| Title : AI-Driven Discovery of Highly Specific and Efficacious hCES2A Inhibitors for Ameliorating Irinotecan-Triggered Gut Toxicity - Sang_2025_J.Med.Chem__ |
| Author(s) : Sang Z , Zhang Y , Fan Y , Luan C , Liu Z , Zhang Q , Zeng H , Song Y , Huang S , Ge G |
| Ref : Journal of Medicinal Chemistry , : , 2025 |
| Abstract : |
| PubMedSearch : Sang_2025_J.Med.Chem__ |
| PubMedID: 40073334 |
| Title : Construction and Manipulation of Serial Gradient Dilution Array on a Microfluidic Slipchip for Screening and Characterizing Inhibitors against Human Pancreatic Lipase - Yang_2023_Biosensors.(Basel)_13_ |
| Author(s) : Yang J , Deng Y , Zhang M , Feng S , Peng S , Yang S , Liu P , Cai G , Ge G |
| Ref : Biosensors (Basel) , 13 : , 2023 |
| Abstract : |
| PubMedSearch : Yang_2023_Biosensors.(Basel)_13_ |
| PubMedID: 36832040 |
| Title : Design, synthesis and biological evaluation of salicylanilides as novel allosteric inhibitors of human pancreatic lipase - Zhao_2023_Bioorg.Med.Chem_91_117413 |
| Author(s) : Zhao Y , Zhang M , Hou X , Han J , Qin X , Yang Y , Song Y , Liu Z , Zhang Y , Xu Z , Jia Q , Li Y , Chen K , Li B , Zhu W , Ge G |
| Ref : Bioorganic & Medicinal Chemistry , 91 :117413 , 2023 |
| Abstract : |
| PubMedSearch : Zhao_2023_Bioorg.Med.Chem_91_117413 |
| PubMedID: 37490786 |
| Gene_locus related to this paper: human-PNLIP |
| Title : New bysspectin A derivatives as potent inhibitors of human carboxylesterase 2A - Li_2023_Eur.J.Med.Chem_259_115708 |
| Author(s) : Li W , Zhang Y , Wu Y , Zhu G , Liu X , Song Y , Ma B , Lin S , Ge G , Jiao X , Xie P |
| Ref : Eur Journal of Medicinal Chemistry , 259 :115708 , 2023 |
| Abstract : |
| PubMedSearch : Li_2023_Eur.J.Med.Chem_259_115708 |
| PubMedID: 37544184 |
| Title : Discovery of seven-membered ring berberine analogues as highly potent and specific hCES2A inhibitors - Yang_2023_Chem.Biol.Interact_378_110501 |
| Author(s) : Yang Y , Xiong Y , Zhu G , Sun M , Zou K , Zhao Y , Zhang Y , Xu Z , Li Y , Zhu W , Jia Q , Li B , Ge G |
| Ref : Chemico-Biological Interactions , 378 :110501 , 2023 |
| Abstract : |
| PubMedSearch : Yang_2023_Chem.Biol.Interact_378_110501 |
| PubMedID: 37080375 |
| Title : The roles of serine hydrolases and serum albumin in alisol B 23-acetate hydrolysis in humans - Zhang_2023_Front.Pharmacol_14_1160665 |
| Author(s) : Zhang T , Zhang F , Zhang Y , Li H , Zhu G , Weng T , Huang C , Wang P , He Y , Hu J , Ge G |
| Ref : Front Pharmacol , 14 :1160665 , 2023 |
| Abstract : |
| PubMedSearch : Zhang_2023_Front.Pharmacol_14_1160665 |
| PubMedID: 37089921 |
| Title : Rationally Engineered hCES2A Near-Infrared Fluorogenic Substrate for Functional Imaging and High-Throughput Inhibitor Screening - Fan_2023_Anal.Chem_95_15665 |
| Author(s) : Fan Y , Zhang T , Song Y , Sang Z , Zeng H , Liu P , Wang P , Ge G |
| Ref : Analytical Chemistry , 95 :15665-15672 , 2023 |
| Abstract : |
| PubMedSearch : Fan_2023_Anal.Chem_95_15665 |
| PubMedID: 37782032 |
| Gene_locus related to this paper: human-CES2 |
| Title : Substrate-dependent inhibition of hypericin on human carboxylesterase 2: implications for herb-drug combination - Wang_2022_Curr.Drug.Metab__ |
| Author(s) : Wang D , Zhao T , Zhao S , Chen J , Dou T , Ge G , Wang C , Sun H , Liu K , Meng Q , Wu J |
| Ref : Curr Drug Metab , : , 2022 |
| Abstract : |
| PubMedSearch : Wang_2022_Curr.Drug.Metab__ |
| PubMedID: 35114918 |
| Title : Synthesis and Structure-Activity Relationships of 3-Arylisoquinolone Analogues as Highly Specific hCES2A Inhibitors - Zhao_2021_ChemMedChem_16_388 |
| Author(s) : Zhao Y , Xiong Y , Dong S , Guan X , Song Y , Yang Y , Zou K , Li Z , Zhang Y , Fang S , Li B , Zhu W , Chen K , Jia Q , Ge G |
| Ref : ChemMedChem , 16 :388 , 2021 |
| Abstract : |
| PubMedSearch : Zhao_2021_ChemMedChem_16_388 |
| PubMedID: 32935462 |
| Title : Comparison of the Inhibitory Effects of Clotrimazoleand Ketoconazole against Human Carboxylesterase 2 - Zhao_2021_Curr.Drug.Metab__ |
| Author(s) : Zhao T , Wang D , Shan Z , Chen J , Dou T , Ge G , Wang C , Meng Q , Sun H , Liu K , Wu J |
| Ref : Curr Drug Metab , : , 2021 |
| Abstract : |
| PubMedSearch : Zhao_2021_Curr.Drug.Metab__ |
| PubMedID: 33568030 |
| Title : Rapid bioluminescence assay for monitoring rat CES1 activity and its alteration by traditional Chinese medicines - Zhang_2020_J.Pharm.Anal_10_253 |
| Author(s) : Zhang J , Wang D , Zou L , Xiao M , Zhang Y , Li Z , Yang L , Ge G , Zuo Z |
| Ref : J Pharm Anal , 10 :253 , 2020 |
| Abstract : |
| PubMedSearch : Zhang_2020_J.Pharm.Anal_10_253 |
| PubMedID: 32612872 |
| Title : Construction and application of a high-content analysis for identifying human carboxylesterase 2 inhibitors in living cell system - Xue_2020_Anal.Bioanal.Chem__ |
| Author(s) : Xue L , Qian X , Jin Q , Zhu Y , Wang X , Wang D , Ge G , Yang L |
| Ref : Anal Bioanal Chem , : , 2020 |
| Abstract : |
| PubMedSearch : Xue_2020_Anal.Bioanal.Chem__ |
| PubMedID: 32123952 |
| Title : Rational Design of a Long-Wavelength Fluorescent Probe for Highly Selective Sensing of Carboxylesterase 1 in Living Systems - Tian_2019_Anal.Chem_91_5638 |
| Author(s) : Tian Z , Ding L , Li K , Song Y , Dou T , Hou J , Tian X , Feng L , Ge G , Cui J |
| Ref : Analytical Chemistry , 91 :5638 , 2019 |
| Abstract : |
| PubMedSearch : Tian_2019_Anal.Chem_91_5638 |
| PubMedID: 30968686 |
| Title : Asymmetric Construction of a Multi-Pharmacophore-Containing Dispirotriheterocyclic Scaffold and Identification of a Human Carboxylesterase 1 Inhibitor - Bao_2018_Org.Lett_20_3394 |
| Author(s) : Bao X , Wei S , Qian X , Qu J , Wang B , Zou L , Ge G |
| Ref : Org Lett , 20 :3394 , 2018 |
| Abstract : |
| PubMedSearch : Bao_2018_Org.Lett_20_3394 |
| PubMedID: 29786435 |
| Title : Human carboxylesterases: a comprehensive review - Wang_2018_Acta.Pharm.Sin.B_8_699 |
| Author(s) : Wang D , Zou L , Jin Q , Hou J , Ge G , Yang L |
| Ref : Acta Pharm Sin B , 8 :699 , 2018 |
| Abstract : |
| PubMedSearch : Wang_2018_Acta.Pharm.Sin.B_8_699 |
| PubMedID: 30245959 |