human-LIPF

Homo sapiens (Human) human gastric lipase

Comment

Gastric lipase, which is stable and active despite the highly acidic stomach environment, plays an important role in the digestion of dietary triglycerides in the gastrointestinal tract, especially in patients suffering from pancreatic lipase deficiencies. The enzyme is secreted by the fundic mucosa of the stomach and hydrolyzes the ester bonds of triglycerides while cholesteryl esters are not attacked

Relationship

Family : Acidic_Lipase

Block : X

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

No mutation

No kinetic

No disease

No substrate

Database

Sequence

Peptide

MWLLLTMASL ISVLGTTHGL FGKLHPGSPE VTMNISQMIT YWGYPNEEYE VVTEDGYILE VNRIPYGKKN SGNTGQRPVV FLQHGLLASA TNWISNLPNN SLAFILADAG YDVWLGNSRG NTWARRNLYY SPDSVEFWAF SFDEMAKYDL PATIDFIVKK TGQKQLHYVG HSQGTTIGFI AFSTNPSLAK RIKTFYALAP VATVKYTKSL INKLRFVPQS LFKFIFGDKI FYPHNFFDQF LATEVCSREM LNLLCSNALF IICGFDSKNF NTSRLDVYLS HNPAGTSVQN MFHWTQAVKS GKFQAYDWGS PVQNRMHYDQ SQPPYYNVTA MNVPIAVWNG GKDLLADPQD VGLLLPKLPN LIYHKEIPFY NHLDFIWAMD APQEVYNDIV SMISEDKK

References (16)

Title : Identification of a new natural gastric lipase inhibitor from star anise - Kamoun_2019_Food.Funct_10_469
Author(s) : Kamoun J , Rahier R , Sellami M , Koubaa I , Mansuelle P , Lebrun R , Berlioz-Barbier A , Fiore M , Alvarez K , Abousalham A , Carriere F , Aloulou A
Ref : Food Funct , 10 :469 , 2019
PubMedID: 30632597
Gene_locus related to this paper: human-LIPF

Title : Constitutive expression of human gastric lipase in Pichia pastoris and site-directed mutagenesis of key lid-stabilizing residues - Sams_2017_Biochim.Biophys.Acta_1862_1025
Author(s) : Sams L , Amara S , Chakroun A , Coudre S , Paume J , Giallo J , Carriere F
Ref : Biochimica & Biophysica Acta , 1862 :1025 , 2017
PubMedID: 28694218
Gene_locus related to this paper: human-LIPF

Title : Slowing down fat digestion and absorption by an oxadiazolone inhibitor targeting selectively gastric lipolysis - Point_2016_Eur.J.Med.Chem_123_834
Author(s) : Point V , Benarouche A , Zarrillo J , Guy A , Magnez R , Fonseca L , Raux B , Leclaire J , Buono G , Fotiadu F , Durand T , Carriere F , Vaysse C , Couedelo L , Cavalier JF
Ref : Eur Journal of Medicinal Chemistry , 123 :834 , 2016
PubMedID: 27543878
Gene_locus related to this paper: canfa-1lipg , human-LIPF

Title : Decreased LIPF expression is correlated with DGKA and predicts poor outcome of gastric cancer - Kong_2016_Oncol.Rep_36_1852
Author(s) : Kong Y , Zheng Y , Jia Y , Li P , Wang Y
Ref : Oncol Rep , 36 :1852 , 2016
PubMedID: 27498782
Gene_locus related to this paper: human-LIPF

Title : Expression of active recombinant human gastric lipase in Nicotiana benthamiana using the CPMV-HT transient expression system - Vardakou_2012_Protein.Expr.Purif_81_69
Author(s) : Vardakou M , Sainsbury F , Rigby N , Mulholland F , Lomonossoff GP
Ref : Protein Expr Purif , 81 :69 , 2012
PubMedID: 21945702
Gene_locus related to this paper: human-LIPF

Title : Comparative studies of mammalian acid lipases: Evidence for a new gene family in mouse and rat (Lipo) - Holmes_2010_Comp.Biochem.Physiol.Part.D.Genomics.Proteomics_5_217
Author(s) : Holmes RS , Cox LA , Vandeberg JL
Ref : Comparative Biochemistry & Physiology Part D Genomics Proteomics , 5 :217 , 2010
PubMedID: 20598663
Gene_locus related to this paper: human-LIPF , human-LIPJ , human-LIPK , human-LIPM , human-LIPN , mouse-LIPK

Title : Importance of the lid and cap domains for the catalytic activity of gastric lipases - Miled_2003_Comp.Biochem.Physiol.B.Biochem.Mol.Biol_136_131
Author(s) : Miled N , Bussetta C , de Caro A , Riviere M , Berti L , Canaan S
Ref : Comparative Biochemistry & Physiology B Biochem Mol Biol , 136 :131 , 2003
PubMedID: 12941646
Gene_locus related to this paper: human-LIPF

Title : Mechanisms of inhibition of triacylglycerol hydrolysis by human gastric lipase - Pafumi_2002_J.Biol.Chem_277_28070
Author(s) : Pafumi Y , Lairon D , de la Porte PL , Juhel C , Storch J , Hamosh M , Armand M
Ref : Journal of Biological Chemistry , 277 :28070 , 2002
PubMedID: 11940604
Gene_locus related to this paper: human-LIPF

Title : Gastric lipase: crystal structure and activity - Canaan_1999_Biochim.Biophys.Acta_1441_197
Author(s) : Canaan S , Roussel A , Verger R , Cambillau C
Ref : Biochimica & Biophysica Acta , 1441 :197 , 1999
PubMedID: 10570247
Gene_locus related to this paper: human-LIPF

Title : Crystal structure of human gastric lipase and model of lysosomal acid lipase, two lipolytic enzymes of medical interest - Roussel_1999_J.Biol.Chem_274_16995
Author(s) : Roussel A , Canaan S , Egloff MP , Riviere M , Dupuis L , Verger R , Cambillau C
Ref : Journal of Biological Chemistry , 274 :16995 , 1999
PubMedID: 10358049
Gene_locus related to this paper: human-LIPF

Title : Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library - Suzuki_1997_Gene_200_149
Author(s) : Suzuki Y , Yoshitomo-Nakagawa K , Maruyama K , Suyama A , Sugano S
Ref : Gene , 200 :149 , 1997
PubMedID: 9373149
Gene_locus related to this paper: human-ACOT2 , human-LIPF , human-LPL , human-PLA1A , human-PLA2G15

Title : The acid lipase gene family: three enzymes, one highly conserved gene structure - Lohse_1997_J.Lipid.Res_38_880
Author(s) : Lohse P , Chahrokh-Zadeh S , Seidel D
Ref : J Lipid Res , 38 :880 , 1997
PubMedID: 9186906
Gene_locus related to this paper: human-LIPF

Title : Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides - Maruyama_1994_Gene_138_171
Author(s) : Maruyama K , Sugano S
Ref : Gene , 138 :171 , 1994
PubMedID: 8125298
Gene_locus related to this paper: human-ACOT2 , human-LIPF , human-LPL , human-PLA1A , human-PLA2G15

Title : Inactivation of gastric and pancreatic lipases by diethyl p-nitrophenyl phosphate - Moreau_1991_Biochemistry_30_1037
Author(s) : Moreau H , Moulin A , Gargouri Y , Noel JP , Verger R
Ref : Biochemistry , 30 :1037 , 1991
PubMedID: 1989675
Gene_locus related to this paper: human-LIPF , human-PNLIP

Title : Human gastric lipase. The N-terminal tetrapeptide is essential for lipid binding and lipase activity - Bernback_1989_Eur.J.Biochem_182_495
Author(s) : Bernback S , Blackberg L
Ref : European Journal of Biochemistry , 182 :495 , 1989
PubMedID: 2753032
Gene_locus related to this paper: human-LIPF

Title : Molecular cloning of a human gastric lipase and expression of the enzyme in yeast - Bodmer_1987_Biochim.Biophys.Acta_909_237
Author(s) : Bodmer MW , Angal S , Yarranton GT , Harris TJ , Lyons A , King DJ , Pieroni G , Riviere C , Verger R , Lowe PA
Ref : Biochimica & Biophysica Acta , 909 :237 , 1987
PubMedID: 3304425
Gene_locus related to this paper: human-LIPF