Type : Natural, Steroid, Phenanthrene
Chemical_Nomenclature : (8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
Canonical SMILES : CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C
InChI : InChI=1S\/C21H30O2\/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3\/h12,16-19H,4-11H2,1-3H3\/t16-,17+,18-,19-,20-,21+\/m0\/s1
InChIKey : RJKFOVLPORLFTN-LEKSSAKUSA-N
Other name(s) : P4 || Pregn-4-ene-3,20-dione || Agolutin || Luteohormone
MW : 314.5
Formula : C21H30O2
CAS_number : 57-83-0
PubChem : 5994
UniChem : RJKFOVLPORLFTN-LEKSSAKUSA-N
Families : abh_upf0017
Protein : human-ABHD2
Title : ABHD2 activity is not required for the non-genomic action of progesterone on human sperm - Arnolds_2025_Biorxiv__ |
Author(s) : Arnolds O , Carter EM , Edwards M , Wigren E , Homan E , Ribera P , Bentley K , Haraldsson M , Theo-Emegano N , Loppnau P , Szewczyk MM , Cao MA , Barsyte-Lovejoy D , Vester K , Thrun A , Amaral A , Lesche R , Munchow J , Zhu WF , Temme L , Brenker C , Strunker T , Sundstrom M , Todd MH , Edwards AM , Tredup C , Gileadi O |
Ref : Biorxiv , : , 2025 |
Abstract : |
PubMedSearch : Arnolds_2025_Biorxiv__ |
PubMedID: |
Gene_locus related to this paper: human-ABHD2 |
Title : Progesterone induces meiosis through two obligate co-receptors with PLA2 activity - Nader_2023_bioRxiv__ |
Author(s) : Nader N , Zarif L , Halama A , Yadav S , Dib M , Attarwala N , Chen Q , Suhre K , Gross SS , Machaca K |
Ref : Biorxiv , : , 2023 |
Abstract : |
PubMedSearch : Nader_2023_bioRxiv__ |
PubMedID: 37905030 |
Gene_locus related to this paper: human-ABHD2 |
Title : Progesterone activates the cyclic AMP-protein kinase A signalling pathway by upregulating ABHD2 in fertile men - Jiang_2021_J.Int.Med.Res_49_300060521999527 |
Author(s) : Jiang F , Zhu Y , Chen Y , Tang X , Liu L , Chen G , Liu Y , Sun X |
Ref : J Internal Medicine Res , 49 :300060521999527 , 2021 |
Abstract : |
PubMedSearch : Jiang_2021_J.Int.Med.Res_49_300060521999527 |
PubMedID: 33752482 |
Gene_locus related to this paper: human-ABHD2 |
Title : Alpha\/Beta Hydrolase Domain-Containing Protein 2 regulates the rhythm of follicular maturation and estrous stages of the female reproductive cycle - Bjorkgren_2021_Front.Cell.Dev.Biol_9_710864 |
Author(s) : Bjorkgren I , Chung DH , Mendoza S , Gabelev-Khasin L , Modzelewski A , He L , Lishko PV |
Ref : Front Cell Developmental Biology , 9 :710864 , 2021 |
Abstract : |
PubMedSearch : Bjorkgren_2021_Front.Cell.Dev.Biol_9_710864 |
PubMedID: 34568325 |
Gene_locus related to this paper: human-ABHD2 , mouse-ABHD2 |
Title : Regulation of the sperm calcium channel CatSper by endogenous steroids and plant triterpenoids - Mannowetz_2017_Proc.Natl.Acad.Sci.U.S.A_114_5743 |
Author(s) : Mannowetz N , Miller MR , Lishko PV |
Ref : Proc Natl Acad Sci U S A , 114 :5743 , 2017 |
Abstract : |
PubMedSearch : Mannowetz_2017_Proc.Natl.Acad.Sci.U.S.A_114_5743 |
PubMedID: 28507119 |
Gene_locus related to this paper: human-ABHD2 |
Title : Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone - Miller_2016_Science_352_555 |
Author(s) : Miller MR , Mannowetz N , Iavarone AT , Safavi R , Gracheva EO , Smith JF , Hill RZ , Bautista DM , Kirichok Y , Lishko PV |
Ref : Science , 352 :555 , 2016 |
Abstract : |
PubMedSearch : Miller_2016_Science_352_555 |
PubMedID: 26989199 |
Gene_locus related to this paper: human-ABHD2 |