| Title : Gene therapy ameliorates bowel dysmotility and enteric neuron degeneration and extends survival in lysosomal storage disorder mouse models - Ziolkowska_2025_Sci.Transl.Med_17_eadj1445 |
| Author(s) : Ziolkowska EA , Jansen MJ , Williams LL , Wang SH , Eultgen EM , Takahashi K , Le SQ , Nelvagal HR , Sharma J , Sardiello M , DeBosch BJ , Dickson PI , Anderson JB , Sax SE , Wright CM , Bradley RP , Whiteman IT , Makita T , Grider JR , Sands MS , Heuckeroth RO , Cooper JD |
| Ref : Sci Transl Med , 17 :eadj1445 , 2025 |
| Abstract : |
| PubMedSearch : Ziolkowska_2025_Sci.Transl.Med_17_eadj1445 |
| PubMedID: 39813314 |
| Gene_locus related to this paper: mouse-ppt , human-PPT1 |
| Title : Gene therapy ameliorates bowel dysmotility and enteric neuron degeneration and extends survival in lysosomal storage disorder mouse models - Ziolkowska_2025_Sci.Transl.Med_17_eadj1445 |
| Author(s) : Ziolkowska EA , Jansen MJ , Williams LL , Wang SH , Eultgen EM , Takahashi K , Le SQ , Nelvagal HR , Sharma J , Sardiello M , DeBosch BJ , Dickson PI , Anderson JB , Sax SE , Wright CM , Bradley RP , Whiteman IT , Makita T , Grider JR , Sands MS , Heuckeroth RO , Cooper JD |
| Ref : Sci Transl Med , 17 :eadj1445 , 2025 |
| Abstract : |
| PubMedSearch : Ziolkowska_2025_Sci.Transl.Med_17_eadj1445 |
| PubMedID: 39813314 |
| Gene_locus related to this paper: mouse-ppt , human-PPT1 |
| Title : Gene therapy ameliorates bowel dysmotility and enteric neuron degeneration and extends survival in lysosomal storage disorder mouse models - Ziolkowska_2025_Sci.Transl.Med_17_eadj1445 |
| Author(s) : Ziolkowska EA , Jansen MJ , Williams LL , Wang SH , Eultgen EM , Takahashi K , Le SQ , Nelvagal HR , Sharma J , Sardiello M , DeBosch BJ , Dickson PI , Anderson JB , Sax SE , Wright CM , Bradley RP , Whiteman IT , Makita T , Grider JR , Sands MS , Heuckeroth RO , Cooper JD |
| Ref : Sci Transl Med , 17 :eadj1445 , 2025 |
| Abstract : |
| PubMedSearch : Ziolkowska_2025_Sci.Transl.Med_17_eadj1445 |
| PubMedID: 39813314 |
| Gene_locus related to this paper: mouse-ppt , human-PPT1 |
| Title : Inhibition of monoacylglycerol lipase attenuates nonsteroidal anti-inflammatory drug-induced gastric hemorrhages in mice - Kinsey_2011_J.Pharmacol.Exp.Ther_338_795 |
| Author(s) : Kinsey SG , Nomura DK , O'Neal ST , Long JZ , Mahadevan A , Cravatt BF , Grider JR , Lichtman AH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 338 :795 , 2011 |
| Abstract : |
| PubMedSearch : Kinsey_2011_J.Pharmacol.Exp.Ther_338_795 |
| PubMedID: 21659471 |
| Title : Inhibition of monoacylglycerol lipase attenuates nonsteroidal anti-inflammatory drug-induced gastric hemorrhages in mice - Kinsey_2011_J.Pharmacol.Exp.Ther_338_795 |
| Author(s) : Kinsey SG , Nomura DK , O'Neal ST , Long JZ , Mahadevan A , Cravatt BF , Grider JR , Lichtman AH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 338 :795 , 2011 |
| Abstract : |
| PubMedSearch : Kinsey_2011_J.Pharmacol.Exp.Ther_338_795 |
| PubMedID: 21659471 |
| Title : Inhibition of monoacylglycerol lipase attenuates nonsteroidal anti-inflammatory drug-induced gastric hemorrhages in mice - Kinsey_2011_J.Pharmacol.Exp.Ther_338_795 |
| Author(s) : Kinsey SG , Nomura DK , O'Neal ST , Long JZ , Mahadevan A , Cravatt BF , Grider JR , Lichtman AH |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 338 :795 , 2011 |
| Abstract : |
| PubMedSearch : Kinsey_2011_J.Pharmacol.Exp.Ther_338_795 |
| PubMedID: 21659471 |
| Title : The timing and location of glial cell line-derived neurotrophic factor expression determine enteric nervous system structure and function - Wang_2010_J.Neurosci_30_1523 |
| Author(s) : Wang H , Hughes I , Planer W , Parsadanian A , Grider JR , Vohra BP , Keller-Peck C , Heuckeroth RO |
| Ref : Journal of Neuroscience , 30 :1523 , 2010 |
| Abstract : |
| PubMedSearch : Wang_2010_J.Neurosci_30_1523 |
| PubMedID: 20107080 |
| Title : The timing and location of glial cell line-derived neurotrophic factor expression determine enteric nervous system structure and function - Wang_2010_J.Neurosci_30_1523 |
| Author(s) : Wang H , Hughes I , Planer W , Parsadanian A , Grider JR , Vohra BP , Keller-Peck C , Heuckeroth RO |
| Ref : Journal of Neuroscience , 30 :1523 , 2010 |
| Abstract : |
| PubMedSearch : Wang_2010_J.Neurosci_30_1523 |
| PubMedID: 20107080 |
| Title : The timing and location of glial cell line-derived neurotrophic factor expression determine enteric nervous system structure and function - Wang_2010_J.Neurosci_30_1523 |
| Author(s) : Wang H , Hughes I , Planer W , Parsadanian A , Grider JR , Vohra BP , Keller-Peck C , Heuckeroth RO |
| Ref : Journal of Neuroscience , 30 :1523 , 2010 |
| Abstract : |
| PubMedSearch : Wang_2010_J.Neurosci_30_1523 |
| PubMedID: 20107080 |
| Title : Differential signalling by muscarinic receptors in smooth muscle: m2-mediated inactivation of myosin light chain kinase via Gi3, Cdc42\/Rac1 and p21-activated kinase 1 pathway, and m3-mediated MLC20 (20 kDa regulatory light chain of myosin II) phosphorylation via Rho-associated kinase\/myosin phosphatase targeting subunit 1 and protein kinase C\/CPI-17 pathway - Murthy_2003_Biochem.J_374_145 |
| Author(s) : Murthy KS , Zhou H , Grider JR , Brautigan DL , Eto M , Makhlouf GM |
| Ref : Biochemical Journal , 374 :145 , 2003 |
| Abstract : |
| PubMedSearch : Murthy_2003_Biochem.J_374_145 |
| PubMedID: 12733988 |
| Title : Inhibition of sustained smooth muscle contraction by PKA and PKG preferentially mediated by phosphorylation of RhoA - Murthy_2003_Am.J.Physiol.Gastrointest.Liver.Physiol_284_G1006 |
| Author(s) : Murthy KS , Zhou H , Grider JR , Makhlouf GM |
| Ref : American Journal of Physiology Gastrointest Liver Physiol , 284 :G1006 , 2003 |
| Abstract : |
| PubMedSearch : Murthy_2003_Am.J.Physiol.Gastrointest.Liver.Physiol_284_G1006 |
| PubMedID: 12736149 |
| Title : Differential signalling by muscarinic receptors in smooth muscle: m2-mediated inactivation of myosin light chain kinase via Gi3, Cdc42\/Rac1 and p21-activated kinase 1 pathway, and m3-mediated MLC20 (20 kDa regulatory light chain of myosin II) phosphorylation via Rho-associated kinase\/myosin phosphatase targeting subunit 1 and protein kinase C\/CPI-17 pathway - Murthy_2003_Biochem.J_374_145 |
| Author(s) : Murthy KS , Zhou H , Grider JR , Brautigan DL , Eto M , Makhlouf GM |
| Ref : Biochemical Journal , 374 :145 , 2003 |
| Abstract : |
| PubMedSearch : Murthy_2003_Biochem.J_374_145 |
| PubMedID: 12733988 |
| Title : Inhibition of sustained smooth muscle contraction by PKA and PKG preferentially mediated by phosphorylation of RhoA - Murthy_2003_Am.J.Physiol.Gastrointest.Liver.Physiol_284_G1006 |
| Author(s) : Murthy KS , Zhou H , Grider JR , Makhlouf GM |
| Ref : American Journal of Physiology Gastrointest Liver Physiol , 284 :G1006 , 2003 |
| Abstract : |
| PubMedSearch : Murthy_2003_Am.J.Physiol.Gastrointest.Liver.Physiol_284_G1006 |
| PubMedID: 12736149 |
| Title : Differential signalling by muscarinic receptors in smooth muscle: m2-mediated inactivation of myosin light chain kinase via Gi3, Cdc42\/Rac1 and p21-activated kinase 1 pathway, and m3-mediated MLC20 (20 kDa regulatory light chain of myosin II) phosphorylation via Rho-associated kinase\/myosin phosphatase targeting subunit 1 and protein kinase C\/CPI-17 pathway - Murthy_2003_Biochem.J_374_145 |
| Author(s) : Murthy KS , Zhou H , Grider JR , Brautigan DL , Eto M , Makhlouf GM |
| Ref : Biochemical Journal , 374 :145 , 2003 |
| Abstract : |
| PubMedSearch : Murthy_2003_Biochem.J_374_145 |
| PubMedID: 12733988 |
| Title : Inhibition of sustained smooth muscle contraction by PKA and PKG preferentially mediated by phosphorylation of RhoA - Murthy_2003_Am.J.Physiol.Gastrointest.Liver.Physiol_284_G1006 |
| Author(s) : Murthy KS , Zhou H , Grider JR , Makhlouf GM |
| Ref : American Journal of Physiology Gastrointest Liver Physiol , 284 :G1006 , 2003 |
| Abstract : |
| PubMedSearch : Murthy_2003_Am.J.Physiol.Gastrointest.Liver.Physiol_284_G1006 |
| PubMedID: 12736149 |
| Title : Heterologous desensitization of response mediated by selective PKC-dependent phosphorylation of G(i-1) and G(i-2) - Murthy_2000_Am.J.Physiol.Cell.Physiol_279_C925 |
| Author(s) : Murthy KS , Grider JR , Makhlouf GM |
| Ref : American Journal of Physiology Cell Physiol , 279 :C925 , 2000 |
| Abstract : |
| PubMedSearch : Murthy_2000_Am.J.Physiol.Cell.Physiol_279_C925 |
| PubMedID: 11003572 |
| Title : Heterologous desensitization of response mediated by selective PKC-dependent phosphorylation of G(i-1) and G(i-2) - Murthy_2000_Am.J.Physiol.Cell.Physiol_279_C925 |
| Author(s) : Murthy KS , Grider JR , Makhlouf GM |
| Ref : American Journal of Physiology Cell Physiol , 279 :C925 , 2000 |
| Abstract : |
| PubMedSearch : Murthy_2000_Am.J.Physiol.Cell.Physiol_279_C925 |
| PubMedID: 11003572 |
| Title : Heterologous desensitization of response mediated by selective PKC-dependent phosphorylation of G(i-1) and G(i-2) - Murthy_2000_Am.J.Physiol.Cell.Physiol_279_C925 |
| Author(s) : Murthy KS , Grider JR , Makhlouf GM |
| Ref : American Journal of Physiology Cell Physiol , 279 :C925 , 2000 |
| Abstract : |
| PubMedSearch : Murthy_2000_Am.J.Physiol.Cell.Physiol_279_C925 |
| PubMedID: 11003572 |
| Title : Enteric GABA: mode of action and role in the regulation of the peristaltic reflex - Grider_1992_Am.J.Physiol_262_G690 |
| Author(s) : Grider JR , Makhlouf GM |
| Ref : American Journal of Physiology , 262 :G690 , 1992 |
| Abstract : |
| PubMedSearch : Grider_1992_Am.J.Physiol_262_G690 |
| PubMedID: 1566850 |
| Title : Enteric GABA: mode of action and role in the regulation of the peristaltic reflex - Grider_1992_Am.J.Physiol_262_G690 |
| Author(s) : Grider JR , Makhlouf GM |
| Ref : American Journal of Physiology , 262 :G690 , 1992 |
| Abstract : |
| PubMedSearch : Grider_1992_Am.J.Physiol_262_G690 |
| PubMedID: 1566850 |
| Title : Enteric GABA: mode of action and role in the regulation of the peristaltic reflex - Grider_1992_Am.J.Physiol_262_G690 |
| Author(s) : Grider JR , Makhlouf GM |
| Ref : American Journal of Physiology , 262 :G690 , 1992 |
| Abstract : |
| PubMedSearch : Grider_1992_Am.J.Physiol_262_G690 |
| PubMedID: 1566850 |
| Title : Identification of bombesin receptors on isolated muscle cells from human intestine - Micheletti_1988_Regul.Pept_21_219 |
| Author(s) : Micheletti R , Grider JR , Makhlouf GM |
| Ref : Regul Pept , 21 :219 , 1988 |
| Abstract : |
| PubMedSearch : Micheletti_1988_Regul.Pept_21_219 |
| PubMedID: 2842822 |
| Title : Characterization of opioid receptors on isolated canine gallbladder smooth muscle cells - Severi_1988_Life.Sci_42_2373 |
| Author(s) : Severi C , Grider JR , Makhlouf GM |
| Ref : Life Sciences , 42 :2373 , 1988 |
| Abstract : |
| PubMedSearch : Severi_1988_Life.Sci_42_2373 |
| PubMedID: 2897608 |
| Title : Functional gradients in muscle cells isolated from gallbladder, cystic duct, and common bile duct - Severi_1988_Am.J.Physiol_255_G647 |
| Author(s) : Severi C , Grider JR , Makhlouf GM |
| Ref : American Journal of Physiology , 255 :G647 , 1988 |
| Abstract : |
| PubMedSearch : Severi_1988_Am.J.Physiol_255_G647 |
| PubMedID: 3189551 |
| Title : Identification of separate bombesin and substance P receptors on isolated muscle cells from canine gallbladder - Severi_1988_J.Pharmacol.Exp.Ther_245_195 |
| Author(s) : Severi C , Grider JR , Makhlouf GM |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 245 :195 , 1988 |
| Abstract : |
| PubMedSearch : Severi_1988_J.Pharmacol.Exp.Ther_245_195 |
| PubMedID: 2452246 |
| Title : Identification of bombesin receptors on isolated muscle cells from human intestine - Micheletti_1988_Regul.Pept_21_219 |
| Author(s) : Micheletti R , Grider JR , Makhlouf GM |
| Ref : Regul Pept , 21 :219 , 1988 |
| Abstract : |
| PubMedSearch : Micheletti_1988_Regul.Pept_21_219 |
| PubMedID: 2842822 |
| Title : Characterization of opioid receptors on isolated canine gallbladder smooth muscle cells - Severi_1988_Life.Sci_42_2373 |
| Author(s) : Severi C , Grider JR , Makhlouf GM |
| Ref : Life Sciences , 42 :2373 , 1988 |
| Abstract : |
| PubMedSearch : Severi_1988_Life.Sci_42_2373 |
| PubMedID: 2897608 |
| Title : Functional gradients in muscle cells isolated from gallbladder, cystic duct, and common bile duct - Severi_1988_Am.J.Physiol_255_G647 |
| Author(s) : Severi C , Grider JR , Makhlouf GM |
| Ref : American Journal of Physiology , 255 :G647 , 1988 |
| Abstract : |
| PubMedSearch : Severi_1988_Am.J.Physiol_255_G647 |
| PubMedID: 3189551 |
| Title : Identification of separate bombesin and substance P receptors on isolated muscle cells from canine gallbladder - Severi_1988_J.Pharmacol.Exp.Ther_245_195 |
| Author(s) : Severi C , Grider JR , Makhlouf GM |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 245 :195 , 1988 |
| Abstract : |
| PubMedSearch : Severi_1988_J.Pharmacol.Exp.Ther_245_195 |
| PubMedID: 2452246 |
| Title : Characterization of opioid receptors on isolated canine gallbladder smooth muscle cells - Severi_1988_Life.Sci_42_2373 |
| Author(s) : Severi C , Grider JR , Makhlouf GM |
| Ref : Life Sciences , 42 :2373 , 1988 |
| Abstract : |
| PubMedSearch : Severi_1988_Life.Sci_42_2373 |
| PubMedID: 2897608 |
| Title : Functional gradients in muscle cells isolated from gallbladder, cystic duct, and common bile duct - Severi_1988_Am.J.Physiol_255_G647 |
| Author(s) : Severi C , Grider JR , Makhlouf GM |
| Ref : American Journal of Physiology , 255 :G647 , 1988 |
| Abstract : |
| PubMedSearch : Severi_1988_Am.J.Physiol_255_G647 |
| PubMedID: 3189551 |
| Title : Identification of separate bombesin and substance P receptors on isolated muscle cells from canine gallbladder - Severi_1988_J.Pharmacol.Exp.Ther_245_195 |
| Author(s) : Severi C , Grider JR , Makhlouf GM |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 245 :195 , 1988 |
| Abstract : |
| PubMedSearch : Severi_1988_J.Pharmacol.Exp.Ther_245_195 |
| PubMedID: 2452246 |
| Title : Identification of bombesin receptors on isolated muscle cells from human intestine - Micheletti_1988_Regul.Pept_21_219 |
| Author(s) : Micheletti R , Grider JR , Makhlouf GM |
| Ref : Regul Pept , 21 :219 , 1988 |
| Abstract : |
| PubMedSearch : Micheletti_1988_Regul.Pept_21_219 |
| PubMedID: 2842822 |
| Title : Identification of muscarinic M2 receptors on single muscle cells of the human and guinea pig intestine - Grider_1987_Gastroenterology_93_951 |
| Author(s) : Grider JR , Bitar KN , Makhlouf GM |
| Ref : Gastroenterology , 93 :951 , 1987 |
| Abstract : |
| PubMedSearch : Grider_1987_Gastroenterology_93_951 |
| PubMedID: 3653644 |
| Title : Role of opioid neurons in the regulation of intestinal peristalsis - Grider_1987_Am.J.Physiol_253_G226 |
| Author(s) : Grider JR , Makhlouf GM |
| Ref : American Journal of Physiology , 253 :G226 , 1987 |
| Abstract : |
| PubMedSearch : Grider_1987_Am.J.Physiol_253_G226 |
| PubMedID: 2887119 |
| Title : Identification of muscarinic M2 receptors on single muscle cells of the human and guinea pig intestine - Grider_1987_Gastroenterology_93_951 |
| Author(s) : Grider JR , Bitar KN , Makhlouf GM |
| Ref : Gastroenterology , 93 :951 , 1987 |
| Abstract : |
| PubMedSearch : Grider_1987_Gastroenterology_93_951 |
| PubMedID: 3653644 |
| Title : Role of opioid neurons in the regulation of intestinal peristalsis - Grider_1987_Am.J.Physiol_253_G226 |
| Author(s) : Grider JR , Makhlouf GM |
| Ref : American Journal of Physiology , 253 :G226 , 1987 |
| Abstract : |
| PubMedSearch : Grider_1987_Am.J.Physiol_253_G226 |
| PubMedID: 2887119 |
| Title : Identification of muscarinic M2 receptors on single muscle cells of the human and guinea pig intestine - Grider_1987_Gastroenterology_93_951 |
| Author(s) : Grider JR , Bitar KN , Makhlouf GM |
| Ref : Gastroenterology , 93 :951 , 1987 |
| Abstract : |
| PubMedSearch : Grider_1987_Gastroenterology_93_951 |
| PubMedID: 3653644 |
| Title : Role of opioid neurons in the regulation of intestinal peristalsis - Grider_1987_Am.J.Physiol_253_G226 |
| Author(s) : Grider JR , Makhlouf GM |
| Ref : American Journal of Physiology , 253 :G226 , 1987 |
| Abstract : |
| PubMedSearch : Grider_1987_Am.J.Physiol_253_G226 |
| PubMedID: 2887119 |
| Title : Colonic peristaltic reflex: identification of vasoactive intestinal peptide as mediator of descending relaxation - Grider_1986_Am.J.Physiol_251_G40 |
| Author(s) : Grider JR , Makhlouf GM |
| Ref : American Journal of Physiology , 251 :G40 , 1986 |
| Abstract : |
| PubMedSearch : Grider_1986_Am.J.Physiol_251_G40 |
| PubMedID: 3014895 |
| Title : Colonic peristaltic reflex: identification of vasoactive intestinal peptide as mediator of descending relaxation - Grider_1986_Am.J.Physiol_251_G40 |
| Author(s) : Grider JR , Makhlouf GM |
| Ref : American Journal of Physiology , 251 :G40 , 1986 |
| Abstract : |
| PubMedSearch : Grider_1986_Am.J.Physiol_251_G40 |
| PubMedID: 3014895 |
| Title : Colonic peristaltic reflex: identification of vasoactive intestinal peptide as mediator of descending relaxation - Grider_1986_Am.J.Physiol_251_G40 |
| Author(s) : Grider JR , Makhlouf GM |
| Ref : American Journal of Physiology , 251 :G40 , 1986 |
| Abstract : |
| PubMedSearch : Grider_1986_Am.J.Physiol_251_G40 |
| PubMedID: 3014895 |
| Title : Receptors for mammalian tachykinins on isolated intestinal smooth muscle cells - Souquet_1985_Am.J.Physiol_249_G533 |
| Author(s) : Souquet JC , Grider JR , Bitar KN , Makhlouf GM |
| Ref : American Journal of Physiology , 249 :G533 , 1985 |
| Abstract : |
| PubMedSearch : Souquet_1985_Am.J.Physiol_249_G533 |
| PubMedID: 2413771 |
| Title : Receptors for mammalian tachykinins on isolated intestinal smooth muscle cells - Souquet_1985_Am.J.Physiol_249_G533 |
| Author(s) : Souquet JC , Grider JR , Bitar KN , Makhlouf GM |
| Ref : American Journal of Physiology , 249 :G533 , 1985 |
| Abstract : |
| PubMedSearch : Souquet_1985_Am.J.Physiol_249_G533 |
| PubMedID: 2413771 |
| Title : Receptors for mammalian tachykinins on isolated intestinal smooth muscle cells - Souquet_1985_Am.J.Physiol_249_G533 |
| Author(s) : Souquet JC , Grider JR , Bitar KN , Makhlouf GM |
| Ref : American Journal of Physiology , 249 :G533 , 1985 |
| Abstract : |
| PubMedSearch : Souquet_1985_Am.J.Physiol_249_G533 |
| PubMedID: 2413771 |