Candesartan-cilexetil
General
Type : Not A\/B H target || Drug || Pro-Drug || Pyrrolidine || Angiotensin-receptor blocker
Chemical_Nomenclature : 1-cyclohexyloxycarbonyloxyethyl 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
Canonical SMILES : CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)OC(C)OC(=O)OC6CCCCC6
InChI : InChI=1S\/C33H34N6O6\/c1-3-42-32-34-28-15-9-14-27(31(40)43-21(2)44-33(41)45-24-10-5-4-6-11-24)29(28)39(32)20-22-16-18-23(19-17-22)25-12-7-8-13-26(25)30-35-37-38-36-30\/h7-9,12-19,21,24H,3-6,10-11,20H2,1-2H3,(H,35,36,37,38)
InChIKey : GHOSNRCGJFBJIB-UHFFFAOYSA-N
Other name(s) : Candesartan cilexetil, Atacand, TCV-116, Blopress, CC, CHEMBL1014, CHEBI:3348
Target
Families : Carb_B_Chordata
References (3)
| Title : Physiologically based pharmacokinetic modeling of candesartan to predict the exposure in hepatic and renal impairment and elderly populations - Guo_2023_Ther.Adv.Drug.Saf_14_20420986231220222 |
| Author(s) : Guo L , Zhu X , Zhang L , Xu Y |
| Ref : Ther Adv Drug Safety , 14 :20420986231220222 , 2023 |
| Abstract : Guo_2023_Ther.Adv.Drug.Saf_14_20420986231220222 |
| ESTHER : Guo_2023_Ther.Adv.Drug.Saf_14_20420986231220222 |
| PubMedSearch : Guo_2023_Ther.Adv.Drug.Saf_14_20420986231220222 |
| PubMedID: 38157240 |
| Title : Hepatic, intestinal, renal, and plasma hydrolysis of prodrugs in human, cynomolgus monkey, dog, and rat: implications for in vitro-in vivo extrapolation of clearance of prodrugs - Nishimuta_2014_Drug.Metab.Dispos_42_1522 |
| Author(s) : Nishimuta H , Houston JB , Galetin A |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 42 :1522 , 2014 |
| Abstract : Nishimuta_2014_Drug.Metab.Dispos_42_1522 |
| ESTHER : Nishimuta_2014_Drug.Metab.Dispos_42_1522 |
| PubMedSearch : Nishimuta_2014_Drug.Metab.Dispos_42_1522 |
| PubMedID: 24994071 |
| Title : Different hydrolases involved in bioactivation of prodrug-type Angiotensin receptor blockers: carboxymethylenebutenolidase and carboxylesterase 1 - Ishizuka_2013_Drug.Metab.Dispos_41_1888 |
| Author(s) : Ishizuka T , Yoshigae Y , Murayama N , Izumi T |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 41 :1888 , 2013 |
| Abstract : Ishizuka_2013_Drug.Metab.Dispos_41_1888 |
| ESTHER : Ishizuka_2013_Drug.Metab.Dispos_41_1888 |
| PubMedSearch : Ishizuka_2013_Drug.Metab.Dispos_41_1888 |
| PubMedID: 23946449 |