Mahadhi HMD

References (1)

Title : Molecular characterization and polymorphisms of butyrylcholinesterase in cynomolgus macaques - Uno_2018_J.Med.Primatol_47_185
Author(s) : Uno Y , Uehara S , Mahadhi HMD , Ohura K , Hosokawa M , Imai T
Ref : J Med Primatol , 47 :185 , 2018
Abstract : BACKGROUND: Butyrylcholinesterase (BChE), an enzyme essential for drug metabolism, has been investigated as antidotes against organophosphorus nerve agents, and the efficacy and safety have been studied in cynomolgus macaques. BChE polymorphisms partly account for variable BChE activities among individuals in humans, but have not been investigated in cynomolgus macaques. METHODS: Molecular characterization was carried out by analyzing primary sequence, gene, tissue expression, and genetic variants. RESULTS: In cynomolgus and human BChE, phylogenetically closely related, amino acid residues important for enzyme function were conserved, and gene and genomic structure were similar. Cynomolgus BChE mRNA was most abundantly expressed in liver among the 10 tissue types analyzed. Re-sequencing found 26 non-synonymous genetic variants in 121 cynomolgus and 23 rhesus macaques, indicating that macaque BChE is polymorphic, although none of these variants corresponded to the null or defective alleles of human BChE. CONCLUSIONS: These results suggest molecular similarities of cynomolgus and human BChE.
ESTHER : Uno_2018_J.Med.Primatol_47_185
PubMedSearch : Uno_2018_J.Med.Primatol_47_185
PubMedID: 29573432
Gene_locus related to this paper: macfa-BCHE