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Substrate Report for: Hepoxilin-B3

Hepoxilins are lipid signaling molecules derived from arachidonic acid through the 12-lipoxygenase pathway. Hepoxilins play a role in inflammation, neurotransmission, and formation of skin barrier function. Mammalian hepoxilin hydrolase degrade hepoxilins to trioxilins


General
Type Natural, Epoxide
Chemical_Nomenclature (5E,8E)-10-hydroxy-10-[3-[(E)-oct-2-enyl]oxiran-2-yl]deca-5,8-dienoic acid
Canonical SMILES CCCCCC=CCC1C(O1)C(C=CCC=CCCCC(=O)O)O
InChI InChI=1S/C20H32O4/c1-2-3-4-5-9-12-15-18-20(24-18)17(21)14-11-8-6-7-10-13-16-19(22)23/h6-7,9,11-12,14,17-18,20-21H,2-5,8,10,13,15-16H2,1H3,(H,22,23)/b7-6+,12-9+,14-11+
InChIKey DWNBPRRXEVJMPO-MRJKEZKPSA-N DWNBPRRXEVJMPO-RZBQNFRCSA-N DWNBPRRXEVJMPO-RNGYDEEPSA-N
Other name(s) trans-epoxy hydroxy eicosanoids hepoxilin A3 ; Epheta ; Hepoxilin B ; Hepoxilin B3 ; Threo-hepoxilin B3 ; Erythro-Hepoxilin B3 ; (5E,8Z)-10-hydroxy-10-[(3S)-3-[(Z)-oct-2-enyl]oxiran-2-yl]deca-5,8-dienoic acid ; 10-hydroxy-11S,12S-epoxy-5Z,8Z,14Z-eicosatrienoic acid ; BML1-C11 ; SCHEMBL3021812 ; CHEBI:34784 ; 71799-95-6
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MW|336.47
Formula|C20H32O4
CAS_number|71799-95-6
PubChem|5353667, 131770447, 16759353
UniChem|DWNBPRRXEVJMPO-MRJKEZKPSA-N, DWNBPRRXEVJMPO-RZBQNFRCSA-N, DWNBPRRXEVJMPO-RNGYDEEPSA-N
IUPHAR|
Wikipedia|

Target
Families | Hepoxilin-B3 ligand of proteins in family: Epoxide_hydrolase
Protein | human-EPHX2

References:
Search PubMed for references concerning: Hepoxilin-B3
    Title: Hepoxilin B3 and its enzymatically formed derivative trioxilin B3 are incorporated into phospholipids in psoriatic lesions
    Anton R, Camacho M, Puig L, Vila L
    Ref: Journal of Investigative Dermatology, 118:139, 2002 : PubMed