human-CES1
Homo sapiens (Human) carboxylesterase CES1 hCE1 & for monocyte/macrophage serine-esterase 1 egasyn
Comment
Mammalian liver carboxylesterases (CESs\; EC 3.1.1.1) hydrolyze various xenobiotics and endogenous substrates with ester, thioester, or amide bonds and are thought to function mainly in drug metabolism and detoxication of harmful chemicals. CES1 is also responsible for hydrolysis of stored cholesterol esters in macrophage foam cells and release of free cholesterol for high density lipoprotein-mediated cholesterol efflux. Alternative names: Acyl-coenzyme A:cholesterol acyltransferase (ACAT) Monocyte\/macrophage serine esterase (HMSE) Serine esterase 1 Brain carboxylesterase hBr1 Triacylglycerol hydrolase (TGH) Egasyn Retinyl ester hydrolase (REH) Cocaine carboxylesterase.(Also named before human-cxesl human-cxest, -mmse, CES, hCES1,CES1A, hBr1 brain carboxylesterase hBr1 on chromosome 16 There are 3 isoforms some times called Ces1b, Ces1c they are not as diffiernt as the different genes if CE1 in mice (a,b,c,d,ef) ). The region is complex with pseudogene localized head to head with CES1. There are different haplotype and in some the pseudogene is replaced by a complete copy of CES1A1. see Rasmussen et al. 2018 for recent evaluation of genotyping procedures. Aso called monocyte-specific esterase or macrophage esterase || Carboxylesterases pI 5.3 is human-CES1 and 4.5 is human-CES2 from human liver Takai 1997
Relationship
Family : Carb_B_Chordata
Block : C
Position in NCBI Life Tree : Homo sapiens
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N EMolecular evidence
A158V_human-CES1
A269S_human-CES1
Asp260GlufsX39_human-CES1
CES1VAR_human-CES1
D203E\/A269S_human-CES1
D203E_human-CES1
D260EfsX39_human-CES1
E220G_human-CES1
G142E_human-CES1
G143E_human-CES1
G143H_human-CES1
G147C_human-CES1
G173D_human-CES1
H284Q_human-CES1
L363E_human-CES1
L363Q_human-CES1
L40X_human-CES1
N340K_human-CES1
Q169P_human-CES1
R171C_human-CES1
R186P_human-CES1
R199H_human-CES1
S75N\/D203E\/A269S_human-CES1
S75N_human-CES1
T167S_human-CES1
T290M_human-CES1
V146H\/L363E_human-CES1
V146H\/L363Q_human-CES1
V146H_human-CES1
V146Q\/L363E_human-CES1
V146Q\/L363Q_human-CES1
V146Q_human-CES1
Y170D_human-CES1
rs2244613_human-CES1
1MX1 - Crystal Structure of Human Liver Carboxylesterase in complex with tacrine
1MX5 - Crystal Structure of Human Liver Carboxylesterase in complex with homatropine, a cocaine analogue
1MX9 - Crystal Structure of Human Liver Carboxylesterase in complex with naloxone methiodide, a heroin analogue
1YA4 - Crystal structure of human liver carboxylesterase 1 in complex with tamoxifen
1YA8 - Crystal structure of human liver carboxylesterase in complex with mevastatin
1YAH - Crystal Structure of Human Liver Carboxylesterase complexed to Etyl Acetate\; A Fatty Acid Ethyl Ester Analogue
1YAJ - Crystal Structure of Human Liver Carboxylesterase in complex with benzil
2DQY - Crystal structure of human carboxylesterase in complex with cholate and palmitate
2DQZ - Crystal structure of human carboxylesterase in complex with homatropine, coenzyme A, and palmitate
2DR0 - Crystal structure of human carboxylesterase in complex with taurocholate
2H7C - Crystal structure of human carboxylesterase in complex with Coenzyme A (CASP Target)
2HRQ - Crystal structure of Human Liver Carboxylesterase 1 (hCE1) in covalent complex with the nerve agent Soman (GD)
2HRR - Crystal structure of Human Liver Carboxylesterase 1 (hCE1) in covalent complex with the nerve agent Tabun (GA)
3K9B - Crystal Structure of Human Liver Carboxylesterase 1 (hCE1) in covalent complex with the nerve agent Cyclosarin (GF)
4AB1 - Recombinant Human Carboxylesterase 1 Isolated from Whole Cabbage Looper Larvae
5A7F - Comparison of the structure and activity of glycosylated and aglycosylated Human Carboxylesterase 1
5A7G - Comparison of the structure and activity of glycosylated and aglycosylated Human Carboxylesterase 1
5A7H - Comparison of the structure and activity of glycosylated and aglycosylated Human Carboxylesterase 1
8EOR - Human liver carboxylesterase 1
9KWL - Human liver carboxylesterase 1 constently binding with compound F-3 (Dichlorophenyl-trifluoroethanol A1EIY) at the catalytic pocket
9KWM - Human liver carboxylesterase 1 constently binding with compound F-4 (Chlorophenyl-trifluoroethanol A1EIZ) at the catalytic pocket
No kinetic
No disease
2-Arachidonylglycerol
2-oxo-clopidogrel
4-MOMMP
Anordrin
Arecoline
BMBT
Bemnifosbuvir
Benazepril
Butyl-gallate
CBZ-FP
CES1-BODIPY-probe
CHC-CES1
Camostat
Candesartan-cilexetil
Cannabinoid-PB-22
Capecitabine
Ciclesonide
Clofibrate
Clopidogrel
Cocaine
Coenzyme-A
CurDD
Cypermethrin
D-luciferin-methyl-ester
Dabigatran-etexilate
Delapril
Diclofop-methyl
Dilazep
Diltiazem
Dimethyl-fumarate
ERBM
Enalapril
Eslicarbazepine-acetate
Esmolol
Ethylacetate
Ethylparaben
Fenofibrate
Fosinopril
Heptylparaben
Heroin
Homatropine
Homocysteine-thiolactone
Imidapril
Irinotecan
Lidocaine
MGS0274
Meperidine
Methylparaben
Methylphenidate
Mycophenolate-mofetil
Mycotoxin-T-2
N-Methylnaloxonium
NLMe
NT-0796
Nintedanib
Oseltamivir
Oxybutinin
PGE2-glyceryl-ester
Phospho-Ibuprofen
Prasugrel
Propylparaben
Prostaglandin-D2-Glyceryl-Ester
QMiPSB
Quinapril
Ramipril
Remdesivir
Remimazolam
Rufinamide
S-bromobenzylglutathione-dicyclopentyl-ester
Selexipag
Simvastatin
Sirpiglenastat
Sivelestat
Temocapril
Tenofovir-alafenamide
Trandolapril
Tyr-DHA
Unecritinib
Vixotrigine
1-Dodecylindoline-2,3-dione
4IPPDPP
4tBPDPP
Avenanthramide-B
Benzil
Betulinic-acid
BysspectinA-cpd20wderivative
CHEMBL1914935
CUA
Chlorophenyl-trifluoroethanol
DETFP
Dichlorophenyl-trifluoroethanol
Dicyclohexylethanedione
JZL195
Loperamide
Mevastatin
Nevadensin
Nonafluoro-[(methylphenyl)hydrazinylidene]-oxoheptanoic-acid
Palmitate
Remdesivir
Soman
Tacrine
Tamoxifen
Tanshinone-IIA
Valproyl-CoA
WWL113
ZINC02141756
Database
Sequence
Peptide
MWLRAFILAT LSASAAWGHP SSPPVVDTVH GKVLGKFVSL EGFAQPVAIF LGIPFAKPPL GPLRFTPPQP AEPWSFVKNA TSYPPMCTQD PKAGQLLSEL FTNRKENIPL KLSEDCLYLN IYTPADLTKK NRLPVMVWIH GGGLMVGAAS TYDGLALAAH ENVVVVTIQY RLGIWGFFST GDEHSRGNWG HLDQVAALRW VQDNIASFGG NPGSVTIFGE SAGGESVSVL VLSPLAKNLF HRAISESGVA LTSVLVKKGD VKPLAEQIAI TAGCKTTTSA VMVHCLRQKT EEELLETTLK MKFLSLDLQG DPRESQPLLG TVIDGMLLLK TPEELQAERN FHTVPYMVGI NKQEFGWLIP MQLMSYPLSE GQLDQKTAMS LLWKSYPLVC IAKELIPEAT EKYLGGTDDT VKKKDLFLDL IADVMFGVPS VIVARNHRDA GAPTYMYEFQ YRPSFSSDMK PKTVIGDHGD ELFSVFGAPF LKEGASEEEI RLSKMVMKFW ANFARNGNPN GEGLPHWPEY NQKEGYLQIG ANTQAAQKLK DKEVAFWTNL FAKKAVEKPP QTEHIEL
References (179)
| Title : Pharmacogenetic Testing for Predicting Methylphenidate Treatment Outcomes in Childhood Attention Deficit Hyperactivity Disorder in Turkey: Focus on Carboxylesterase 1, Latrophilin-3, and Catechol-O-Methyltransferase - Suzer Gamli_2025_Am.J.Med.Genet.B.Neuropsychiatr.Genet__e33024 |
| Author(s) : Suzer Gamli I , van Veggel A , Karaaslan RS , Kuerec AH , Marzoukah Z , Adak I , Bulut G , Tunc H , Hizel CP , Parlayan C , Ekinci O , Van Schaik R , Akin D |
| Ref : American Journal of Medicine Genet B Neuropsychiatr Genet , :e33024 , 2025 |
| Abstract : |
| PubMedSearch : Suzer Gamli_2025_Am.J.Med.Genet.B.Neuropsychiatr.Genet__e33024 |
| PubMedID: 39868802 |
| Gene_locus related to this paper: human-CES1 |
| Title : Impact of genetic polymorphisms and drug-drug interactions mediated by carboxylesterase 1 on remimazolam deactivation - Wang_2025_Drug.Metab.Dispos_53_100023 |
| Author(s) : Wang Z , McCalla Z , Lin L , Tornichio D , Agyemang Y , Bastulli JA , Zhang XS , Zhu HJ , Wang X |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 53 :100023 , 2025 |
| Abstract : |
| PubMedSearch : Wang_2025_Drug.Metab.Dispos_53_100023 |
| PubMedID: 39884809 |
| Gene_locus related to this paper: human-CES1 |
| Title : Carboxylesterase 1-mediated endocannabinoid metabolism in skin: role in melanoma progression in BRaf(V600E)\/Pten(-\/-) mice - Morozova_2025_Cancer.Metab_13_8 |
| Author(s) : Morozova V , Pellegata D , Charles RP , Gertsch J |
| Ref : Cancer Metab , 13 :8 , 2025 |
| Abstract : |
| PubMedSearch : Morozova_2025_Cancer.Metab_13_8 |
| PubMedID: 39934865 |
| Gene_locus related to this paper: human-CES1 |
| Title : Role of CES1 and ABCB1 Genetic Polymorphisms on Functional Response to Dabigatran in Patients with Atrial Fibrillation - Cumitini_2024_J.Clin.Med_13_2545 |
| Author(s) : Cumitini L , Renda G , Giordano M , Rolla R , Shail T , Sacchetti S , Iezzi L , Giacomini L , Zanotti V , Auciello R , Angilletta I , Foglietta M , Zucchelli M , Antonucci I , Stuppia L , Gallina S , Dianzani U , Patti G |
| Ref : J Clin Med , 13 :2545 , 2024 |
| Abstract : |
| PubMedSearch : Cumitini_2024_J.Clin.Med_13_2545 |
| PubMedID: 38731074 |
| Gene_locus related to this paper: human-CES1 |
| Title : Carboxylesterase 1 mediates a distinctive metabolic profile of dendritic cells to attain an inflammatory phenotype - Elfiky_2024_J.Leukoc.Biol__ |
| Author(s) : Elfiky AMI , Lopez Cannizares J , Li J , Li Yim AYF , Verhoeven AJ , Ghiboub M , de Jonge WJ |
| Ref : J Leukoc Biol , : , 2024 |
| Abstract : |
| PubMedSearch : Elfiky_2024_J.Leukoc.Biol__ |
| PubMedID: 38869086 |
| Gene_locus related to this paper: human-CES1 |
| Title : Carboxylesterase 1-Based Drug-Drug Interaction Potential of Remimazolam: In-Vitro Studies and Literature Review - Petersen_2024_Curr.Drug.Metab__1 |
| Author(s) : Petersen KU , Schmalix W , Pesic M , Stohr T |
| Ref : Curr Drug Metab , : , 2024 |
| Abstract : |
| PubMedSearch : Petersen_2024_Curr.Drug.Metab__1 |
| PubMedID: 39108117 |
| Gene_locus related to this paper: human-CES1 |
| Title : Drug-Drug Interaction Potential of Remimazolam Mediated by CYP 450, Transporters, and Protein Binding - Petersen_2024_Curr.Drug.Metab__2 |
| Author(s) : Petersen KU , Schmalix W , Pesic M , Stohr T |
| Ref : Curr Drug Metab , : , 2024 |
| Abstract : |
| PubMedSearch : Petersen_2024_Curr.Drug.Metab__2 |
| PubMedID: 38818914 |
| Gene_locus related to this paper: human-CES1 |
| Title : The study of halogen effect on the reactivity of the serine-targeting covalent warheads - Gai_2024_Front.Chem_12_1504453 |
| Author(s) : Gai C , Zhang Y , Zhang S , Hu X , Song YQ , Zhuang X , Chai X , Zou Y , Ge GB , Zhao Q |
| Ref : Front Chem , 12 :1504453 , 2024 |
| Abstract : |
| PubMedSearch : Gai_2024_Front.Chem_12_1504453 |
| PubMedID: 39691824 |
| Gene_locus related to this paper: human-CES1 |
| Title : Impact of Genetic Polymorphisms and Drug-Drug Interactions Mediated by Carboxylesterase1 on Remimazolam Deactivation - Wang_2024_Drug.Metab.Dispos__ |
| Author(s) : Wang Z , McCalla Z , Lin L , Tornichio D , Agyemang Y , Bastulli JA , Zhang XS , Zhu HJ , Wang X |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , : , 2024 |
| Abstract : |
| PubMedSearch : Wang_2024_Drug.Metab.Dispos__ |
| PubMedID: 39500567 |
| Gene_locus related to this paper: human-CES1 |
| Title : Role of carboxylesterase and arylacetamide deacetylase in drug metabolism, physiology, and pathology - Nagaoka_2024_Biochem.Pharmacol__116128 |
| Author(s) : Nagaoka M , Sakai Y , Nakajima M , Fukami T |
| Ref : Biochemical Pharmacology , :116128 , 2024 |
| Abstract : |
| PubMedSearch : Nagaoka_2024_Biochem.Pharmacol__116128 |
| PubMedID: 38492781 |
| Gene_locus related to this paper: human-AADAC , human-CES1 , human-CES2 |
| Title : Pharmacogenetic study of CES1 gene and enalapril efficacy - Hussain_2024_J.Appl.Genet__ |
| Author(s) : Hussain M , Basheer S , Khalil A , Haider QUA , Saeed H , Faizan M |
| Ref : J Appl Genet , : , 2024 |
| Abstract : |
| PubMedSearch : Hussain_2024_J.Appl.Genet__ |
| PubMedID: 38261266 |
| Gene_locus related to this paper: human-CES1 |
| Title : Natural deletion of mouse carboxylesterases Ces1c\/d\/e impacts drug metabolism and metabolic syndrome development - Gan_2023_Biomed.Pharmacother_164_114956 |
| Author(s) : Gan C , Wang J , Wang Y , Martinez-Chavez A , Hillebrand M , de Vries N , Beukers J , Lebre MC , Wagenaar E , Rosing H , Klarenbeek S , Bleijerveld OB , Song JY , Altelaar M , Beijnen JH , Schinkel AH |
| Ref : Biomed Pharmacother , 164 :114956 , 2023 |
| Abstract : |
| PubMedSearch : Gan_2023_Biomed.Pharmacother_164_114956 |
| PubMedID: 37267638 |
| Gene_locus related to this paper: human-CES1 , mouse-Ces1c , mouse-Ces1d , mouse-Ces1e |
| Title : Hydrolysis of dibutyl phthalate and di(2-ethylhexyl) phthalate in human liver, small intestine, kidney, and lung: An in vitro analysis using organ subcellular fractions and recombinant carboxylesterases - Isobe_2023_Chem.Biol.Interact_372_110353 |
| Author(s) : Isobe T , Ohkawara S , Mori Y , Jinno H , Tanaka-Kagawa T , Hanioka N |
| Ref : Chemico-Biological Interactions , 372 :110353 , 2023 |
| Abstract : |
| PubMedSearch : Isobe_2023_Chem.Biol.Interact_372_110353 |
| PubMedID: 36657734 |
| Gene_locus related to this paper: human-CES1 , mouse-Ces1c |
| Title : Human carboxylesterase 1A plays a predominant role in hydrolysis of the anti-dyslipidemia agent fenofibrate in humans - Li_2023_Drug.Metab.Dispos__ |
| Author(s) : Li HX , Sun MR , Zhang Y , Song LL , Zhang F , Song YQ , Hou XD , Ge GB |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , : , 2023 |
| Abstract : |
| PubMedSearch : Li_2023_Drug.Metab.Dispos__ |
| PubMedID: 37550069 |
| Gene_locus related to this paper: human-CES1 |
| Title : High-resolution structural-omics of human liver enzymes - Su_2023_Cell.Rep_42_112609 |
| Author(s) : Su CC , Lyu M , Zhang Z , Miyagi M , Huang W , Taylor DJ , Yu EW |
| Ref : Cell Rep , 42 :112609 , 2023 |
| Abstract : |
| PubMedSearch : Su_2023_Cell.Rep_42_112609 |
| PubMedID: 37289586 |
| Gene_locus related to this paper: human-CES1 |
| Title : Major implications of single nucleotide polymorphisms in human carboxylesterase 1 on substrate bioavailability - Yerrakula_2022_Biotechnol.Genet.Eng.Rev__ |
| Author(s) : Yerrakula G , Abraham S , John S , Zeharvi M , George SG , Senthil V , Maiz F , Rahman MH |
| Ref : Biotechnol Genet Eng Rev , :1 , 2022 |
| Abstract : |
| PubMedSearch : Yerrakula_2022_Biotechnol.Genet.Eng.Rev__ |
| PubMedID: 35946821 |
| Gene_locus related to this paper: human-CES1 |
| Title : The Influence of Structural Variants of the CES1 Gene on the Pharmacokinetics of Enalapril, Presumably Due to Linkage Disequilibrium with the Intronic rs2244613 - Ikonnikova_2022_Genes.(Basel)_13_ |
| Author(s) : Ikonnikova A , Kazakov R , Rodina T , Dmitriev A , Melnikov E , Zasedatelev A , Nasedkina T |
| Ref : Genes (Basel) , 13 : , 2022 |
| Abstract : |
| PubMedSearch : Ikonnikova_2022_Genes.(Basel)_13_ |
| PubMedID: 36553492 |
| Gene_locus related to this paper: human-CES1 |
| Title : Identification of regulatory variants of carboxylesterase 1 (CES1): A proof-of-concept study for the application of the Allele-Specific Protein Expression (ASPE) assay in identifying cis-acting regulatory genetic polymorphisms - Her_2022_Proteomics__e2200176 |
| Author(s) : Her L , Shi J , Wang X , He B , Smith L , Jiang H , Zhu HJ |
| Ref : Proteomics , :e2200176 , 2022 |
| Abstract : |
| PubMedSearch : Her_2022_Proteomics__e2200176 |
| PubMedID: 36413357 |
| Gene_locus related to this paper: human-CES1 |
| Title : The Influence of the CES1 Genotype on the Pharmacokinetics of Enalapril in Patients with Arterial Hypertension - Ikonnikova_2022_J.Pers.Med_12_580 |
| Author(s) : Ikonnikova A , Rodina T , Dmitriev A , Melnikov E , Kazakov R , Nasedkina T |
| Ref : J Pers Med , 12 : , 2022 |
| Abstract : |
| PubMedSearch : Ikonnikova_2022_J.Pers.Med_12_580 |
| PubMedID: 35455696 |
| Gene_locus related to this paper: human-CES1 |
| Title : Transcriptional regulation of carboxylesterase 1 (CES1) in human liver: role of the nuclear receptor NR1H3 (LXRalpha) and its splice isoforms - Collins_2021_Drug.Metab.Dispos__ |
| Author(s) : Collins JM , Lu R , Wang X , Zhu HJ , Wang D |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , : , 2021 |
| Abstract : |
| PubMedSearch : Collins_2021_Drug.Metab.Dispos__ |
| PubMedID: 34697082 |
| Gene_locus related to this paper: human-CES1 |
| Title : Contributions of Cathepsin A and Carboxylesterase 1 to the hydrolysis of Tenofovir Alafenamide in the Human Liver, and the Effect of CES1 Genetic Variation on Tenofovir Alafenamide Hydrolysis - Li_2021_Drug.Metab.Dispos__ |
| Author(s) : Li J , Shi J , Xiao J , Tran L , Wang X , Zhu HJ |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , : , 2021 |
| Abstract : |
| PubMedSearch : Li_2021_Drug.Metab.Dispos__ |
| PubMedID: 34933885 |
| Gene_locus related to this paper: human-CES1 , human-CTSA |
| Title : Human carboxylesterase 1A plays a predominant role in the hydrolytic activation of remdesivir in humans - Zhang_2021_Chem.Biol.Interact_351_109744 |
| Author(s) : Zhang F , Li HX , Zhang TT , Xiong Y , Wang HN , Lu ZH , Xiong L , He YQ , Ge GB |
| Ref : Chemico-Biological Interactions , 351 :109744 , 2021 |
| Abstract : |
| PubMedSearch : Zhang_2021_Chem.Biol.Interact_351_109744 |
| PubMedID: 34774545 |
| Gene_locus related to this paper: human-CES1 |
| Title : Clock gene Bmal1 controls diurnal rhythms in expression and activity of intestinal carboxylesterase 1 - Chen_2021_J.Pharm.Pharmacol_73_52 |
| Author(s) : Chen X , Yu F , Guo X , Su C , Li SS , Wu B |
| Ref : J Pharm Pharmacol , 73 :52 , 2021 |
| Abstract : |
| PubMedSearch : Chen_2021_J.Pharm.Pharmacol_73_52 |
| PubMedID: 33791812 |
| Gene_locus related to this paper: human-CES1 |
| Title : Carboxylesterase-1 assisted targeting of HDAC inhibitors to mononuclear myeloid cells in Inflammatory Bowel Disease - Elfiky_2021_J.Crohns.Colitis__ |
| Author(s) : Elfiky AMI , Ghiboub M , Li Yim AYF , Hageman IL , Verhoeff J , de Krijger M , van Hamersveld PHP , Welting O , Admiraal I , Rahman S , Garcia-Vallejo JJ , Wildenberg ME , Tomlinson L , Gregory R , Rioja I , Prinjha RK , Furze RC , Lewis HD , Mander PK , Heinsbroek SEM , Bell MJ , de Jonge WJ |
| Ref : J Crohns Colitis , : , 2021 |
| Abstract : |
| PubMedSearch : Elfiky_2021_J.Crohns.Colitis__ |
| PubMedID: 34633041 |
| Gene_locus related to this paper: human-CES1 |
| Title : Enhanced triacylglycerol catabolism by Carboxylesterase 1 promotes aggressive colorectal carcinoma - Capece_2021_J.Clin.Invest__ |
| Author(s) : Capece D , D'Andrea D , Begalli F , Goracci L , Tornatore L , Alexander JL , Di Veroli A , Leow SC , Vaiyapuri TS , Ellis JK , Verzella D , Bennett J , Savino L , Ma Y , McKenzie JS , Doria ML , Mason SE , Chng KR , Keun HC , Frost G , Tergaonkar V , Broniowska K , Stunkel W , Takats Z , Kinross JM , Cruciani G , Franzoso G |
| Ref : J Clinical Investigation , : , 2021 |
| Abstract : |
| PubMedSearch : Capece_2021_J.Clin.Invest__ |
| PubMedID: 33878036 |
| Gene_locus related to this paper: human-CES1 |
| Title : Copy number variation in the CES1 gene and the risk of non-alcoholic fatty liver in a Chinese Han population - Chen_2021_Sci.Rep_11_13984 |
| Author(s) : Chen BB , Yan JH , Zheng J , Peng HW , Cai XL , Pan XT , Li HQ , Hong QZ , Peng XE |
| Ref : Sci Rep , 11 :13984 , 2021 |
| Abstract : |
| PubMedSearch : Chen_2021_Sci.Rep_11_13984 |
| PubMedID: 34234263 |
| Gene_locus related to this paper: human-CES1 |
| Title : Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1 - Zhou_2021_Clin.Transl.Med_11_e449 |
| Author(s) : Zhou L , Zhang C , Yang X , Liu L , Hu J , Hou Y , Tao H , Sugimura H , Chen Z , Wang L , Chen K |
| Ref : Clin Transl Med , 11 :e449 , 2021 |
| Abstract : |
| PubMedSearch : Zhou_2021_Clin.Transl.Med_11_e449 |
| PubMedID: 34185414 |
| Gene_locus related to this paper: human-CES1 |
| Title : Inactivation of CES1 Blocks Prostaglandin D(2) Glyceryl Ester Catabolism in Monocytes\/Macrophages and Enhances Its Anti-inflammatory Effects, Whereas the Pro-inflammatory Effects of Prostaglandin E(2) Glyceryl Ester Are Attenuated - Scheaffer_2020_ACS.Omega_5_29177 |
| Author(s) : Scheaffer HL , Borazjani A , Szafran BN , Ross MK |
| Ref : ACS Omega , 5 :29177 , 2020 |
| Abstract : |
| PubMedSearch : Scheaffer_2020_ACS.Omega_5_29177 |
| PubMedID: 33225149 |
| Gene_locus related to this paper: human-CES1 |
| Title : Potential Regulatory Role of Human-Carboxylesterase-1 Glycosylation in Liver Cancer Cell Growth - Na_2020_J.Proteome.Res_19_4867 |
| Author(s) : Na K , Kim M , Kim CY , Lim JS , Cho JY , Shin H , Lee HJ , Kang BJ , Han DH , Kim H , Baik JH , Swiatek-de Lange M , Karl J , Paik YK |
| Ref : J Proteome Res , 19 :4867 , 2020 |
| Abstract : |
| PubMedSearch : Na_2020_J.Proteome.Res_19_4867 |
| PubMedID: 33206527 |
| Gene_locus related to this paper: human-CES1 |
| Title : Carboxylesterase 1 and Precision Pharmacotherapy: Pharmacogenetics and Nongenetic Regulators - Her_2020_Drug.Metab.Dispos_48_230 |
| Author(s) : Her L , Zhu HJ |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 48 :230 , 2020 |
| Abstract : |
| PubMedSearch : Her_2020_Drug.Metab.Dispos_48_230 |
| PubMedID: 31871135 |
| Gene_locus related to this paper: human-CES1 |
| Title : Human leukocytes differentially express endocannabinoid-glycerol lipases and hydrolyze 2-arachidonoyl-glycerol and its metabolites from the 15-lipoxygenase and cyclooxygenase pathways - Turcotte_2019_J.Leukoc.Biol_106_1337 |
| Author(s) : Turcotte C , Dumais E , Archambault AS , Martin C , Blanchet MR , Bissonnette E , Boulet LP , Laviolette M , Di Marzo V , Flamand N |
| Ref : J Leukoc Biol , 106 :1337 , 2019 |
| Abstract : |
| PubMedSearch : Turcotte_2019_J.Leukoc.Biol_106_1337 |
| PubMedID: 31556464 |
| Gene_locus related to this paper: human-ABHD6 , human-ABHD12 , human-ABHD16A , human-CES1 , human-LYPLA2 , human-PPT1 |
| Title : The impact of human CES1 genetic variation on enzyme activity assessed by ritalinic acid\/methylphenidate ratios - Stage_2019_Basic.Clin.Pharmacol.Toxicol_125_54 |
| Author(s) : Stage C , Dalhoff K , Rasmussen HB , Schow Guski L , Thomsen R , Bjerre D , Ferrero-Miliani L , Busk Madsen M , Jurgens G |
| Ref : Basic Clin Pharmacol Toxicol , 125 :54 , 2019 |
| Abstract : |
| PubMedSearch : Stage_2019_Basic.Clin.Pharmacol.Toxicol_125_54 |
| PubMedID: 30801959 |
| Gene_locus related to this paper: human-CES1 |
| Title : Catalytic Hydrolysis Mechanism of Cocaine by Human Carboxylesterase 1: An Orthoester Intermediate Slows Down the Reaction - Yan_2019_Molecules_24_ |
| Author(s) : Yan M , Zhang Z , Liu Z , Zhang C , Zhang J , Fan S , Yang Z |
| Ref : Molecules , 24 : , 2019 |
| Abstract : |
| PubMedSearch : Yan_2019_Molecules_24_ |
| PubMedID: 31717501 |
| Gene_locus related to this paper: human-CES1 |
| Title : Influence of CYP450 Enzymes, CES1, PON1, ABCB1, and P2RY12 Polymorphisms on Clopidogrel Response in Patients Subjected to a Percutaneous Neurointervention - Saiz-Rodriguez_2019_Clin.Ther_41_1199 |
| Author(s) : Saiz-Rodriguez M , Belmonte C , Caniego JL , Koller D , Zubiaur P , Barcena E , Romero-Palacian D , Eugene AR , Ochoa D , Abad-Santos F |
| Ref : Clin Ther , 41 :1199 , 2019 |
| Abstract : |
| PubMedSearch : Saiz-Rodriguez_2019_Clin.Ther_41_1199 |
| PubMedID: 31128980 |
| Gene_locus related to this paper: human-CES1 |
| Title : In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites - Qian_2019_Drug.Metab.Dispos_47_465 |
| Author(s) : Qian Y , Wang X , Markowitz JS |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 47 :465 , 2019 |
| Abstract : |
| PubMedSearch : Qian_2019_Drug.Metab.Dispos_47_465 |
| PubMedID: 30833288 |
| Gene_locus related to this paper: human-CES1 |
| Title : Genetic determinants of dabigatran safety (CES1 gene rs2244613 polymorphism) in the Russian population: multi-ethnic analysis - Sychev_2019_Mol.Biol.Rep_46_2761 |
| Author(s) : Sychev DA , Abdullaev SP , Mirzaev KB , Ryzhikova KA , Shuyev GN , Sozaeva ZA , Grishina EA , Mammaev SN , Gafurov DM , Kitaeva EY , Shprakh VV , Suleymanov SS , Bolieva LZ , Sozaeva MS , Zhuchkova SM , Gimaldinova NE , Sidukova EE , Asoskova AV , Mumladze RB |
| Ref : Mol Biol Rep , 46 :2761 , 2019 |
| Abstract : |
| PubMedSearch : Sychev_2019_Mol.Biol.Rep_46_2761 |
| PubMedID: 30850966 |
| Gene_locus related to this paper: human-CES1 |
| Title : Clinical implications of genetic variation in carboxylesterase drug metabolism - Chen_2018_Expert.Opin.Drug.Metab.Toxicol_14_131 |
| Author(s) : Chen F , Zhang B , Parker RB , Laizure SC |
| Ref : Expert Opin Drug Metab Toxicol , 14 :131 , 2018 |
| Abstract : |
| PubMedSearch : Chen_2018_Expert.Opin.Drug.Metab.Toxicol_14_131 |
| PubMedID: 29264996 |
| Gene_locus related to this paper: human-CES1 , human-CES2 |
| Title : Silencing carboxylesterase 1 in human THP-1 macrophages perturbs genes regulated by PPARgamma\/RXR and RAR\/RXR: down-regulation of CYP27A1-LXRalpha signaling - Mangum_2018_Biochem.J_475_621 |
| Author(s) : Mangum LC , Hou X , Borazjani A , Lee JH , Ross MK , Crow JA |
| Ref : Biochemical Journal , 475 :621 , 2018 |
| Abstract : |
| PubMedSearch : Mangum_2018_Biochem.J_475_621 |
| PubMedID: 29321244 |
| Gene_locus related to this paper: human-CES1 |
| Title : Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects - Neuvonen_2018_Basic.Clin.Pharmacol.Toxicol_122_341 |
| Author(s) : Neuvonen M , Tarkiainen EK , Tornio A , Hirvensalo P , Tapaninen T , Paile-Hyvarinen M , Itkonen MK , Holmberg MT , Karja V , Mannisto VT , Neuvonen PJ , Pihlajamaki J , Backman JT , Niemi M |
| Ref : Basic Clin Pharmacol Toxicol , 122 :341 , 2018 |
| Abstract : |
| PubMedSearch : Neuvonen_2018_Basic.Clin.Pharmacol.Toxicol_122_341 |
| PubMedID: 28990360 |
| Gene_locus related to this paper: human-CES1 |
| Title : Genetic variation in human carboxylesterase CES1 confers resistance to hepatic steatosis - Lian_2018_Biochim.Biophys.Acta_1863_688 |
| Author(s) : Lian J , Bahitham W , Panigrahi R , Nelson R , Li L , Watts R , Thiesen A , Lemieux MJ , Lehner R |
| Ref : Biochimica & Biophysica Acta , 1863 :688 , 2018 |
| Abstract : |
| PubMedSearch : Lian_2018_Biochim.Biophys.Acta_1863_688 |
| PubMedID: 29631096 |
| Gene_locus related to this paper: human-CES1 |
| Title : Carboxylesterases in lipid metabolism: from mouse to human - Lian_2018_Protein.Cell_9_178 |
| Author(s) : Lian J , Nelson R , Lehner R |
| Ref : Protein Cell , 9 :178 , 2018 |
| Abstract : |
| PubMedSearch : Lian_2018_Protein.Cell_9_178 |
| PubMedID: 28677105 |
| Gene_locus related to this paper: human-CES1 |
| Title : Potent, Irreversible Inhibition of Human Carboxylesterases by Tanshinone Anhydrides Isolated from Salvia miltiorrhiza (Danshen) - Hatfield_2018_J.Nat.Prod_81_2410 |
| Author(s) : Hatfield MJ , Binder RJ , Gannon R , Fratt EM , Bowling J , Potter PM |
| Ref : Journal of Natural Products , 81 :2410 , 2018 |
| Abstract : |
| PubMedSearch : Hatfield_2018_J.Nat.Prod_81_2410 |
| PubMedID: 30351923 |
| Gene_locus related to this paper: human-CES1 , human-CES2 |
| Title : Carboxylesterase 1 genes: systematic review and evaluation of existing genotyping procedures - Rasmussen_2018_Drug.Metab.Pers.Ther_33_3 |
| Author(s) : Rasmussen HB , Madsen MB |
| Ref : Drug Metab Pers Ther , 33 :3 , 2018 |
| Abstract : |
| PubMedSearch : Rasmussen_2018_Drug.Metab.Pers.Ther_33_3 |
| PubMedID: 29427553 |
| Gene_locus related to this paper: human-CES1 |
| Title : Novel procedure with improved resolution and specificity for amplification and differentiation of variants of the gene encoding carboxylesterase 1 - Bjerre_2017_Pharmacogenet.Genomics_27_155 |
| Author(s) : Bjerre D , Rasmussen HB |
| Ref : Pharmacogenet Genomics , 27 :155 , 2017 |
| Abstract : |
| PubMedSearch : Bjerre_2017_Pharmacogenet.Genomics_27_155 |
| PubMedID: 28146010 |
| Gene_locus related to this paper: human-CES1 |
| Title : Nomenclature for alleles of the human carboxylesterase 1 gene - |
| Author(s) : Rasmussen HB , Madsen MB , Hansen PR |
| Ref : Pharmacogenet Genomics , 27 :78 , 2017 |
| PubMedID: 27831961 |
| Gene_locus related to this paper: human-CES1 |
| Title : Effect of carboxylesterase 1 S75N on clopidogrel therapy among acute coronary syndrome patients - Xiao_2017_Sci.Rep_7_7244 |
| Author(s) : Xiao FY , Luo JQ , Liu M , Chen BL , Cao S , Liu ZQ , Zhou HH , Zhou G , Zhang W |
| Ref : Sci Rep , 7 :7244 , 2017 |
| Abstract : |
| PubMedSearch : Xiao_2017_Sci.Rep_7_7244 |
| PubMedID: 28775293 |
| Gene_locus related to this paper: human-CES1 |
| Title : A Comprehensive Functional Assessment of Carboxylesterase 1 Nonsynonymous Polymorphisms - Wang_2017_Drug.Metab.Dispos_45_1149 |
| Author(s) : Wang X , Rida N , Shi J , Wu AH , Bleske BE , Zhu HJ |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 45 :1149 , 2017 |
| Abstract : |
| PubMedSearch : Wang_2017_Drug.Metab.Dispos_45_1149 |
| PubMedID: 28838926 |
| Gene_locus related to this paper: human-CES1 |
| Title : The impact of CES1 genotypes on the pharmacokinetics of methylphenidate in healthy Danish subjects - Stage_2017_Br.J.Clin.Pharmacol_83_1506 |
| Author(s) : Stage C , Jurgens G , Guski LS , Thomsen R , Bjerre D , Ferrero-Miliani L , Lyauk YK , Rasmussen HB , Dalhoff K |
| Ref : British Journal of Clinical Pharmacology , 83 :1506 , 2017 |
| Abstract : |
| PubMedSearch : Stage_2017_Br.J.Clin.Pharmacol_83_1506 |
| PubMedID: 28087982 |
| Gene_locus related to this paper: human-CES1 |
| Title : The Pharmacokinetics of Enalapril in Relation to CES1 Genotype in Healthy Danish Volunteers - Stage_2017_Basic.Clin.Pharmacol.Toxicol_121_487 |
| Author(s) : Stage C , Jurgens G , Guski LS , Thomsen R , Bjerre D , Ferrero-Miliani L , Lyauk YK , Rasmussen HB , Dalhoff K |
| Ref : Basic Clin Pharmacol Toxicol , 121 :487 , 2017 |
| Abstract : |
| PubMedSearch : Stage_2017_Basic.Clin.Pharmacol.Toxicol_121_487 |
| PubMedID: 28639420 |
| Gene_locus related to this paper: human-CES1 |
| Title : Predominant contributions of carboxylesterase 1 and 2 in hydrolysis of anordrin in humans - Jiang_2017_Xenobiotica__1 |
| Author(s) : Jiang J , Chen X , Zhong D |
| Ref : Xenobiotica , :1 , 2017 |
| Abstract : |
| PubMedSearch : Jiang_2017_Xenobiotica__1 |
| PubMedID: 28532270 |
| Gene_locus related to this paper: human-CES1 |
| Title : Reduced carboxylesterase 1 is associated with endothelial injury in methamphetamine-induced pulmonary arterial hypertension - Orcholski_2017_Am.J.Physiol.Lung.Cell.Mol.Physiol_313_L252 |
| Author(s) : Orcholski ME , Khurshudyan A , Shamskhou EA , Yuan K , Chen IY , Kodani SD , Morisseau C , Hammock BD , Hong EM , Alexandrova L , Alastalo TP , Berry G , Zamanian RT , de Jesus Perez VA |
| Ref : American Journal of Physiology Lung Cell Mol Physiol , 313 :L252 , 2017 |
| Abstract : |
| PubMedSearch : Orcholski_2017_Am.J.Physiol.Lung.Cell.Mol.Physiol_313_L252 |
| PubMedID: 28473326 |
| Gene_locus related to this paper: human-CES1 |
| Title : Novel Genetic Variants in Carboxylesterase 1 Predict Severe Early-Onset Capecitabine-Related Toxicity - Hamzic_2017_Clin.Pharmacol.Ther_102_796 |
| Author(s) : Hamzic S , Kummer D , Milesi S , Mueller D , Joerger M , Aebi S , Amstutz U , Largiader CR |
| Ref : Clinical Pharmacology & Therapeutics , 102 :796 , 2017 |
| Abstract : |
| PubMedSearch : Hamzic_2017_Clin.Pharmacol.Ther_102_796 |
| PubMedID: 28139840 |
| Gene_locus related to this paper: human-CES1 |
| Title : Dabigatran etexilate activation is affected by the CES1 genetic polymorphism G143E (rs71647871) and gender - Shi_2016_Biochem.Pharmacol_119_76 |
| Author(s) : Shi J , Wang X , Nguyen JH , Bleske BE , Liang Y , Liu L , Zhu HJ |
| Ref : Biochemical Pharmacology , 119 :76 , 2016 |
| Abstract : |
| PubMedSearch : Shi_2016_Biochem.Pharmacol_119_76 |
| PubMedID: 27614009 |
| Gene_locus related to this paper: human-CES1 |
| Title : Association of Oseltamivir Activation with Gender and Carboxylesterase 1 Genetic Polymorphisms - Shi_2016_Basic.Clin.Pharmacol.Toxicol_119_555 |
| Author(s) : Shi J , Wang X , Eyler RF , Liang Y , Liu L , Mueller BA , Zhu HJ |
| Ref : Basic Clin Pharmacol Toxicol , 119 :555 , 2016 |
| Abstract : |
| PubMedSearch : Shi_2016_Basic.Clin.Pharmacol.Toxicol_119_555 |
| PubMedID: 27228223 |
| Gene_locus related to this paper: human-CES1 |
| Title : CES1 genetic variation affects the activation of angiotensin-converting enzyme inhibitors - Wang_2016_Pharmacogenomics.J_16_220 |
| Author(s) : Wang X , Wang G , Shi J , Aa JY , Comas R , Liang Y , Zhu HJ |
| Ref : Pharmacogenomics J , 16 :220 , 2016 |
| Abstract : |
| PubMedSearch : Wang_2016_Pharmacogenomics.J_16_220 |
| PubMedID: 26076923 |
| Gene_locus related to this paper: human-CES1 |
| Title : Investigating the impact of missense mutations in hCES1 by in silico structure-based approaches - Nzabonimpa_2016_Drug.Metab.Pers.Ther__ |
| Author(s) : Nzabonimpa GS , Rasmussen HB , Brunak S , Taboureau O |
| Ref : Drug Metab Pers Ther , : , 2016 |
| Abstract : |
| PubMedSearch : Nzabonimpa_2016_Drug.Metab.Pers.Ther__ |
| PubMedID: 26900165 |
| Gene_locus related to this paper: human-CES1 |
| Title : Regulatory effects of genomic translocations at the human carboxylesterase-1 (CES1) gene locus - Sanford_2016_Pharmacogenet.Genomics_26_197 |
| Author(s) : Sanford JC , Wang X , Shi J , Barrie ES , Wang D , Zhu HJ , Sadee W |
| Ref : Pharmacogenet Genomics , 26 :197 , 2016 |
| Abstract : |
| PubMedSearch : Sanford_2016_Pharmacogenet.Genomics_26_197 |
| PubMedID: 26871237 |
| Gene_locus related to this paper: human-CES1 |
| Title : Prognostic impact of carboxylesterase 1 gene variants in patients with congestive heart failure treated with angiotensin-converting enzyme inhibitors - Nelveg-Kristensen_2016_Pharmacogenet.Genomics_26_169 |
| Author(s) : Nelveg-Kristensen KE , Madsen MB , Torp-Pedersen C , Kober L , Egfjord M , Hansen T , Pedersen O , Rasmussen HB , Hansen PR |
| Ref : Pharmacogenet Genomics , 26 :169 , 2016 |
| Abstract : |
| PubMedSearch : Nelveg-Kristensen_2016_Pharmacogenet.Genomics_26_169 |
| PubMedID: 26761119 |
| Gene_locus related to this paper: human-CES1 |
| Title : Population Pharmacokinetics of Methylphenidate in Healthy Adults Emphasizing Novel and Known Effects of Several Carboxylesterase 1 (CES1) Variants - Lyauk_2016_Clin.Transl.Sci_9_337 |
| Author(s) : Lyauk YK , Stage C , Bergmann TK , Ferrero-Milliani L , Bjerre D , Thomsen R , Dalhoff KP , Rasmussen HB , Jurgens G |
| Ref : Clin Transl Sci , 9 :337 , 2016 |
| Abstract : |
| PubMedSearch : Lyauk_2016_Clin.Transl.Sci_9_337 |
| PubMedID: 27754602 |
| Gene_locus related to this paper: human-CES1 |
| Title : Fluoxetine reduces CES1, CES2, and CYP3A4 expression through decreasing PXR and increasing DEC1 in HepG2 cells - Shang_2016_Xenobiotica_46_393 |
| Author(s) : Shang W , Liu J , Chen R , Ning R , Xiong J , Liu W , Mao Z , Hu G , Yang J |
| Ref : Xenobiotica , 46 :393 , 2016 |
| Abstract : |
| PubMedSearch : Shang_2016_Xenobiotica_46_393 |
| PubMedID: 26340669 |
| Gene_locus related to this paper: human-CES1 |
| Title : Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation - Shi_2016_Drug.Metab.Dispos_44_554 |
| Author(s) : Shi J , Wang X , Nguyen J , Wu AH , Bleske BE , Zhu HJ |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 44 :554 , 2016 |
| Abstract : |
| PubMedSearch : Shi_2016_Drug.Metab.Dispos_44_554 |
| PubMedID: 26817948 |
| Gene_locus related to this paper: human-CES1 |
| Title : Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny - Hines_2016_Drug.Metab.Dispos_44_959 |
| Author(s) : Hines RN , Simpson PM , McCarver DG |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 44 :959 , 2016 |
| Abstract : |
| PubMedSearch : Hines_2016_Drug.Metab.Dispos_44_959 |
| PubMedID: 26825642 |
| Gene_locus related to this paper: human-CES1 |
| Title : Establishment and Characterization of a Novel Caco-2 Subclone with a Similar Low Expression Level of Human Carboxylesterase 1 to Human Small Intestine - Ohura_2016_Drug.Metab.Dispos_44_1890 |
| Author(s) : Ohura K , Nishiyama H , Saco S , Kurokawa K , Imai T |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 44 :1890 , 2016 |
| Abstract : |
| PubMedSearch : Ohura_2016_Drug.Metab.Dispos_44_1890 |
| PubMedID: 27638507 |
| Gene_locus related to this paper: human-CES1 |
| Title : Biotransformation Capacity of Carboxylesterase in Skin and Keratinocytes for the Penta-Ethyl Ester Prodrug of DTPA - Fu_2016_Drug.Metab.Dispos_44_1313 |
| Author(s) : Fu J , Sadgrove M , Marson L , Jay M |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 44 :1313 , 2016 |
| Abstract : |
| PubMedSearch : Fu_2016_Drug.Metab.Dispos_44_1313 |
| PubMedID: 27130352 |
| Gene_locus related to this paper: human-CES1 |
| Title : Carboxylesterase 1 Is Regulated by Hepatocyte Nuclear Factor 4alpha and Protects Against Alcohol- and MCD diet-induced Liver Injury - Xu_2016_Sci.Rep_6_24277 |
| Author(s) : Xu J , Xu Y , Li Y , Jadhav K , You M , Yin L , Zhang Y |
| Ref : Sci Rep , 6 :24277 , 2016 |
| Abstract : |
| PubMedSearch : Xu_2016_Sci.Rep_6_24277 |
| PubMedID: 27075303 |
| Gene_locus related to this paper: human-CES1 |
| Title : CES1P1 variant -816A>C is not associated with hepatic carboxylesterase 1 expression and activity or antihypertensive effect of trandolapril - Zhu_2016_Eur.J.Clin.Pharmacol_72_681 |
| Author(s) : Zhu HJ , Langaee TY , Gong Y , Wang X , Pepine CJ , Cooper-DeHoff RM , Johnson JA , Markowitz JS |
| Ref : European Journal of Clinical Pharmacology , 72 :681 , 2016 |
| Abstract : |
| PubMedSearch : Zhu_2016_Eur.J.Clin.Pharmacol_72_681 |
| PubMedID: 26915813 |
| Gene_locus related to this paper: human-CES1 |
| Title : Impact of genetic polymorphisms related to clopidogrel or acetylsalicylic acid pharmacology on clinical outcome in Chinese patients with symptomatic extracranial or intracranial stenosis - Zhao_2016_Eur.J.Clin.Pharmacol_72_1195 |
| Author(s) : Zhao Z , Li X , Sun S , Mei S , Ma N , Miao Z , Zhao M , Peng S |
| Ref : European Journal of Clinical Pharmacology , 72 :1195 , 2016 |
| Abstract : |
| PubMedSearch : Zhao_2016_Eur.J.Clin.Pharmacol_72_1195 |
| PubMedID: 27450232 |
| Gene_locus related to this paper: human-CES1 |
| Title : Carboxylesterase 1 c.428G>\;A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans - Tarkiainen_2015_Clin.Pharmacol.Ther_97_650 |
| Author(s) : Tarkiainen EK , Holmberg MT , Tornio A , Neuvonen M , Neuvonen PJ , Backman JT , Niemi M |
| Ref : Clinical Pharmacology & Therapeutics , 97 :650 , 2015 |
| Abstract : |
| PubMedSearch : Tarkiainen_2015_Clin.Pharmacol.Ther_97_650 |
| PubMedID: 25704243 |
| Gene_locus related to this paper: human-CES1 |
| Title : Effect of carboxylesterase 1 c.428G >\; A single nucleotide variation on the pharmacokinetics of quinapril and enalapril - Tarkiainen_2015_Br.J.Clin.Pharmacol_80_1131 |
| Author(s) : Tarkiainen EK , Tornio A , Holmberg MT , Launiainen T , Neuvonen PJ , Backman JT , Niemi M |
| Ref : British Journal of Clinical Pharmacology , 80 :1131 , 2015 |
| Abstract : |
| PubMedSearch : Tarkiainen_2015_Br.J.Clin.Pharmacol_80_1131 |
| PubMedID: 25919042 |
| Gene_locus related to this paper: human-CES1 |
| Title : Comparison of the Structure and Activity of Glycosylated and Aglycosylated Human Carboxylesterase 1 - Arena de Souza_2015_PLoS.One_10_e0143919 |
| Author(s) : Arena de Souza V , Scott DJ , Nettleship JE , Rahman N , Charlton MH , Walsh MA , Owens RJ |
| Ref : PLoS ONE , 10 :e0143919 , 2015 |
| Abstract : |
| PubMedSearch : Arena de Souza_2015_PLoS.One_10_e0143919 |
| PubMedID: 26657071 |
| Gene_locus related to this paper: human-CES1 |
| Title : CYP2C19 and CES1 polymorphisms and efficacy of clopidogrel and aspirin dual antiplatelet therapy in patients with symptomatic intracranial atherosclerotic disease - Hoh_2015_J.Neurosurg__1 |
| Author(s) : Hoh BL , Gong Y , McDonough CW , Waters MF , Royster AJ , Sheehan TO , Burkley B , Langaee TY , Mocco J , Zuckerman SL , Mummareddy N , Stephens ML, 2nd , Ingram C , Shaffer CM , Denny JC , Brilliant MH , Kitchner TE , Linneman JG , Roden DM , Johnson JA |
| Ref : Journal of Neurosurgery , :1 , 2015 |
| Abstract : |
| PubMedSearch : Hoh_2015_J.Neurosurg__1 |
| PubMedID: 26587656 |
| Gene_locus related to this paper: human-CES1 |
| Title : Comparison of substrate specificity among human arylacetamide deacetylase and carboxylesterases - Fukami_2015_Eur.J.Pharm.Sci_78_47 |
| Author(s) : Fukami T , Kariya M , Kurokawa T , Iida A , Nakajima M |
| Ref : Eur J Pharm Sci , 78 :47 , 2015 |
| Abstract : |
| PubMedSearch : Fukami_2015_Eur.J.Pharm.Sci_78_47 |
| PubMedID: 26164127 |
| Gene_locus related to this paper: human-AADAC , human-CES1 , human-CES2 |
| Title : Substrate-Competitive Activity-Based Profiling of Ester Prodrug Activating Enzymes - Xu_2015_Mol.Pharm_12_3399 |
| Author(s) : Xu H , Majmudar JD , Davda D , Ghanakota P , Kim KH , Carlson HA , Showalter HD , Martin BR , Amidon GL |
| Ref : Mol Pharm , 12 :3399 , 2015 |
| Abstract : |
| PubMedSearch : Xu_2015_Mol.Pharm_12_3399 |
| PubMedID: 26262434 |
| Gene_locus related to this paper: human-CES1 |
| Title : Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors - Birkus_2015_Antimicrob.Agents.Chemother_60_316 |
| Author(s) : Birkus G , Bam RA , Willkom M , Frey CR , Tsai L , Stray KM , Yant SR , Cihlar T |
| Ref : Antimicrobial Agents & Chemotherapy , 60 :316 , 2015 |
| Abstract : |
| PubMedSearch : Birkus_2015_Antimicrob.Agents.Chemother_60_316 |
| PubMedID: 26503655 |
| Gene_locus related to this paper: human-CES1 |
| Title : Distinct patterns of aging effects on the expression and activity of carboxylesterases in rat liver and intestine - Ohura_2014_Drug.Metab.Dispos_42_264 |
| Author(s) : Ohura K , Tasaka K , Hashimoto M , Imai T |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 42 :264 , 2014 |
| Abstract : |
| PubMedSearch : Ohura_2014_Drug.Metab.Dispos_42_264 |
| PubMedID: 24271336 |
| Gene_locus related to this paper: human-CES1 |
| Title : Screening of specific inhibitors for human carboxylesterases or arylacetamide deacetylase - Shimizu_2014_Drug.Metab.Dispos_42_1103 |
| Author(s) : Shimizu M , Fukami T , Nakajima M , Yokoi T |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 42 :1103 , 2014 |
| Abstract : |
| PubMedSearch : Shimizu_2014_Drug.Metab.Dispos_42_1103 |
| PubMedID: 24751575 |
| Gene_locus related to this paper: human-AADAC , human-CES1 , human-CES2 |
| Title : The pharmacogenetics of carboxylesterases: CES1 and CES2 genetic variants and their clinical effect - Merali_2014_Drug.Metabol.Drug.Interact_29_143 |
| Author(s) : Merali Z , Ross S , Pare G |
| Ref : Drug Metabol Drug Interact , 29 :143 , 2014 |
| Abstract : |
| PubMedSearch : Merali_2014_Drug.Metabol.Drug.Interact_29_143 |
| PubMedID: 24988246 |
| Gene_locus related to this paper: human-CES1 , human-CES2 |
| Title : In vitro drug metabolism by human carboxylesterase 1: focus on Angiotensin-converting enzyme inhibitors - Thomsen_2014_Drug.Metab.Dispos_42_126 |
| Author(s) : Thomsen R , Rasmussen HB , Linnet K |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 42 :126 , 2014 |
| Abstract : |
| PubMedSearch : Thomsen_2014_Drug.Metab.Dispos_42_126 |
| PubMedID: 24141856 |
| Gene_locus related to this paper: human-CES1 |
| Title : Multiple Cytochrome P450 Isoforms Are Involved in the Generation of a Pharmacologically Active Thiol Metabolite, whereas Paraoxonase 1 and Carboxylesterase 1 Catalyze the Formation of a Thiol Metabolite Isomer from Ticlopidine - Kim_2014_Drug.Metab.Dispos_42_141 |
| Author(s) : Kim MJ , Jeong ES , Park JS , Lee SJ , Ghim JL , Choi CS , Shin JG , Kim DH |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 42 :141 , 2014 |
| Abstract : |
| PubMedSearch : Kim_2014_Drug.Metab.Dispos_42_141 |
| PubMedID: 24170778 |
| Gene_locus related to this paper: human-CES1 |
| Title : Identification of carboxylesterase-dependent dabigatran etexilate hydrolysis - Laizure_2014_Drug.Metab.Dispos_42_201 |
| Author(s) : Laizure SC , Parker RB , Herring VL , Hu ZY |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 42 :201 , 2014 |
| Abstract : |
| PubMedSearch : Laizure_2014_Drug.Metab.Dispos_42_201 |
| PubMedID: 24212379 |
| Gene_locus related to this paper: human-CES1 |
| Title : Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation - Zhu_2013_J.Pharmacol.Exp.Ther_344_665 |
| Author(s) : Zhu HJ , Wang X , Gawronski BE , Brinda BJ , Angiolillo DJ , Markowitz JS |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 344 :665 , 2013 |
| Abstract : |
| PubMedSearch : Zhu_2013_J.Pharmacol.Exp.Ther_344_665 |
| PubMedID: 23275066 |
| Gene_locus related to this paper: human-CES1 |
| Title : Control of RhoA methylation by carboxylesterase I - Cushman_2013_J.Biol.Chem_288_19177 |
| Author(s) : Cushman I , Cushman SM , Potter PM , Casey PJ |
| Ref : Journal of Biological Chemistry , 288 :19177 , 2013 |
| Abstract : |
| PubMedSearch : Cushman_2013_J.Biol.Chem_288_19177 |
| PubMedID: 23658012 |
| Gene_locus related to this paper: human-CES1 |
| Title : Carboxylesterase 1 gene duplication and mRNA expression in adipose tissue are linked to obesity and metabolic function - Friedrichsen_2013_PLoS.One_8_e56861 |
| Author(s) : Friedrichsen M , Poulsen P , Wojtaszewski J , Hansen PR , Vaag A , Rasmussen HB |
| Ref : PLoS ONE , 8 :e56861 , 2013 |
| Abstract : |
| PubMedSearch : Friedrichsen_2013_PLoS.One_8_e56861 |
| PubMedID: 23468884 |
| Gene_locus related to this paper: human-CES1 |
| Title : The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active metabolite levels and greater clopidogrel response - Lewis_2013_Pharmacogenet.Genomics_23_1 |
| Author(s) : Lewis JP , Horenstein RB , Ryan K , O'Connell JR , Gibson Q , Mitchell BD , Tanner K , Chai S , Bliden KP , Tantry US , Peer CJ , Figg WD , Spencer SD , Pacanowski MA , Gurbel PA , Shuldiner AR |
| Ref : Pharmacogenet Genomics , 23 :1 , 2013 |
| Abstract : |
| PubMedSearch : Lewis_2013_Pharmacogenet.Genomics_23_1 |
| PubMedID: 23111421 |
| Gene_locus related to this paper: human-CES1 |
| Title : Methylphenidate Side Effect Profile Is Influenced by Genetic Variation in the Attention-Deficit\/Hyperactivity Disorder-Associated CES1 Gene - Johnson_2013_J.Child.Adolesc.Psychopharmacol_23_655 |
| Author(s) : Johnson KA , Barry E , Lambert D , FitzGerald M , McNicholas F , Kirley A , Gill M , Bellgrove MA , Hawi Z |
| Ref : J Child Adolesc Psychopharmacol , 23 :655 , 2013 |
| Abstract : |
| PubMedSearch : Johnson_2013_J.Child.Adolesc.Psychopharmacol_23_655 |
| PubMedID: 24350812 |
| Gene_locus related to this paper: human-CES1 |
| Title : Association of a carboxylesterase 1 polymorphism with appetite reduction in children and adolescents with attention-deficit\/hyperactivity disorder treated with methylphenidate - Bruxel_2013_Pharmacogenomics.J_13_476 |
| Author(s) : Bruxel EM , Salatino-Oliveira A , Genro JP , Zeni CP , Polanczyk GV , Chazan R , Rohde LA , Hutz MH |
| Ref : Pharmacogenomics J , 13 :476 , 2013 |
| Abstract : |
| PubMedSearch : Bruxel_2013_Pharmacogenomics.J_13_476 |
| PubMedID: 22688218 |
| Gene_locus related to this paper: human-CES1 |
| Title : Carboxylesterase 1 polymorphism impairs oseltamivir bioactivation in humans - Tarkiainen_2012_Clin.Pharmacol.Ther_92_68 |
| Author(s) : Tarkiainen EK , Backman JT , Neuvonen M , Neuvonen PJ , Schwab M , Niemi M |
| Ref : Clinical Pharmacology & Therapeutics , 92 :68 , 2012 |
| Abstract : |
| PubMedSearch : Tarkiainen_2012_Clin.Pharmacol.Ther_92_68 |
| PubMedID: 22588607 |
| Gene_locus related to this paper: human-CES1 |
| Title : A discriminative analytical method for detection of CES1A1 and CES1A2\/CES1A3 genetic variants - Zhu_2012_Pharmacogenet.Genomics_22_215 |
| Author(s) : Zhu HJ , Brinda B , Froehlich TE , Markowitz JS |
| Ref : Pharmacogenet Genomics , 22 :215 , 2012 |
| Abstract : |
| PubMedSearch : Zhu_2012_Pharmacogenet.Genomics_22_215 |
| PubMedID: 22237548 |
| Gene_locus related to this paper: human-CES1 |
| Title : Structure of Recombinant Human Carboxylesterase 1 Isolated from Whole Cabbage Looper Larvae - Greenblatt_2012_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_F68_269 |
| Author(s) : Greenblatt HM , Otto TC , Kirkpatrick MG , Kovaleva E , Brown S , Buchman G , Cerasoli DM , Sussman JL |
| Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , F68 :269 , 2012 |
| Abstract : |
| PubMedSearch : Greenblatt_2012_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_F68_269 |
| PubMedID: 22442219 |
| Gene_locus related to this paper: human-CES1 |
| Title : Nerve agent hydrolysis activity designed into a human drug metabolism enzyme - Hemmert_2011_PLoS.One_6_e17441 |
| Author(s) : Hemmert AC , Otto TC , Chica RA , Wierdl M , Edwards JS , Lewis SM , Edwards CC , Tsurkan L , Cadieux CL , Kasten SA , Cashman JR , Mayo SL , Potter PM , Cerasoli DM , Redinbo MR |
| Ref : PLoS ONE , 6 :e17441 , 2011 |
| Abstract : |
| PubMedSearch : Hemmert_2011_PLoS.One_6_e17441 |
| PubMedID: 21445272 |
| Gene_locus related to this paper: human-CES1 |
| Title : Association of carboxylesterase 1A genotypes with irinotecan pharmacokinetics in Japanese cancer patients - Sai_2010_Br.J.Clin.Pharmacol_70_222 |
| Author(s) : Sai K , Saito Y , Tatewaki N , Hosokawa M , Kaniwa N , Nishimaki-Mogami T , Naito M , Sawada J , Shirao K , Hamaguchi T , Yamamoto N , Kunitoh H , Tamura T , Yamada Y , Ohe Y , Yoshida T , Minami H , Ohtsu A , Matsumura Y , Saijo N , Okuda H |
| Ref : British Journal of Clinical Pharmacology , 70 :222 , 2010 |
| Abstract : |
| PubMedSearch : Sai_2010_Br.J.Clin.Pharmacol_70_222 |
| PubMedID: 20653675 |
| Gene_locus related to this paper: human-CES1 |
| Title : Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins - Holmes_2010_Mamm.Genome_21_427 |
| Author(s) : Holmes RS , Wright MW , Laulederkind SJ , Cox LA , Hosokawa M , Imai T , Ishibashi S , Lehner R , Miyazaki M , Perkins EJ , Potter PM , Redinbo MR , Robert J , Satoh T , Yamashita T , Yan B , Yokoi T , Zechner R , Maltais LJ |
| Ref : Mamm Genome , 21 :427 , 2010 |
| Abstract : |
| PubMedSearch : Holmes_2010_Mamm.Genome_21_427 |
| PubMedID: 20931200 |
| Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3 , human-CES4A , human-CES5A |
| Title : Transcriptional regulation of human carboxylesterase 1A1 by nuclear factor-erythroid 2 related factor 2 (Nrf2) - Maruichi_2010_Biochem.Pharmacol_79_288 |
| Author(s) : Maruichi T , Fukami T , Nakajima M , Yokoi T |
| Ref : Biochemical Pharmacology , 79 :288 , 2010 |
| Abstract : |
| PubMedSearch : Maruichi_2010_Biochem.Pharmacol_79_288 |
| PubMedID: 19715681 |
| Gene_locus related to this paper: human-CES1 |
| Title : In silico prediction of human carboxylesterase-1 (hCES1) metabolism combining docking analyses and MD simulations - Vistoli_2010_Bioorg.Med.Chem_18_320 |
| Author(s) : Vistoli G , Pedretti A , Mazzolari A , Testa B |
| Ref : Bioorganic & Medicinal Chemistry , 18 :320 , 2010 |
| Abstract : |
| PubMedSearch : Vistoli_2010_Bioorg.Med.Chem_18_320 |
| PubMedID: 19932971 |
| Gene_locus related to this paper: human-CES1 |
| Title : Biochemical and molecular analysis of carboxylesterase-mediated hydrolysis of cocaine and heroin - Hatfield_2010_Br.J.Pharmacol_160_1916 |
| Author(s) : Hatfield MJ , Tsurkan LG , Hyatt JL , Yu X , Edwards CC , Hicks LD , Wadkins RM , Potter PM |
| Ref : British Journal of Pharmacology , 160 :1916 , 2010 |
| Abstract : |
| PubMedSearch : Hatfield_2010_Br.J.Pharmacol_160_1916 |
| PubMedID: 20649590 |
| Gene_locus related to this paper: human-CES1 |
| Title : Activity-based protein profiling identifies a host enzyme, carboxylesterase 1, which is differentially active during hepatitis C virus replication - Blais_2010_J.Biol.Chem_285_25602 |
| Author(s) : Blais DR , Lyn RK , Joyce MA , Rouleau Y , Steenbergen R , Barsby N , Zhu LF , Pegoraro AF , Stolow A , Tyrrell DL , Pezacki JP |
| Ref : Journal of Biological Chemistry , 285 :25602 , 2010 |
| Abstract : |
| PubMedSearch : Blais_2010_J.Biol.Chem_285_25602 |
| PubMedID: 20530478 |
| Gene_locus related to this paper: human-CES1 |
| Title : Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin - Hemmert_2010_Mol.Pharmacol_77_508 |
| Author(s) : Hemmert AC , Otto TC , Wierdl M , Edwards CC , Fleming CD , MacDonald M , Cashman JR , Potter PM , Cerasoli DM , Redinbo MR |
| Ref : Molecular Pharmacology , 77 :508 , 2010 |
| Abstract : |
| PubMedSearch : Hemmert_2010_Mol.Pharmacol_77_508 |
| PubMedID: 20051531 |
| Gene_locus related to this paper: human-CES1 |
| Title : Carboxylesterase 1 gene polymorphism and methylphenidate response in ADHD - Nemoda_2009_Neuropharmacol_57_731 |
| Author(s) : Nemoda Z , Angyal N , Tarnok Z , Gadoros J , Sasvari-Szekely M |
| Ref : Neuropharmacology , 57 :731 , 2009 |
| Abstract : |
| PubMedSearch : Nemoda_2009_Neuropharmacol_57_731 |
| PubMedID: 19733552 |
| Gene_locus related to this paper: human-CES1 |
| Title : Activation of the antiviral prodrug oseltamivir is impaired by two newly identified carboxylesterase 1 variants - Zhu_2009_Drug.Metab.Dispos_37_264 |
| Author(s) : Zhu HJ , Markowitz JS |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 37 :264 , 2009 |
| Abstract : |
| PubMedSearch : Zhu_2009_Drug.Metab.Dispos_37_264 |
| PubMedID: 19022936 |
| Gene_locus related to this paper: human-CES1 |
| Title : Human carboxylesterases HCE1 and HCE2: ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin - Yang_2009_Biochem.Pharmacol_77_238 |
| Author(s) : Yang D , Pearce RE , Wang X , Gaedigk R , Wan YJ , Yan B |
| Ref : Biochemical Pharmacology , 77 :238 , 2009 |
| Abstract : |
| PubMedSearch : Yang_2009_Biochem.Pharmacol_77_238 |
| PubMedID: 18983829 |
| Gene_locus related to this paper: human-CES1 , human-CES2 |
| Title : Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril - Zhu_2009_Biochem.Pharmacol_77_1266 |
| Author(s) : Zhu HJ , Appel DI , Johnson JA , Chavin KD , Markowitz JS |
| Ref : Biochemical Pharmacology , 77 :1266 , 2009 |
| Abstract : |
| PubMedSearch : Zhu_2009_Biochem.Pharmacol_77_1266 |
| PubMedID: 19185566 |
| Gene_locus related to this paper: human-CES1 |
| Title : Regulation of carboxylesterase 1 (CES1) in human adipose tissue - Jernas_2009_Biochem.Biophys.Res.Commun_383_63 |
| Author(s) : Jernas M , Olsson B , Arner P , Jacobson P , Sjostrom L , Walley A , Froguel P , McTernan PG , Hoffstedt J , Carlsson LM |
| Ref : Biochemical & Biophysical Research Communications , 383 :63 , 2009 |
| Abstract : |
| PubMedSearch : Jernas_2009_Biochem.Biophys.Res.Commun_383_63 |
| PubMedID: 19332024 |
| Gene_locus related to this paper: human-CES1 |
| Title : Human plasma carboxylesterase 1, a novel serologic biomarker candidate for hepatocellular carcinoma - Na_2009_Proteomics_9_3989 |
| Author(s) : Na K , Lee EY , Lee HJ , Kim KY , Lee H , Jeong SK , Jeong AS , Cho SY , Kim SA , Song SY , Kim KS , Cho SW , Kim H , Paik YK |
| Ref : Proteomics , 9 :3989 , 2009 |
| Abstract : |
| PubMedSearch : Na_2009_Proteomics_9_3989 |
| PubMedID: 19658107 |
| Gene_locus related to this paper: human-CES1 |
| Title : Human carboxylesterases: an update on CES1, CES2 and CES3 - Sanghani_2009_Protein.Pept.Lett_16_1207 |
| Author(s) : Sanghani SP , Sanghani PC , Schiel MA , Bosron WF |
| Ref : Protein Pept Lett , 16 :1207 , 2009 |
| Abstract : |
| PubMedSearch : Sanghani_2009_Protein.Pept.Lett_16_1207 |
| PubMedID: 19508181 |
| Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3 |
| Title : Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis - Zhu_2008_Am.J.Hum.Genet_82_1241 |
| Author(s) : Zhu HJ , Patrick KS , Yuan HJ , Wang JS , Donovan JL , DeVane CL , Malcolm R , Johnson JA , Youngblood GL , Sweet DH , Langaee TY , Markowitz JS |
| Ref : American Journal of Human Genetics , 82 :1241 , 2008 |
| Abstract : |
| PubMedSearch : Zhu_2008_Am.J.Hum.Genet_82_1241 |
| PubMedID: 18485328 |
| Gene_locus related to this paper: human-CES1 |
| Title : Hepatic overexpression of cholesteryl ester hydrolase enhances cholesterol elimination and in vivo reverse cholesterol transport - Zhao_2008_J.Lipid.Res_49_2212 |
| Author(s) : Zhao B , Song J , Ghosh S |
| Ref : J Lipid Res , 49 :2212 , 2008 |
| Abstract : |
| PubMedSearch : Zhao_2008_J.Lipid.Res_49_2212 |
| PubMedID: 18599737 |
| Gene_locus related to this paper: human-CES1 |
| Title : Inhibition of carboxylesterase 1 is associated with cholesteryl ester retention in human THP-1 monocyte\/macrophages - Crow_2008_Biochim.Biophys.Acta_1781_643 |
| Author(s) : Crow JA , Middleton BL , Borazjani A , Hatfield MJ , Potter PM , Ross MK |
| Ref : Biochimica & Biophysica Acta , 1781 :643 , 2008 |
| Abstract : |
| PubMedSearch : Crow_2008_Biochim.Biophys.Acta_1781_643 |
| PubMedID: 18762277 |
| Gene_locus related to this paper: human-CES1 |
| Title : Structure and characterization of human carboxylesterase 1A1, 1A2, and 1A3 genes - Fukami_2008_Pharmacogenet.Genomics_18_911 |
| Author(s) : Fukami T , Nakajima M , Maruichi T , Takahashi S , Takamiya M , Aoki Y , McLeod HL , Yokoi T |
| Ref : Pharmacogenet Genomics , 18 :911 , 2008 |
| Abstract : |
| PubMedSearch : Fukami_2008_Pharmacogenet.Genomics_18_911 |
| PubMedID: 18794728 |
| Gene_locus related to this paper: human-CES1 |
| Title : Functional polymorphisms in carboxylesterase1A2 (CES1A2) gene involves specific protein 1 (Sp1) binding sites - Yoshimura_2008_Biochem.Biophys.Res.Commun_369_939 |
| Author(s) : Yoshimura M , Kimura T , Ishii M , Ishii K , Matsuura T , Geshi E , Hosokawa M , Muramatsu M |
| Ref : Biochemical & Biophysical Research Communications , 369 :939 , 2008 |
| Abstract : |
| PubMedSearch : Yoshimura_2008_Biochem.Biophys.Res.Commun_369_939 |
| PubMedID: 18328811 |
| Gene_locus related to this paper: human-CES1 |
| Title : Structural organization and characterization of the regulatory element of the human carboxylesterase (CES1A1 and CES1A2) genes - Hosokawa_2008_Drug.Metab.Pharmacokinet_23_73 |
| Author(s) : Hosokawa M , Furihata T , Yaginuma Y , Yamamoto N , Watanabe N , Tsukada E , Ohhata Y , Kobayashi K , Satoh T , Chiba K |
| Ref : Drug Metab Pharmacokinet , 23 :73 , 2008 |
| Abstract : |
| PubMedSearch : Hosokawa_2008_Drug.Metab.Pharmacokinet_23_73 |
| PubMedID: 18305377 |
| Gene_locus related to this paper: human-CES1 |
| Title : Crystal structures of human carboxylesterase 1 in covalent complexes with the chemical warfare agents soman and tabun - Fleming_2007_Biochemistry_46_5063 |
| Author(s) : Fleming CD , Edwards CC , Kirby SD , Maxwell DM , Potter PM , Cerasoli DM , Redinbo MR |
| Ref : Biochemistry , 46 :5063 , 2007 |
| Abstract : |
| PubMedSearch : Fleming_2007_Biochemistry_46_5063 |
| PubMedID: 17407327 |
| Gene_locus related to this paper: human-CES1 |
| Title : Stable overexpression of human macrophage cholesteryl ester hydrolase results in enhanced free cholesterol efflux from human THP1 macrophages - Zhao_Am.J.Physiol.Cell.Physiol_292_C405 |
| Author(s) : Zhao B , Song J , St Clair RW , Ghosh S |
| Ref : American Journal of Physiology Cell Physiol , 292 :C405 , 2007 |
| Abstract : |
| PubMedSearch : Zhao_Am.J.Physiol.Cell.Physiol_292_C405 |
| PubMedID: 16971496 |
| Gene_locus related to this paper: human-CES1 |
| Title : Genomic structure and transcriptional regulation of the rat, mouse, and human carboxylesterase genes - Hosokawa_2007_Drug.Metab.Rev_39_1 |
| Author(s) : Hosokawa M , Furihata T , Yaginuma Y , Yamamoto N , Koyano N , Fujii A , Nagahara Y , Satoh T , Chiba K |
| Ref : Drug Metabolism Reviews , 39 :1 , 2007 |
| Abstract : |
| PubMedSearch : Hosokawa_2007_Drug.Metab.Rev_39_1 |
| PubMedID: 17364878 |
| Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3 , human-CES4A , human-CES5A |
| Title : Interleukin-6 alters the cellular responsiveness to clopidogrel, irinotecan, and oseltamivir by suppressing the expression of carboxylesterases HCE1 and HCE2 - Yang_2007_Mol.Pharmacol_72_686 |
| Author(s) : Yang J , Shi D , Yang D , Song X , Yan B |
| Ref : Molecular Pharmacology , 72 :686 , 2007 |
| Abstract : |
| PubMedSearch : Yang_2007_Mol.Pharmacol_72_686 |
| PubMedID: 17537833 |
| Gene_locus related to this paper: human-CES1 , human-CES2 |
| Title : Human carboxylesterase isozymes: catalytic properties and rational drug design - Imai_2006_Drug.Metab.Pharmacokinet_21_173 |
| Author(s) : Imai T |
| Ref : Drug Metab Pharmacokinet , 21 :173 , 2006 |
| Abstract : |
| PubMedSearch : Imai_2006_Drug.Metab.Pharmacokinet_21_173 |
| PubMedID: 16858120 |
| Gene_locus related to this paper: human-CES1 |
| Title : Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in human liver and small intestine - Imai_2006_Drug.Metab.Dispos_34_1734 |
| Author(s) : Imai T , Taketani M , Shii M , Hosokawa M , Chiba K |
| Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 34 :1734 , 2006 |
| Abstract : |
| PubMedSearch : Imai_2006_Drug.Metab.Dispos_34_1734 |
| PubMedID: 16837570 |
| Gene_locus related to this paper: human-CES1 , human-CES2 |
| Title : Mutation of F417 but not of L418 or L420 in the lipid binding domain decreases the activity of triacylglycerol hydrolase - Alam_2006_J.Lipid.Res_47_375 |
| Author(s) : Alam M , Gilham D , Vance DE , Lehner R |
| Ref : J Lipid Res , 47 :375 , 2006 |
| Abstract : |
| PubMedSearch : Alam_2006_J.Lipid.Res_47_375 |
| PubMedID: 16282638 |
| Gene_locus related to this paper: human-CES1 |
| Title : Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1 - Bencharit_2006_J.Mol.Biol_363_201 |
| Author(s) : Bencharit S , Edwards CC , Morton CL , Howard-Williams EL , Kuhn P , Potter PM , Redinbo MR |
| Ref : Journal of Molecular Biology , 363 :201 , 2006 |
| Abstract : |
| PubMedSearch : Bencharit_2006_J.Mol.Biol_363_201 |
| PubMedID: 16962139 |
| Gene_locus related to this paper: human-CES1 |
| Title : Characterization of pyrethroid hydrolysis by the human liver carboxylesterases hCE-1 and hCE-2 - Nishi_2006_Arch.Biochem.Biophys_445_115 |
| Author(s) : Nishi K , Huang H , Kamita SG , Kim IH , Morisseau C , Hammock BD |
| Ref : Archives of Biochemistry & Biophysics , 445 :115 , 2006 |
| Abstract : |
| PubMedSearch : Nishi_2006_Arch.Biochem.Biophys_445_115 |
| PubMedID: 16359636 |
| Gene_locus related to this paper: human-CES1 , human-CES2 |
| Title : Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol - Tang_2006_J.Pharmacol.Exp.Ther_319_1467 |
| Author(s) : Tang M , Mukundan M , Yang J , Charpentier N , LeCluyse EL , Black C , Yang D , Shi D , Yan B |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 319 :1467 , 2006 |
| Abstract : |
| PubMedSearch : Tang_2006_J.Pharmacol.Exp.Ther_319_1467 |
| PubMedID: 16943252 |
| Gene_locus related to this paper: human-CES1 |
| Title : Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil - Fleming_2005_J.Mol.Biol_352_165 |
| Author(s) : Fleming CD , Bencharit S , Edwards CC , Hyatt JL , Tsurkan L , Bai F , Fraga C , Morton CL , Howard-Williams EL , Potter PM , Redinbo MR |
| Ref : Journal of Molecular Biology , 352 :165 , 2005 |
| Abstract : |
| PubMedSearch : Fleming_2005_J.Mol.Biol_352_165 |
| PubMedID: 16081098 |
| Gene_locus related to this paper: human-CES1 |
| Title : A single nucleotide polymorphism in the carboxylesterase gene is associated with the responsiveness to imidapril medication and the promoter activity - Geshi_2005_Hypertens.Res_28_719 |
| Author(s) : Geshi E , Kimura T , Yoshimura M , Suzuki H , Koba S , Sakai T , Saito T , Koga A , Muramatsu M , Katagiri T |
| Ref : Hypertens Res , 28 :719 , 2005 |
| Abstract : |
| PubMedSearch : Geshi_2005_Hypertens.Res_28_719 |
| PubMedID: 16419644 |
| Gene_locus related to this paper: human-CES1 |
| Title : Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide - Quinney_2005_J.Pharmacol.Exp.Ther_313_1011 |
| Author(s) : Quinney SK , Sanghani SP , Davis WI , Hurley TD , Sun Z , Murry DJ , Bosron WF |
| Ref : Journal of Pharmacology & Experimental Therapeutics , 313 :1011 , 2005 |
| Abstract : |
| PubMedSearch : Quinney_2005_J.Pharmacol.Exp.Ther_313_1011 |
| PubMedID: 15687373 |
| Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3 |
| Title : Extremely sensitive biomarker of acute organophosphorus insecticide exposure - Fujikawa_2005_Hum.Exp.Toxicol_24_333 |
| Author(s) : Fujikawa Y , Satoh T , Suganuma A , Suzuki S , Niikura Y , Yui S , Yamaura Y |
| Ref : Hum Exp Toxicol , 24 :333 , 2005 |
| Abstract : |
| PubMedSearch : Fujikawa_2005_Hum.Exp.Toxicol_24_333 |
| PubMedID: 16004201 |
| Gene_locus related to this paper: human-CES1 , mouse-Ces1e , ratno-Ces1e |
| Title : Pharmacogenomic assessment of carboxylesterases 1 and 2 - Marsh_2004_Genomics_84_661 |
| Author(s) : Marsh S , Xiao M , Yu J , Ahluwalia R , Minton M , Freimuth RR , Kwok PY , McLeod HL |
| Ref : Genomics , 84 :661 , 2004 |
| Abstract : |
| PubMedSearch : Marsh_2004_Genomics_84_661 |
| PubMedID: 15475243 |
| Gene_locus related to this paper: human-CES1 , human-CES2 |
| Title : Triacylglycerol hydrolase: role in intracellular lipid metabolism - Dolinsky_2004_Cell.Mol.Life.Sci_61_1633 |
| Author(s) : Dolinsky VW , Gilham D , Alam M , Vance DE , Lehner R |
| Ref : Cell Mol Life Sciences , 61 :1633 , 2004 |
| Abstract : |
| PubMedSearch : Dolinsky_2004_Cell.Mol.Life.Sci_61_1633 |
| PubMedID: 15224187 |
| Gene_locus related to this paper: human-CES1 |
| Title : Human carboxylesterase 1: from drug metabolism to drug discovery - Redinbo_2003_Biochem.Soc.Trans_31_620 |
| Author(s) : Redinbo MR , Bencharit S , Potter PM |
| Ref : Biochemical Society Transactions , 31 :620 , 2003 |
| Abstract : |
| PubMedSearch : Redinbo_2003_Biochem.Soc.Trans_31_620 |
| PubMedID: 12773168 |
| Gene_locus related to this paper: human-CES1 |
| Title : Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition - Bencharit_2003_Chem.Biol_10_341 |
| Author(s) : Bencharit S , Morton CL , Hyatt JL , Kuhn P , Danks MK , Potter PM , Redinbo MR |
| Ref : Chemical Biology , 10 :341 , 2003 |
| Abstract : |
| PubMedSearch : Bencharit_2003_Chem.Biol_10_341 |
| PubMedID: 12725862 |
| Gene_locus related to this paper: human-CES1 |
| Title : Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme - Bencharit_2003_Nat.Struct.Biol_10_349 |
| Author(s) : Bencharit S , Morton CL , Xue Y , Potter PM , Redinbo MR |
| Ref : Nat Struct Biol , 10 :349 , 2003 |
| Abstract : |
| PubMedSearch : Bencharit_2003_Nat.Struct.Biol_10_349 |
| PubMedID: 12679808 |
| Gene_locus related to this paper: human-CES1 |
| Title : Structure-function analysis of human triacylglycerol hydrolase by site-directed mutagenesis: identification of the catalytic triad and a glycosylation site - Alam_2002_Biochemistry_41_6679 |
| Author(s) : Alam M , Vance DE , Lehner R |
| Ref : Biochemistry , 41 :6679 , 2002 |
| Abstract : |
| PubMedSearch : Alam_2002_Biochemistry_41_6679 |
| PubMedID: 12022871 |
| Gene_locus related to this paper: human-CES1 |
| Title : Heterologous expression, purification, and characterization of human triacylglycerol hydrolase - Alam_2002_Protein.Expr.Purif_24_33 |
| Author(s) : Alam M , Ho S , Vance DE , Lehner R |
| Ref : Protein Expr Purif , 24 :33 , 2002 |
| Abstract : |
| PubMedSearch : Alam_2002_Protein.Expr.Purif_24_33 |
| PubMedID: 11812220 |
| Gene_locus related to this paper: human-CES1 |
| Title : Organophosphates and their impact on the global environment - Satoh_2000_Neurotoxicol_21_223 |
| Author(s) : Satoh T , Hosokawa M |
| Ref : Neurotoxicology , 21 :223 , 2000 |
| Abstract : |
| PubMedSearch : Satoh_2000_Neurotoxicol_21_223 |
| PubMedID: 10794404 |
| Gene_locus related to this paper: human-CES1 |
| Title : Biology of monocyte-specific esterase - Uphoff_2000_Leuk.Lymphoma_39_257 |
| Author(s) : Uphoff CC , Drexler HG |
| Ref : Leuk Lymphoma , 39 :257 , 2000 |
| Abstract : |
| PubMedSearch : Uphoff_2000_Leuk.Lymphoma_39_257 |
| PubMedID: 11342306 |
| Gene_locus related to this paper: human-CES1 |
| Title : Cholesteryl ester hydrolase in human monocyte\/macrophage: cloning, sequencing, and expression of full-length cDNA - Ghosh_2000_Physiol.Genomics_2_1 |
| Author(s) : Ghosh S |
| Ref : Physiol Genomics , 2 :1 , 2000 |
| Abstract : |
| PubMedSearch : Ghosh_2000_Physiol.Genomics_2_1 |
| PubMedID: 11015575 |
| Gene_locus related to this paper: human-CES1 |
| Title : Human egasyn binds beta-glucuronidase but neither the esterase active site of egasyn nor the C terminus of beta-glucuronidase is involved in their interaction - Islam_1999_Arch.Biochem.Biophys_372_53 |
| Author(s) : Islam MR , Waheed A , Shah GN , Tomatsu S , Sly WS |
| Ref : Archives of Biochemistry & Biophysics , 372 :53 , 1999 |
| Abstract : |
| PubMedSearch : Islam_1999_Arch.Biochem.Biophys_372_53 |
| PubMedID: 10562416 |
| Gene_locus related to this paper: human-CES1 |
| Title : cDNA cloning, characterization and stable expression of novel human brain carboxylesterase - Mori_1999_FEBS.Lett_458_17 |
| Author(s) : Mori M , Hosokawa M , Ogasawara Y , Tsukada E , Chiba K |
| Ref : FEBS Letters , 458 :17 , 1999 |
| Abstract : |
| PubMedSearch : Mori_1999_FEBS.Lett_458_17 |
| PubMedID: 10518925 |
| Gene_locus related to this paper: human-CES1 , mouse-Ces1d |
| Title : Identification and androgen regulation of egasyn in the mouse epididymis - Abou-Haila_1998_Biochim.Biophys.Acta_1401_177 |
| Author(s) : Abou-Haila A , Orgebin-Crist MC , Skudlarek MD , Tulsiani DR |
| Ref : Biochimica & Biophysica Acta , 1401 :177 , 1998 |
| Abstract : |
| PubMedSearch : Abou-Haila_1998_Biochim.Biophys.Acta_1401_177 |
| PubMedID: 9531973 |
| Gene_locus related to this paper: human-CES1 |
| Title : Purification and characterization of retinyl ester hydrolase as a member of the non-specific carboxylesterase supergene family - Schindler_1998_Eur.J.Biochem_251_863 |
| Author(s) : Schindler R , Mentlein R , Feldheim W |
| Ref : European Journal of Biochemistry , 251 :863 , 1998 |
| Abstract : |
| PubMedSearch : Schindler_1998_Eur.J.Biochem_251_863 |
| PubMedID: 9490062 |
| Gene_locus related to this paper: human-CES1 , pig-EST1 |
| Title : Hydrolytic profile for ester- or amide-linkage by carboxylesterases pI 5.3 and 4.5 from human liver - Takai_1997_Biol.Pharm.Bull_20_869 |
| Author(s) : Takai S , Matsuda A , Usami Y , Adachi T , Sugiyama T , Katagiri Y , Tatematsu M , Hirano K |
| Ref : Biol Pharm Bull , 20 :869 , 1997 |
| Abstract : |
| PubMedSearch : Takai_1997_Biol.Pharm.Bull_20_869 |
| PubMedID: 9300133 |
| Gene_locus related to this paper: human-CES1 , human-CES2 |
| Title : Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin - Pindel_1997_J.Biol.Chem_272_14769 |
| Author(s) : Pindel EV , Kedishvili NY , Abraham TL , Brzezinski MR , Zhang J , Dean RA , Bosron WF |
| Ref : Journal of Biological Chemistry , 272 :14769 , 1997 |
| Abstract : |
| PubMedSearch : Pindel_1997_J.Biol.Chem_272_14769 |
| PubMedID: 9169443 |
| Gene_locus related to this paper: human-CES1 , human-CES2 |
| Title : Androgen regulation of molecular forms of beta-D-glucuronidase in the mouse epididymis: comparison with liver and kidney - Abou-Haila_1996_J.Androl_17_194 |
| Author(s) : Abou-Haila A , Tulsiani DR , Skudlarek MD , Orgebin-Crist MC |
| Ref : J Androl , 17 :194 , 1996 |
| Abstract : |
| PubMedSearch : Abou-Haila_1996_J.Androl_17_194 |
| PubMedID: 8792210 |
| Gene_locus related to this paper: human-CES1 |
| Title : Bile salt stimulated cholesterol esterase increases uptake of high density lipoprotein-associated cholesteryl esters by HepG2 cells - Li_1996_Biochemistry_35_6657 |
| Author(s) : Li F , Huang Y , Hui DY |
| Ref : Biochemistry , 35 :6657 , 1996 |
| Abstract : |
| PubMedSearch : Li_1996_Biochemistry_35_6657 |
| PubMedID: 8639615 |
| Gene_locus related to this paper: human-CES1 |
| Title : The beta-glucuronidase propeptide contains a serpin-related octamer necessary for complex formation with egasyn esterase and for retention within the endoplasmic reticulum - Zhen_1995_J.Biol.Chem_270_11912 |
| Author(s) : Zhen L , Rusiniak ME , Swank RT |
| Ref : Journal of Biological Chemistry , 270 :11912 , 1995 |
| Abstract : |
| PubMedSearch : Zhen_1995_J.Biol.Chem_270_11912 |
| PubMedID: 7744842 |
| Gene_locus related to this paper: human-CES1 |
| Title : Rat serum carboxylesterase. Cloning, expression, regulation, and evidence of secretion from liver - Yan_1995_J.Biol.Chem_270_19128 |
| Author(s) : Yan B , Yang D , Bullock P , Parkinson A |
| Ref : Journal of Biological Chemistry , 270 :19128 , 1995 |
| Abstract : |
| PubMedSearch : Yan_1995_J.Biol.Chem_270_19128 |
| PubMedID: 7642579 |
| Gene_locus related to this paper: human-CES1 |
| Title : Molecular aspects of carboxylesterase isoforms in comparison with other esterases - Satoh_1995_Toxicol.Lett_82-83_439 |
| Author(s) : Satoh T , Hosokawa M |
| Ref : Toxicol Lett , 82-83 :439 , 1995 |
| Abstract : |
| PubMedSearch : Satoh_1995_Toxicol.Lett_82-83_439 |
| PubMedID: 8597091 |
| Gene_locus related to this paper: human-CES1 , ratno-lmcxe , ratno-q68g49 |
| Title : Heterogeneity of Wistar rats with respect to acid beta-D-glucuronidase (EC 3.2.1.31) in liver - Loffler_1994_Biochem.Mol.Biol.Int_33_235 |
| Author(s) : Loffler BM , Mielenz E , Kunze H |
| Ref : Biochemistry & Molecular Biology International , 33 :235 , 1994 |
| Abstract : |
| PubMedSearch : Loffler_1994_Biochem.Mol.Biol.Int_33_235 |
| PubMedID: 7951044 |
| Gene_locus related to this paper: human-CES1 |
| Title : Purification and characterization of a human liver cocaine carboxylesterase that catalyzes the production of benzoylecgonine and the formation of cocaethylene from alcohol and cocaine - Brzezinski_1994_Biochem.Pharmacol_48_1747 |
| Author(s) : Brzezinski MR , Abraham TL , Stone CL , Dean RA , Bosron WF |
| Ref : Biochemical Pharmacology , 48 :1747 , 1994 |
| Abstract : |
| PubMedSearch : Brzezinski_1994_Biochem.Pharmacol_48_1747 |
| PubMedID: 7980644 |
| Gene_locus related to this paper: human-CES1 |
| Title : Purification, cloning, and expression of a human enzyme with acyl coenzyme A: cholesterol acyltransferase activity, which is identical to liver carboxylesterase - Becker_1994_Arterioscler.Thromb_14_1346 |
| Author(s) : Becker A , Bottcher A , Lackner KJ , Fehringer P , Notka F , Aslanidis C , Schmitz G |
| Ref : Arterioscler Thromb , 14 :1346 , 1994 |
| Abstract : |
| PubMedSearch : Becker_1994_Arterioscler.Thromb_14_1346 |
| PubMedID: 8049197 |
| Gene_locus related to this paper: human-CES1 , pig-EST1 |
| Title : The signal for retention of the egasyn-glucuronidase complex within the endoplasmic reticulum - Zhen_1993_Arch.Biochem.Biophys_304_402 |
| Author(s) : Zhen L , Baumann H , Novak EK , Swank RT |
| Ref : Archives of Biochemistry & Biophysics , 304 :402 , 1993 |
| Abstract : |
| PubMedSearch : Zhen_1993_Arch.Biochem.Biophys_304_402 |
| PubMedID: 8346916 |
| Gene_locus related to this paper: human-CES1 |
| Title : Glycosylation-dependent activity of baculovirus-expressed human liver carboxylesterases: cDNA cloning and characterization of two highly similar enzyme forms - Kroetz_1993_Biochemistry_32_11606 |
| Author(s) : Kroetz DL , McBride OW , Gonzalez FJ |
| Ref : Biochemistry , 32 :11606 , 1993 |
| Abstract : |
| PubMedSearch : Kroetz_1993_Biochemistry_32_11606 |
| PubMedID: 8218228 |
| Gene_locus related to this paper: human-CES1 |
| Title : Molecular cloning and characterization of a human carboxylesterase gene - Shibata_1993_Genomics_17_76 |
| Author(s) : Shibata F , Takagi Y , Kitajima M , Kuroda T , Omura T |
| Ref : Genomics , 17 :76 , 1993 |
| Abstract : |
| PubMedSearch : Shibata_1993_Genomics_17_76 |
| PubMedID: 8406473 |
| Gene_locus related to this paper: human-CES1 |
| Title : Expression of egasyn-esterase in mammalian cells. Sequestration in the endoplasmic reticulum and complexation with beta-glucuronidase - Novak_1991_J.Biol.Chem_266_6377 |
| Author(s) : Novak EK , Baumann H , Ovnic M , Swank RT |
| Ref : Journal of Biological Chemistry , 266 :6377 , 1991 |
| Abstract : |
| PubMedSearch : Novak_1991_J.Biol.Chem_266_6377 |
| PubMedID: 2007590 |
| Gene_locus related to this paper: human-CES1 |
| Title : Release of liver microsomal beta-glucuronidase from hepatocytes in vitro and in vivo by organophosphates and hepatotoxic agents - Satoh_1991_J.Toxicol.Sci_16 Suppl 1_133 |
| Author(s) : Satoh T |
| Ref : Journal of Toxicological Sciences , 16 Suppl 1 :133 , 1991 |
| Abstract : |
| PubMedSearch : Satoh_1991_J.Toxicol.Sci_16 Suppl 1_133 |
| PubMedID: 1920540 |
| Gene_locus related to this paper: human-CES1 |
| Title : The COOH terminus of several liver carboxylesterases targets these enzymes to the lumen of the endoplasmic reticulum - Robbi_1991_J.Biol.Chem_266_20498 |
| Author(s) : Robbi M , Beaufay H |
| Ref : Journal of Biological Chemistry , 266 :20498 , 1991 |
| Abstract : |
| PubMedSearch : Robbi_1991_J.Biol.Chem_266_20498 |
| PubMedID: 1939102 |
| Gene_locus related to this paper: human-CES1 |
| Title : Structural requirements for the inhibition of human monocyte carboxylesterase by organophosphorus compounds - Saboori_1991_Chem.Biol.Interact_80_327 |
| Author(s) : Saboori AM , Lang DM , Newcombe DS |
| Ref : Chemico-Biological Interactions , 80 :327 , 1991 |
| Abstract : |
| PubMedSearch : Saboori_1991_Chem.Biol.Interact_80_327 |
| PubMedID: 1954660 |
| Gene_locus related to this paper: human-CES1 |
| Title : Cloning and analysis of a cDNA encoding a human liver carboxylesterase - Riddles_1991_Gene_108_289 |
| Author(s) : Riddles PW , Richards LJ , Bowles MR , Pond SM |
| Ref : Gene , 108 :289 , 1991 |
| Abstract : |
| PubMedSearch : Riddles_1991_Gene_108_289 |
| PubMedID: 1748313 |
| Gene_locus related to this paper: human-CES1 |
| Title : cDNA cloning and characterization of human monocyte\/macrophage serine esterase-1 - Zschunke_1991_Blood_78_506 |
| Author(s) : Zschunke F , Salmassi A , Kreipe H , Buck F , Parwaresch MR , Radzun HJ |
| Ref : Blood , 78 :506 , 1991 |
| Abstract : |
| PubMedSearch : Zschunke_1991_Blood_78_506 |
| PubMedID: 2070086 |
| Gene_locus related to this paper: human-CES1 |
| Title : Cloning and sequencing of a human liver carboxylesterase isoenzyme - Long_1991_Life.Sci_48_PL43 |
| Author(s) : Long RM , Calabrese MR , Martin BM , Pohl LR |
| Ref : Life Sciences , 48 :PL43 , 1991 |
| Abstract : |
| PubMedSearch : Long_1991_Life.Sci_48_PL43 |
| PubMedID: 1997784 |
| Gene_locus related to this paper: human-CES1 |
| Title : A serine esterase released by human alveolar macrophages is closely related to liver microsomal carboxylesterases - Munger_1991_J.Biol.Chem_266_18832 |
| Author(s) : Munger JS , Shi GP , Mark EA , Chin DT , Gerard C , Chapman HA |
| Ref : Journal of Biological Chemistry , 266 :18832 , 1991 |
| Abstract : |
| PubMedSearch : Munger_1991_J.Biol.Chem_266_18832 |
| PubMedID: 1918003 |
| Gene_locus related to this paper: human-CES1 |
| Title : beta-Glucuronidase is transported slowly to lysosomes in BW5147 mouse lymphoma cells: evidence that the prelysosomal enzyme is not restricted to the endoplasmic reticulum - Lazzarino_1990_Arch.Biochem.Biophys_282_100 |
| Author(s) : Lazzarino D , Gabel CA |
| Ref : Archives of Biochemistry & Biophysics , 282 :100 , 1990 |
| Abstract : |
| PubMedSearch : Lazzarino_1990_Arch.Biochem.Biophys_282_100 |
| PubMedID: 2221912 |
| Gene_locus related to this paper: human-CES1 |
| Title : The propeptide of beta-glucuronidase. Further evidence of its involvement in compartmentalization of beta-glucuronidase and sequence similarity with portions of the reactive site region of the serpin superfamily - Li_1990_J.Biol.Chem_265_14732 |
| Author(s) : Li H , Takeuchi KH , Manly K , Chapman V , Swank RT |
| Ref : Journal of Biological Chemistry , 265 :14732 , 1990 |
| Abstract : |
| PubMedSearch : Li_1990_J.Biol.Chem_265_14732 |
| PubMedID: 2394691 |
| Gene_locus related to this paper: human-CES1 |
| Title : Involvement of the carboxyl-terminal propeptide of beta-glucuronidase in its compartmentalization within the endoplasmic reticulum as determined by a synthetic peptide approach - Medda_1989_J.Biol.Chem_264_15824 |
| Author(s) : Medda S , Chemelli RM , Martin JL , Pohl LR , Swank RT |
| Ref : Journal of Biological Chemistry , 264 :15824 , 1989 |
| Abstract : |
| PubMedSearch : Medda_1989_J.Biol.Chem_264_15824 |
| PubMedID: 2777765 |
| Gene_locus related to this paper: human-CES1 |
| Title : Strain differences of rat liver carboxylesterase activities related to the phenotype difference of esterase-3 (egasyn) - Nakamura_1989_Res.Commun.Chem.Pathol.Pharmacol_66_451 |
| Author(s) : Nakamura T , Satoh T , Horie T , Sagami F , Tagaya O |
| Ref : Res Commun Chem Pathol Pharmacol , 66 :451 , 1989 |
| Abstract : |
| PubMedSearch : Nakamura_1989_Res.Commun.Chem.Pathol.Pharmacol_66_451 |
| PubMedID: 2609020 |
| Gene_locus related to this paper: human-CES1 |
| Title : Egasyn affects the processing of beta-glucuronidase in mouse liver - Pfister_1988_Biochem.J_255_825 |
| Author(s) : Pfister K , Bosshard N , Zopfi M , Gitzelmann R |
| Ref : Biochemical Journal , 255 :825 , 1988 |
| Abstract : |
| PubMedSearch : Pfister_1988_Biochem.J_255_825 |
| PubMedID: 3214427 |
| Gene_locus related to this paper: human-CES1 |
| Title : Involvement of the esterase active site of egasyn in compartmentalization of beta-glucuronidase within the endoplasmic reticulum - Medda_1987_Cell_50_301 |
| Author(s) : Medda S , Stevens AM , Swank RT |
| Ref : Cell , 50 :301 , 1987 |
| Abstract : |
| PubMedSearch : Medda_1987_Cell_50_301 |
| PubMedID: 3594574 |
| Gene_locus related to this paper: human-CES1 |
| Title : Lumenal location of the microsomal beta-glucuronidase-egasyn complex - Brown_1987_J.Cell.Biol_105_1571 |
| Author(s) : Brown J , Novak EK , Takeuchi K , Moore K , Medda S , Swank RT |
| Ref : Journal of Cell Biology , 105 :1571 , 1987 |
| Abstract : |
| PubMedSearch : Brown_1987_J.Cell.Biol_105_1571 |
| PubMedID: 3667691 |
| Gene_locus related to this paper: human-CES1 |
| Title : The egasyn gene affects the processing of oligosaccharides of lysosomal beta-glucuronidase in liver - Swank_1986_Biochem.J_240_445 |
| Author(s) : Swank RT , Pfister K , Miller D , Chapman V |
| Ref : Biochemical Journal , 240 :445 , 1986 |
| Abstract : |
| PubMedSearch : Swank_1986_Biochem.J_240_445 |
| PubMedID: 3101673 |
| Gene_locus related to this paper: human-CES1 |
| Title : Identity of esterase-22 and egasyn, the protein which complexes with microsomal beta-glucuronidase - Medda_1986_Biochem.Genet_24_229 |
| Author(s) : Medda S , von Deimling O , Swank RT |
| Ref : Biochemical Genetics , 24 :229 , 1986 |
| Abstract : |
| PubMedSearch : Medda_1986_Biochem.Genet_24_229 |
| PubMedID: 3729927 |
| Gene_locus related to this paper: human-CES1 |
| Title : Egasyn, a protein which determines the subcellular distribution of beta-glucuronidase, has esterase activity - Medda_1985_J.Biol.Chem_260_15802 |
| Author(s) : Medda S , Swank RT |
| Ref : Journal of Biological Chemistry , 260 :15802 , 1985 |
| Abstract : |
| PubMedSearch : Medda_1985_J.Biol.Chem_260_15802 |
| PubMedID: 4066695 |
| Gene_locus related to this paper: human-CES1 |
| Title : Preparation of microsomal beta-glucuronidase and its membrane anchor protein, egasyn - |
| Author(s) : Lusis AJ |
| Ref : Methods Enzymol , 96 :557 , 1983 |
| PubMedID: 6656645 |
| Gene_locus related to this paper: human-CES1 |
| Title : The synthesis and processing of beta-glucuronidase in normal and egasyn deficient mouse kidney - |
| Author(s) : Brown JA , Jahreis GP , Swank RT |
| Ref : Biochemical & Biophysical Research Communications , 99 :691 , 1981 |
| PubMedID: 7236294 |
| Gene_locus related to this paper: human-CES1 |
| Title : Demonstration of a rat liver microsomal binding protein specific for beta-glucuronidase - Strawser_1979_J.Biol.Chem_254_3716 |
| Author(s) : Strawser LD , Touster O |
| Ref : Journal of Biological Chemistry , 254 :3716 , 1979 |
| Abstract : |
| PubMedSearch : Strawser_1979_J.Biol.Chem_254_3716 |
| PubMedID: 438156 |
| Gene_locus related to this paper: human-CES1 |
| Title : Relationships between levels of membrane-bound glucuronidase and the associated protein egasyn in mouse tissues - Lusis_1977_J.Cell.Biol_73_728 |
| Author(s) : Lusis AJ , Paigen K |
| Ref : Journal of Cell Biology , 73 :728 , 1977 |
| Abstract : |
| PubMedSearch : Lusis_1977_J.Cell.Biol_73_728 |
| PubMedID: 873997 |
| Gene_locus related to this paper: human-CES1 |
| Title : Inheritance in mice of the membrane anchor protein egasyn: the Eg locus determines egasyn levels - Lusis_1977_Biochem.Genet_15_115 |
| Author(s) : Lusis AJ , Tomino S , Paigen K |
| Ref : Biochemical Genetics , 15 :115 , 1977 |
| Abstract : |
| PubMedSearch : Lusis_1977_Biochem.Genet_15_115 |
| PubMedID: 849245 |
| Gene_locus related to this paper: human-CES1 |
| Title : Isolation, characterization, and radioimmunoassay of murine egasyn, a protein stabilizing glucuronidase membrane binding - Lusis_1976_J.Biol.Chem_251_7753 |
| Author(s) : Lusis AJ , Tomino S , Paigen K |
| Ref : Journal of Biological Chemistry , 251 :7753 , 1976 |
| Abstract : |
| PubMedSearch : Lusis_1976_J.Biol.Chem_251_7753 |
| PubMedID: 826534 |
| Gene_locus related to this paper: human-CES1 |
| Title : Phenobarbital induction of egasyn: availability of egasyn in vivo determines glucuronidase binding to membrane - |
| Author(s) : Owerbach D , Luis AJ |
| Ref : Biochemical & Biophysical Research Communications , 69 :628 , 1976 |
| PubMedID: 1267808 |
| Gene_locus related to this paper: human-CES1 |
| Title : Egasyn, a protein complexed with microsomal beta-glucuronidase - Tominco_1975_J.Biol.Chem_250_1146 |
| Author(s) : Tominco S , Paigen K |
| Ref : Journal of Biological Chemistry , 250 :1146 , 1975 |
| Abstract : |
| PubMedSearch : Tominco_1975_J.Biol.Chem_250_1146 |
| PubMedID: 1112792 |
| Gene_locus related to this paper: human-CES1 |