human-CES2

Homo sapiens (Human) carboxylesterase hCE-2,iCE, hiCE, CES2 gene cDNA FLJ76104 Cocaine esterase

Comment

human carboxylesterase iCE gene intestine and liver, Q8IUP4 (Strausberg R.) contains 65 extra amino acid in N-term

Relationship

Family : Carb_B_Chordata

Block : C

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Sequence

Peptide

MRLHRLRARL SAVACGLLLL LVRGQGQDSA SPIRTTHTGQ VLGSLVHVKG ANAGVQTFLG IPFAKPPLGP LRFAPPEPPE SWSGVRDGTT HPAMCLQDLT AVESEFLSQF NMTFPSDSMS EDCLYLSIYT PAHSHEGSNL PVMVWIHGGA LVFGMASLYD GSMLAALENV VVVIIQYRLG VLGFFSTGDK HATGNWGYLD QVAALRWVQQ NIAHFGGNPD RVTIFGESAG GTSVSSLVVS PISQGLFHGA IMESGVALLP GLIASSADVI STVVANLSAC DQVDSEALVG CLRGKSKEEI LAINKPFKMI PGVVDGVFLP RHPQELLASA DFQPVPSIVG VNNNEFGWLI PKVMRIYDTQ KEMDREASQA ALQKMLTLLM LPPTFGDLLR EEYIGDNGDP QTLQAQFQEM MADSMFVIPA LQVAHFQCSR APVYFYEFQH QPSWLKNIRP PHMKADHGDE LPFVFRSFFG GNYIKFTEEE EQLSRKMMKY WANFARNGNP NGEGLPHWPL FDQEEQYLQL NLQPAVGRAL KAHRLQFWKK ALPQKIQELE EPEERHTEL

References (47)

Title : Role of carboxylesterase and arylacetamide deacetylase in drug metabolism, physiology, and pathology - Nagaoka_2024_Biochem.Pharmacol__116128
Author(s) : Nagaoka M , Sakai Y , Nakajima M , Fukami T
Ref : Biochemical Pharmacology , :116128 , 2024
PubMedID: 38492781
Gene_locus related to this paper: human-AADAC , human-CES1 , human-CES2

Title : Tight-Binding Small-Molecule Carboxylesterase 2 Inhibitors Reduce Intracellular Irinotecan Activation - Kailass_2024_J.Med.Chem__
Author(s) : Kailass K , Casalena D , Jenane L , McEdwards G , Auld DS , Sadovski O , Kaye EG , Hudson E , Nettleton D , Currie MA , Beharry AA
Ref : Journal of Medicinal Chemistry , : , 2024
PubMedID: 38265364
Gene_locus related to this paper: human-CES2

Title : Rationally Engineered hCES2A Near-Infrared Fluorogenic Substrate for Functional Imaging and High-Throughput Inhibitor Screening - Fan_2023_Anal.Chem_95_15665
Author(s) : Fan Y , Zhang T , Song Y , Sang Z , Zeng H , Liu P , Wang P , Ge G
Ref : Analytical Chemistry , 95 :15665-15672 , 2023
PubMedID: 37782032
Gene_locus related to this paper: human-CES2

Title : Design, synthesis, and biological evaluation studies of novel carboxylesterase 2 inhibitors for the treatment of irinotecan-induced delayed diarrhea - Yang_2023_Bioorg.Chem_138_106625
Author(s) : Yang Z , Cao Z , Wang W , Chen Y , Huang W , Jiao S , Chen S , Chen L , Liu Y , Mao J , Zhang L , Li Z
Ref : Bioorg Chem , 138 :106625 , 2023
PubMedID: 37300962
Gene_locus related to this paper: human-CES2

Title : A molecular imaging tool for monitoring carboxylesterase 2 during early diagnosis of liver-related diseases - Li_2023_Sens.Actuators.B.Chem_377_133122
Author(s) : Li J , Cao J , Wu W , Xu L , Zhang S , Ma P , Wu Q , Song D
Ref : Sensors and Actuators B: Chemical , 377 :133122 , 2023
PubMedID:
Gene_locus related to this paper: human-CES2

Title : Prognostic and Immunological Roles of CES2 in Breast Cancer and Potential Application of CES2-Targeted Fluorescent Probe DDAB in Breast Surgery - Qu_2023_Int.J.Gen.Med_16_1567
Author(s) : Qu W , Yao Y , Liu Y , Jo H , Zhang Q , Zhao H
Ref : Int J Gen Med , 16 :1567 , 2023
PubMedID: 37139258
Gene_locus related to this paper: human-CES2

Title : Carboxylesterase 2 proteins are efficient diglyceride and monoglyceride lipases possibly implicated in metabolic disease - Chalhoub_2021_J.Lipid.Res__100075
Author(s) : Chalhoub G , Kolleritsch S , Maresch LK , Taschler U , Pajed L , Tilp A , Natmessnig H , Rosina P , Kien B , Radner FPW , Schicho R , Oberer M , Schoiswohl G , Haemmerle G
Ref : J Lipid Res , :100075 , 2021
PubMedID: 33872605
Gene_locus related to this paper: human-CES2 , mouse-Ces2a , mouse-Ces2b , mouse-Ces2c

Title : Determination of carboxylesterase 2 by fluorescence probe to guide pancreatic adenocarcinoma profiling - Zhang_2021_Chem.Phys.Lett_785_139143
Author(s) : Zhang MM , Li P , Hai F , Jia Y
Ref : Chem Phys Lett , 785 :139143 , 2021
PubMedID:
Gene_locus related to this paper: human-CES2

Title : Rapalogues as hCES2A Inhibitors: In Vitro and In Silico Investigations - Shi_2021_Eur.J.Drug.Metab.Pharmacokinet_46_129
Author(s) : Shi CC , Song YQ , He RJ , Guan XQ , Song LL , Chen ST , Sun MR , Ge GB , Zhang LR
Ref : Eur J Drug Metab Pharmacokinet , 46 :129 , 2021
PubMedID: 33140264
Gene_locus related to this paper: human-CES2

Title : Remdesivir potently inhibits carboxylesterase-2 through covalent modifications: signifying strong drug-drug interactions - Shen_2021_Fundam.Clin.Pharmacol_35_432
Author(s) : Shen Y , Eades W , Yan B
Ref : Fundamental & Clinical Toxicology , 35 :432 , 2021
PubMedID: 33369768
Gene_locus related to this paper: human-CES2

Title : Discovery and Characterization of the Biflavones From Ginkgo biloba as Highly Specific and Potent Inhibitors Against Human Carboxylesterase 2 - Song_2021_Front.Pharmacol_12_655659
Author(s) : Song YQ , He RJ , Pu D , Guan XQ , Shi JH , Li YG , Hou J , Jia SN , Qin WW , Fang SQ , Ge GB
Ref : Front Pharmacol , 12 :655659 , 2021
PubMedID: 34084136
Gene_locus related to this paper: human-CES2

Title : Overexpressed CES2 has prognostic value in CRC and knockdown CES2 reverses L-OHP-resistance in CRC cells by inhibition of the PI3K signaling pathway - Zhang_2020_Exp.Cell.Res__111856
Author(s) : Zhang Y , Sun L , Sun Y , Chen Y , Wang X , Xu M , Chi P , Xu Z , Lu X
Ref : Experimental Cell Research , :111856 , 2020
PubMedID: 31981591
Gene_locus related to this paper: human-CES2

Title : Prognostic Impact of Carboxylesterase 2 in Cholangiocarcinoma - Goeppert_2019_Sci.Rep_9_4338
Author(s) : Goeppert B , Renner M , Singer S , Albrecht T , Zhang Q , Mehrabi A , Pathil A , Springfeld C , Kohler B , Rupp C , Weiss KH , Kuhl AA , Arsenic R , Pape UF , Vogel A , Schirmacher P , Roessler S , Utku N
Ref : Sci Rep , 9 :4338 , 2019
PubMedID: 30867471
Gene_locus related to this paper: human-CES2

Title : Endoplasmic Reticulum Targeting Ratiometric Fluorescent Probe for Carboxylesterase 2 Detection in Drug-Induced Acute Liver Injury - Tian_2019_Anal.Chem_91_15840
Author(s) : Tian X , Yan F , Zheng J , Cui X , Feng L , Li S , Jin L , James TD , Ma X
Ref : Analytical Chemistry , 91 :15840 , 2019
PubMedID: 31713417
Gene_locus related to this paper: human-CES2

Title : Measuring human carboxylesterase 2 activity in pancreatic cancer patient-derived xenografts using a ratiometric fluorescent chemosensor - Kailass_2019_Chem.Sci_10_8428
Author(s) : Kailass K , Sadovski O , Capello M , Kang Y , Fleming JB , Hanash SM , Beharry AA
Ref : Chem Sci , 10 :8428 , 2019
PubMedID: 31803422
Gene_locus related to this paper: human-CES2

Title : Clinical implications of genetic variation in carboxylesterase drug metabolism - Chen_2018_Expert.Opin.Drug.Metab.Toxicol_14_131
Author(s) : Chen F , Zhang B , Parker RB , Laizure SC
Ref : Expert Opin Drug Metab Toxicol , 14 :131 , 2018
PubMedID: 29264996
Gene_locus related to this paper: human-CES1 , human-CES2

Title : Potent, Irreversible Inhibition of Human Carboxylesterases by Tanshinone Anhydrides Isolated from Salvia miltiorrhiza (Danshen) - Hatfield_2018_J.Nat.Prod_81_2410
Author(s) : Hatfield MJ , Binder RJ , Gannon R , Fratt EM , Bowling J , Potter PM
Ref : Journal of Natural Products , 81 :2410 , 2018
PubMedID: 30351923
Gene_locus related to this paper: human-CES1 , human-CES2

Title : Age-Dependent Absolute Abundance of Hepatic Carboxylesterases (CES1 and CES2) by LC-MS\/MS Proteomics: Application to PBPK Modeling of Oseltamivir In Vivo Pharmacokinetics in Infants - Boberg_2017_Drug.Metab.Dispos_45_216
Author(s) : Boberg M , Vrana M , Mehrotra A , Pearce RE , Gaedigk A , Bhatt DK , Leeder JS , Prasad B
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 45 :216 , 2017
PubMedID: 27895113
Gene_locus related to this paper: human-CES2

Title : Comparison of substrate specificity among human arylacetamide deacetylase and carboxylesterases - Fukami_2015_Eur.J.Pharm.Sci_78_47
Author(s) : Fukami T , Kariya M , Kurokawa T , Iida A , Nakajima M
Ref : Eur J Pharm Sci , 78 :47 , 2015
PubMedID: 26164127
Gene_locus related to this paper: human-AADAC , human-CES1 , human-CES2

Title : Identification of Tissue-Restricted Bioreaction Suitable for in Vivo Targeting by Fluorescent Substrate Library-Based Enzyme Discovery - Yoshioka_2015_J.Am.Chem.Soc_137_12187
Author(s) : Yoshioka K , Komatsu T , Nakada A , Onagi J , Kuriki Y , Kawaguchi M , Terai T , Ueno T , Hanaoka K , Nagano T , Urano Y
Ref : Journal of the American Chemical Society , 137 :12187 , 2015
PubMedID: 26360463
Gene_locus related to this paper: human-CES2

Title : A highly selective long-wavelength fluorescent probe for the detection of human carboxylesterase 2 and its biomedical applications - Feng_2014_Chem.Commun.(Camb)_50_14519
Author(s) : Feng L , Liu ZM , Xu L , Lv X , Ning J , Hou J , Ge GB , Cui JN , Yang L
Ref : Chem Commun (Camb) , 50 :14519 , 2014
PubMedID: 25303144
Gene_locus related to this paper: human-CES2

Title : The pharmacogenetics of carboxylesterases: CES1 and CES2 genetic variants and their clinical effect - Merali_2014_Drug.Metabol.Drug.Interact_29_143
Author(s) : Merali Z , Ross S , Pare G
Ref : Drug Metabol Drug Interact , 29 :143 , 2014
PubMedID: 24988246
Gene_locus related to this paper: human-CES2

Title : Screening of specific inhibitors for human carboxylesterases or arylacetamide deacetylase - Shimizu_2014_Drug.Metab.Dispos_42_1103
Author(s) : Shimizu M , Fukami T , Nakajima M , Yokoi T
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 42 :1103 , 2014
PubMedID: 24751575
Gene_locus related to this paper: human-AADAC , human-CES1 , human-CES2

Title : Carboxylesterase-2 is a highly sensitive target of the antiobesity agent orlistat with profound implications in the activation of anticancer prodrugs - Xiao_2013_Biochem.Pharmacol_85_439
Author(s) : Xiao D , Shi D , Yang D , Barthel B , Koch TH , Yan B
Ref : Biochemical Pharmacology , 85 :439 , 2013
PubMedID: 23228697
Gene_locus related to this paper: human-CES2

Title : Relationship between CES2 genetic variations and rifampicin metabolism - Song_2013_J.Antimicrob.Chemother_68_1281
Author(s) : Song SH , Chang HE , Jun SH , Park KU , Lee JH , Lee EM , Song YH , Song J
Ref : J Antimicrob Chemother , 68 :1281 , 2013
PubMedID: 23471941
Gene_locus related to this paper: human-CES2

Title : Characterization of recombinant human carboxylesterases: fluorescein diacetate as a probe substrate for human carboxylesterase 2 - Wang_2011_Drug.Metab.Dispos_39_1329
Author(s) : Wang J , Williams ET , Bourgea J , Wong YN , Patten CJ
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 39 :1329 , 2011
PubMedID: 21540359
Gene_locus related to this paper: human-CES2

Title : Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins - Holmes_2010_Mamm.Genome_21_427
Author(s) : Holmes RS , Wright MW , Laulederkind SJ , Cox LA , Hosokawa M , Imai T , Ishibashi S , Lehner R , Miyazaki M , Perkins EJ , Potter PM , Redinbo MR , Robert J , Satoh T , Yamashita T , Yan B , Yokoi T , Zechner R , Maltais LJ
Ref : Mamm Genome , 21 :427 , 2010
PubMedID: 20931200
Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3 , human-CES4A , human-CES5A

Title : Human carboxylesterases HCE1 and HCE2: ontogenic expression, inter-individual variability and differential hydrolysis of oseltamivir, aspirin, deltamethrin and permethrin - Yang_2009_Biochem.Pharmacol_77_238
Author(s) : Yang D , Pearce RE , Wang X , Gaedigk R , Wan YJ , Yan B
Ref : Biochemical Pharmacology , 77 :238 , 2009
PubMedID: 18983829
Gene_locus related to this paper: human-CES1 , human-CES2

Title : Human carboxylesterases: an update on CES1, CES2 and CES3 - Sanghani_2009_Protein.Pept.Lett_16_1207
Author(s) : Sanghani SP , Sanghani PC , Schiel MA , Bosron WF
Ref : Protein Pept Lett , 16 :1207 , 2009
PubMedID: 19508181
Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3

Title : Functional study of the 830C>G polymorphism of the human carboxylesterase 2 gene - Bellott_2008_Cancer.Chemother.Pharmacol_61_481
Author(s) : Bellott R , Le Morvan V , Charasson V , Laurand A , Colotte M , Zanger UM , Klein K , Smith D , Bonnet J , Robert J
Ref : Cancer Chemother Pharmacol , 61 :481 , 2008
PubMedID: 17483951
Gene_locus related to this paper: human-CES2

Title : Genomic structure and transcriptional regulation of the rat, mouse, and human carboxylesterase genes - Hosokawa_2007_Drug.Metab.Rev_39_1
Author(s) : Hosokawa M , Furihata T , Yaginuma Y , Yamamoto N , Koyano N , Fujii A , Nagahara Y , Satoh T , Chiba K
Ref : Drug Metabolism Reviews , 39 :1 , 2007
PubMedID: 17364878
Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3 , human-CES4A , human-CES5A

Title : Haplotypes and a novel defective allele of CES2 found in a Japanese population - Kim_2007_Drug.Metab.Dispos_35_1865
Author(s) : Kim SR , Sai K , Tanaka-Kagawa T , Jinno H , Ozawa S , Kaniwa N , Saito Y , Akasawa A , Matsumoto K , Saito H , Kamatani N , Shirao K , Yamamoto N , Yoshida T , Minami H , Ohtsu A , Saijo N , Sawada J
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 35 :1865 , 2007
PubMedID: 17640957
Gene_locus related to this paper: human-CES2

Title : Interleukin-6 alters the cellular responsiveness to clopidogrel, irinotecan, and oseltamivir by suppressing the expression of carboxylesterases HCE1 and HCE2 - Yang_2007_Mol.Pharmacol_72_686
Author(s) : Yang J , Shi D , Yang D , Song X , Yan B
Ref : Molecular Pharmacology , 72 :686 , 2007
PubMedID: 17537833
Gene_locus related to this paper: human-CES1 , human-CES2

Title : Characterization of pyrethroid hydrolysis by the human liver carboxylesterases hCE-1 and hCE-2 - Nishi_2006_Arch.Biochem.Biophys_445_115
Author(s) : Nishi K , Huang H , Kamita SG , Kim IH , Morisseau C , Hammock BD
Ref : Archives of Biochemistry & Biophysics , 445 :115 , 2006
PubMedID: 16359636
Gene_locus related to this paper: human-CES1 , human-CES2

Title : Substrate specificity of carboxylesterase isozymes and their contribution to hydrolase activity in human liver and small intestine - Imai_2006_Drug.Metab.Dispos_34_1734
Author(s) : Imai T , Taketani M , Shii M , Hosokawa M , Chiba K
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 34 :1734 , 2006
PubMedID: 16837570
Gene_locus related to this paper: human-CES1 , human-CES2

Title : Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide - Quinney_2005_J.Pharmacol.Exp.Ther_313_1011
Author(s) : Quinney SK , Sanghani SP , Davis WI , Hurley TD , Sun Z , Murry DJ , Bosron WF
Ref : Journal of Pharmacology & Experimental Therapeutics , 313 :1011 , 2005
PubMedID: 15687373
Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3

Title : Pharmacogenomic assessment of carboxylesterases 1 and 2 - Marsh_2004_Genomics_84_661
Author(s) : Marsh S , Xiao M , Yu J , Ahluwalia R , Minton M , Freimuth RR , Kwok PY , McLeod HL
Ref : Genomics , 84 :661 , 2004
PubMedID: 15475243
Gene_locus related to this paper: human-CES1 , human-CES2

Title : Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3 - Sanghani_2004_Drug.Metab.Dispos_32_505
Author(s) : Sanghani SP , Quinney SK , Fredenburg TB , Davis WI , Murry DJ , Bosron WF
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , 32 :505 , 2004
PubMedID: 15100172
Gene_locus related to this paper: human-CES2 , human-CES3

Title : Determination and analysis of single nucleotide polymorphisms and haplotype structure of the human carboxylesterase 2 gene - Wu_2004_Pharmacogenet_14_595
Author(s) : Wu MH , Chen P , Wu X , Liu W , Strom S , Das S , Cook EH, Jr. , Rosner GL , Dolan ME
Ref : Pharmacogenetics , 14 :595 , 2004
PubMedID: 15475733
Gene_locus related to this paper: human-CES2

Title : Pharmacogenetics of human carboxylesterase 2, an enzyme involved in the activation of irinotecan into SN-38 - Charasson_2004_Clin.Pharmacol.Ther_76_528
Author(s) : Charasson V , Bellott R , Meynard D , Longy M , Gorry P , Robert J
Ref : Clinical Pharmacology & Therapeutics , 76 :528 , 2004
PubMedID: 15592324
Gene_locus related to this paper: human-CES2

Title : The sequence and analysis of duplication-rich human chromosome 16 - Martin_2004_Nature_432_988
Author(s) : Martin J , Han C , Gordon LA , Terry A , Prabhakar S , She X , Xie G , Hellsten U , Chan YM , Altherr M , Couronne O , Aerts A , Bajorek E , Black S , Blumer H , Branscomb E , Brown NC , Bruno WJ , Buckingham JM , Callen DF , Campbell CS , Campbell ML , Campbell EW , Caoile C , Challacombe JF , Chasteen LA , Chertkov O , Chi HC , Christensen M , Clark LM , Cohn JD , Denys M , Detter JC , Dickson M , Dimitrijevic-Bussod M , Escobar J , Fawcett JJ , Flowers D , Fotopulos D , Glavina T , Gomez M , Gonzales E , Goodstein D , Goodwin LA , Grady DL , Grigoriev I , Groza M , Hammon N , Hawkins T , Haydu L , Hildebrand CE , Huang W , Israni S , Jett J , Jewett PB , Kadner K , Kimball H , Kobayashi A , Krawczyk MC , Leyba T , Longmire JL , Lopez F , Lou Y , Lowry S , Ludeman T , Manohar CF , Mark GA , McMurray KL , Meincke LJ , Morgan J , Moyzis RK , Mundt MO , Munk AC , Nandkeshwar RD , Pitluck S , Pollard M , Predki P , Parson-Quintana B , Ramirez L , Rash S , Retterer J , Ricke DO , Robinson DL , Rodriguez A , Salamov A , Saunders EH , Scott D , Shough T , Stallings RL , Stalvey M , Sutherland RD , Tapia R , Tesmer JG , Thayer N , Thompson LS , Tice H , Torney DC , Tran-Gyamfi M , Tsai M , Ulanovsky LE , Ustaszewska A , Vo N , White PS , Williams AL , Wills PL , Wu JR , Wu K , Yang J , DeJong P , Bruce D , Doggett NA , Deaven L , Schmutz J , Grimwood J , Richardson P , Rokhsar DS , Eichler EE , Gilna P , Lucas SM , Myers RM , Rubin EM , Pennacchio LA
Ref : Nature , 432 :988 , 2004
PubMedID: 15616553
Gene_locus related to this paper: human-CES1 , human-CES2 , human-CES3 , human-CES4A , human-CES5A

Title : Characterization of multiple promoters in the human carboxylesterase 2 gene - Wu_2003_Pharmacogenet_13_425
Author(s) : Wu MH , Chen P , Remo BF , Cook EH, Jr. , Das S , Dolan ME
Ref : Pharmacogenetics , 13 :425 , 2003
PubMedID: 12835618
Gene_locus related to this paper: human-CES2

Title : Twelve novel single nucleotide polymorphisms in the CES2 gene encoding human carboxylesterase 2 (hCE-2) - Kim_2003_Drug.Metab.Pharmacokinet_18_327
Author(s) : Kim SR , Nakamura T , Saito Y , Sai K , Nakajima T , Saito H , Shirao K , Minami H , Ohtsu A , Yoshida T , Saijo N , Ozawa S , Sawada J
Ref : Drug Metab Pharmacokinet , 18 :327 , 2003
PubMedID: 15618752
Gene_locus related to this paper: human-CES2

Title : Catalog of 680 variations among eight cytochrome p450 ( CYP) genes, nine esterase genes, and two other genes in the Japanese population - Saito_2003_J.Hum.Genet_48_249
Author(s) : Saito S , Iida A , Sekine A , Kawauchi S , Higuchi S , Ogawa C , Nakamura Y
Ref : J Hum Genet , 48 :249 , 2003
PubMedID: 12721789
Gene_locus related to this paper: human-CES2 , human-ESD

Title : Irinotecan pathway genotype analysis to predict pharmacokinetics - Mathijssen_2003_Clin.Cancer.Res_9_3246
Author(s) : Mathijssen RH , Marsh S , Karlsson MO , Xie R , Baker SD , Verweij J , Sparreboom A , McLeod HL
Ref : Clin Cancer Research , 9 :3246 , 2003
PubMedID: 12960109
Gene_locus related to this paper: human-CES2

Title : Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver - Schwer_1997_Biochem.Biophys.Res.Commun_233_117
Author(s) : Schwer H , Langmann T , Daig R , Becker A , Aslanidis C , Schmitz G
Ref : Biochemical & Biophysical Research Communications , 233 :117 , 1997
PubMedID: 9144407
Gene_locus related to this paper: human-CES2

Title : Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin - Pindel_1997_J.Biol.Chem_272_14769
Author(s) : Pindel EV , Kedishvili NY , Abraham TL , Brzezinski MR , Zhang J , Dean RA , Bosron WF
Ref : Journal of Biological Chemistry , 272 :14769 , 1997
PubMedID: 9169443
Gene_locus related to this paper: human-CES1 , human-CES2