Title : Goodyschle A, a new butenolide with significant BchE inhibitory activity from Goodyera schlechtendaliana - Dai_2020_Nat.Prod.Res__1 |
Author(s) : Dai LY , Yin QM , Qiu JK , Zhang ZY , Li G , Huang MN , Liu L |
Ref : Nat Prod Res , :1 , 2020 |
Abstract :
Goodyschle A (1), a new butenolide, was isolated from the whole grass of Goodyera schlechtendaliana, an orchidaceous edible medicinal plant. The structure of the new compound was elucidated by 1 D and 2 D NMR experiments in addition to HRESIMS analyses. Compound 1 was evaluated for its bioactivities including cytotoxic activity against human gastric cancer (SGC-7901) and human hepatocellular carcinoma (HepG2) cell lines, inhibitory activity on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and DPPH radical scavenging activity. As a result, compound 1 showed potent BChE inhibitory activity (IC50 value = 6.88 +/- 1.63 muM), moderate DPPH radical scavenging activity (IC50 value = 16.25 +/- 0.21 muM), and slight AChE inhibitory and cytotoxic activities. These findings suggest that compound 1 is worthy for further investigations in terms of its selective BChE inhibitory activity. |
PubMedSearch : Dai_2020_Nat.Prod.Res__1 |
PubMedID: 32208851 |
Inhibitor | Goodyschle-A |
Dai LY, Yin QM, Qiu JK, Zhang ZY, Li G, Huang MN, Liu L (2020)
Goodyschle A, a new butenolide with significant BchE inhibitory activity from Goodyera schlechtendaliana
Nat Prod Res
:1
Dai LY, Yin QM, Qiu JK, Zhang ZY, Li G, Huang MN, Liu L (2020)
Nat Prod Res
:1