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| Title : Phase 1 and pre-clinical profiling of ESM-HDAC391, a myeloid-targeted histone deacetylase inhibitor, shows enhanced pharmacology and monocytopaenia - Furze_2022_Br.J.Clin.Pharmacol__ |
| Author(s) : Furze RC , Molnar J , Parr NJ , Ahmad F , Henry Y , Howe D , Singh R , Toal M , Bassil AK , Bernard SG , Davis RP , Gibson A , Maller NC , Sharp C , Tough DF , Prinjha RK , Lewis HD |
| Ref : British Journal of Clinical Pharmacology , : , 2022 |
| Abstract : Furze_2022_Br.J.Clin.Pharmacol__ |
| ESTHER : Furze_2022_Br.J.Clin.Pharmacol__ |
| PubMedSearch : Furze_2022_Br.J.Clin.Pharmacol__ |
| PubMedID: 35655123 |
| Title : A BET Protein Inhibitor Targeting Mononuclear Myeloid Cells Affects Specific Inflammatory Mediators and Pathways in Crohn's Disease - Elfiky_2022_Cells_11_ |
| Author(s) : Elfiky AMI , Hageman IL , Becker MAJ , Verhoeff J , Li Yim AYF , Joustra VW , Mulders L , Fung I , Rioja I , Prinjha RK , Smithers NN , Furze RC , Mander PK , Bell MJ , Buskens CJ , D'Haens GR , Wildenberg ME , de Jonge WJ |
| Ref : Cells , 11 : , 2022 |
| Abstract : Elfiky_2022_Cells_11_ |
| ESTHER : Elfiky_2022_Cells_11_ |
| PubMedSearch : Elfiky_2022_Cells_11_ |
| PubMedID: 36139421 |
| Title : Carboxylesterase-1 assisted targeting of HDAC inhibitors to mononuclear myeloid cells in Inflammatory Bowel Disease - Elfiky_2021_J.Crohns.Colitis__ |
| Author(s) : Elfiky AMI , Ghiboub M , Li Yim AYF , Hageman IL , Verhoeff J , de Krijger M , van Hamersveld PHP , Welting O , Admiraal I , Rahman S , Garcia-Vallejo JJ , Wildenberg ME , Tomlinson L , Gregory R , Rioja I , Prinjha RK , Furze RC , Lewis HD , Mander PK , Heinsbroek SEM , Bell MJ , de Jonge WJ |
| Ref : J Crohns Colitis , : , 2021 |
| Abstract : Elfiky_2021_J.Crohns.Colitis__ |
| ESTHER : Elfiky_2021_J.Crohns.Colitis__ |
| PubMedSearch : Elfiky_2021_J.Crohns.Colitis__ |
| PubMedID: 34633041 |
| Gene_locus related to this paper: human-CES1 |
| Title : Targeting Histone Deacetylases in Myeloid Cells Inhibits Their Maturation and Inflammatory Function With Limited Effects on Atherosclerosis - Luque-Martin_2019_Front.Pharmacol_10_1242 |
| Author(s) : Luque-Martin R , Van den Bossche J , Furze RC , Neele AE , van der Velden S , Gijbels MJJ , van Roomen C , Bernard SG , de Jonge WJ , Rioja I , Prinjha RK , Lewis HD , Mander PK , de Winther MPJ |
| Ref : Front Pharmacol , 10 :1242 , 2019 |
| Abstract : Luque-Martin_2019_Front.Pharmacol_10_1242 |
| ESTHER : Luque-Martin_2019_Front.Pharmacol_10_1242 |
| PubMedSearch : Luque-Martin_2019_Front.Pharmacol_10_1242 |
| PubMedID: 31736752 |