HTCF

Esters of HTCF can be hydrolysed rapidly by specific enzymes depending on the acidic moiety and the alcool product triggers a strong NIR signal enhancement at 670nm

General

Type : Fluorescent Probe, Near-Infrared fluorescent Probe, Coumarin

Chemical_Nomenclature : 2-[3-cyano-4-[(E)-2-(7-hydroxy-2-oxochromen-3-yl)ethenyl]-5,5-dimethylfuran-2-ylidene]propanedinitrile

Canonical SMILES : CC1(C(=C(C(=C(C#N)C#N)O1)C#N)C=CC2=CC3=C(C=C(C=C3)O)OC2=O)C

InChI : InChI=1S\/C21H13N3O4\/c1-21(2)17(16(11-24)19(28-21)14(9-22)10-23)6-4-13-7-12-3-5-15(25)8-18(12)27-20(13)26\/h3-8,25H,1-2H3\/b6-4+

InChIKey : KFWSNXYOIOVIGD-GQCTYLIASA-N

Other name(s) : (E)-2-(3-Cyano-4-(2-(7-hydroxy-2-oxo-2H-chromen-3-yl)vinyl)-5,5-dimethylfuran-2(5H)-ylidene)malononitrile || 7-HTCF || CS-0104571 || D76422 || 2-(3-Cyano-4-(2-(7-hydroxy-2-oxo-2H-chromen-3-yl)vinyl)-5,5-dimethylfuran-2(5H)-ylidene)malononitrile


MW : 371.3

Formula : C21H13N3O4

CAS_number : 2123485-87-8

PubChem : 102112935

UniChem : KFWSNXYOIOVIGD-GQCTYLIASA-N

Target

Families : No family

Protein : No protein

References (2)

Title : Rationally Engineered hCES2A Near-Infrared Fluorogenic Substrate for Functional Imaging and High-Throughput Inhibitor Screening - Fan_2023_Anal.Chem_95_15665
Author(s) : Fan Y , Zhang T , Song Y , Sang Z , Zeng H , Liu P , Wang P , Ge G
Ref : Analytical Chemistry , 95 :15665-15672 , 2023
Abstract : Fan_2023_Anal.Chem_95_15665
ESTHER : Fan_2023_Anal.Chem_95_15665
PubMedSearch : Fan_2023_Anal.Chem_95_15665
PubMedID: 37782032
Gene_locus related to this paper: human-CES2

Title : A rationally engineered specific near-infrared fluorogenic substrate of human pancreatic lipase for functional imaging and inhibitor screening - Hou_2023_Analyst__
Author(s) : Hou FB , Zhang N , Hou XD , Liu W , Fan YF , Zhu GH , Wu Y , Sun MR , Zhao B , Ge GB , Wang P
Ref : Analyst , : , 2023
Abstract : Hou_2023_Analyst__
ESTHER : Hou_2023_Analyst__
PubMedSearch : Hou_2023_Analyst__
PubMedID: 37092796