| Title : Bioconversion and P-gp-mediated transport of depot fluphenazine prodrugs after intramuscular injection - Ohura_2023_J.Pharm.Sci__ |
| Author(s) : Ohura K , Nakada Y , Imai T |
| Ref : J Pharm Sci , : , 2023 |
| Abstract : |
| PubMedSearch : Ohura_2023_J.Pharm.Sci__ |
| PubMedID: 37019360 |
| Title : Esterases Involved in the Rapid Bioconversion of Esmolol after Intravenous Injection in Humans - Imai_2022_Biol.Pharm.Bull_45_1544 |
| Author(s) : Imai T , Isozaki M , Ohura K |
| Ref : Biol Pharm Bull , 45 :1544 , 2022 |
| Abstract : |
| PubMedSearch : Imai_2022_Biol.Pharm.Bull_45_1544 |
| PubMedID: 36184514 |
| Title : Effect of Calcium on the Hydrolysis Activity of Human Butyrylcholinesterase - Imai_2020_J.Pharm.Sci_109_1417 |
| Author(s) : Imai T , Bahar FG , Ohura K , Toda A |
| Ref : J Pharm Sci , 109 :1417 , 2020 |
| Abstract : |
| PubMedSearch : Imai_2020_J.Pharm.Sci_109_1417 |
| PubMedID: 31837977 |
| Title : Identification and Characterization of a New Carboxylesterase 2 Isozyme, mfCES2C, in the Small Intestine of Cynomolgus Monkeys - Ohura_2020_Drug.Metab.Dispos_48_146 |
| Author(s) : Ohura K , Igawa Y , Tanaka M , Matsumoto K , Kasahara A , Wada N , Kubota K , Uno Y , Imai T |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 48 :146 , 2020 |
| Abstract : |
| PubMedSearch : Ohura_2020_Drug.Metab.Dispos_48_146 |
| PubMedID: 31836607 |
| Gene_locus related to this paper: macfa-a0a2k5uar1 |
| Title : [Comparative Study of Hydrolase Activity in Skin with Liver and Intestine, and Its Aging Relation of Carboxylesterase Expression in Cynomolgus Monkey and Beagle Dog] - Imai_2019_Yakugaku.Zasshi_139_837 |
| Author(s) : Imai T , Nakada Y , Ohura K |
| Ref : Yakugaku Zasshi , 139 :837 , 2019 |
| Abstract : |
| PubMedSearch : Imai_2019_Yakugaku.Zasshi_139_837 |
| PubMedID: 31061351 |
| Title : Analysis of carboxylesterase 2 transcript variants in cynomolgus macaque liver - Uno_2018_Xenobiotica__1 |
| Author(s) : Uno Y , Igawa Y , Tanaka M , Kayoko O , Hosokawa M , Imai T |
| Ref : Xenobiotica , :1 , 2018 |
| Abstract : |
| PubMedSearch : Uno_2018_Xenobiotica__1 |
| PubMedID: 29384423 |
| Title : Development of simultaneous quantification method of loteprednol etabonate (LE) and its acidic metabolites, and analysis of LE metabolism in rat - Samir_2018_Xenobiotica__1 |
| Author(s) : Samir A , Kage A , Kayoko O , Imai T |
| Ref : Xenobiotica , :1 , 2018 |
| Abstract : |
| PubMedSearch : Samir_2018_Xenobiotica__1 |
| PubMedID: 29781759 |
| Title : A novel quantification method for serine hydrolases in cellular expression system using fluorophosphonate-biotin probe - Abdel-Daim_2018_Eur.J.Pharm.Sci_114_267 |
| Author(s) : Abdel-Daim A , Ohura K , Imai T |
| Ref : Eur J Pharm Sci , 114 :267 , 2018 |
| Abstract : |
| PubMedSearch : Abdel-Daim_2018_Eur.J.Pharm.Sci_114_267 |
| PubMedID: 29289670 |
| Title : Molecular characterization and polymorphisms of butyrylcholinesterase in cynomolgus macaques - Uno_2018_J.Med.Primatol_47_185 |
| Author(s) : Uno Y , Uehara S , Mahadhi HMD , Ohura K , Hosokawa M , Imai T |
| Ref : J Med Primatol , 47 :185 , 2018 |
| Abstract : |
| PubMedSearch : Uno_2018_J.Med.Primatol_47_185 |
| PubMedID: 29573432 |
| Gene_locus related to this paper: macfa-BCHE |
| Title : Prescription of Antidementia Drugs and Antipsychotics for Elderly Patients in Japan: A Descriptive Study Using Pharmacy Prescription Data - Tsukada_2018_J.Geriatr.Psychiatry.Neurol__891988718785775 |
| Author(s) : Tsukada T , Sato I , Matsuoka N , Imai T , Doi Y , Arai M , Fujii Y , Matsunaga T , Kawakami K |
| Ref : J Geriatr Psychiatry Neurol , :891988718785775 , 2018 |
| Abstract : |
| PubMedSearch : Tsukada_2018_J.Geriatr.Psychiatry.Neurol__891988718785775 |
| PubMedID: 30016896 |
| Title : Development of a Caco-2 Cell Line Carrying the Human Intestine-Type CES Expression Profile as a Promising Tool for Ester-Containing Drug Permeability Studies - Ishizaki_2018_Biol.Pharm.Bull_41_697 |
| Author(s) : Ishizaki Y , Furihata T , Oyama Y , Ohura K , Imai T , Hosokawa M , Akita H , Chiba K |
| Ref : Biol Pharm Bull , 41 :697 , 2018 |
| Abstract : |
| PubMedSearch : Ishizaki_2018_Biol.Pharm.Bull_41_697 |
| PubMedID: 29709907 |
| Title : Effect of alcohol on skin permeation and metabolism of an ester-type prodrug in Yucatan micropig skin - Fujii_2017_Eur.J.Pharm.Sci_109_280 |
| Author(s) : Fujii M , Ohara R , Matsumi A , Ohura K , Koizumi N , Imai T , Watanabe Y |
| Ref : Eur J Pharm Sci , 109 :280 , 2017 |
| Abstract : |
| PubMedSearch : Fujii_2017_Eur.J.Pharm.Sci_109_280 |
| PubMedID: 28821439 |
| Title : Differences in Intestinal Hydrolytic Activities between Cynomolgus Monkeys and Humans: Evaluation of Substrate Specificities Using Recombinant Carboxylesterase 2 Isozymes - Igawa_2016_Mol.Pharm_13_3176 |
| Author(s) : Igawa Y , Fujiwara S , Ohura K , Hirokawa T , Nishizawa Y , Uehara S , Uno Y , Imai T |
| Ref : Mol Pharm , 13 :3176 , 2016 |
| Abstract : |
| PubMedSearch : Igawa_2016_Mol.Pharm_13_3176 |
| PubMedID: 27454346 |
| Title : Establishment and Characterization of a Novel Caco-2 Subclone with a Similar Low Expression Level of Human Carboxylesterase 1 to Human Small Intestine - Ohura_2016_Drug.Metab.Dispos_44_1890 |
| Author(s) : Ohura K , Nishiyama H , Saco S , Kurokawa K , Imai T |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 44 :1890 , 2016 |
| Abstract : |
| PubMedSearch : Ohura_2016_Drug.Metab.Dispos_44_1890 |
| PubMedID: 27638507 |
| Gene_locus related to this paper: human-CES1 |
| Title : Expression of Carboxylesterase Isozymes and Their Role in the Behavior of a Fexofenadine Prodrug in Rat Skin - Imai_2016_J.Pharm.Sci_105_714 |
| Author(s) : Imai T , Ariyoshi S , Ohura K , Sawada T , Nakada Y |
| Ref : J Pharm Sci , 105 :714 , 2016 |
| Abstract : |
| PubMedSearch : Imai_2016_J.Pharm.Sci_105_714 |
| PubMedID: 26444870 |
| Title : 3D-fibroblast tissues constructed by a cell-coat technology enhance tight-junction formation of human colon epithelial cells - Matsusaki_2015_Biochem.Biophys.Res.Commun_457_363 |
| Author(s) : Matsusaki M , Hikimoto D , Nishiguchi A , Kadowaki K , Ohura K , Imai T , Akashi M |
| Ref : Biochemical & Biophysical Research Communications , 457 :363 , 2015 |
| Abstract : |
| PubMedSearch : Matsusaki_2015_Biochem.Biophys.Res.Commun_457_363 |
| PubMedID: 25576862 |
| Title : Isolation and characterization of arylacetamide deacetylase in cynomolgus macaques - Uno_2015_J.Vet.Med.Sci_77_721 |
| Author(s) : Uno Y , Hosokawa M , Imai T |
| Ref : J Vet Med Sci , 77 :721 , 2015 |
| Abstract : |
| PubMedSearch : Uno_2015_J.Vet.Med.Sci_77_721 |
| PubMedID: 25715734 |
| Title : Design of Fexofenadine Prodrugs Based on Tissue-Specific Esterase Activity and Their Dissimilar Recognition by P-Glycoprotein - Ohura_2015_J.Pharm.Sci_104_3076 |
| Author(s) : Ohura K , Nakada Y , Kotani S , Imai T |
| Ref : J Pharm Sci , 104 :3076 , 2015 |
| Abstract : |
| PubMedSearch : Ohura_2015_J.Pharm.Sci_104_3076 |
| PubMedID: 25953731 |
| Title : Monitoring of the effects of transfection with baculovirus on Sf9 cell line and expression of human dipeptidyl peptidase IV - Ustun-Aytekin_2014_Cytotech_66_159 |
| Author(s) : Ustun-Aytekin O , Gurhan ID , Ohura K , Imai T , Ongen G |
| Ref : Cytotechnology , 66 :159 , 2014 |
| Abstract : |
| PubMedSearch : Ustun-Aytekin_2014_Cytotech_66_159 |
| PubMedID: 23715645 |
| Title : Quality of life in purely ocular myasthenia in Japan - Suzuki_2014_BMC.Neurol_14_142 |
| Author(s) : Suzuki S , Murai H , Imai T , Nagane Y , Masuda M , Tsuda E , Konno S , Oji S , Nakane S , Motomura M , Suzuki N , Utsugisawa K |
| Ref : BMC Neurol , 14 :142 , 2014 |
| Abstract : |
| PubMedSearch : Suzuki_2014_BMC.Neurol_14_142 |
| PubMedID: 24996227 |
| Title : Systematic identification and characterization of carboxylesterases in cynomolgus macaques - Uno_2014_Drug.Metab.Dispos_42_2002 |
| Author(s) : Uno Y , Uehara S , Hosokawa M , Imai T |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 42 :2002 , 2014 |
| Abstract : |
| PubMedSearch : Uno_2014_Drug.Metab.Dispos_42_2002 |
| PubMedID: 25256558 |
| Gene_locus related to this paper: macfa-CES1v2 , macfa-CES1v1 , macfa-CES5 , macfa-CES2v3 |
| Title : Distinct patterns of aging effects on the expression and activity of carboxylesterases in rat liver and intestine - Ohura_2014_Drug.Metab.Dispos_42_264 |
| Author(s) : Ohura K , Tasaka K , Hashimoto M , Imai T |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 42 :264 , 2014 |
| Abstract : |
| PubMedSearch : Ohura_2014_Drug.Metab.Dispos_42_264 |
| PubMedID: 24271336 |
| Gene_locus related to this paper: human-CES1 |
| Title : Involvement of Carboxylesterase in Hydrolysis of Propranolol Prodrug during Permeation across Rat Skin - Imai_2013_Pharmaceutics_5_371 |
| Author(s) : Imai T , Takase Y , Iwase H , Hashimoto M |
| Ref : Pharmaceutics , 5 :371 , 2013 |
| Abstract : |
| PubMedSearch : Imai_2013_Pharmaceutics_5_371 |
| PubMedID: 24300511 |
| Title : Aspirin hydrolysis in human and experimental animal plasma and the effect of metal cations on hydrolase activities - Bahar_2013_Drug.Metab.Dispos_41_1450 |
| Author(s) : Bahar FG , Imai T |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 41 :1450 , 2013 |
| Abstract : |
| PubMedSearch : Bahar_2013_Drug.Metab.Dispos_41_1450 |
| PubMedID: 23649702 |
| Title : Species difference of esterase expression and hydrolase activity in plasma - Bahar_2012_J.Pharm.Sci_101_3979 |
| Author(s) : Bahar FG , Ohura K , Ogihara T , Imai T |
| Ref : J Pharm Sci , 101 :3979 , 2012 |
| Abstract : |
| PubMedSearch : Bahar_2012_J.Pharm.Sci_101_3979 |
| PubMedID: 22833171 |
| Title : Prediction of human intestinal absorption of the prodrug temocapril by in situ single-pass perfusion using rat intestine with modified hydrolase activity - Nozawa_2011_Drug.Metab.Dispos_39_1263 |
| Author(s) : Nozawa T , Imai T |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 39 :1263 , 2011 |
| Abstract : |
| PubMedSearch : Nozawa_2011_Drug.Metab.Dispos_39_1263 |
| PubMedID: 21474683 |
| Title : Evaluation of transport mechanism of prodrugs and parent drugs formed by intracellular metabolism in Caco-2 cells with modified carboxylesterase activity: temocapril as a model case - Ohura_2011_J.Pharm.Sci_100_3985 |
| Author(s) : Ohura K , Nozawa T , Murakami K , Imai T |
| Ref : J Pharm Sci , 100 :3985 , 2011 |
| Abstract : |
| PubMedSearch : Ohura_2011_J.Pharm.Sci_100_3985 |
| PubMedID: 21618543 |
| Title : Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins - Holmes_2010_Mamm.Genome_21_427 |
| Author(s) : Holmes RS , Wright MW , Laulederkind SJ , Cox LA , Hosokawa M , Imai T , Ishibashi S , Lehner R , Miyazaki M , Perkins EJ , Potter PM , Redinbo MR , Robert J , Satoh T , Yamashita T , Yan B , Yokoi T , Zechner R , Maltais LJ |
| Ref : Mamm Genome , 21 :427 , 2010 |
| Abstract : |
| PubMedSearch : Holmes_2010_Mamm.Genome_21_427 |
| PubMedID: 20931200 |
| Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3 , human-CES4A , human-CES5A |
| Title : Prodrug approach using carboxylesterases activity: catalytic properties and gene regulation of carboxylesterase in mammalian tissue - Imai_2010_J.Pestic.Sci_35_229 |
| Author(s) : Imai T , Hosokawa M |
| Ref : Journal of Pesticide Science , 35 :229 , 2010 |
| Abstract : |
| PubMedSearch : Imai_2010_J.Pestic.Sci_35_229 |
| PubMedID: |
| Title : Development of a novel system for estimating human intestinal absorption using Caco-2 cells in the absence of esterase activity - Ohura_2010_Drug.Metab.Dispos_38_323 |
| Author(s) : Ohura K , Sakamoto H , Ninomiya S , Imai T |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 38 :323 , 2010 |
| Abstract : |
| PubMedSearch : Ohura_2010_Drug.Metab.Dispos_38_323 |
| PubMedID: 19923255 |
| Title : The role of intestinal carboxylesterase in the oral absorption of prodrugs - Imai_2010_Curr.Drug.Metab_11_793 |
| Author(s) : Imai T , Ohura K |
| Ref : Curr Drug Metab , 11 :793 , 2010 |
| Abstract : |
| PubMedSearch : Imai_2010_Curr.Drug.Metab_11_793 |
| PubMedID: 21189138 |
| Title : Carboxylesterase in the liver and small intestine of experimental animals and human - Taketani_2007_Life.Sci_81_924 |
| Author(s) : Taketani M , Shii M , Ohura K , Ninomiya S , Imai T |
| Ref : Life Sciences , 81 :924 , 2007 |
| Abstract : |
| PubMedSearch : Taketani_2007_Life.Sci_81_924 |
| PubMedID: 17764701 |
| Title : [Hydrolysis by carboxylesterase and disposition of prodrug with ester moiety] - Imai_2007_Yakugaku.Zasshi_127_611 |
| Author(s) : Imai T |
| Ref : Yakugaku Zasshi , 127 :611 , 2007 |
| Abstract : |
| PubMedSearch : Imai_2007_Yakugaku.Zasshi_127_611 |
| PubMedID: 17409690 |
| Title : Involvement of up-regulation of hepatic breast cancer resistance protein in decreased plasma concentration of 7-ethyl-10-hydroxycamptothecin (SN-38) by coadministration of S-1 in rats - Yokoo_2007_Drug.Metab.Dispos_35_1511 |
| Author(s) : Yokoo K , Hamada A , Watanabe H , Matsuzaki T , Imai T , Fujimoto H , Masa K , Saito H |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 35 :1511 , 2007 |
| Abstract : |
| PubMedSearch : Yokoo_2007_Drug.Metab.Dispos_35_1511 |
| PubMedID: 17537871 |
| Title : Thyroglobulin gene mutations producing defective intracellular transport of thyroglobulin are associated with increased thyroidal type 2 iodothyronine deiodinase activity - Kanou_2007_J.Clin.Endocrinol.Metab_92_1451 |
| Author(s) : Kanou Y , Hishinuma A , Tsunekawa K , Seki K , Mizuno Y , Fujisawa H , Imai T , Miura Y , Nagasaka T , Yamada C , Ieiri T , Murakami M , Murata Y |
| Ref : J Clinical Endocrinology Metab , 92 :1451 , 2007 |
| Abstract : |
| PubMedSearch : Kanou_2007_J.Clin.Endocrinol.Metab_92_1451 |
| PubMedID: 17244789 |
| Title : Assessment of induction of cytochrome P450 by NO-1886 (ibrolipim), a lipoprotein lipase-promoting agent, in primary cultures of human hepatocytes and in female rat liver - Morioka_2006_Drug.Metab.Pharmacokinet_21_19 |
| Author(s) : Morioka Y , Nishimura M , Imai T , Suzuki S , Harada M , Satoh T , Naito S |
| Ref : Drug Metab Pharmacokinet , 21 :19 , 2006 |
| Abstract : |
| PubMedSearch : Morioka_2006_Drug.Metab.Pharmacokinet_21_19 |
| PubMedID: 16547390 |
| Title : Human carboxylesterase isozymes: catalytic properties and rational drug design - Imai_2006_Drug.Metab.Pharmacokinet_21_173 |
| Author(s) : Imai T |
| Ref : Drug Metab Pharmacokinet , 21 :173 , 2006 |
| Abstract : |
| PubMedSearch : Imai_2006_Drug.Metab.Pharmacokinet_21_173 |
| PubMedID: 16858120 |
| Gene_locus related to this paper: human-CES1 |
| Title : Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in human liver and small intestine - Imai_2006_Drug.Metab.Dispos_34_1734 |
| Author(s) : Imai T , Taketani M , Shii M , Hosokawa M , Chiba K |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 34 :1734 , 2006 |
| Abstract : |
| PubMedSearch : Imai_2006_Drug.Metab.Dispos_34_1734 |
| PubMedID: 16837570 |
| Gene_locus related to this paper: human-CES1 , human-CES2 |
| Title : Effects of NO-1886 (Ibrolipim), a lipoprotein lipase-promoting agent, on gene induction of cytochrome P450s, carboxylesterases, and sulfotransferases in primary cultures of human hepatocytes - Nishimura_2004_Drug.Metab.Pharmacokinet_19_422 |
| Author(s) : Nishimura M , Imai T , Morioka Y , Kuribayashi S , Kamataki T , Naito S |
| Ref : Drug Metab Pharmacokinet , 19 :422 , 2004 |
| Abstract : |
| PubMedSearch : Nishimura_2004_Drug.Metab.Pharmacokinet_19_422 |
| PubMedID: 15681896 |