BemPPOX
General
Type : Oxadiazol,Phenoxyphenyl
Chemical_Nomenclature : 3-(3-phenoxyphenyl)-5-(2-phenylmethoxyethoxy)-1,3,4-oxadiazol-2-one
Canonical SMILES : C1=CC=C(C=C1)COCCOC2=NN(C(=O)O2)C3=CC(=CC=C3)OC4=CC=CC=C4
InChI : InChI=1S\/C23H20N2O5\/c26-23-25(19-10-7-13-21(16-19)29-20-11-5-2-6-12-20)24-22(30-23)28-15-14-27-17-18-8-3-1-4-9-18\/h1-13,16H,14-15,17H2
InChIKey : MNELGUVPZVFXCB-UHFFFAOYSA-N
Other name(s) : 5-(2-(Benzyloxy)ethoxy)-3-(3-PhenoxyPhenyl)-1,3,4-Oxadiazol-2(3H)-one,CHEMBL4756536,AKOS040747939
MW : 404.4
Formula : C23H20N2O5
CAS_number : 1998101-23-7
PubChem : 132838385
UniChem : MNELGUVPZVFXCB-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
Families : BemPPOX ligand of proteins in family: Acidic_Lipase
Stucture :
Protein : canfa-1lipg || human-LIPF
References (3)
| Title : Dissecting the antibacterial activity of oxadiazolone-core derivatives against Mycobacterium abscessus - Madani_2020_PLoS.One_15_e0238178 |
| Author(s) : Madani A , Mallick I , Guy A , Crauste C , Durand T , Fourquet P , Audebert S , Camoin L , Canaan S , Cavalier JF |
| Ref : PLoS ONE , 15 :e0238178 , 2020 |
| Abstract : Madani_2020_PLoS.One_15_e0238178 |
| ESTHER : Madani_2020_PLoS.One_15_e0238178 |
| PubMedSearch : Madani_2020_PLoS.One_15_e0238178 |
| PubMedID: 32946441 |
| Title : Slowing down fat digestion and absorption by an oxadiazolone inhibitor targeting selectively gastric lipolysis - Point_2016_Eur.J.Med.Chem_123_834 |
| Author(s) : Point V , Benarouche A , Zarrillo J , Guy A , Magnez R , Fonseca L , Raux B , Leclaire J , Buono G , Fotiadu F , Durand T , Carriere F , Vaysse C , Couedelo L , Cavalier JF |
| Ref : Eur Journal of Medicinal Chemistry , 123 :834 , 2016 |
| Abstract : Point_2016_Eur.J.Med.Chem_123_834 |
| ESTHER : Point_2016_Eur.J.Med.Chem_123_834 |
| PubMedSearch : Point_2016_Eur.J.Med.Chem_123_834 |
| PubMedID: 27543878 |
| Gene_locus related to this paper: canfa-1lipg , human-LIPF |
| Title : Effect of preduodenal lipase inhibition in suckling rats on dietary octanoic acid (C8:0) gastric absorption and plasma octanoylated ghrelin concentration - Lemarie_2016_Biochim.Biophys.Acta_1861_1111 |
| Author(s) : Lemarie F , Cavalier JF , Garcia C , Boissel F , Point V , Catheline D , Legrand P , Carriere F , Rioux V |
| Ref : Biochimica & Biophysica Acta , 1861 :1111 , 2016 |
| Abstract : Lemarie_2016_Biochim.Biophys.Acta_1861_1111 |
| ESTHER : Lemarie_2016_Biochim.Biophys.Acta_1861_1111 |
| PubMedSearch : Lemarie_2016_Biochim.Biophys.Acta_1861_1111 |
| PubMedID: 27317984 |