Eto M

References (15)

Title : Diagnosis and management of type I and type V hyperlipoproteinemia - Gotoda_2012_J.Atheroscler.Thromb_19_1
Author(s) : Gotoda T , Shirai K , Ohta T , Kobayashi J , Yokoyama S , Oikawa S , Bujo H , Ishibashi S , Arai H , Yamashita S , Harada-Shiba M , Eto M , Hayashi T , Sone H , Suzuki H , Yamada N
Ref : J Atheroscler Thromb , 19 :1 , 2012
Abstract : Both type I and type V hyperlipoproteinemia are characterized by severe hypertriglyceridemia due to an increase in chylomicrons. Type I hyperlipoproteinemia is caused by a decisive abnormality of the lipoprotein lipase (LPL)- apolipoprotein C-II system, whereas the cause of type V hyperlipoproteinemia is more complicated and more closely related to acquired environmental factors. Since the relationship of hypertriglyceridemia with atherosclerosis is not as clear as that of hypercholesterolemia, and since type I and V hyperlipoproteinemia are relatively rare, few guidelines for their diagnosis and treatment have been established; however, type I and V hyperlipoproteinemia are clinically important as underlying disorders of acute pancreatitis, and appropriate management is necessary to prevent or treat such complications. Against such a background, here we propose guidelines primarily concerning the diagnosis and management of type I and V hyperlipoproteinemia in Japanese.
ESTHER : Gotoda_2012_J.Atheroscler.Thromb_19_1
PubMedSearch : Gotoda_2012_J.Atheroscler.Thromb_19_1
PubMedID: 22129523

Title : Pre-heparin serum lipoprotein lipase concentrations in obese men of contrasting physical activity status: a preliminary study -
Author(s) : Miyashita M , Eto M , Sasai H , Tsujimoto T , So R , Nomata Y , Tanaka K
Ref : J Atheroscler Thromb , 17 :1110 , 2010
PubMedID: 20585191

Title : Twelve-week jogging training increases pre-heparin serum lipoprotein lipase concentrations in overweight\/obese middle-aged men - Miyashita_2010_J.Atheroscler.Thromb_17_21
Author(s) : Miyashita M , Eto M , Sasai H , Tsujimoto T , Nomata Y , Tanaka K
Ref : J Atheroscler Thromb , 17 :21 , 2010
Abstract : AIM: Enhancement of lipoprotein lipase (LPL) activity through drug administration has been shown to increase pre-heparin serum LPL concentrations; however, pre-heparin serum LPL responses to exercise training have not been determined. The present study was undertaken to investigate the effects of 12 weeks of supervised aerobic exercise training on pre-heparin serum LPL concentrations in overweight/obese men. METHODS: Fifteen overweight/obese middle-aged men were assigned to one of two 12-week supervised exercise interventions: a walking group (eight participants gradually increasing brisk walking to 60 min/day 3 days a week) or a jogging group (seven participants gradually increasing jogging to 60 min/day 3 days a week). All participants maintained ad libitum diets. Blood samples were collected at baseline and immediately after 12 weeks. The primary outcome was pre-heparin serum LPL. RESULTS: Pre-heparin serum LPL concentrations were increased in the jogging group after 12 weeks compared with the baseline values (mean+/-SEM: 37.6+/-4.7 vs. 51.0+/-6.6 ng/mL, respectively, p= 0.033). In the walking group, pre-heparin serum LPL concentrations remained unchanged after 12 weeks. CONCLUSIONS: This study demonstrates that 12 weeks of jogging training increases pre-heparin serum LPL concentrations in overweight/obese middle-aged men.
ESTHER : Miyashita_2010_J.Atheroscler.Thromb_17_21
PubMedSearch : Miyashita_2010_J.Atheroscler.Thromb_17_21
PubMedID: 20075597

Title : A novel complex deletion-insertion mutation mediated by Alu repetitive elements leads to lipoprotein lipase deficiency - Okubo_2007_Mol.Genet.Metab_92_229
Author(s) : Okubo M , Horinishi A , Saito M , Ebara T , Endo Y , Kaku K , Murase T , Eto M
Ref : Mol Genet Metab , 92 :229 , 2007
Abstract : Lipoprotein lipase (LPL) deficiency is a rare autosomal recessive inherited disorder, characterized by marked hypertriglyceridemia, eruptive xanthoma, hepatosplenomegaly, recurrent attacks of pancreatitis, and markedly low or absent LPL activity in postheparin plasma. A majority of LPL deficient patients have been reported to have point mutations in the LPL gene; however, we find a complex deletion-insertion mutation by Alu elements, mobile retrotransposons, in a patient with LPL deficiency. This patient suffered from acute pancreatitis, showed chylomicronemia and lacked detectable LPL activity or mass in her postheparin plasma. Southern blot analysis and long-range PCR of the patient's DNA demonstrated a 2.2-kb deletion encompassing exon 2. Sequence analysis revealed (1) a 2.3-kb deletion between an AT-rich region adjacent to an Alu element in intron 1 and another Alu element in intron 2; (2) an insertion of approximately 150bp 5'-truncated Alu sequence with a poly (A) tail at the deletion point. The inserted sequence belongs to Alu Yb9, the youngest subfamily of Alu elements. The deletion occurred at the consensus cleavage site (3'-A|TTTT-5') without target site duplication. These findings indicated that Alu retrotransposition caused the complex deletion-insertion. The patient was homozygous for this complex mutation, which eliminates exon 2 and leads to LPL deficiency. To our knowledge, the patient is the first case with LPL deficiency due to a complex deletion-insertion mediated by Alu repetitive elements.
ESTHER : Okubo_2007_Mol.Genet.Metab_92_229
PubMedSearch : Okubo_2007_Mol.Genet.Metab_92_229
PubMedID: 17706445

Title : Differential signalling by muscarinic receptors in smooth muscle: m2-mediated inactivation of myosin light chain kinase via Gi3, Cdc42\/Rac1 and p21-activated kinase 1 pathway, and m3-mediated MLC20 (20 kDa regulatory light chain of myosin II) phosphorylation via Rho-associated kinase\/myosin phosphatase targeting subunit 1 and protein kinase C\/CPI-17 pathway - Murthy_2003_Biochem.J_374_145
Author(s) : Murthy KS , Zhou H , Grider JR , Brautigan DL , Eto M , Makhlouf GM
Ref : Biochemical Journal , 374 :145 , 2003
Abstract : Signalling via m3 and m2 receptors in smooth muscles involved activation of two G-protein-dependent pathways by each receptor. m2 receptors were coupled via Gbetagammai3 with activation of phospholipase C-beta3, phosphoinositide 3-kinase and Cdc42/Rac1 (where Cdc stands for cell division cycle) and p21-activated kinase 1 (PAK1), resulting in phosphorylation and inactivation of myosin light chain kinase (MLCK). Each step was inhibited by methoctramine and pertussis toxin. PAK1 activity was abolished in cells expressing both Cdc42-DN (where DN stands for dominant negative) and Rac1-DN. MLCK phosphorylation was inhibited by PAK1 antibody, and in cells expressing Cdc42-DN and Rac1-DN. m3 receptors were coupled via Galpha(q/11) with activation of phospholipase C-beta1 and via RhoA with activation of Rho-associated kinase (Rho kinase), phospholipase D and protein kinase C (PKC). Rho kinase and phospholipase D activities were inhibited by C3 exoenzyme and in cells expressing RhoA-DN. PKC activity was inhibited by bisindolylmaleimide, and in cells expressing RhoA-DN; PKC activity was also inhibited partly by Y27632 (44+/-5%). PKC-induced phosphorylation of PKC-activated 17 kDa inhibitor protein of type 1 phosphatase (CPI-17) at Thr38 was abolished by bisindolylmaleimide and inhibited partly by Y27632 (28+/-3%). Rho-kinase-induced phosphorylation of myosin phosphatase targeting subunit (MYPT1) and was abolished by Y27632. Sustained phosphorylation of 20 kDa regulatory light chain of myosin II (MLC20) and contraction were abolished by bisindolylmaleimide Y27632 and C3 exoenzyme and in cells expressing RhoA-DN. The results suggest that Rho-kinase-dependent phosphorylation of MYPT1 and PKC-dependent phosphorylation and enhancement of CPI-17 binding to the catalytic subunit of MLC phosphatase (MLCP) act co-operatively to inhibit MLCP activity, leading to sustained stimulation of MLC20 phosphorylation and contraction. Because Y27632 inhibited both Rho kinase and PKC activities, it could not be used to ascertain the contribution of MYPT1 to inhibition of MLCP activity. m2-dependent phosphorylation and inactivation of MLCK precluded its involvement in sustained MLC20 phosphorylation and contraction.
ESTHER : Murthy_2003_Biochem.J_374_145
PubMedSearch : Murthy_2003_Biochem.J_374_145
PubMedID: 12733988

Title : Docking study of enantiomeric fonofos oxon bound to the active site of Torpedo californica acetylcholinesterase - Hirashima_2000_Bioorg.Med.Chem_8_653
Author(s) : Hirashima A , Kuwano E , Eto M
Ref : Bioorganic & Medicinal Chemistry , 8 :653 , 2000
Abstract : Molecular interaction between enantiomeric fonofos oxon (O-ethyl S-phenyl ethylphosphonothiolate) and acetylcholinesterase (AChE) of Torpedo californica was evaluated by using the Cerius2 program. It was suggested that the difference in the inhibitory activity of the two enantiomers of fonofos oxon on AChE is due to the steric hindrance in binding to the AChE active site.
ESTHER : Hirashima_2000_Bioorg.Med.Chem_8_653
PubMedSearch : Hirashima_2000_Bioorg.Med.Chem_8_653
PubMedID: 10732982

Title : Effect of Octopamine Agonists on Larval-Pupal Transformation of Red Flour Beetle (Tribolium freemani Hinton) - Hirashima_1995_Pestic.Biochem.Physiol_51_83
Author(s) : Hirashima A , Ueno R , Takeya R , Taniguchi E , Eto M
Ref : Pesticide Biochemistry and Physiology , 51 :83 , 1995
Abstract : When a larva of the flour beetle Tribolium freemani (Hinton) was isolated (one larva per vial), the larva pupated within 6 days, whereas at higher larval densities (two and four larvae per vial) pupation was delayed. Meanwhile, there was an increase of whole-body octopamine (OA) levels, measured using radioenzymatic assay, during the last part of intermoult before pupation in the three groups of insects. The onset of the OA increase was delayed by increased larval density. At larval densities of 1 and 2 larvae per vial the pupation coincided with the OA decrease, whereas at increasing larval density (four larvae per vial) the pupation started after the onset of the OA decline. Juvenile hormone (JH) I reduced the pupation of an isolated larva of T. freemani. Chlordimeform and other OA agonists and precocene II accelerated the pupation of crowded larvae, which was antagonized by JH I. JH esterase (JHE) of larvae treated with an OA agonist was higher than that of control larvae. Hence, OA may be responsible for stimulated pupation of isolated T. freemani, possibly by activating JHE.
ESTHER : Hirashima_1995_Pestic.Biochem.Physiol_51_83
PubMedSearch : Hirashima_1995_Pestic.Biochem.Physiol_51_83

Title : Quantitative structure-activity study of insecticidal 2-methoxy-5-(substituted-phenyl)-1, 3, 2-oxazaphospholidine 2-sulfides against Musca domestica L. by topical application - Hirashima_1992_Pest.Sci_35_223
Author(s) : Hirashima A , Yoshii Y , Takeya R , Eto M
Ref : Pest Sci , 35 :223 , 1992
Abstract : The quantitative relationship between the structure of 2-methoxy-5-(substituted-phenyl)-1, 3, 2-oxazaphospholidine 2-sulfides (5-PMOS) and their insecticidal activity against the house fly. Musca domestica L., was analyzed using reported physicochemical parameters and regression analysis. The electronic nature of the substituent on the phenyl group of 5-PMOS has the most significant effect on the activity, followed by hydrophobic and steric effects; the optimum value of Ep is zero and the more hydrophobic the substituents on the phenyl group, the higher the insecticidal activity. The plots of observed pLD50, values against calculated pLD50 values for compounds having substituents in the ortho-position deviated downwards from those of compounds having substituents at the meta and/or para positions. This ortho-effect, which reduces the insecticidal activity of compounds having substituents at the ortho-position, was expressed by a dummy parameter D, which has the value 2 for di-ortho-substituted derivatives, 1 for mono-ortho-substituted derivatives and zero for others. Thus, the highest activity was obtained for 2-methoxy-5-phenyl-1, 3, 2-oxazaphospholidine 2-sulfide, and the activity was decreased by the introduction of any substituents on the phenyl group.
ESTHER : Hirashima_1992_Pest.Sci_35_223
PubMedSearch : Hirashima_1992_Pest.Sci_35_223

Title : Quantitative structure activity studies of optically active 2-methoxy-1,3,2-oxazaphospholidine 2-sulfides against Musca domestica L - Hirashima_1992_Pest.Sci_34_329
Author(s) : Hirashima A , Eto M
Ref : Pest Sci , 34 :329 , 1992
Abstract : The quantitative relationship between the structure of optically active 4-substituted 2-methoxy-1,3,2-oxazaphospholidine 2-sulfides (4-RMOS) and their insecticidal activity on the house fly, Musca domestica L., was analysed using reported physicochemical parameters and regression analysis. The configuration at the C4 atom was more important for insecticidal activity than that at the phosphorus atom, since the coefficient of the dummy parameter for the C4- configuration was larger than that for the configuration of the phosphorus atom: (S)c(R)p diastereoisomers showed the highest insecticidal activity, and the activity decreased in the order of (S)c(R)p > (S)c(S)p > (R)c(R)p > (R)c(S)p. The electronic nature of the substituent at the C4 position was the most important, followed by the steric and hydrophobic effects: the more electron-donating, the less bulky and the more hydrophobic the 4-substituent, the higher the insecticidal activity. Thus the highest activity was obtained for the isopropyl derivatives, and the activity decreased in the order of isopropyl > isobutyl > ethyl > sec-butyl > benzyl > phenyl > methyl > tert-butyl.
ESTHER : Hirashima_1992_Pest.Sci_34_329
PubMedSearch : Hirashima_1992_Pest.Sci_34_329

Title : Effects of various stressors on larval growth and whole-body octopamine levels of Tribolium castaneum - Hirashima_1992_Pestic.Biochem.Physiol_44_217
Author(s) : Hirashima A , Ueno R , Eto M
Ref : Pesticide Biochemistry and Physiology , 44 :217 , 1992
Abstract : Dietary chemical stressors including insecticidal acetylcholinesterase (AChE)-inhibiting organophosphorus compounds and carbamate induced an increase of whole-body octopamine levels and a reduction of weight gain of Tribolium castaneum larvae 72 hr after treatment. Organophosphorus compounds with very poor or no anti-AChE nor insecticidal activities did not have any significant effects, suggesting that the inhibition of AChE may be responsible for these biological phenomena. Rotenone, ethofenprox, nereistoxin, lindane, mechanical stress (40 rpm), high temperature (40 C), and starvation for 48 hr were also effective in reducing larval growth and increasing the whole-body octopamine level of T. castaneum. Social stress, nicotine, and low temperature (20degC) diminished whole-body octopamine levels, whereas allethrin and KK-42 increased the octopamine levels without affecting the larval growth. There seems to be a correlation between increased whole-body octopamine levels and reduced larval-weight gain, indicating that various stressors may play an important role in regulating insect growth, in which octopamine is involved.
ESTHER : Hirashima_1992_Pestic.Biochem.Physiol_44_217
PubMedSearch : Hirashima_1992_Pestic.Biochem.Physiol_44_217

Title : Effect of five-membered cyclic phosphorothionates on larval growth, trehalase, digestive enzymes, acetylcholinesterase, and cyclic adenosine 3',5'-monophosphate level of Tribolium castaneum and Musca domestica - Hirashima_1989_Pestic.Biochem.Physiol_35_127
Author(s) : Hirashima A , Ueno R , Oyama K , Ishaaya I , Eto M
Ref : Pesticide Biochemistry and Physiology , 35 :127 , 1989
Abstract : The 4-isobutyl (iBMOS) and 5-phenyl (5-PMOS) derivatives of 1,3,2-oxazaphospholidine 2-sulfide suppressed the larval growth, pupation, and emergence of Tribolium castaneum and Musca domestica. Feeding larvae iBMOS or 5-PMOS for 2 days reduced weight gain, suppressed soluble gut trehalase activity, and increased whole body levels of cyclic adenosine 3',5'-monophosphate (cAMP) relative to control. Invertase was slightly suppressed and neither amylase nor protease was affected in vivo by these phosphorus compounds. At a concentration of 10-4 M, iBMOS and 5-PMOS had no direct effect on these enzymes in vitro. At a dose needed for 50% mortality (LD50) 20 hr after topical application, 5-PMOS caused a 50% inhibition of M. domestica adult females acetylcholinesterase activity (AChE), 60 min after topical application. T. castaneum larvae fed for 24 hr on a diet containing 80 to 320 ppm iBMOS underwent AChE inhibition of 61 to 86%; cAMP content was increased up to 186% and mortality up to 34%, relative to control. Similar phenomena were observed with 80 to 320 ppm of 5-PMOS. It can be concluded that at sublethal concentrations, these compounds reduced trehalase activity, which is important for energy supply in insects, whereas at lethal concentrations they inhibited AChE activity similar to other acyclic phosphorus compounds.
ESTHER : Hirashima_1989_Pestic.Biochem.Physiol_35_127
PubMedSearch : Hirashima_1989_Pestic.Biochem.Physiol_35_127

Title : Development of insecticidal cyclic phosphoryl compounds through chemical and biochemical approaches - Eto_1983_J.Environ.Sci.Health.B_18_119
Author(s) : Eto M
Ref : J Environ Sci Health B , 18 :119 , 1983
Abstract : Chemical and biochemical studies on three types of cyclic phosphoryl compounds are discussed in connection with the development of insecticides. They are five-membered cyclic phosphoramidates (I), six-membered cyclic phosphates (II) and bridged bicyclic phosphates (III). Development of I has started from the finding of L-leucine as a neuroactive substance in silkworm blood, followed by its combination with chemically active five-membered cyclic phosphates. Studies on the metabolism of neurotoxic tri-o-tolyl phosphate caused the invention of the insecticide salithion in the series of II. Salithion was chemically converted into its thiolo isomers, which is a convenient phosphorylating agent useful to synthesize biologically interesting phosphate esters. III does not inhibit acetylcholin-esterase but acts as an anti-GABA agent.
ESTHER : Eto_1983_J.Environ.Sci.Health.B_18_119
PubMedSearch : Eto_1983_J.Environ.Sci.Health.B_18_119
PubMedID: 6339599

Title : Organophosphorus and methylcarbamate teratogens: structural requirements for inducing embryonic abnormalities in chickens and kynurenine formamidase inhibition in mouse liver -
Author(s) : Eto M , Seifert J , Engel JL , Casida JE
Ref : Toxicol Appl Pharmacol , 54 :20 , 1980
PubMedID: 6156523

Title : Potentiation and neurotoxicity induced by certain organophosphates - Casida_1963_Biochem.Pharmacol_12_73
Author(s) : Casida JE , Baron RL , Eto M , Engel JL
Ref : Biochemical Pharmacology , 12 :73 , 1963
Abstract : The following types of phosphorus compounds were found to be active in potentiating the toxicity of malathion to mice: triphenyl phosphates and phosphonates containing o- and p-, methyl and ethyl substitutents; certain di-(substituted-phenyl) phenylphosphonates and N-methylphosphoramidates; S,S,S-trialkyl phosphorotrithioites and phosphorotrithioates; and certain saligenin cyclic phosphorus esters. Some compounds in the latter two groups also produced ataxia in hens. Certain of the saligenin cyclic phosphorus esters were as potent in effecting ataxia as the dialkyl phosphorofluoridates, but required much larger doses to produce parasympathomimetic effects. Also considered are the activity of the 112 phosphorus esters investigated for inhibition in vitro of mouse plasma esterases hydrolyzing malathion and propionylcholine, and the stability of the saligenin cyclic phosphorus esters to enzymatic and nonenzymatic hydrolysis."
ESTHER : Casida_1963_Biochem.Pharmacol_12_73
PubMedSearch : Casida_1963_Biochem.Pharmacol_12_73
PubMedID: 14019076

Title : Biological activity of a tri-o-cresyl phosphate metabolite - Casida_1961_Nature_191_1396
Author(s) : Casida JE , Eto M , Baron RL
Ref : Nature , 191 :1396 , 1961
Abstract : TRI-O-CRESYL PHOSPHATE (TOCP) is metabolized in vitro and in vivo to form potent esterase inhibitors15. The nature and biological activity of the metabolites were investigated"
ESTHER : Casida_1961_Nature_191_1396
PubMedSearch : Casida_1961_Nature_191_1396