| Title : N-[5-(5-fluoropyridin-3-yl)-1H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775): a medicinal chemistry effort toward an alpha7 nicotinic acetylcholine receptor agonist preclinical candidate - Zanaletti_2012_J.Med.Chem_55_10277 |
| Author(s) : Zanaletti R , Bettinetti L , Castaldo C , Ceccarelli I , Cocconcelli G , Comery TA , Dunlop J , Genesio E , Ghiron C , Haydar SN , Jow F , Maccari L , Micco I , Nencini A , Pratelli C , Scali C , Turlizzi E , Valacchi M |
| Ref : Journal of Medicinal Chemistry , 55 :10277 , 2012 |
| PubMedID: 23083093 |
| Title : Discovery of a novel alpha-7 nicotinic acetylcholine receptor agonist series and characterization of the potent, selective, and orally efficacious agonist 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide (SEN15924, WAY-361789) - Zanaletti_2012_J.Med.Chem_55_4806 |
| Author(s) : Zanaletti R , Bettinetti L , Castaldo C , Cocconcelli G , Comery T , Dunlop J , Gaviraghi G , Ghiron C , Haydar SN , Jow F , Maccari L , Micco I , Nencini A , Scali C , Turlizzi E , Valacchi M |
| Ref : Journal of Medicinal Chemistry , 55 :4806 , 2012 |
| PubMedID: 22468936 |
| Title : Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1-[6-(4-fluorophenyl)pyridin-3-yl]-3-(4-piperidin-1-ylbutyl) urea (SEN34625\/WYE-103914) - Ghiron_2010_J.Med.Chem_53_4379 |
| Author(s) : Ghiron C , Haydar SN , Aschmies S , Bothmann H , Castaldo C , Cocconcelli G , Comery TA , Di L , Dunlop J , Lock T , Kramer A , Kowal D , Jow F , Grauer S , Harrison B , La Rosa S , Maccari L , Marquis KL , Micco I , Nencini A , Quinn J , Robichaud AJ , Roncarati R , Scali C , Terstappen GC , Turlizzi E , Valacchi M , Varrone M , Zanaletti R , Zanelli U |
| Ref : Journal of Medicinal Chemistry , 53 :4379 , 2010 |
| PubMedID: 20465311 |
| Title : Neuronal nicotinic acetylcholine receptors - targets for the development of drugs to treat cognitive impairment associated with schizophrenia and Alzheimer's disease - Haydar_2010_Curr.Top.Med.Chem_10_144 |
| Author(s) : Haydar SN , Dunlop J |
| Ref : Curr Top Med Chem , 10 :144 , 2010 |
| PubMedID: 20166959 |
| Title : SAR and biological evaluation of SEN12333\/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist - Haydar_2009_Bioorg.Med.Chem_17_5247 |
| Author(s) : Haydar SN , Ghiron C , Bettinetti L , Bothmann H , Comery TA , Dunlop J , La Rosa S , Micco I , Pollastrini M , Quinn J , Roncarati R , Scali C , Valacchi M , Varrone M , Zanaletti R |
| Ref : Bioorganic & Medicinal Chemistry , 17 :5247 , 2009 |
| PubMedID: 19515567 |