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DS-8190a

Potent piperidinylpyrazolopyridine activator of LCAT Kobayashi H, Ohkawa N, Takano M, Kubota H, Onoda T, Kaneko T, Arai M, Terasaka N, inventors. Piperidinylpyrazolopyridine derivative. 9150575. United States Patent. 2015a, Onoda T, Kaneko T, Arai M, Kobayashi H, Terasaka N, inventors. Imidazopyridine Derivative. 2015087996. World Intellectual Property Organization. 2015

General

Type : Trifluoro, Pyridine, Piperidine, Pyrazole

Chemical_Nomenclature : (4R)-4-hydroxy-4-(trifluoromethyl)-3-[1-[5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl]-5,7-dihydro-2H-pyrazolo[3,4-b]pyridin-6-one

Canonical SMILES : C1CN(CCC1C2=C3C(=NN2)NC(=O)CC3(C(F)(F)F)O)C4=NC=C(C=C4)C(F)(F)F

InChI : InChI=1S\/C18H17F6N5O2\/c19-17(20,21)10-1-2-11(25-8-10)29-5-3-9(4-6-29)14-13-15(28-27-14)26-12(30)7-16(13,31)18(22,23)24\/h1-2,8-9,31H,3-7H2,(H2,26,27,28,30)\/t16-\/m1\/s1

InChIKey : HNXQXQMRFKVNKY-MRXNPFEDSA-N

Other name(s) :

MW : 449.3

Formula : C18H17F6N5O2

CAS_number :

PubChem : 140273988

UniChem : HNXQXQMRFKVNKY-MRXNPFEDSA-N

Target

Families : PC-sterol_acyltransferase

Protein : human-LCAT

References (3)

Title : Novel LCAT (Lecithin:Cholesterol Acyltransferase) Activator DS-8190a Prevents the Progression of Plaque Accumulation in Atherosclerosis Models - Sasaki_2021_Arterioscler.Thromb.Vasc.Biol_41_360
Author(s) : Sasaki M , Delawary M , Sakurai H , Kobayashi H , Nakao N , Tsuru H , Fukushima Y , Honzumi S , Moriyama S , Wada N , Kaneko T , Yamada K , Terasaka N , Kubota K
Ref : Arterioscler Thromb Vasc Biol , 41 :360 , 2021
Abstract :
PubMedSearch : Sasaki_2021_Arterioscler.Thromb.Vasc.Biol_41_360
PubMedID: 33086872

Title : Controversial Role of Lecithin:Cholesterol Acyltransferase in the Development of Atherosclerosis: New Insights From an LCAT Activator -
Author(s) : Vitali C , Cuchel M
Ref : Arterioscler Thromb Vasc Biol , 41 :377 , 2021
PubMedID: 33356367

Title : Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol - Manthei_2018_Elife_7_
Author(s) : Manthei KA , Yang SM , Baljinnyam B , Chang L , Glukhova A , Yuan W , Freeman LA , Maloney DJ , Schwendeman A , Remaley AT , Jadhav A , Tesmer JJ
Ref : Elife , 7 : , 2018
Abstract :
PubMedSearch : Manthei_2018_Elife_7_
PubMedID: 30479275
Gene_locus related to this paper: human-LCAT