GD29
IC50 value of 0.3 microM for hAChE and an IC50 0.003 microM for hGSK-3
General
Type : GSK-3 kinase inhibitor,Multitarget,Thiazole,Pyridine,Piperidine,Cyclopropyl,Carboxamide,Derivative of Donepezil
Chemical_Nomenclature : 2-[2-(cyclopropanecarbonylamino)pyridin-4-yl]-4-[3-[1-[(4-fluorophenyl)methyl]piperidin-4-yl]propoxy]-1,3-thiazole-5-carboxamide
Canonical SMILES : C1CC1C(=O)NC2=NC=CC(=C2)C3=NC(=C(S3)C(=O)N)OCCCC4CCN(CC4)CC5=CC=C(C=C5)F
InChI : InChI=1S\/C28H32FN5O3S\/c29-22-7-3-19(4-8-22)17-34-13-10-18(11-14-34)2-1-15-37-27-24(25(30)35)38-28(33-27)21-9-12-31-23(16-21)32-26(36)20-5-6-20\/h3-4,7-9,12,16,18,20H,1-2,5-6,10-11,13-15,17H2,(H2,30,35)(H,31,32,36)
InChIKey : LQLBWZJHRARWDB-UHFFFAOYSA-N
Other name(s) : CHEMBL4747992,SCHEMBL23106152,BDBM50552452
MW : 537.7
Formula : C28H32FN5O3S
CAS_number :
PubChem : 156165678
UniChem : LQLBWZJHRARWDB-UHFFFAOYSA-N
IUPHAR :
Wikipedia :
Target
References (1)
| Title : Discovery of potent glycogen synthase kinase 3\/cholinesterase inhibitors with neuroprotection as potential therapeutic agent for Alzheimer's disease - Jiang_2021_Bioorg.Med.Chem_30_115940 |
| Author(s) : Jiang X , Wang Y , Liu C , Xing C , Lyu W , Wang S , Li Q , Chen T , Chen Y , Feng F , Liu W , Sun H |
| Ref : Bioorganic & Medicinal Chemistry , 30 :115940 , 2021 |
| Abstract : Jiang_2021_Bioorg.Med.Chem_30_115940 |
| ESTHER : Jiang_2021_Bioorg.Med.Chem_30_115940 |
| PubMedSearch : Jiang_2021_Bioorg.Med.Chem_30_115940 |
| PubMedID: 33340937 |