polymer Polyhydroxyalkanoate
Arbutin Lipase_3 Natural Antioxidant
Cholesterol PC-sterol_acyltransferase Bacterial_lip_FamI.6 Natural Steroid Phenanthrene
Coelenterazine Haloalkane_dehalogenase-HLD2 Luciferin Natural
Fumonisin-B1 Carb_B_Bacteria Mycotoxin-metabolite Natural Toxin
Deacetylcephalosporin-C Homoserine_transacetylase Natural Antibiotic Azabicyclo
Pheophytin-a Pheophytinase Chlorophyllase_Plant Chlorophyllase Natural Chlorophyll-like
PAF PAF-Acetylhydrolase LYsophospholipase_carboxylesterase Natural Trimethylammonium Water-insoluble medium and long chain ester Choline ester Not AlphaBeta Hydrolase target Phosphatidylcholine
Aclarubicin Aclacinomycin-methylesterase_RdmC Antibiotic Natural Polyketide
Aclacinomycin Aclacinomycin-methylesterase_RdmC Antibiotic Natural Polyketide
2-Arachidonylglycerol Monoglyceridelipase_lysophospholip ABHD6-Lip Carb_B_Chordata ABHD12-PHARC abh_upf0017 Acyl-Glycerol Cannabinoid-Receptor-ligand Natural Arachidonate
Methyl-Gallate Tannase Plant_carboxylesterase Tannase_Bact Derivative of Gallate Benzoate Natural
Bacteriochlorophyll-a Chlorophyllase_Plant Chlorophyllase Natural Chlorophyll-like
Chlorophyll-a Chlorophyllase_Plant Chlorophyllase Pheophytinase Natural Chlorophyll-like
Memogain Carb_B_Chordata Derivative of Galanthamine Alkaloid Natural_modified Benzoate Benzazepin Azepane
Atropine BCHE AlphaBeta_hydrolase Not AlphaBeta Hydrolase target Muscarinic antagonist Drug Alkaloid Natural Azabicyclo Propionate
Juvenile-hormone-II Epoxide_hydrolase Natural Lactone Epoxide
Juvenile-hormone-III Epoxide_hydrolase Juvenile_hormone_esterase Natural Lactone Epoxide
Octylacetate Carb_B_Arthropoda Acetate Alkyl ester Plant volatile Natural
Hexylacetate Carb_B_Arthropoda Acetate Alkyl ester Plant volatile Natural
isoamyl-butyrate Polyesterase-lipase-cutinase Lipase_3 Acetate Flavor Natural Pheromone
3-methyl-butylacetate ACHE Canar_LipB Polyesterase-lipase-cutinase Acetate Flavor Natural
Acetylcholine ACHE BCHE Cholinesterase Cholinesterase-like Acetate Trimethylammonium Natural Choline ester Nicotinic agonist Muscarinic agonist
Cocaine BCHE Carb_B_Chordata Cocaine_esterase Natural Drug Alkaloid Benzoate Azabicyclo
Methyl-cinnamate FaeC Lipase_3 Tannase Esterase_phb Natural Hydroxycinnamic-ester Aryl ester
Menthylacetate Hormone-sensitive_lipase_like Carb_B_Bacteria Aryl ester Acetate Flavor Natural Terpenoid
6-monoacetylmorphine BCHE Natural Drug Isoquinoline Alkaloid
Heroin BCHE Carb_B_Chordata Natural Drug Isoquinoline Alkaloid
Oleoyl-CoA Carboxylesterase Carb_B_Chordata Natural CoA Aminopurin Purine
4-Acetoxyphenol Hormone-sensitive_lipase_like Aryl ester Natural
3-Methyl-3-butenyl-acetate Natural Acetate
Geranyl-acetate Canar_LipB Carb_B_Arthropoda Alkenyl ester Acetate Natural Plant volatile