human-CES1

Homo sapiens (Human) carboxylesterase CES1 hCE1 & for monocyte/macrophage serine-esterase 1 egasyn

Comment

Mammalian liver carboxylesterases (CESs\; EC 3.1.1.1) hydrolyze various xenobiotics and endogenous substrates with ester, thioester, or amide bonds and are thought to function mainly in drug metabolism and detoxication of harmful chemicals. CES1 is also responsible for hydrolysis of stored cholesterol esters in macrophage foam cells and release of free cholesterol for high density lipoprotein-mediated cholesterol efflux. Alternative names: Acyl-coenzyme A:cholesterol acyltransferase (ACAT) Monocyte\/macrophage serine esterase (HMSE) Serine esterase 1 Brain carboxylesterase hBr1 Triacylglycerol hydrolase (TGH) Egasyn Retinyl ester hydrolase (REH) Cocaine carboxylesterase.(Also named before human-cxesl human-cxest, -mmse, CES, hCES1,CES1A, hBr1 brain carboxylesterase hBr1 on chromosome 16 There are 3 isoforms some times called Ces1b, Ces1c they are not as diffiernt as the different genes if CE1 in mice (a,b,c,d,ef) ). The region is complex with pseudogene localized head to head with CES1. There are different haplotype and in some the pseudogene is replaced by a complete copy of CES1A1. see Rasmussen et al. 2018 for recent evaluation of genotyping procedures. Aso called monocyte-specific esterase or macrophage esterase

Relationship

Family : Carb_B_Chordata

Block : C

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

No mutation

1YA4 - Crystal structure of human liver carboxylesterase 1 in complex with tamoxifen 1YA8 - Crystal structure of human liver carboxylesterase in complex with mevastatin 8EOR - Human liver carboxylesterase 1 5A7G - Comparison of the structure and activity of glycosylated and aglycosylated Human Carboxylesterase 1 5A7H - Comparison of the structure and activity of glycosylated and aglycosylated Human Carboxylesterase 1 5A7F - Comparison of the structure and activity of glycosylated and aglycosylated Human Carboxylesterase 1 4AB1 - Recombinant Human Carboxylesterase 1 Isolated from Whole Cabbage Looper Larvae 3K9B - Crystal Structure of Human Liver Carboxylesterase 1 (hCE1) in covalent complex with the nerve agent Cyclosarin (GF) 2HRR - Crystal structure of Human Liver Carboxylesterase 1 (hCE1) in covalent complex with the nerve agent Tabun (GA) 2HRQ - Crystal structure of Human Liver Carboxylesterase 1 (hCE1) in covalent complex with the nerve agent Soman (GD) 2DQY - Crystal structure of human carboxylesterase in complex with cholate and palmitate 2DQZ - Crystal structure of human carboxylesterase in complex with homatropine, coenzyme A, and palmitate 2DR0 - Crystal structure of human carboxylesterase in complex with taurocholate 2H7C - Crystal structure of human carboxylesterase in complex with Coenzyme A (CASP Target) 1MX1 - Crystal Structure of Human Liver Carboxylesterase in complex with tacrine 1MX5 - Crystal Structure of Human Liver Carboxylesterase in complex with homatropine, a cocaine analogue 1MX9 - Crystal Structure of Human Liver Carboxylesterase in complex with naloxone methiodide, a heroin analogue 1YAH - Crystal Structure of Human Liver Carboxylesterase complexed to Etyl Acetate\; A Fatty Acid Ethyl Ester Analogue 1YAJ - Crystal Structure of Human Liver Carboxylesterase in complex with benzil

No kinetic

No disease

Sequence

Peptide

MWLRAFILAT LSASAAWGHP SSPPVVDTVH GKVLGKFVSL EGFAQPVAIF LGIPFAKPPL GPLRFTPPQP AEPWSFVKNA TSYPPMCTQD PKAGQLLSEL FTNRKENIPL KLSEDCLYLN IYTPADLTKK NRLPVMVWIH GGGLMVGAAS TYDGLALAAH ENVVVVTIQY RLGIWGFFST GDEHSRGNWG HLDQVAALRW VQDNIASFGG NPGSVTIFGE SAGGESVSVL VLSPLAKNLF HRAISESGVA LTSVLVKKGD VKPLAEQIAI TAGCKTTTSA VMVHCLRQKT EEELLETTLK MKFLSLDLQG DPRESQPLLG TVIDGMLLLK TPEELQAERN FHTVPYMVGI NKQEFGWLIP MQLMSYPLSE GQLDQKTAMS LLWKSYPLVC IAKELIPEAT EKYLGGTDDT VKKKDLFLDL IADVMFGVPS VIVARNHRDA GAPTYMYEFQ YRPSFSSDMK PKTVIGDHGD ELFSVFGAPF LKEGASEEEI RLSKMVMKFW ANFARNGNPN GEGLPHWPEY NQKEGYLQIG ANTQAAQKLK DKEVAFWTNL FAKKAVEKPP QTEHIEL

References (168)

Title : Role of carboxylesterase and arylacetamide deacetylase in drug metabolism, physiology, and pathology - Nagaoka_2024_Biochem.Pharmacol__116128
Author(s) : Nagaoka M , Sakai Y , Nakajima M , Fukami T
Ref : Biochemical Pharmacology , :116128 , 2024
PubMedID: 38492781
Gene_locus related to this paper: human-AADAC , human-CES1 , human-CES2

Title : Role of CES1 and ABCB1 Genetic Polymorphisms on Functional Response to Dabigatran in Patients with Atrial Fibrillation - Cumitini_2024_J.Clin.Med_13_2545
Author(s) : Cumitini L , Renda G , Giordano M , Rolla R , Shail T , Sacchetti S , Iezzi L , Giacomini L , Zanotti V , Auciello R , Angilletta I , Foglietta M , Zucchelli M , Antonucci I , Stuppia L , Gallina S , Dianzani U , Patti G
Ref : J Clin Med , 13 :2545 , 2024
PubMedID: 38731074
Gene_locus related to this paper: human-CES1

Title : Pharmacogenetic study of CES1 gene and enalapril efficacy - Hussain_2024_J.Appl.Genet__
Author(s) : Hussain M , Basheer S , Khalil A , Haider QUA , Saeed H , Faizan M
Ref : J Appl Genet , : , 2024
PubMedID: 38261266
Gene_locus related to this paper: human-CES1

Title : Hydrolysis of dibutyl phthalate and di(2-ethylhexyl) phthalate in human liver, small intestine, kidney, and lung: An in vitro analysis using organ subcellular fractions and recombinant carboxylesterases - Isobe_2023_Chem.Biol.Interact_372_110353
Author(s) : Isobe T , Ohkawara S , Mori Y , Jinno H , Tanaka-Kagawa T , Hanioka N
Ref : Chemico-Biological Interactions , 372 :110353 , 2023
PubMedID: 36657734
Gene_locus related to this paper: human-CES1 , mouse-Ces1c

Title : Human carboxylesterase 1A plays a predominant role in hydrolysis of the anti-dyslipidemia agent fenofibrate in humans - Li_2023_Drug.Metab.Dispos__
Author(s) : Li HX , Sun MR , Zhang Y , Song LL , Zhang F , Song YQ , Hou XD , Ge GB
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , : , 2023
PubMedID: 37550069
Gene_locus related to this paper: human-CES1

Title : High-resolution structural-omics of human liver enzymes - Su_2023_Cell.Rep_42_112609
Author(s) : Su CC , Lyu M , Zhang Z , Miyagi M , Huang W , Taylor DJ , Yu EW
Ref : Cell Rep , 42 :112609 , 2023
PubMedID: 37289586
Gene_locus related to this paper: human-CES1

Title : Natural deletion of mouse carboxylesterases Ces1c\/d\/e impacts drug metabolism and metabolic syndrome development - Gan_2023_Biomed.Pharmacother_164_114956
Author(s) : Gan C , Wang J , Wang Y , Martinez-Chavez A , Hillebrand M , de Vries N , Beukers J , Lebre MC , Wagenaar E , Rosing H , Klarenbeek S , Bleijerveld OB , Song JY , Altelaar M , Beijnen JH , Schinkel AH
Ref : Biomed Pharmacother , 164 :114956 , 2023
PubMedID: 37267638
Gene_locus related to this paper: human-CES1 , mouse-Ces1c , mouse-Ces1d , mouse-Ces1e

Title : Major implications of single nucleotide polymorphisms in human carboxylesterase 1 on substrate bioavailability - Yerrakula_2022_Biotechnol.Genet.Eng.Rev__
Author(s) : Yerrakula G , Abraham S , John S , Zeharvi M , George SG , Senthil V , Maiz F , Rahman MH
Ref : Biotechnol Genet Eng Rev , :1 , 2022
PubMedID: 35946821
Gene_locus related to this paper: human-CES1

Title : The Influence of Structural Variants of the CES1 Gene on the Pharmacokinetics of Enalapril, Presumably Due to Linkage Disequilibrium with the Intronic rs2244613 - Ikonnikova_2022_Genes.(Basel)_13_
Author(s) : Ikonnikova A , Kazakov R , Rodina T , Dmitriev A , Melnikov E , Zasedatelev A , Nasedkina T
Ref : Genes (Basel) , 13 : , 2022
PubMedID: 36553492
Gene_locus related to this paper: human-CES1

Title : Identification of regulatory variants of carboxylesterase 1 (CES1): A proof-of-concept study for the application of the Allele-Specific Protein Expression (ASPE) assay in identifying cis-acting regulatory genetic polymorphisms - Her_2022_Proteomics__e2200176
Author(s) : Her L , Shi J , Wang X , He B , Smith L , Jiang H , Zhu HJ
Ref : Proteomics , :e2200176 , 2022
PubMedID: 36413357
Gene_locus related to this paper: human-CES1

Title : The Influence of the CES1 Genotype on the Pharmacokinetics of Enalapril in Patients with Arterial Hypertension - Ikonnikova_2022_J.Pers.Med_12_580
Author(s) : Ikonnikova A , Rodina T , Dmitriev A , Melnikov E , Kazakov R , Nasedkina T
Ref : J Pers Med , 12 : , 2022
PubMedID: 35455696
Gene_locus related to this paper: human-CES1

Title : Transcriptional regulation of carboxylesterase 1 (CES1) in human liver: role of the nuclear receptor NR1H3 (LXRalpha) and its splice isoforms - Collins_2021_Drug.Metab.Dispos__
Author(s) : Collins JM , Lu R , Wang X , Zhu HJ , Wang D
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , : , 2021
PubMedID: 34697082
Gene_locus related to this paper: human-CES1

Title : Contributions of Cathepsin A and Carboxylesterase 1 to the hydrolysis of Tenofovir Alafenamide in the Human Liver, and the Effect of CES1 Genetic Variation on Tenofovir Alafenamide Hydrolysis - Li_2021_Drug.Metab.Dispos__
Author(s) : Li J , Shi J , Xiao J , Tran L , Wang X , Zhu HJ
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , : , 2021
PubMedID: 34933885
Gene_locus related to this paper: human-CES1 , human-CTSA

Title : Human carboxylesterase 1A plays a predominant role in the hydrolytic activation of remdesivir in humans - Zhang_2021_Chem.Biol.Interact_351_109744
Author(s) : Zhang F , Li HX , Zhang TT , Xiong Y , Wang HN , Lu ZH , Xiong L , He YQ , Ge GB
Ref : Chemico-Biological Interactions , 351 :109744 , 2021
PubMedID: 34774545
Gene_locus related to this paper: human-CES1

Title : Clock gene Bmal1 controls diurnal rhythms in expression and activity of intestinal carboxylesterase 1 - Chen_2021_J.Pharm.Pharmacol_73_52
Author(s) : Chen X , Yu F , Guo X , Su C , Li SS , Wu B
Ref : J Pharm Pharmacol , 73 :52 , 2021
PubMedID: 33791812
Gene_locus related to this paper: human-CES1

Title : Carboxylesterase-1 assisted targeting of HDAC inhibitors to mononuclear myeloid cells in Inflammatory Bowel Disease - Elfiky_2021_J.Crohns.Colitis__
Author(s) : Elfiky AMI , Ghiboub M , Li Yim AYF , Hageman IL , Verhoeff J , de Krijger M , van Hamersveld PHP , Welting O , Admiraal I , Rahman S , Garcia-Vallejo JJ , Wildenberg ME , Tomlinson L , Gregory R , Rioja I , Prinjha RK , Furze RC , Lewis HD , Mander PK , Heinsbroek SEM , Bell MJ , de Jonge WJ
Ref : J Crohns Colitis , : , 2021
PubMedID: 34633041
Gene_locus related to this paper: human-CES1

Title : Enhanced triacylglycerol catabolism by Carboxylesterase 1 promotes aggressive colorectal carcinoma - Capece_2021_J.Clin.Invest__
Author(s) : Capece D , D'Andrea D , Begalli F , Goracci L , Tornatore L , Alexander JL , Di Veroli A , Leow SC , Vaiyapuri TS , Ellis JK , Verzella D , Bennett J , Savino L , Ma Y , McKenzie JS , Doria ML , Mason SE , Chng KR , Keun HC , Frost G , Tergaonkar V , Broniowska K , Stunkel W , Takats Z , Kinross JM , Cruciani G , Franzoso G
Ref : J Clinical Investigation , : , 2021
PubMedID: 33878036
Gene_locus related to this paper: human-CES1

Title : Copy number variation in the CES1 gene and the risk of non-alcoholic fatty liver in a Chinese Han population - Chen_2021_Sci.Rep_11_13984
Author(s) : Chen BB , Yan JH , Zheng J , Peng HW , Cai XL , Pan XT , Li HQ , Hong QZ , Peng XE
Ref : Sci Rep , 11 :13984 , 2021
PubMedID: 34234263
Gene_locus related to this paper: human-CES1

Title : Melatonin inhibits lipid accumulation to repress prostate cancer progression by mediating the epigenetic modification of CES1 - Zhou_2021_Clin.Transl.Med_11_e449
Author(s) : Zhou L , Zhang C , Yang X , Liu L , Hu J , Hou Y , Tao H , Sugimura H , Chen Z , Wang L , Chen K
Ref : Clin Transl Med , 11 :e449 , 2021
PubMedID: 34185414
Gene_locus related to this paper: human-CES1

Title : Inactivation of CES1 Blocks Prostaglandin D(2) Glyceryl Ester Catabolism in Monocytes\/Macrophages and Enhances Its Anti-inflammatory Effects, Whereas the Pro-inflammatory Effects of Prostaglandin E(2) Glyceryl Ester Are Attenuated - Scheaffer_2020_ACS.Omega_5_29177
Author(s) : Scheaffer HL , Borazjani A , Szafran BN , Ross MK
Ref : ACS Omega , 5 :29177 , 2020
PubMedID: 33225149
Gene_locus related to this paper: human-CES1

Title : Potential Regulatory Role of Human-Carboxylesterase-1 Glycosylation in Liver Cancer Cell Growth - Na_2020_J.Proteome.Res_19_4867
Author(s) : Na K , Kim M , Kim CY , Lim JS , Cho JY , Shin H , Lee HJ , Kang BJ , Han DH , Kim H , Baik JH , Swiatek-de Lange M , Karl J , Paik YK
Ref : J Proteome Res , 19 :4867 , 2020
PubMedID: 33206527
Gene_locus related to this paper: human-CES1

Title : Carboxylesterase 1 and Precision Pharmacotherapy: Pharmacogenetics and Nongenetic Regulators - Her_2020_Drug.Metab.Dispos_48_230
Author(s) : Her L , Zhu HJ
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 48 :230 , 2020
PubMedID: 31871135
Gene_locus related to this paper: human-CES1

Title : The impact of human CES1 genetic variation on enzyme activity assessed by ritalinic acid\/methylphenidate ratios - Stage_2019_Basic.Clin.Pharmacol.Toxicol_125_54
Author(s) : Stage C , Dalhoff K , Rasmussen HB , Schow Guski L , Thomsen R , Bjerre D , Ferrero-Miliani L , Busk Madsen M , Jurgens G
Ref : Basic Clin Pharmacol Toxicol , 125 :54 , 2019
PubMedID: 30801959
Gene_locus related to this paper: human-CES1

Title : Human leukocytes differentially express endocannabinoid-glycerol lipases and hydrolyze 2-arachidonoyl-glycerol and its metabolites from the 15-lipoxygenase and cyclooxygenase pathways - Turcotte_2019_J.Leukoc.Biol_106_1337
Author(s) : Turcotte C , Dumais E , Archambault AS , Martin C , Blanchet MR , Bissonnette E , Boulet LP , Laviolette M , Di Marzo V , Flamand N
Ref : J Leukoc Biol , 106 :1337 , 2019
PubMedID: 31556464
Gene_locus related to this paper: human-ABHD6 , human-ABHD12 , human-ABHD16A , human-CES1 , human-LYPLA2 , human-PPT1

Title : Catalytic Hydrolysis Mechanism of Cocaine by Human Carboxylesterase 1: An Orthoester Intermediate Slows Down the Reaction - Yan_2019_Molecules_24_
Author(s) : Yan M , Zhang Z , Liu Z , Zhang C , Zhang J , Fan S , Yang Z
Ref : Molecules , 24 : , 2019
PubMedID: 31717501
Gene_locus related to this paper: human-CES1

Title : Influence of CYP450 Enzymes, CES1, PON1, ABCB1, and P2RY12 Polymorphisms on Clopidogrel Response in Patients Subjected to a Percutaneous Neurointervention - Saiz-Rodriguez_2019_Clin.Ther_41_1199
Author(s) : Saiz-Rodriguez M , Belmonte C , Caniego JL , Koller D , Zubiaur P , Barcena E , Romero-Palacian D , Eugene AR , Ochoa D , Abad-Santos F
Ref : Clin Ther , 41 :1199 , 2019
PubMedID: 31128980
Gene_locus related to this paper: human-CES1

Title : In Vitro Inhibition of Carboxylesterase 1 by Major Cannabinoids and Selected Metabolites - Qian_2019_Drug.Metab.Dispos_47_465
Author(s) : Qian Y , Wang X , Markowitz JS
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 47 :465 , 2019
PubMedID: 30833288
Gene_locus related to this paper: human-CES1

Title : Genetic determinants of dabigatran safety (CES1 gene rs2244613 polymorphism) in the Russian population: multi-ethnic analysis - Sychev_2019_Mol.Biol.Rep_46_2761
Author(s) : Sychev DA , Abdullaev SP , Mirzaev KB , Ryzhikova KA , Shuyev GN , Sozaeva ZA , Grishina EA , Mammaev SN , Gafurov DM , Kitaeva EY , Shprakh VV , Suleymanov SS , Bolieva LZ , Sozaeva MS , Zhuchkova SM , Gimaldinova NE , Sidukova EE , Asoskova AV , Mumladze RB
Ref : Mol Biol Rep , 46 :2761 , 2019
PubMedID: 30850966
Gene_locus related to this paper: human-CES1

Title : Effects of Genetic Variants on Carboxylesterase 1 Gene Expression, and Clopidogrel Pharmacokinetics and Antiplatelet Effects - Neuvonen_2018_Basic.Clin.Pharmacol.Toxicol_122_341
Author(s) : Neuvonen M , Tarkiainen EK , Tornio A , Hirvensalo P , Tapaninen T , Paile-Hyvarinen M , Itkonen MK , Holmberg MT , Karja V , Mannisto VT , Neuvonen PJ , Pihlajamaki J , Backman JT , Niemi M
Ref : Basic Clin Pharmacol Toxicol , 122 :341 , 2018
PubMedID: 28990360
Gene_locus related to this paper: human-CES1

Title : Genetic variation in human carboxylesterase CES1 confers resistance to hepatic steatosis - Lian_2018_Biochim.Biophys.Acta_1863_688
Author(s) : Lian J , Bahitham W , Panigrahi R , Nelson R , Li L , Watts R , Thiesen A , Lemieux MJ , Lehner R
Ref : Biochimica & Biophysica Acta , 1863 :688 , 2018
PubMedID: 29631096
Gene_locus related to this paper: human-CES1

Title : Clinical implications of genetic variation in carboxylesterase drug metabolism - Chen_2018_Expert.Opin.Drug.Metab.Toxicol_14_131
Author(s) : Chen F , Zhang B , Parker RB , Laizure SC
Ref : Expert Opin Drug Metab Toxicol , 14 :131 , 2018
PubMedID: 29264996
Gene_locus related to this paper: human-CES1 , human-CES2

Title : Silencing carboxylesterase 1 in human THP-1 macrophages perturbs genes regulated by PPARgamma\/RXR and RAR\/RXR: down-regulation of CYP27A1-LXRalpha signaling - Mangum_2018_Biochem.J_475_621
Author(s) : Mangum LC , Hou X , Borazjani A , Lee JH , Ross MK , Crow JA
Ref : Biochemical Journal , 475 :621 , 2018
PubMedID: 29321244
Gene_locus related to this paper: human-CES1

Title : Carboxylesterases in lipid metabolism: from mouse to human - Lian_2018_Protein.Cell_9_178
Author(s) : Lian J , Nelson R , Lehner R
Ref : Protein Cell , 9 :178 , 2018
PubMedID: 28677105
Gene_locus related to this paper: human-CES1

Title : Potent, Irreversible Inhibition of Human Carboxylesterases by Tanshinone Anhydrides Isolated from Salvia miltiorrhiza (Danshen) - Hatfield_2018_J.Nat.Prod_81_2410
Author(s) : Hatfield MJ , Binder RJ , Gannon R , Fratt EM , Bowling J , Potter PM
Ref : Journal of Natural Products , 81 :2410 , 2018
PubMedID: 30351923
Gene_locus related to this paper: human-CES1 , human-CES2

Title : Carboxylesterase 1 genes: systematic review and evaluation of existing genotyping procedures - Rasmussen_2018_Drug.Metab.Pers.Ther_33_3
Author(s) : Rasmussen HB , Madsen MB
Ref : Drug Metab Pers Ther , 33 :3 , 2018
PubMedID: 29427553
Gene_locus related to this paper: human-CES1

Title : Nomenclature for alleles of the human carboxylesterase 1 gene -
Author(s) : Rasmussen HB , Madsen MB , Hansen PR
Ref : Pharmacogenet Genomics , 27 :78 , 2017
PubMedID: 27831961
Gene_locus related to this paper: human-CES1

Title : Effect of carboxylesterase 1 S75N on clopidogrel therapy among acute coronary syndrome patients - Xiao_2017_Sci.Rep_7_7244
Author(s) : Xiao FY , Luo JQ , Liu M , Chen BL , Cao S , Liu ZQ , Zhou HH , Zhou G , Zhang W
Ref : Sci Rep , 7 :7244 , 2017
PubMedID: 28775293
Gene_locus related to this paper: human-CES1

Title : A Comprehensive Functional Assessment of Carboxylesterase 1 Nonsynonymous Polymorphisms - Wang_2017_Drug.Metab.Dispos_45_1149
Author(s) : Wang X , Rida N , Shi J , Wu AH , Bleske BE , Zhu HJ
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 45 :1149 , 2017
PubMedID: 28838926
Gene_locus related to this paper: human-CES1

Title : The impact of CES1 genotypes on the pharmacokinetics of methylphenidate in healthy Danish subjects - Stage_2017_Br.J.Clin.Pharmacol_83_1506
Author(s) : Stage C , Jurgens G , Guski LS , Thomsen R , Bjerre D , Ferrero-Miliani L , Lyauk YK , Rasmussen HB , Dalhoff K
Ref : British Journal of Clinical Pharmacology , 83 :1506 , 2017
PubMedID: 28087982
Gene_locus related to this paper: human-CES1

Title : The Pharmacokinetics of Enalapril in Relation to CES1 Genotype in Healthy Danish Volunteers - Stage_2017_Basic.Clin.Pharmacol.Toxicol_121_487
Author(s) : Stage C , Jurgens G , Guski LS , Thomsen R , Bjerre D , Ferrero-Miliani L , Lyauk YK , Rasmussen HB , Dalhoff K
Ref : Basic Clin Pharmacol Toxicol , 121 :487 , 2017
PubMedID: 28639420
Gene_locus related to this paper: human-CES1

Title : Predominant contributions of carboxylesterase 1 and 2 in hydrolysis of anordrin in humans - Jiang_2017_Xenobiotica__1
Author(s) : Jiang J , Chen X , Zhong D
Ref : Xenobiotica , :1 , 2017
PubMedID: 28532270
Gene_locus related to this paper: human-CES1

Title : Reduced carboxylesterase 1 is associated with endothelial injury in methamphetamine-induced pulmonary arterial hypertension - Orcholski_2017_Am.J.Physiol.Lung.Cell.Mol.Physiol_313_L252
Author(s) : Orcholski ME , Khurshudyan A , Shamskhou EA , Yuan K , Chen IY , Kodani SD , Morisseau C , Hammock BD , Hong EM , Alexandrova L , Alastalo TP , Berry G , Zamanian RT , de Jesus Perez VA
Ref : American Journal of Physiology Lung Cell Mol Physiol , 313 :L252 , 2017
PubMedID: 28473326
Gene_locus related to this paper: human-CES1

Title : Novel Genetic Variants in Carboxylesterase 1 Predict Severe Early-Onset Capecitabine-Related Toxicity - Hamzic_2017_Clin.Pharmacol.Ther_102_796
Author(s) : Hamzic S , Kummer D , Milesi S , Mueller D , Joerger M , Aebi S , Amstutz U , Largiader CR
Ref : Clinical Pharmacology & Therapeutics , 102 :796 , 2017
PubMedID: 28139840
Gene_locus related to this paper: human-CES1

Title : Novel procedure with improved resolution and specificity for amplification and differentiation of variants of the gene encoding carboxylesterase 1 - Bjerre_2017_Pharmacogenet.Genomics_27_155
Author(s) : Bjerre D , Rasmussen HB
Ref : Pharmacogenet Genomics , 27 :155 , 2017
PubMedID: 28146010
Gene_locus related to this paper: human-CES1

Title : Population Pharmacokinetics of Methylphenidate in Healthy Adults Emphasizing Novel and Known Effects of Several Carboxylesterase 1 (CES1) Variants - Lyauk_2016_Clin.Transl.Sci_9_337
Author(s) : Lyauk YK , Stage C , Bergmann TK , Ferrero-Milliani L , Bjerre D , Thomsen R , Dalhoff KP , Rasmussen HB , Jurgens G
Ref : Clin Transl Sci , 9 :337 , 2016
PubMedID: 27754602
Gene_locus related to this paper: human-CES1

Title : Sacubitril Is Selectively Activated by Carboxylesterase 1 (CES1) in the Liver and the Activation Is Affected by CES1 Genetic Variation - Shi_2016_Drug.Metab.Dispos_44_554
Author(s) : Shi J , Wang X , Nguyen J , Wu AH , Bleske BE , Zhu HJ
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 44 :554 , 2016
PubMedID: 26817948
Gene_locus related to this paper: human-CES1

Title : Dabigatran etexilate activation is affected by the CES1 genetic polymorphism G143E (rs71647871) and gender - Shi_2016_Biochem.Pharmacol_119_76
Author(s) : Shi J , Wang X , Nguyen JH , Bleske BE , Liang Y , Liu L , Zhu HJ
Ref : Biochemical Pharmacology , 119 :76 , 2016
PubMedID: 27614009
Gene_locus related to this paper: human-CES1

Title : Association of Oseltamivir Activation with Gender and Carboxylesterase 1 Genetic Polymorphisms - Shi_2016_Basic.Clin.Pharmacol.Toxicol_119_555
Author(s) : Shi J , Wang X , Eyler RF , Liang Y , Liu L , Mueller BA , Zhu HJ
Ref : Basic Clin Pharmacol Toxicol , 119 :555 , 2016
PubMedID: 27228223
Gene_locus related to this paper: human-CES1

Title : CES1 genetic variation affects the activation of angiotensin-converting enzyme inhibitors - Wang_2016_Pharmacogenomics.J_16_220
Author(s) : Wang X , Wang G , Shi J , Aa JY , Comas R , Liang Y , Zhu HJ
Ref : Pharmacogenomics J , 16 :220 , 2016
PubMedID: 26076923
Gene_locus related to this paper: human-CES1

Title : Investigating the impact of missense mutations in hCES1 by in silico structure-based approaches - Nzabonimpa_2016_Drug.Metab.Pers.Ther__
Author(s) : Nzabonimpa GS , Rasmussen HB , Brunak S , Taboureau O
Ref : Drug Metab Pers Ther , : , 2016
PubMedID: 26900165
Gene_locus related to this paper: human-CES1

Title : Fluoxetine reduces CES1, CES2, and CYP3A4 expression through decreasing PXR and increasing DEC1 in HepG2 cells - Shang_2016_Xenobiotica_46_393
Author(s) : Shang W , Liu J , Chen R , Ning R , Xiong J , Liu W , Mao Z , Hu G , Yang J
Ref : Xenobiotica , 46 :393 , 2016
PubMedID: 26340669
Gene_locus related to this paper: human-CES1

Title : Age-Dependent Human Hepatic Carboxylesterase 1 (CES1) and Carboxylesterase 2 (CES2) Postnatal Ontogeny - Hines_2016_Drug.Metab.Dispos_44_959
Author(s) : Hines RN , Simpson PM , McCarver DG
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 44 :959 , 2016
PubMedID: 26825642
Gene_locus related to this paper: human-CES1

Title : Establishment and Characterization of a Novel Caco-2 Subclone with a Similar Low Expression Level of Human Carboxylesterase 1 to Human Small Intestine - Ohura_2016_Drug.Metab.Dispos_44_1890
Author(s) : Ohura K , Nishiyama H , Saco S , Kurokawa K , Imai T
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 44 :1890 , 2016
PubMedID: 27638507
Gene_locus related to this paper: human-CES1

Title : Biotransformation Capacity of Carboxylesterase in Skin and Keratinocytes for the Penta-Ethyl Ester Prodrug of DTPA - Fu_2016_Drug.Metab.Dispos_44_1313
Author(s) : Fu J , Sadgrove M , Marson L , Jay M
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 44 :1313 , 2016
PubMedID: 27130352
Gene_locus related to this paper: human-CES1

Title : Carboxylesterase 1 Is Regulated by Hepatocyte Nuclear Factor 4alpha and Protects Against Alcohol- and MCD diet-induced Liver Injury - Xu_2016_Sci.Rep_6_24277
Author(s) : Xu J , Xu Y , Li Y , Jadhav K , You M , Yin L , Zhang Y
Ref : Sci Rep , 6 :24277 , 2016
PubMedID: 27075303
Gene_locus related to this paper: human-CES1

Title : CES1P1 variant -816A>C is not associated with hepatic carboxylesterase 1 expression and activity or antihypertensive effect of trandolapril - Zhu_2016_Eur.J.Clin.Pharmacol_72_681
Author(s) : Zhu HJ , Langaee TY , Gong Y , Wang X , Pepine CJ , Cooper-DeHoff RM , Johnson JA , Markowitz JS
Ref : European Journal of Clinical Pharmacology , 72 :681 , 2016
PubMedID: 26915813
Gene_locus related to this paper: human-CES1

Title : Impact of genetic polymorphisms related to clopidogrel or acetylsalicylic acid pharmacology on clinical outcome in Chinese patients with symptomatic extracranial or intracranial stenosis - Zhao_2016_Eur.J.Clin.Pharmacol_72_1195
Author(s) : Zhao Z , Li X , Sun S , Mei S , Ma N , Miao Z , Zhao M , Peng S
Ref : European Journal of Clinical Pharmacology , 72 :1195 , 2016
PubMedID: 27450232
Gene_locus related to this paper: human-CES1

Title : Prognostic impact of carboxylesterase 1 gene variants in patients with congestive heart failure treated with angiotensin-converting enzyme inhibitors - Nelveg-Kristensen_2016_Pharmacogenet.Genomics_26_169
Author(s) : Nelveg-Kristensen KE , Madsen MB , Torp-Pedersen C , Kober L , Egfjord M , Hansen T , Pedersen O , Rasmussen HB , Hansen PR
Ref : Pharmacogenet Genomics , 26 :169 , 2016
PubMedID: 26761119
Gene_locus related to this paper: human-CES1

Title : Regulatory effects of genomic translocations at the human carboxylesterase-1 (CES1) gene locus - Sanford_2016_Pharmacogenet.Genomics_26_197
Author(s) : Sanford JC , Wang X , Shi J , Barrie ES , Wang D , Zhu HJ , Sadee W
Ref : Pharmacogenet Genomics , 26 :197 , 2016
PubMedID: 26871237
Gene_locus related to this paper: human-CES1

Title : Comparison of substrate specificity among human arylacetamide deacetylase and carboxylesterases - Fukami_2015_Eur.J.Pharm.Sci_78_47
Author(s) : Fukami T , Kariya M , Kurokawa T , Iida A , Nakajima M
Ref : Eur J Pharm Sci , 78 :47 , 2015
PubMedID: 26164127
Gene_locus related to this paper: human-AADAC , human-CES1 , human-CES2

Title : Carboxylesterase 1 c.428G>\;A single nucleotide variation increases the antiplatelet effects of clopidogrel by reducing its hydrolysis in humans - Tarkiainen_2015_Clin.Pharmacol.Ther_97_650
Author(s) : Tarkiainen EK , Holmberg MT , Tornio A , Neuvonen M , Neuvonen PJ , Backman JT , Niemi M
Ref : Clinical Pharmacology & Therapeutics , 97 :650 , 2015
PubMedID: 25704243
Gene_locus related to this paper: human-CES1

Title : Effect of carboxylesterase 1 c.428G >\; A single nucleotide variation on the pharmacokinetics of quinapril and enalapril - Tarkiainen_2015_Br.J.Clin.Pharmacol_80_1131
Author(s) : Tarkiainen EK , Tornio A , Holmberg MT , Launiainen T , Neuvonen PJ , Backman JT , Niemi M
Ref : British Journal of Clinical Pharmacology , 80 :1131 , 2015
PubMedID: 25919042
Gene_locus related to this paper: human-CES1

Title : Comparison of the Structure and Activity of Glycosylated and Aglycosylated Human Carboxylesterase 1 - Arena de Souza_2015_PLoS.One_10_e0143919
Author(s) : Arena de Souza V , Scott DJ , Nettleship JE , Rahman N , Charlton MH , Walsh MA , Owens RJ
Ref : PLoS ONE , 10 :e0143919 , 2015
PubMedID: 26657071
Gene_locus related to this paper: human-CES1

Title : CYP2C19 and CES1 polymorphisms and efficacy of clopidogrel and aspirin dual antiplatelet therapy in patients with symptomatic intracranial atherosclerotic disease - Hoh_2015_J.Neurosurg__1
Author(s) : Hoh BL , Gong Y , McDonough CW , Waters MF , Royster AJ , Sheehan TO , Burkley B , Langaee TY , Mocco J , Zuckerman SL , Mummareddy N , Stephens ML, 2nd , Ingram C , Shaffer CM , Denny JC , Brilliant MH , Kitchner TE , Linneman JG , Roden DM , Johnson JA
Ref : Journal of Neurosurgery , :1 , 2015
PubMedID: 26587656
Gene_locus related to this paper: human-CES1

Title : Substrate-Competitive Activity-Based Profiling of Ester Prodrug Activating Enzymes - Xu_2015_Mol.Pharm_12_3399
Author(s) : Xu H , Majmudar JD , Davda D , Ghanakota P , Kim KH , Carlson HA , Showalter HD , Martin BR , Amidon GL
Ref : Mol Pharm , 12 :3399 , 2015
PubMedID: 26262434
Gene_locus related to this paper: human-CES1

Title : Intracellular Activation of Tenofovir Alafenamide and the Effect of Viral and Host Protease Inhibitors - Birkus_2015_Antimicrob.Agents.Chemother_60_316
Author(s) : Birkus G , Bam RA , Willkom M , Frey CR , Tsai L , Stray KM , Yant SR , Cihlar T
Ref : Antimicrobial Agents & Chemotherapy , 60 :316 , 2015
PubMedID: 26503655
Gene_locus related to this paper: human-CES1

Title : Distinct patterns of aging effects on the expression and activity of carboxylesterases in rat liver and intestine - Ohura_2014_Drug.Metab.Dispos_42_264
Author(s) : Ohura K , Tasaka K , Hashimoto M , Imai T
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 42 :264 , 2014
PubMedID: 24271336
Gene_locus related to this paper: human-CES1

Title : In vitro drug metabolism by human carboxylesterase 1: focus on Angiotensin-converting enzyme inhibitors - Thomsen_2014_Drug.Metab.Dispos_42_126
Author(s) : Thomsen R , Rasmussen HB , Linnet K
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 42 :126 , 2014
PubMedID: 24141856
Gene_locus related to this paper: human-CES1

Title : Multiple Cytochrome P450 Isoforms Are Involved in the Generation of a Pharmacologically Active Thiol Metabolite, whereas Paraoxonase 1 and Carboxylesterase 1 Catalyze the Formation of a Thiol Metabolite Isomer from Ticlopidine - Kim_2014_Drug.Metab.Dispos_42_141
Author(s) : Kim MJ , Jeong ES , Park JS , Lee SJ , Ghim JL , Choi CS , Shin JG , Kim DH
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 42 :141 , 2014
PubMedID: 24170778
Gene_locus related to this paper: human-CES1

Title : Identification of carboxylesterase-dependent dabigatran etexilate hydrolysis - Laizure_2014_Drug.Metab.Dispos_42_201
Author(s) : Laizure SC , Parker RB , Herring VL , Hu ZY
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 42 :201 , 2014
PubMedID: 24212379
Gene_locus related to this paper: human-CES1

Title : Screening of specific inhibitors for human carboxylesterases or arylacetamide deacetylase - Shimizu_2014_Drug.Metab.Dispos_42_1103
Author(s) : Shimizu M , Fukami T , Nakajima M , Yokoi T
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 42 :1103 , 2014
PubMedID: 24751575
Gene_locus related to this paper: human-AADAC , human-CES1 , human-CES2

Title : Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation - Zhu_2013_J.Pharmacol.Exp.Ther_344_665
Author(s) : Zhu HJ , Wang X , Gawronski BE , Brinda BJ , Angiolillo DJ , Markowitz JS
Ref : Journal of Pharmacology & Experimental Therapeutics , 344 :665 , 2013
PubMedID: 23275066
Gene_locus related to this paper: human-CES1

Title : Control of RhoA methylation by carboxylesterase I - Cushman_2013_J.Biol.Chem_288_19177
Author(s) : Cushman I , Cushman SM , Potter PM , Casey PJ
Ref : Journal of Biological Chemistry , 288 :19177 , 2013
PubMedID: 23658012
Gene_locus related to this paper: human-CES1

Title : Carboxylesterase 1 gene duplication and mRNA expression in adipose tissue are linked to obesity and metabolic function - Friedrichsen_2013_PLoS.One_8_e56861
Author(s) : Friedrichsen M , Poulsen P , Wojtaszewski J , Hansen PR , Vaag A , Rasmussen HB
Ref : PLoS ONE , 8 :e56861 , 2013
PubMedID: 23468884
Gene_locus related to this paper: human-CES1

Title : The functional G143E variant of carboxylesterase 1 is associated with increased clopidogrel active metabolite levels and greater clopidogrel response - Lewis_2013_Pharmacogenet.Genomics_23_1
Author(s) : Lewis JP , Horenstein RB , Ryan K , O'Connell JR , Gibson Q , Mitchell BD , Tanner K , Chai S , Bliden KP , Tantry US , Peer CJ , Figg WD , Spencer SD , Pacanowski MA , Gurbel PA , Shuldiner AR
Ref : Pharmacogenet Genomics , 23 :1 , 2013
PubMedID: 23111421
Gene_locus related to this paper: human-CES1

Title : Methylphenidate Side Effect Profile Is Influenced by Genetic Variation in the Attention-Deficit\/Hyperactivity Disorder-Associated CES1 Gene - Johnson_2013_J.Child.Adolesc.Psychopharmacol_23_655
Author(s) : Johnson KA , Barry E , Lambert D , FitzGerald M , McNicholas F , Kirley A , Gill M , Bellgrove MA , Hawi Z
Ref : J Child Adolesc Psychopharmacol , 23 :655 , 2013
PubMedID: 24350812
Gene_locus related to this paper: human-CES1

Title : Association of a carboxylesterase 1 polymorphism with appetite reduction in children and adolescents with attention-deficit\/hyperactivity disorder treated with methylphenidate - Bruxel_2013_Pharmacogenomics.J_13_476
Author(s) : Bruxel EM , Salatino-Oliveira A , Genro JP , Zeni CP , Polanczyk GV , Chazan R , Rohde LA , Hutz MH
Ref : Pharmacogenomics J , 13 :476 , 2013
PubMedID: 22688218
Gene_locus related to this paper: human-CES1

Title : Carboxylesterase 1 polymorphism impairs oseltamivir bioactivation in humans - Tarkiainen_2012_Clin.Pharmacol.Ther_92_68
Author(s) : Tarkiainen EK , Backman JT , Neuvonen M , Neuvonen PJ , Schwab M , Niemi M
Ref : Clinical Pharmacology & Therapeutics , 92 :68 , 2012
PubMedID: 22588607
Gene_locus related to this paper: human-CES1

Title : A discriminative analytical method for detection of CES1A1 and CES1A2\/CES1A3 genetic variants - Zhu_2012_Pharmacogenet.Genomics_22_215
Author(s) : Zhu HJ , Brinda B , Froehlich TE , Markowitz JS
Ref : Pharmacogenet Genomics , 22 :215 , 2012
PubMedID: 22237548
Gene_locus related to this paper: human-CES1

Title : Structure of Recombinant Human Carboxylesterase 1 Isolated from Whole Cabbage Looper Larvae - Greenblatt_2012_Acta.Crystallogr.Sect.F.Struct.Biol.Cryst.Commun_F68_269
Author(s) : Greenblatt HM , Otto TC , Kirkpatrick MG , Kovaleva E , Brown S , Buchman G , Cerasoli DM , Sussman JL
Ref : Acta Crystallographica Sect F Struct Biol Cryst Commun , F68 :269 , 2012
PubMedID: 22442219
Gene_locus related to this paper: human-CES1

Title : Nerve agent hydrolysis activity designed into a human drug metabolism enzyme - Hemmert_2011_PLoS.One_6_e17441
Author(s) : Hemmert AC , Otto TC , Chica RA , Wierdl M , Edwards JS , Lewis SM , Edwards CC , Tsurkan L , Cadieux CL , Kasten SA , Cashman JR , Mayo SL , Potter PM , Cerasoli DM , Redinbo MR
Ref : PLoS ONE , 6 :e17441 , 2011
PubMedID: 21445272
Gene_locus related to this paper: human-CES1

Title : Association of carboxylesterase 1A genotypes with irinotecan pharmacokinetics in Japanese cancer patients - Sai_2010_Br.J.Clin.Pharmacol_70_222
Author(s) : Sai K , Saito Y , Tatewaki N , Hosokawa M , Kaniwa N , Nishimaki-Mogami T , Naito M , Sawada J , Shirao K , Hamaguchi T , Yamamoto N , Kunitoh H , Tamura T , Yamada Y , Ohe Y , Yoshida T , Minami H , Ohtsu A , Matsumura Y , Saijo N , Okuda H
Ref : British Journal of Clinical Pharmacology , 70 :222 , 2010
PubMedID: 20653675
Gene_locus related to this paper: human-CES1

Title : Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins - Holmes_2010_Mamm.Genome_21_427
Author(s) : Holmes RS , Wright MW , Laulederkind SJ , Cox LA , Hosokawa M , Imai T , Ishibashi S , Lehner R , Miyazaki M , Perkins EJ , Potter PM , Redinbo MR , Robert J , Satoh T , Yamashita T , Yan B , Yokoi T , Zechner R , Maltais LJ
Ref : Mamm Genome , 21 :427 , 2010
PubMedID: 20931200
Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3 , human-CES4A , human-CES5A

Title : Transcriptional regulation of human carboxylesterase 1A1 by nuclear factor-erythroid 2 related factor 2 (Nrf2) - Maruichi_2010_Biochem.Pharmacol_79_288
Author(s) : Maruichi T , Fukami T , Nakajima M , Yokoi T
Ref : Biochemical Pharmacology , 79 :288 , 2010
PubMedID: 19715681
Gene_locus related to this paper: human-CES1

Title : In silico prediction of human carboxylesterase-1 (hCES1) metabolism combining docking analyses and MD simulations - Vistoli_2010_Bioorg.Med.Chem_18_320
Author(s) : Vistoli G , Pedretti A , Mazzolari A , Testa B
Ref : Bioorganic & Medicinal Chemistry , 18 :320 , 2010
PubMedID: 19932971
Gene_locus related to this paper: human-CES1

Title : Biochemical and molecular analysis of carboxylesterase-mediated hydrolysis of cocaine and heroin - Hatfield_2010_Br.J.Pharmacol_160_1916
Author(s) : Hatfield MJ , Tsurkan LG , Hyatt JL , Yu X , Edwards CC , Hicks LD , Wadkins RM , Potter PM
Ref : British Journal of Pharmacology , 160 :1916 , 2010
PubMedID: 20649590
Gene_locus related to this paper: human-CES1

Title : Activity-based protein profiling identifies a host enzyme, carboxylesterase 1, which is differentially active during hepatitis C virus replication - Blais_2010_J.Biol.Chem_285_25602
Author(s) : Blais DR , Lyn RK , Joyce MA , Rouleau Y , Steenbergen R , Barsby N , Zhu LF , Pegoraro AF , Stolow A , Tyrrell DL , Pezacki JP
Ref : Journal of Biological Chemistry , 285 :25602 , 2010
PubMedID: 20530478
Gene_locus related to this paper: human-CES1

Title : Human carboxylesterase 1 stereoselectively binds the nerve agent cyclosarin and spontaneously hydrolyzes the nerve agent sarin - Hemmert_2010_Mol.Pharmacol_77_508
Author(s) : Hemmert AC , Otto TC , Wierdl M , Edwards CC , Fleming CD , MacDonald M , Cashman JR , Potter PM , Cerasoli DM , Redinbo MR
Ref : Molecular Pharmacology , 77 :508 , 2010
PubMedID: 20051531
Gene_locus related to this paper: human-CES1

Title : Carboxylesterase 1 gene polymorphism and methylphenidate response in ADHD - Nemoda_2009_Neuropharmacol_57_731
Author(s) : Nemoda Z , Angyal N , Tarnok Z , Gadoros J , Sasvari-Szekely M
Ref : Neuropharmacology , 57 :731 , 2009
PubMedID: 19733552
Gene_locus related to this paper: human-CES1

Title : Activation of the antiviral prodrug oseltamivir is impaired by two newly identified carboxylesterase 1 variants - Zhu_2009_Drug.Metab.Dispos_37_264
Author(s) : Zhu HJ , Markowitz JS
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 37 :264 , 2009
PubMedID: 19022936
Gene_locus related to this paper: human-CES1

Title : Human carboxylesterases HCE1 and HCE2: ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin - Yang_2009_Biochem.Pharmacol_77_238
Author(s) : Yang D , Pearce RE , Wang X , Gaedigk R , Wan YJ , Yan B
Ref : Biochemical Pharmacology , 77 :238 , 2009
PubMedID: 18983829
Gene_locus related to this paper: human-CES1 , human-CES2

Title : Role of carboxylesterase 1 and impact of natural genetic variants on the hydrolysis of trandolapril - Zhu_2009_Biochem.Pharmacol_77_1266
Author(s) : Zhu HJ , Appel DI , Johnson JA , Chavin KD , Markowitz JS
Ref : Biochemical Pharmacology , 77 :1266 , 2009
PubMedID: 19185566
Gene_locus related to this paper: human-CES1

Title : Regulation of carboxylesterase 1 (CES1) in human adipose tissue - Jernas_2009_Biochem.Biophys.Res.Commun_383_63
Author(s) : Jernas M , Olsson B , Arner P , Jacobson P , Sjostrom L , Walley A , Froguel P , McTernan PG , Hoffstedt J , Carlsson LM
Ref : Biochemical & Biophysical Research Communications , 383 :63 , 2009
PubMedID: 19332024
Gene_locus related to this paper: human-CES1

Title : Human plasma carboxylesterase 1, a novel serologic biomarker candidate for hepatocellular carcinoma - Na_2009_Proteomics_9_3989
Author(s) : Na K , Lee EY , Lee HJ , Kim KY , Lee H , Jeong SK , Jeong AS , Cho SY , Kim SA , Song SY , Kim KS , Cho SW , Kim H , Paik YK
Ref : Proteomics , 9 :3989 , 2009
PubMedID: 19658107
Gene_locus related to this paper: human-CES1

Title : Human carboxylesterases: an update on CES1, CES2 and CES3 - Sanghani_2009_Protein.Pept.Lett_16_1207
Author(s) : Sanghani SP , Sanghani PC , Schiel MA , Bosron WF
Ref : Protein Pept Lett , 16 :1207 , 2009
PubMedID: 19508181
Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3

Title : Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis - Zhu_2008_Am.J.Hum.Genet_82_1241
Author(s) : Zhu HJ , Patrick KS , Yuan HJ , Wang JS , Donovan JL , DeVane CL , Malcolm R , Johnson JA , Youngblood GL , Sweet DH , Langaee TY , Markowitz JS
Ref : American Journal of Human Genetics , 82 :1241 , 2008
PubMedID: 18485328
Gene_locus related to this paper: human-CES1

Title : Hepatic overexpression of cholesteryl ester hydrolase enhances cholesterol elimination and in vivo reverse cholesterol transport - Zhao_2008_J.Lipid.Res_49_2212
Author(s) : Zhao B , Song J , Ghosh S
Ref : J Lipid Res , 49 :2212 , 2008
PubMedID: 18599737
Gene_locus related to this paper: human-CES1

Title : Inhibition of carboxylesterase 1 is associated with cholesteryl ester retention in human THP-1 monocyte\/macrophages - Crow_2008_Biochim.Biophys.Acta_1781_643
Author(s) : Crow JA , Middleton BL , Borazjani A , Hatfield MJ , Potter PM , Ross MK
Ref : Biochimica & Biophysica Acta , 1781 :643 , 2008
PubMedID: 18762277
Gene_locus related to this paper: human-CES1

Title : Structure and characterization of human carboxylesterase 1A1, 1A2, and 1A3 genes - Fukami_2008_Pharmacogenet.Genomics_18_911
Author(s) : Fukami T , Nakajima M , Maruichi T , Takahashi S , Takamiya M , Aoki Y , McLeod HL , Yokoi T
Ref : Pharmacogenet Genomics , 18 :911 , 2008
PubMedID: 18794728
Gene_locus related to this paper: human-CES1

Title : Functional polymorphisms in carboxylesterase1A2 (CES1A2) gene involves specific protein 1 (Sp1) binding sites - Yoshimura_2008_Biochem.Biophys.Res.Commun_369_939
Author(s) : Yoshimura M , Kimura T , Ishii M , Ishii K , Matsuura T , Geshi E , Hosokawa M , Muramatsu M
Ref : Biochemical & Biophysical Research Communications , 369 :939 , 2008
PubMedID: 18328811
Gene_locus related to this paper: human-CES1

Title : Structural organization and characterization of the regulatory element of the human carboxylesterase (CES1A1 and CES1A2) genes - Hosokawa_2008_Drug.Metab.Pharmacokinet_23_73
Author(s) : Hosokawa M , Furihata T , Yaginuma Y , Yamamoto N , Watanabe N , Tsukada E , Ohhata Y , Kobayashi K , Satoh T , Chiba K
Ref : Drug Metab Pharmacokinet , 23 :73 , 2008
PubMedID: 18305377
Gene_locus related to this paper: human-CES1

Title : Crystal structures of human carboxylesterase 1 in covalent complexes with the chemical warfare agents soman and tabun - Fleming_2007_Biochemistry_46_5063
Author(s) : Fleming CD , Edwards CC , Kirby SD , Maxwell DM , Potter PM , Cerasoli DM , Redinbo MR
Ref : Biochemistry , 46 :5063 , 2007
PubMedID: 17407327
Gene_locus related to this paper: human-CES1

Title : Stable overexpression of human macrophage cholesteryl ester hydrolase results in enhanced free cholesterol efflux from human THP1 macrophages - Zhao_Am.J.Physiol.Cell.Physiol_292_C405
Author(s) : Zhao B , Song J , St Clair RW , Ghosh S
Ref : American Journal of Physiology Cell Physiol , 292 :C405 , 2007
PubMedID: 16971496
Gene_locus related to this paper: human-CES1

Title : Genomic structure and transcriptional regulation of the rat, mouse, and human carboxylesterase genes - Hosokawa_2007_Drug.Metab.Rev_39_1
Author(s) : Hosokawa M , Furihata T , Yaginuma Y , Yamamoto N , Koyano N , Fujii A , Nagahara Y , Satoh T , Chiba K
Ref : Drug Metabolism Reviews , 39 :1 , 2007
PubMedID: 17364878
Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3 , human-CES4A , human-CES5A

Title : Interleukin-6 alters the cellular responsiveness to clopidogrel, irinotecan, and oseltamivir by suppressing the expression of carboxylesterases HCE1 and HCE2 - Yang_2007_Mol.Pharmacol_72_686
Author(s) : Yang J , Shi D , Yang D , Song X , Yan B
Ref : Molecular Pharmacology , 72 :686 , 2007
PubMedID: 17537833
Gene_locus related to this paper: human-CES1 , human-CES2

Title : Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1 - Bencharit_2006_J.Mol.Biol_363_201
Author(s) : Bencharit S , Edwards CC , Morton CL , Howard-Williams EL , Kuhn P , Potter PM , Redinbo MR
Ref : Journal of Molecular Biology , 363 :201 , 2006
PubMedID: 16962139
Gene_locus related to this paper: human-CES1

Title : Characterization of pyrethroid hydrolysis by the human liver carboxylesterases hCE-1 and hCE-2 - Nishi_2006_Arch.Biochem.Biophys_445_115
Author(s) : Nishi K , Huang H , Kamita SG , Kim IH , Morisseau C , Hammock BD
Ref : Archives of Biochemistry & Biophysics , 445 :115 , 2006
PubMedID: 16359636
Gene_locus related to this paper: human-CES1 , human-CES2

Title : Antiplatelet agents aspirin and clopidogrel are hydrolyzed by distinct carboxylesterases, and clopidogrel is transesterificated in the presence of ethyl alcohol - Tang_2006_J.Pharmacol.Exp.Ther_319_1467
Author(s) : Tang M , Mukundan M , Yang J , Charpentier N , LeCluyse EL , Black C , Yang D , Shi D , Yan B
Ref : Journal of Pharmacology & Experimental Therapeutics , 319 :1467 , 2006
PubMedID: 16943252
Gene_locus related to this paper: human-CES1

Title : Human carboxylesterase isozymes: catalytic properties and rational drug design - Imai_2006_Drug.Metab.Pharmacokinet_21_173
Author(s) : Imai T
Ref : Drug Metab Pharmacokinet , 21 :173 , 2006
PubMedID: 16858120
Gene_locus related to this paper: human-CES1

Title : Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in human liver and small intestine - Imai_2006_Drug.Metab.Dispos_34_1734
Author(s) : Imai T , Taketani M , Shii M , Hosokawa M , Chiba K
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 34 :1734 , 2006
PubMedID: 16837570
Gene_locus related to this paper: human-CES1 , human-CES2

Title : Mutation of F417 but not of L418 or L420 in the lipid binding domain decreases the activity of triacylglycerol hydrolase - Alam_2006_J.Lipid.Res_47_375
Author(s) : Alam M , Gilham D , Vance DE , Lehner R
Ref : J Lipid Res , 47 :375 , 2006
PubMedID: 16282638
Gene_locus related to this paper: human-CES1

Title : Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil - Fleming_2005_J.Mol.Biol_352_165
Author(s) : Fleming CD , Bencharit S , Edwards CC , Hyatt JL , Tsurkan L , Bai F , Fraga C , Morton CL , Howard-Williams EL , Potter PM , Redinbo MR
Ref : Journal of Molecular Biology , 352 :165 , 2005
PubMedID: 16081098
Gene_locus related to this paper: human-CES1

Title : A single nucleotide polymorphism in the carboxylesterase gene is associated with the responsiveness to imidapril medication and the promoter activity - Geshi_2005_Hypertens.Res_28_719
Author(s) : Geshi E , Kimura T , Yoshimura M , Suzuki H , Koba S , Sakai T , Saito T , Koga A , Muramatsu M , Katagiri T
Ref : Hypertens Res , 28 :719 , 2005
PubMedID: 16419644
Gene_locus related to this paper: human-CES1

Title : Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide - Quinney_2005_J.Pharmacol.Exp.Ther_313_1011
Author(s) : Quinney SK , Sanghani SP , Davis WI , Hurley TD , Sun Z , Murry DJ , Bosron WF
Ref : Journal of Pharmacology & Experimental Therapeutics , 313 :1011 , 2005
PubMedID: 15687373
Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3

Title : Extremely sensitive biomarker of acute organophosphorus insecticide exposure - Fujikawa_2005_Hum.Exp.Toxicol_24_333
Author(s) : Fujikawa Y , Satoh T , Suganuma A , Suzuki S , Niikura Y , Yui S , Yamaura Y
Ref : Hum Exp Toxicol , 24 :333 , 2005
PubMedID: 16004201
Gene_locus related to this paper: human-CES1 , mouse-Ces1e , ratno-Ces1e

Title : Complete sequencing and characterization of 21,243 full-length human cDNAs - Ota_2004_Nat.Genet_36_40
Author(s) : Ota T , Suzuki Y , Nishikawa T , Otsuki T , Sugiyama T , Irie R , Wakamatsu A , Hayashi K , Sato H , Nagai K , Kimura K , Makita H , Sekine M , Obayashi M , Nishi T , Shibahara T , Tanaka T , Ishii S , Yamamoto J , Saito K , Kawai Y , Isono Y , Nakamura Y , Nagahari K , Murakami K , Yasuda T , Iwayanagi T , Wagatsuma M , Shiratori A , Sudo H , Hosoiri T , Kaku Y , Kodaira H , Kondo H , Sugawara M , Takahashi M , Kanda K , Yokoi T , Furuya T , Kikkawa E , Omura Y , Abe K , Kamihara K , Katsuta N , Sato K , Tanikawa M , Yamazaki M , Ninomiya K , Ishibashi T , Yamashita H , Murakawa K , Fujimori K , Tanai H , Kimata M , Watanabe M , Hiraoka S , Chiba Y , Ishida S , Ono Y , Takiguchi S , Watanabe S , Yosida M , Hotuta T , Kusano J , Kanehori K , Takahashi-Fujii A , Hara H , Tanase TO , Nomura Y , Togiya S , Komai F , Hara R , Takeuchi K , Arita M , Imose N , Musashino K , Yuuki H , Oshima A , Sasaki N , Aotsuka S , Yoshikawa Y , Matsunawa H , Ichihara T , Shiohata N , Sano S , Moriya S , Momiyama H , Satoh N , Takami S , Terashima Y , Suzuki O , Nakagawa S , Senoh A , Mizoguchi H , Goto Y , Shimizu F , Wakebe H , Hishigaki H , Watanabe T , Sugiyama A , Takemoto M , Kawakami B , Watanabe K , Kumagai A , Itakura S , Fukuzumi Y , Fujimori Y , Komiyama M , Tashiro H , Tanigami A , Fujiwara T , Ono T , Yamada K , Fujii Y , Ozaki K , Hirao M , Ohmori Y , Kawabata A , Hikiji T , Kobatake N , Inagaki H , Ikema Y , Okamoto S , Okitani R , Kawakami T , Noguchi S , Itoh T , Shigeta K , Senba T , Matsumura K , Nakajima Y , Mizuno T , Morinaga M , Sasaki M , Togashi T , Oyama M , Hata H , Komatsu T , Mizushima-Sugano J , Satoh T , Shirai Y , Takahashi Y , Nakagawa K , Okumura K , Nagase T , Nomura N , Kikuchi H , Masuho Y , Yamashita R , Nakai K , Yada T , Ohara O , Isogai T , Sugano S
Ref : Nat Genet , 36 :40 , 2004
PubMedID: 14702039
Gene_locus related to this paper: human-ABHD1 , human-ABHD4 , human-ABHD12 , human-ABHD16A , human-ACOT1 , human-LDAH , human-ABHD18 , human-CES1 , human-CES4A , human-CES5A , human-CPVL , human-DAGLB , human-EPHX2 , human-KANSL3 , human-LIPA , human-LPL , human-MEST , human-NDRG1 , human-NLGN1 , human-NLGN4X , human-PRCP , human-PRSS16 , human-SERAC1 , human-TMEM53

Title : Pharmacogenomic assessment of carboxylesterases 1 and 2 - Marsh_2004_Genomics_84_661
Author(s) : Marsh S , Xiao M , Yu J , Ahluwalia R , Minton M , Freimuth RR , Kwok PY , McLeod HL
Ref : Genomics , 84 :661 , 2004
PubMedID: 15475243
Gene_locus related to this paper: human-CES1 , human-CES2

Title : Triacylglycerol hydrolase: role in intracellular lipid metabolism - Dolinsky_2004_Cell.Mol.Life.Sci_61_1633
Author(s) : Dolinsky VW , Gilham D , Alam M , Vance DE , Lehner R
Ref : Cell Mol Life Sciences , 61 :1633 , 2004
PubMedID: 15224187
Gene_locus related to this paper: human-CES1

Title : The sequence and analysis of duplication-rich human chromosome 16 - Martin_2004_Nature_432_988
Author(s) : Martin J , Han C , Gordon LA , Terry A , Prabhakar S , She X , Xie G , Hellsten U , Chan YM , Altherr M , Couronne O , Aerts A , Bajorek E , Black S , Blumer H , Branscomb E , Brown NC , Bruno WJ , Buckingham JM , Callen DF , Campbell CS , Campbell ML , Campbell EW , Caoile C , Challacombe JF , Chasteen LA , Chertkov O , Chi HC , Christensen M , Clark LM , Cohn JD , Denys M , Detter JC , Dickson M , Dimitrijevic-Bussod M , Escobar J , Fawcett JJ , Flowers D , Fotopulos D , Glavina T , Gomez M , Gonzales E , Goodstein D , Goodwin LA , Grady DL , Grigoriev I , Groza M , Hammon N , Hawkins T , Haydu L , Hildebrand CE , Huang W , Israni S , Jett J , Jewett PB , Kadner K , Kimball H , Kobayashi A , Krawczyk MC , Leyba T , Longmire JL , Lopez F , Lou Y , Lowry S , Ludeman T , Manohar CF , Mark GA , McMurray KL , Meincke LJ , Morgan J , Moyzis RK , Mundt MO , Munk AC , Nandkeshwar RD , Pitluck S , Pollard M , Predki P , Parson-Quintana B , Ramirez L , Rash S , Retterer J , Ricke DO , Robinson DL , Rodriguez A , Salamov A , Saunders EH , Scott D , Shough T , Stallings RL , Stalvey M , Sutherland RD , Tapia R , Tesmer JG , Thayer N , Thompson LS , Tice H , Torney DC , Tran-Gyamfi M , Tsai M , Ulanovsky LE , Ustaszewska A , Vo N , White PS , Williams AL , Wills PL , Wu JR , Wu K , Yang J , DeJong P , Bruce D , Doggett NA , Deaven L , Schmutz J , Grimwood J , Richardson P , Rokhsar DS , Eichler EE , Gilna P , Lucas SM , Myers RM , Rubin EM , Pennacchio LA
Ref : Nature , 432 :988 , 2004
PubMedID: 15616553
Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3 , human-CES4A , human-CES5A

Title : Human carboxylesterase 1: from drug metabolism to drug discovery - Redinbo_2003_Biochem.Soc.Trans_31_620
Author(s) : Redinbo MR , Bencharit S , Potter PM
Ref : Biochemical Society Transactions , 31 :620 , 2003
PubMedID: 12773168
Gene_locus related to this paper: human-CES1

Title : Crystal structure of human carboxylesterase 1 complexed with the Alzheimer's drug tacrine: from binding promiscuity to selective inhibition - Bencharit_2003_Chem.Biol_10_341
Author(s) : Bencharit S , Morton CL , Hyatt JL , Kuhn P , Danks MK , Potter PM , Redinbo MR
Ref : Chemical Biology , 10 :341 , 2003
PubMedID: 12725862
Gene_locus related to this paper: human-CES1

Title : Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme - Bencharit_2003_Nat.Struct.Biol_10_349
Author(s) : Bencharit S , Morton CL , Xue Y , Potter PM , Redinbo MR
Ref : Nat Struct Biol , 10 :349 , 2003
PubMedID: 12679808
Gene_locus related to this paper: human-CES1

Title : Structure-function analysis of human triacylglycerol hydrolase by site-directed mutagenesis: identification of the catalytic triad and a glycosylation site - Alam_2002_Biochemistry_41_6679
Author(s) : Alam M , Vance DE , Lehner R
Ref : Biochemistry , 41 :6679 , 2002
PubMedID: 12022871
Gene_locus related to this paper: human-CES1

Title : Heterologous expression, purification, and characterization of human triacylglycerol hydrolase - Alam_2002_Protein.Expr.Purif_24_33
Author(s) : Alam M , Ho S , Vance DE , Lehner R
Ref : Protein Expr Purif , 24 :33 , 2002
PubMedID: 11812220
Gene_locus related to this paper: human-CES1

Title : Organophosphates and their impact on the global environment - Satoh_2000_Neurotoxicol_21_223
Author(s) : Satoh T , Hosokawa M
Ref : Neurotoxicology , 21 :223 , 2000
PubMedID: 10794404
Gene_locus related to this paper: human-CES1

Title : Biology of monocyte-specific esterase - Uphoff_2000_Leuk.Lymphoma_39_257
Author(s) : Uphoff CC , Drexler HG
Ref : Leuk Lymphoma , 39 :257 , 2000
PubMedID: 11342306
Gene_locus related to this paper: human-CES1

Title : Cholesteryl ester hydrolase in human monocyte\/macrophage: cloning, sequencing, and expression of full-length cDNA - Ghosh_2000_Physiol.Genomics_2_1
Author(s) : Ghosh S
Ref : Physiol Genomics , 2 :1 , 2000
PubMedID: 11015575
Gene_locus related to this paper: human-CES1

Title : Human egasyn binds beta-glucuronidase but neither the esterase active site of egasyn nor the C terminus of beta-glucuronidase is involved in their interaction - Islam_1999_Arch.Biochem.Biophys_372_53
Author(s) : Islam MR , Waheed A , Shah GN , Tomatsu S , Sly WS
Ref : Archives of Biochemistry & Biophysics , 372 :53 , 1999
PubMedID: 10562416
Gene_locus related to this paper: human-CES1

Title : cDNA cloning, characterization and stable expression of novel human brain carboxylesterase - Mori_1999_FEBS.Lett_458_17
Author(s) : Mori M , Hosokawa M , Ogasawara Y , Tsukada E , Chiba K
Ref : FEBS Letters , 458 :17 , 1999
PubMedID: 10518925
Gene_locus related to this paper: human-CES1 , mouse-Ces1d

Title : Identification and androgen regulation of egasyn in the mouse epididymis - Abou-Haila_1998_Biochim.Biophys.Acta_1401_177
Author(s) : Abou-Haila A , Orgebin-Crist MC , Skudlarek MD , Tulsiani DR
Ref : Biochimica & Biophysica Acta , 1401 :177 , 1998
PubMedID: 9531973
Gene_locus related to this paper: human-CES1

Title : Purification and characterization of retinyl ester hydrolase as a member of the non-specific carboxylesterase supergene family - Schindler_1998_Eur.J.Biochem_251_863
Author(s) : Schindler R , Mentlein R , Feldheim W
Ref : European Journal of Biochemistry , 251 :863 , 1998
PubMedID: 9490062
Gene_locus related to this paper: human-CES1 , pig-EST1

Title : Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin - Pindel_1997_J.Biol.Chem_272_14769
Author(s) : Pindel EV , Kedishvili NY , Abraham TL , Brzezinski MR , Zhang J , Dean RA , Bosron WF
Ref : Journal of Biological Chemistry , 272 :14769 , 1997
PubMedID: 9169443
Gene_locus related to this paper: human-CES1 , human-CES2

Title : Androgen regulation of molecular forms of beta-D-glucuronidase in the mouse epididymis: comparison with liver and kidney - Abou-Haila_1996_J.Androl_17_194
Author(s) : Abou-Haila A , Tulsiani DR , Skudlarek MD , Orgebin-Crist MC
Ref : J Androl , 17 :194 , 1996
PubMedID: 8792210
Gene_locus related to this paper: human-CES1

Title : Bile salt stimulated cholesterol esterase increases uptake of high density lipoprotein-associated cholesteryl esters by HepG2 cells - Li_1996_Biochemistry_35_6657
Author(s) : Li F , Huang Y , Hui DY
Ref : Biochemistry , 35 :6657 , 1996
PubMedID: 8639615
Gene_locus related to this paper: human-CES1

Title : The beta-glucuronidase propeptide contains a serpin-related octamer necessary for complex formation with egasyn esterase and for retention within the endoplasmic reticulum - Zhen_1995_J.Biol.Chem_270_11912
Author(s) : Zhen L , Rusiniak ME , Swank RT
Ref : Journal of Biological Chemistry , 270 :11912 , 1995
PubMedID: 7744842
Gene_locus related to this paper: human-CES1

Title : Rat serum carboxylesterase. Cloning, expression, regulation, and evidence of secretion from liver - Yan_1995_J.Biol.Chem_270_19128
Author(s) : Yan B , Yang D , Bullock P , Parkinson A
Ref : Journal of Biological Chemistry , 270 :19128 , 1995
PubMedID: 7642579
Gene_locus related to this paper: human-CES1

Title : Molecular aspects of carboxylesterase isoforms in comparison with other esterases - Satoh_1995_Toxicol.Lett_82-83_439
Author(s) : Satoh T , Hosokawa M
Ref : Toxicol Lett , 82-83 :439 , 1995
PubMedID: 8597091
Gene_locus related to this paper: human-CES1 , ratno-lmcxe , ratno-q68g49

Title : Heterogeneity of Wistar rats with respect to acid beta-D-glucuronidase (EC 3.2.1.31) in liver - Loffler_1994_Biochem.Mol.Biol.Int_33_235
Author(s) : Loffler BM , Mielenz E , Kunze H
Ref : Biochemistry & Molecular Biology International , 33 :235 , 1994
PubMedID: 7951044
Gene_locus related to this paper: human-CES1

Title : Purification and characterization of a human liver cocaine carboxylesterase that catalyzes the production of benzoylecgonine and the formation of cocaethylene from alcohol and cocaine - Brzezinski_1994_Biochem.Pharmacol_48_1747
Author(s) : Brzezinski MR , Abraham TL , Stone CL , Dean RA , Bosron WF
Ref : Biochemical Pharmacology , 48 :1747 , 1994
PubMedID: 7980644
Gene_locus related to this paper: human-CES1

Title : Purification, cloning, and expression of a human enzyme with acyl coenzyme A: cholesterol acyltransferase activity, which is identical to liver carboxylesterase - Becker_1994_Arterioscler.Thromb_14_1346
Author(s) : Becker A , Bottcher A , Lackner KJ , Fehringer P , Notka F , Aslanidis C , Schmitz G
Ref : Arterioscler Thromb , 14 :1346 , 1994
PubMedID: 8049197
Gene_locus related to this paper: human-CES1 , pig-EST1

Title : The signal for retention of the egasyn-glucuronidase complex within the endoplasmic reticulum - Zhen_1993_Arch.Biochem.Biophys_304_402
Author(s) : Zhen L , Baumann H , Novak EK , Swank RT
Ref : Archives of Biochemistry & Biophysics , 304 :402 , 1993
PubMedID: 8346916
Gene_locus related to this paper: human-CES1

Title : Glycosylation-dependent activity of baculovirus-expressed human liver carboxylesterases: cDNA cloning and characterization of two highly similar enzyme forms - Kroetz_1993_Biochemistry_32_11606
Author(s) : Kroetz DL , McBride OW , Gonzalez FJ
Ref : Biochemistry , 32 :11606 , 1993
PubMedID: 8218228
Gene_locus related to this paper: human-CES1

Title : Molecular cloning and characterization of a human carboxylesterase gene - Shibata_1993_Genomics_17_76
Author(s) : Shibata F , Takagi Y , Kitajima M , Kuroda T , Omura T
Ref : Genomics , 17 :76 , 1993
PubMedID: 8406473
Gene_locus related to this paper: human-CES1

Title : Expression of egasyn-esterase in mammalian cells. Sequestration in the endoplasmic reticulum and complexation with beta-glucuronidase - Novak_1991_J.Biol.Chem_266_6377
Author(s) : Novak EK , Baumann H , Ovnic M , Swank RT
Ref : Journal of Biological Chemistry , 266 :6377 , 1991
PubMedID: 2007590
Gene_locus related to this paper: human-CES1

Title : Release of liver microsomal beta-glucuronidase from hepatocytes in vitro and in vivo by organophosphates and hepatotoxic agents - Satoh_1991_J.Toxicol.Sci_16 Suppl 1_133
Author(s) : Satoh T
Ref : Journal of Toxicological Sciences , 16 Suppl 1 :133 , 1991
PubMedID: 1920540
Gene_locus related to this paper: human-CES1

Title : The COOH terminus of several liver carboxylesterases targets these enzymes to the lumen of the endoplasmic reticulum - Robbi_1991_J.Biol.Chem_266_20498
Author(s) : Robbi M , Beaufay H
Ref : Journal of Biological Chemistry , 266 :20498 , 1991
PubMedID: 1939102
Gene_locus related to this paper: human-CES1

Title : Cloning and analysis of a cDNA encoding a human liver carboxylesterase - Riddles_1991_Gene_108_289
Author(s) : Riddles PW , Richards LJ , Bowles MR , Pond SM
Ref : Gene , 108 :289 , 1991
PubMedID: 1748313
Gene_locus related to this paper: human-CES1

Title : cDNA cloning and characterization of human monocyte\/macrophage serine esterase-1 - Zschunke_1991_Blood_78_506
Author(s) : Zschunke F , Salmassi A , Kreipe H , Buck F , Parwaresch MR , Radzun HJ
Ref : Blood , 78 :506 , 1991
PubMedID: 2070086
Gene_locus related to this paper: human-CES1

Title : Cloning and sequencing of a human liver carboxylesterase isoenzyme - Long_1991_Life.Sci_48_PL43
Author(s) : Long RM , Calabrese MR , Martin BM , Pohl LR
Ref : Life Sciences , 48 :PL43 , 1991
PubMedID: 1997784
Gene_locus related to this paper: human-CES1

Title : A serine esterase released by human alveolar macrophages is closely related to liver microsomal carboxylesterases - Munger_1991_J.Biol.Chem_266_18832
Author(s) : Munger JS , Shi GP , Mark EA , Chin DT , Gerard C , Chapman HA
Ref : Journal of Biological Chemistry , 266 :18832 , 1991
PubMedID: 1918003
Gene_locus related to this paper: human-CES1

Title : beta-Glucuronidase is transported slowly to lysosomes in BW5147 mouse lymphoma cells: evidence that the prelysosomal enzyme is not restricted to the endoplasmic reticulum - Lazzarino_1990_Arch.Biochem.Biophys_282_100
Author(s) : Lazzarino D , Gabel CA
Ref : Archives of Biochemistry & Biophysics , 282 :100 , 1990
PubMedID: 2221912
Gene_locus related to this paper: human-CES1

Title : The propeptide of beta-glucuronidase. Further evidence of its involvement in compartmentalization of beta-glucuronidase and sequence similarity with portions of the reactive site region of the serpin superfamily - Li_1990_J.Biol.Chem_265_14732
Author(s) : Li H , Takeuchi KH , Manly K , Chapman V , Swank RT
Ref : Journal of Biological Chemistry , 265 :14732 , 1990
PubMedID: 2394691
Gene_locus related to this paper: human-CES1

Title : Involvement of the carboxyl-terminal propeptide of beta-glucuronidase in its compartmentalization within the endoplasmic reticulum as determined by a synthetic peptide approach - Medda_1989_J.Biol.Chem_264_15824
Author(s) : Medda S , Chemelli RM , Martin JL , Pohl LR , Swank RT
Ref : Journal of Biological Chemistry , 264 :15824 , 1989
PubMedID: 2777765
Gene_locus related to this paper: human-CES1

Title : Strain differences of rat liver carboxylesterase activities related to the phenotype difference of esterase-3 (egasyn) - Nakamura_1989_Res.Commun.Chem.Pathol.Pharmacol_66_451
Author(s) : Nakamura T , Satoh T , Horie T , Sagami F , Tagaya O
Ref : Res Commun Chem Pathol Pharmacol , 66 :451 , 1989
PubMedID: 2609020
Gene_locus related to this paper: human-CES1

Title : Egasyn affects the processing of beta-glucuronidase in mouse liver - Pfister_1988_Biochem.J_255_825
Author(s) : Pfister K , Bosshard N , Zopfi M , Gitzelmann R
Ref : Biochemical Journal , 255 :825 , 1988
PubMedID: 3214427
Gene_locus related to this paper: human-CES1

Title : Involvement of the esterase active site of egasyn in compartmentalization of beta-glucuronidase within the endoplasmic reticulum - Medda_1987_Cell_50_301
Author(s) : Medda S , Stevens AM , Swank RT
Ref : Cell , 50 :301 , 1987
PubMedID: 3594574
Gene_locus related to this paper: human-CES1

Title : Lumenal location of the microsomal beta-glucuronidase-egasyn complex - Brown_1987_J.Cell.Biol_105_1571
Author(s) : Brown J , Novak EK , Takeuchi K , Moore K , Medda S , Swank RT
Ref : Journal of Cell Biology , 105 :1571 , 1987
PubMedID: 3667691
Gene_locus related to this paper: human-CES1

Title : The egasyn gene affects the processing of oligosaccharides of lysosomal beta-glucuronidase in liver - Swank_1986_Biochem.J_240_445
Author(s) : Swank RT , Pfister K , Miller D , Chapman V
Ref : Biochemical Journal , 240 :445 , 1986
PubMedID: 3101673
Gene_locus related to this paper: human-CES1

Title : Identity of esterase-22 and egasyn, the protein which complexes with microsomal beta-glucuronidase - Medda_1986_Biochem.Genet_24_229
Author(s) : Medda S , von Deimling O , Swank RT
Ref : Biochemical Genetics , 24 :229 , 1986
PubMedID: 3729927
Gene_locus related to this paper: human-CES1

Title : Egasyn, a protein which determines the subcellular distribution of beta-glucuronidase, has esterase activity - Medda_1985_J.Biol.Chem_260_15802
Author(s) : Medda S , Swank RT
Ref : Journal of Biological Chemistry , 260 :15802 , 1985
PubMedID: 4066695
Gene_locus related to this paper: human-CES1

Title : Preparation of microsomal beta-glucuronidase and its membrane anchor protein, egasyn -
Author(s) : Lusis AJ
Ref : Methods Enzymol , 96 :557 , 1983
PubMedID: 6656645
Gene_locus related to this paper: human-CES1

Title : The synthesis and processing of beta-glucuronidase in normal and egasyn deficient mouse kidney -
Author(s) : Brown JA , Jahreis GP , Swank RT
Ref : Biochemical & Biophysical Research Communications , 99 :691 , 1981
PubMedID: 7236294
Gene_locus related to this paper: human-CES1

Title : Demonstration of a rat liver microsomal binding protein specific for beta-glucuronidase - Strawser_1979_J.Biol.Chem_254_3716
Author(s) : Strawser LD , Touster O
Ref : Journal of Biological Chemistry , 254 :3716 , 1979
PubMedID: 438156
Gene_locus related to this paper: human-CES1

Title : Relationships between levels of membrane-bound glucuronidase and the associated protein egasyn in mouse tissues - Lusis_1977_J.Cell.Biol_73_728
Author(s) : Lusis AJ , Paigen K
Ref : Journal of Cell Biology , 73 :728 , 1977
PubMedID: 873997
Gene_locus related to this paper: human-CES1

Title : Inheritance in mice of the membrane anchor protein egasyn: the Eg locus determines egasyn levels - Lusis_1977_Biochem.Genet_15_115
Author(s) : Lusis AJ , Tomino S , Paigen K
Ref : Biochemical Genetics , 15 :115 , 1977
PubMedID: 849245
Gene_locus related to this paper: human-CES1

Title : Isolation, characterization, and radioimmunoassay of murine egasyn, a protein stabilizing glucuronidase membrane binding - Lusis_1976_J.Biol.Chem_251_7753
Author(s) : Lusis AJ , Tomino S , Paigen K
Ref : Journal of Biological Chemistry , 251 :7753 , 1976
PubMedID: 826534
Gene_locus related to this paper: human-CES1

Title : Phenobarbital induction of egasyn: availability of egasyn in vivo determines glucuronidase binding to membrane -
Author(s) : Owerbach D , Luis AJ
Ref : Biochemical & Biophysical Research Communications , 69 :628 , 1976
PubMedID: 1267808
Gene_locus related to this paper: human-CES1

Title : Egasyn, a protein complexed with microsomal beta-glucuronidase - Tominco_1975_J.Biol.Chem_250_1146
Author(s) : Tominco S , Paigen K
Ref : Journal of Biological Chemistry , 250 :1146 , 1975
PubMedID: 1112792
Gene_locus related to this paper: human-CES1