| Title : AI-Driven Discovery of Highly Specific and Efficacious hCES2A Inhibitors for Ameliorating Irinotecan-Triggered Gut Toxicity - Sang_2025_J.Med.Chem__ |
| Author(s) : Sang Z , Zhang Y , Fan Y , Luan C , Liu Z , Zhang Q , Zeng H , Song Y , Huang S , Ge G |
| Ref : Journal of Medicinal Chemistry , : , 2025 |
| Abstract : |
| PubMedSearch : Sang_2025_J.Med.Chem__ |
| PubMedID: 40073334 |
| Title : Development of novel rivastigmine derivatives as selective BuChE inhibitors for the treatment of AD - Li_2025_Bioorg.Chem_157_108245 |
| Author(s) : Li Y , Zhang Q , Wang X , Liu Z , Chen H , Su Z , Xu Y , Zhang W , Du Y , Tan Z , Huang S , Liu W , Sang Z |
| Ref : Bioorg Chem , 157 :108245 , 2025 |
| Abstract : |
| PubMedSearch : Li_2025_Bioorg.Chem_157_108245 |
| PubMedID: 39954353 |
| Title : Discovery of novel butyrylcholinesterase inhibitors for treating Alzheimers disease - Sang_2025_Acta.Pharm.Sin.B__ |
| Author(s) : Sang Z , Huang S , Tan W , Ban Y , Wang K , Fan Y , Chen H , Zhang Q , Liang C , Mi J , Gao Y , Zhang Y , Liu W , Wang J , Dong W , Tan Z , Tang L , Luo H |
| Ref : Acta Pharm Sin B , : , 2025 |
| Abstract : |
| PubMedSearch : Sang_2025_Acta.Pharm.Sin.B__ |
| PubMedID: |
| Title : Artificial intelligence-driven development of natural multi-target derivatives with BuChE inhibitory activity for treating Alzheimer's disease - Zhang_2025_Chin.Chem.Lett__110964 |
| Author(s) : Zhang Q , Li Y , Jin Q , Liu Z , Chen H , Huang J , Liu T , Liu X , Tan Z , Huang S , Dong W , Sang Z |
| Ref : Chin Chem Lett , :110964 , 2025 |
| Abstract : |
| PubMedSearch : Zhang_2025_Chin.Chem.Lett__110964 |
| PubMedID: |
| Title : Design, synthesis and evaluation of quinoline-O-carbamate derivatives as multifunctional agents for the treatment of Alzheimer's disease - Chen_2023_J.Enzyme.Inhib.Med.Chem_38_2169682 |
| Author(s) : Chen H , Mi J , Li S , Liu Z , Yang J , Chen R , Wang Y , Ban Y , Zhou Y , Dong W , Sang Z |
| Ref : J Enzyme Inhib Med Chem , 38 :2169682 , 2023 |
| Abstract : |
| PubMedSearch : Chen_2023_J.Enzyme.Inhib.Med.Chem_38_2169682 |
| PubMedID: 36688444 |
| Title : Development of novel salicylic acid-donepezil-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease - Zhou_2023_J.Enzyme.Inhib.Med.Chem_38_2231661 |
| Author(s) : Zhou Y , He Y , Teng X , Mi J , Yang J , Wei R , Liu W , Ma Q , Tan Z , Sang Z |
| Ref : J Enzyme Inhib Med Chem , 38 :2231661 , 2023 |
| Abstract : |
| PubMedSearch : Zhou_2023_J.Enzyme.Inhib.Med.Chem_38_2231661 |
| PubMedID: 37414563 |
| Title : Rationally Engineered hCES2A Near-Infrared Fluorogenic Substrate for Functional Imaging and High-Throughput Inhibitor Screening - Fan_2023_Anal.Chem_95_15665 |
| Author(s) : Fan Y , Zhang T , Song Y , Sang Z , Zeng H , Liu P , Wang P , Ge G |
| Ref : Analytical Chemistry , 95 :15665-15672 , 2023 |
| Abstract : |
| PubMedSearch : Fan_2023_Anal.Chem_95_15665 |
| PubMedID: 37782032 |
| Gene_locus related to this paper: human-CES2 |
| Title : A Novel Multifunctional 5,6-Dimethoxy-Indanone-Chalcone-Carbamate Hybrids Alleviates Cognitive Decline in Alzheimer's Disease by Dual Inhibition of Acetylcholinesterase and Inflammation - Liu_2022_Front.Aging.Neurosci_14_922650 |
| Author(s) : Liu C , Sang Z , Pan H , Wu Q , Qiu Y , Shi J |
| Ref : Front Aging Neurosci , 14 :922650 , 2022 |
| Abstract : |
| PubMedSearch : Liu_2022_Front.Aging.Neurosci_14_922650 |
| PubMedID: 35860673 |
| Title : Novel donepezil-chalcone-rivastigmine hybrids as potential multifunctional anti-Alzheimer's agents: Design, synthesis, in vitro biological evaluation, in vivo and in silico studies - Sang_2022_Bioorg.Chem_127_106007 |
| Author(s) : Sang Z , Bai P , Ban Y , Wang K , Wu A , Mi J , Hu J , Xu R , Zhu G , Wang J , Zhang J , Wang C , Tan Z , Tang L |
| Ref : Bioorg Chem , 127 :106007 , 2022 |
| Abstract : |
| PubMedSearch : Sang_2022_Bioorg.Chem_127_106007 |
| PubMedID: 35849893 |
| Title : Design, synthesis, and evaluation of novel O-alkyl ferulamide derivatives as multifunctional ligands for treating Alzheimer's disease - Zhu_2022_J.Enzyme.Inhib.Med.Chem_37_1375 |
| Author(s) : Zhu G , Bai P , Wang K , Mi J , Yang J , Hu J , Ban Y , Xu R , Chen R , Wang C , Tang L , Sang Z |
| Ref : J Enzyme Inhib Med Chem , 37 :1375 , 2022 |
| Abstract : |
| PubMedSearch : Zhu_2022_J.Enzyme.Inhib.Med.Chem_37_1375 |
| PubMedID: 35549612 |
| Title : Development of naringenin-O-carbamate derivatives as multi-target-directed liagnds for the treatment of Alzheimer's disease - Mi_2022_Bioorg.Med.Chem.Lett_60_128574 |
| Author(s) : Mi J , He Y , Yang J , Zhou Y , Zhu G , Wu A , Liu W , Sang Z |
| Ref : Bioorganic & Medicinal Chemistry Lett , 60 :128574 , 2022 |
| Abstract : |
| PubMedSearch : Mi_2022_Bioorg.Med.Chem.Lett_60_128574 |
| PubMedID: 35065231 |
| Title : Characterization of the insecticide detoxification carboxylesterase Boest1 from Bradysia odoriphaga Yang et Zhang (Diptera:Sciaridae) - Ding_2021_Pest.Manag.Sci__ |
| Author(s) : Ding Q , Xu X , Sang Z , Wang R , Ullah F , Gao X , Song D |
| Ref : Pest Manag Sci , : , 2021 |
| Abstract : |
| PubMedSearch : Ding_2021_Pest.Manag.Sci__ |
| PubMedID: 34596943 |
| Gene_locus related to this paper: 9dipt-Boest1 , braco-est1 |
| Title : Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease - Sang_2020_Eur.J.Med.Chem_194_112265 |
| Author(s) : Sang Z , Wang K , Bai P , Wu A , Shi J , Liu W , Zhu G , Wang Y , Lan Y , Chen Z , Zhao Y , Qiao Z , Wang C , Tan Z |
| Ref : Eur Journal of Medicinal Chemistry , 194 :112265 , 2020 |
| Abstract : |
| PubMedSearch : Sang_2020_Eur.J.Med.Chem_194_112265 |
| PubMedID: 32240904 |
| Title : Development of chalcone-O-alkylamine derivatives as multifunctional agents against Alzheimer's disease - Bai_2019_Eur.J.Med.Chem_183_111737 |
| Author(s) : Bai P , Wang K , Zhang P , Shi J , Cheng X , Zhang Q , Zheng C , Cheng Y , Yang J , Lu X , Sang Z |
| Ref : Eur Journal of Medicinal Chemistry , 183 :111737 , 2019 |
| Abstract : |
| PubMedSearch : Bai_2019_Eur.J.Med.Chem_183_111737 |
| PubMedID: 31581002 |
| Title : Design, Synthesis, and Evaluation of Novel Ferulic Acid Derivatives as Multi-Target-Directed Ligands for the Treatment of Alzheimer's Disease - Sang_2019_ACS.Chem.Neurosci_10_1008 |
| Author(s) : Sang Z , Wang K , Han X , Cao M , Tan Z , Liu W |
| Ref : ACS Chem Neurosci , 10 :1008 , 2019 |
| Abstract : |
| PubMedSearch : Sang_2019_ACS.Chem.Neurosci_10_1008 |
| PubMedID: 30537804 |
| Title : The development of 2-acetylphenol-donepezil hybrids as multifunctional agents for the treatment of Alzheimer's disease - Zhu_2019_Bioorg.Med.Chem.Lett_29_126625 |
| Author(s) : Zhu G , Wang K , Shi J , Zhang P , Yang D , Fan X , Zhang Z , Liu W , Sang Z |
| Ref : Bioorganic & Medicinal Chemistry Lett , 29 :126625 , 2019 |
| Abstract : |
| PubMedSearch : Zhu_2019_Bioorg.Med.Chem.Lett_29_126625 |
| PubMedID: 31444085 |
| Title : Design, synthesis and biological evaluation of phthalimide-alkylamine derivatives as balanced multifunctional cholinesterase and monoamine oxidase-B inhibitors for the treatment of Alzheimer's disease - Sang_2017_Bioorg.Med.Chem.Lett_27_5053 |
| Author(s) : Sang Z , Wang K , Wang H , Yu L , Ma Q , Ye M , Han X , Liu W |
| Ref : Bioorganic & Medicinal Chemistry Lett , 27 :5053 , 2017 |
| Abstract : |
| PubMedSearch : Sang_2017_Bioorg.Med.Chem.Lett_27_5053 |
| PubMedID: 29033232 |
| Title : Design, synthesis and evaluation of novel ferulic acid-O-alkylamine derivatives as potential multifunctional agents for the treatment of Alzheimer's disease - Sang_2017_Eur.J.Med.Chem_130_379 |
| Author(s) : Sang Z , Pan W , Wang K , Ma Q , Yu L , Yang Y , Bai P , Leng C , Xu Q , Li X , Tan Z , Liu W |
| Ref : Eur Journal of Medicinal Chemistry , 130 :379 , 2017 |
| Abstract : |
| PubMedSearch : Sang_2017_Eur.J.Med.Chem_130_379 |
| PubMedID: 28279845 |
| Title : Design, synthesis and evaluation of scutellarein-O-acetamidoalkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease - Sang_2017_Eur.J.Med.Chem_135_307 |
| Author(s) : Sang Z , Qiang X , Li Y , Xu R , Cao Z , Song Q , Wang T , Zhang X , Liu H , Tan Z , Deng Y |
| Ref : Eur Journal of Medicinal Chemistry , 135 :307 , 2017 |
| Abstract : |
| PubMedSearch : Sang_2017_Eur.J.Med.Chem_135_307 |
| PubMedID: 28458136 |
| Title : Design, synthesis and biological evaluation of 3,4-dihydro-2(1H)-quinoline-O-alkylamine derivatives as new multipotent cholinesterase\/monoamine oxidase inhibitors for the treatment of Alzheimer's disease - Sang_2017_Bioorg.Med.Chem_25_3006 |
| Author(s) : Sang Z , Pan W , Wang K , Ma Q , Yu L , Liu W |
| Ref : Bioorganic & Medicinal Chemistry , 25 :3006 , 2017 |
| Abstract : |
| PubMedSearch : Sang_2017_Bioorg.Med.Chem_25_3006 |
| PubMedID: 28487125 |
| Title : Multitarget drug design strategy against Alzheimer's disease: Homoisoflavonoid Mannich base derivatives serve as acetylcholinesterase and monoamine oxidase B dual inhibitors with multifunctional properties - Li_2017_Bioorg.Med.Chem_25_714 |
| Author(s) : Li Y , Qiang X , Luo L , Yang X , Xiao G , Zheng Y , Cao Z , Sang Z , Su F , Deng Y |
| Ref : Bioorganic & Medicinal Chemistry , 25 :714 , 2017 |
| Abstract : |
| PubMedSearch : Li_2017_Bioorg.Med.Chem_25_714 |
| PubMedID: 27923535 |
| Title : Design, synthesis and biological evaluation of 4'-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease - Xiao_2017_Bioorg.Med.Chem_25_1030 |
| Author(s) : Xiao G , Li Y , Qiang X , Xu R , Zheng Y , Cao Z , Luo L , Yang X , Sang Z , Su F , Deng Y |
| Ref : Bioorganic & Medicinal Chemistry , 25 :1030 , 2017 |
| Abstract : |
| PubMedSearch : Xiao_2017_Bioorg.Med.Chem_25_1030 |
| PubMedID: 28011206 |
| Title : Design, synthesis and evaluation of novel ferulic acid-memoquin hybrids as potential multifunctional agents for the treatment of Alzheimer's disease - Pan_2016_Bioorg.Med.Chem.Lett_26_2539 |
| Author(s) : Pan W , Hu K , Bai P , Yu L , Ma Q , Li T , Zhang X , Chen C , Peng K , Liu W , Sang Z |
| Ref : Bioorganic & Medicinal Chemistry Lett , 26 :2539 , 2016 |
| Abstract : |
| PubMedSearch : Pan_2016_Bioorg.Med.Chem.Lett_26_2539 |
| PubMedID: 27072909 |
| Title : Design, synthesis and evaluation of scutellarein-O-alkylamines as multifunctional agents for the treatment of Alzheimer's disease - Sang_2015_Eur.J.Med.Chem_94_348 |
| Author(s) : Sang Z , Qiang X , Li Y , Yuan W , Liu Q , Shi Y , Ang W , Luo Y , Tan Z , Deng Y |
| Ref : Eur Journal of Medicinal Chemistry , 94 :348 , 2015 |
| Abstract : |
| PubMedSearch : Sang_2015_Eur.J.Med.Chem_94_348 |
| PubMedID: 25778991 |
| Title : Design, synthesis and evaluation of chromone-2-carboxamido-alkylbenzylamines as multifunctional agents for the treatment of Alzheimer's disease - Liu_2015_Bioorg.Med.Chem_23_911 |
| Author(s) : Liu Q , Qiang X , Li Y , Sang Z , Tan Z , Deng Y |
| Ref : Bioorganic & Medicinal Chemistry , 23 :911 , 2015 |
| Abstract : |
| PubMedSearch : Liu_2015_Bioorg.Med.Chem_23_911 |
| PubMedID: 25678013 |
| Title : Multifunctional scutellarin-rivastigmine hybrids with cholinergic, antioxidant, biometal chelating and neuroprotective properties for the treatment of Alzheimer's disease - Sang_2015_Bioorg.Med.Chem_23_668 |
| Author(s) : Sang Z , Li Y , Qiang X , Xiao G , Liu Q , Tan Z , Deng Y |
| Ref : Bioorganic & Medicinal Chemistry , 23 :668 , 2015 |
| Abstract : |
| PubMedSearch : Sang_2015_Bioorg.Med.Chem_23_668 |
| PubMedID: 25614117 |
| Title : Design, synthesis and evaluation of genistein-O-alkylbenzylamines as potential multifunctional agents for the treatment of Alzheimer's disease - Qiang_2014_Eur.J.Med.Chem_76_314 |
| Author(s) : Qiang X , Sang Z , Yuan W , Li Y , Liu Q , Bai P , Shi Y , Ang W , Tan Z , Deng Y |
| Ref : Eur Journal of Medicinal Chemistry , 76C :314 , 2014 |
| Abstract : |
| PubMedSearch : Qiang_2014_Eur.J.Med.Chem_76_314 |
| PubMedID: 24589487 |