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Amitriptyline

Antidepressant with preference for norepinephrine transporter, but also block serotonin reuptake; high affinity in vitro for histamine H1 and muscarinic receptors C20H23N 50-48-6, 277.41 || Amitriptyline hydrochloride [549-18-8] C20H24ClN MW 313.9 Elavil

General

Type : Not A\/B H target,Muscarinic antagonist

Chemical_Nomenclature : 3-(10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride

Canonical SMILES : CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31.Cl

InChI : InChI=1S\/C20H23N.ClH\/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20\;\/h3-6,8-12H,7,13-15H2,1-2H3\;1H

InChIKey : KFYRPLNVJVHZGT-UHFFFAOYSA-N

Other name(s) : Emitrip,Endep,Enovil,Elavil hydrochloride,Amitid,Amitril,Deprex,Domical,Euplit,Lentizol,Miketorin,Saroten,Sylvemid,Tryptizol,Theda-T,Adepril,Amineurin,Laroxyl,Redomex,Sarotex,Tryptanol,Triptizol

MW : 277.4

Formula : C20H23N.HCl

CAS_number : 549-18-8

PubChem : 11065

UniChem : KFYRPLNVJVHZGT-UHFFFAOYSA-N

Wikipedia : Amitriptyline

Target

Families : Amitriptyline ligand of proteins in family
BCHE

References (6)

Title : In vitro effect of central nervous system active drugs on the ATPase- ADPase activity and acetylcholinesterase activity from cerebral cortex of adult rats - Barcellos_1998_Gen.Pharmacol_31_563
Author(s) : Barcellos CK , Schetinger MR , Dias RD , Sarkis JJ
Ref : General Pharmacology , 31 :563 , 1998
Abstract : Barcellos_1998_Gen.Pharmacol_31_563
ESTHER : Barcellos_1998_Gen.Pharmacol_31_563
PubMedSearch : Barcellos_1998_Gen.Pharmacol_31_563
PubMedID: 9792215

Title : Amitriptyline: a potent inhibitor of butyrylcholinesterase from human serum - Cokugras_1997_Gen.Pharmacol_29_835
Author(s) : Cokugras AN , Tezcan EF
Ref : General Pharmacology , 29 :835 , 1997
Abstract : Cokugras_1997_Gen.Pharmacol_29_835
ESTHER : Cokugras_1997_Gen.Pharmacol_29_835
PubMedSearch : Cokugras_1997_Gen.Pharmacol_29_835
PubMedID: 9347335

Title : Prevention of amitriptyline-induced avoidance impairment by tacrine in mice - Pavone_1997_Behav.Brain.Res_89_229
Author(s) : Pavone F , Battaglia M , Sansone M
Ref : Behavioural Brain Research , 89 :229 , 1997
Abstract : Pavone_1997_Behav.Brain.Res_89_229
ESTHER : Pavone_1997_Behav.Brain.Res_89_229
PubMedSearch : Pavone_1997_Behav.Brain.Res_89_229
PubMedID: 9475630

Title : [The toxicological characteristics of the interaction of cholinolytics with aminostigmine--a new reversible cholinesterase inhibitor]. [Russian] - Prozorovskii_1995_Eksp.Klin.Farmakol_58_57
Author(s) : Prozorovskii VB , Sazonova AV
Ref : Eksperimentalnaia i Klinicheskaia Farmakologiia , 58 :57 , 1995
Abstract : Prozorovskii_1995_Eksp.Klin.Farmakol_58_57
ESTHER : Prozorovskii_1995_Eksp.Klin.Farmakol_58_57
PubMedSearch : Prozorovskii_1995_Eksp.Klin.Farmakol_58_57
PubMedID: 8704593

Title : Effect of YM796, a novel muscarinic agonist, on the impairment of passive avoidance response in senescence-accelerated mice - Suzuki_1995_Pharmacol.Biochem.Behav_51_623
Author(s) : Suzuki M , Yamaguchi T , Ozawa Y , Iwai A , Yamamoto M
Ref : Pharmacology, Biochemistry & Behavior , 51 :623 , 1995
Abstract : Suzuki_1995_Pharmacol.Biochem.Behav_51_623
ESTHER : Suzuki_1995_Pharmacol.Biochem.Behav_51_623
PubMedSearch : Suzuki_1995_Pharmacol.Biochem.Behav_51_623
PubMedID: 7675834

Title : Comparative effects of chronic administration of some psychotropic drugs on rat brain cortex acetylcholinesterase activity - Bekpinar_1994_Prog.Neuropsychopharmacol.Biol.Psychiatry_18_555
Author(s) : Bekpinar S , Oner P , Eryurek FG
Ref : Prog Neuropsychopharmacol Biological Psychiatry , 18 :555 , 1994
Abstract : Bekpinar_1994_Prog.Neuropsychopharmacol.Biol.Psychiatry_18_555
ESTHER : Bekpinar_1994_Prog.Neuropsychopharmacol.Biol.Psychiatry_18_555
PubMedSearch : Bekpinar_1994_Prog.Neuropsychopharmacol.Biol.Psychiatry_18_555
PubMedID: 8078989 
Array
(
    [id] => 4704
    [inhibitor] => Amitriptyline
    [type] => Array
        (
            [0] => Not A\/B H target
            [1] => Muscarinic antagonist
        )

    [other_name] => Array
        (
            [0] => Emitrip
            [1] => Endep
            [2] => Enovil
            [3] => Elavil hydrochloride
            [4] => Amitid
            [5] => Amitril
            [6] => Deprex
            [7] => Domical
            [8] => Euplit
            [9] => Lentizol
            [10] => Miketorin
            [11] => Saroten
            [12] => Sylvemid
            [13] => Tryptizol
            [14] => Theda-T
            [15] => Adepril
            [16] => Amineurin
            [17] => Laroxyl
            [18] => Redomex
            [19] => Sarotex
            [20] => Tryptanol
            [21] => Triptizol
        )

    [chemical_nomenclature] => 3-(10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride
    [formula] => C20H23N.HCl
    [cas_number] => 549-18-8
    [mw] => 277.4
    [pick_me_to_call] => display_script
    [kinetic_parameter] => 
    [paper] => Bekpinar_1994_Prog.Neuropsychopharmacol.Biol.Psychiatry_18_555 || Cokugras_1997_Gen.Pharmacol_29_835 || Pavone_1997_Behav.Brain.Res_89_229 || Prozorovskii_1995_Eksp.Klin.Farmakol_58_57 || Suzuki_1995_Pharmacol.Biochem.Behav_51_623 || Barcellos_1998_Gen.Pharmacol_31_563
    [comment] => Antidepressant with preference for norepinephrine transporter, but also block serotonin reuptake\; high affinity in vitro for histamine H1 and muscarinic receptors C20H23N 50-48-6, 277.41 || Amitriptyline hydrochloride  [549-18-8] C20H24ClN  MW 313.9 Elavil
    [gene_locus] => 
    [kin_inhibitor] => 
    [cid] => 11065
    [family] => BCHE
    [inchikey] => KFYRPLNVJVHZGT-UHFFFAOYSA-N
    [canonicalsmiles] => CN(C)CCC=C1C2=CC=CC=C2CCC3=CC=CC=C31.Cl
    [inchi] => InChI=1S\/C20H23N.ClH\/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20\;\/h3-6,8-12H,7,13-15H2,1-2H3\;1H
    [wikipedia] => Amitriptyline
    [iupharlig] => 
    [structure] => 
    [substrate] => 
    [interact_gene_locus] => 
    [mutation] => 
    [comment2] => 
    [extoxnet] => 
    [news] => 
    [theoretical_model] => 
)