Yin QM

References (2)

Title : Goodyschle A, a new butenolide with significant BchE inhibitory activity from Goodyera schlechtendaliana - Dai_2020_Nat.Prod.Res__1
Author(s) : Dai LY , Yin QM , Qiu JK , Zhang ZY , Li G , Huang MN , Liu L
Ref : Nat Prod Res , :1 , 2020
Abstract : Goodyschle A (1), a new butenolide, was isolated from the whole grass of Goodyera schlechtendaliana, an orchidaceous edible medicinal plant. The structure of the new compound was elucidated by 1 D and 2 D NMR experiments in addition to HRESIMS analyses. Compound 1 was evaluated for its bioactivities including cytotoxic activity against human gastric cancer (SGC-7901) and human hepatocellular carcinoma (HepG2) cell lines, inhibitory activity on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and DPPH radical scavenging activity. As a result, compound 1 showed potent BChE inhibitory activity (IC50 value = 6.88 +/- 1.63 muM), moderate DPPH radical scavenging activity (IC50 value = 16.25 +/- 0.21 muM), and slight AChE inhibitory and cytotoxic activities. These findings suggest that compound 1 is worthy for further investigations in terms of its selective BChE inhibitory activity.
ESTHER : Dai_2020_Nat.Prod.Res__1
PubMedSearch : Dai_2020_Nat.Prod.Res__1
PubMedID: 32208851

Title : New biphenanthrenes with butyrylcholinesterase inhibitory activitiy from Cremastra appendiculata - Liu_2019_Nat.Prod.Res__1
Author(s) : Liu L , Yin QM , Gao Q , Li J , Jiang Y , Tu PF
Ref : Nat Prod Res , :1 , 2019
Abstract : Encouraged by the in vitro potent inhibitory activity on butyrylcholinesterase (BChE) of 95% ethanol extract of Cremastra appendiculata (D. Don) Makino tubers, a further phytochemical investigation on C. appendiculata tubers was conducted, which led to the isolation of a pair of new biphenanthrene atropisomers, namely cremaphenanthrene F-G (1-2). Their structures were elucidated on the basis of extensive spectroscopic analyses and chemical method. It is the first time that biphenanthrene atropisomers have been isolated from the plant kingdom. Compound 1 showed potent BChE inhibitory effect with IC50 value of 14.62 +/- 2.15 muM. Compound 2 exhibited weak BChE inhibitory effect with IC50 value of 79.56 +/- 0.78 muM. Meanwhile, 1 and 2 were found to be inactive for acetylcholinesterase (AChE) inhibition. These findings suggested that compound 1 was a promising selective BChE inhibitor for AD prevention and treatment.
ESTHER : Liu_2019_Nat.Prod.Res__1
PubMedSearch : Liu_2019_Nat.Prod.Res__1
PubMedID: 31117825