abh_upf0017

Relationship

Family: abh_upf0017

Block: X

Parent Family: Hydrolase_4

Comment

This family includes: Escherichia coli yheT (Zhang et al. 1998); Yeast YBR177c (octanoyl-CoA:ethanol acyltransferase thioesterase), YMR210w, YPL095c; Mammalian ABHD1/2/3/15 are included. Human protein ABHD1, ABHD2 (pHPS1-2), ABHD3, ABHD15 (an essential component in the development of adipocytes as well as in apoptosis Walenta et al. 2013) Human ABHD3 is a phospholipase that may play a role in phospholipids remodeling. It may selectively cleave myristate (C14)-containing phosphatidylcholines through its predominant phospholipase 1 activity, cleaving preferentially acyl groups in sn1 position; Enhanced neointimal hyperplasia was observed in Abhd2-deficient mice, using an experimental vascular cuff placement injury model. Abhd2 is expressed in vascular smooth muscle cells (SMCs). An association between the human ABHD2 gene and colorectal cancer and with Risks for Chronic Obstructive Pulmonary Diseaseis reported. ABHD2 is involved in virus propagation, immune response, and fertilization namely in the P4-stimulated acrosome reaction. Monoacylglycerol lipase ABHD2 is a steroid-activated (progesterone P4) enzyme that hydrolyzes 2-arachidonoylglycerol. ABHD2 is expressed in sperm and in ovaries. ABHD2 regulates the rhythm of follicular maturation and estrous stages of the female reproductive cycle (Bjorkgren et al.) The family also contains: Drosophila protein ABHD2 anon-23D; Picea glauca (white spruce) late embryogenesis abundant protein EMB8 (Dong et al. 1999); and Caenorhabditis elegans C44C1.5. (UPF0017_hydro-like_CS abh_upf0017 IPR000952 (conserved site) is included in IPR012020 Hydrolase_YheT in Interpro. ABHD15 does not have a serine in the position of the catalytic triad. TAMRA-FP probe does not interact with ABHD15. ABHD15 has no hydrolase activity. (These entries where previously included in AlphaBeta_hydrolase family in ESTHER). Main substrates include: ABHD2 triacylglycerols, esters; ABHD3 medium-chain phospholipids, phosphatidylcholines containing C14 acyl chain, oxidatively truncated phospholipids

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

No structure scheme yet for this family

Genes Proteins in abh_upf0017 family (730)

Fragments of genes in abh_upf0017 family (50)

No fragment of genes

Substrates in abh_upf0017 family (9)

Inhibitors in abh_upf0017 family (5)

References (24)

Title : Lipidomic QTL in Diversity Outbred mice identifies a novel function for alpha\/beta hydrolase domain 2 (Abhd2) as an enzyme that metabolizes phosphatidylcholine and cardiolipin - Price_2023_bioRxiv__
Author(s) : Price TR , Stapleton DS , Schueler KL , Norris MK , Parks BW , Yandell BS , Churchill GA , Holland WL , Keller MP , Attie AD
Ref : Biorxiv , : , 2023
PubMedID: 36993241
Gene_locus related to this paper: human-ABHD2 , mouse-ABHD2

Title : Progesterone activates the cyclic AMP-protein kinase A signalling pathway by upregulating ABHD2 in fertile men - Jiang_2021_J.Int.Med.Res_49_300060521999527
Author(s) : Jiang F , Zhu Y , Chen Y , Tang X , Liu L , Chen G , Liu Y , Sun X
Ref : J Internal Medicine Res , 49 :300060521999527 , 2021
PubMedID: 33752482
Gene_locus related to this paper: human-ABHD2

Title : Alpha\/Beta Hydrolase Domain-Containing Protein 2 regulates the rhythm of follicular maturation and estrous stages of the female reproductive cycle - Bjorkgren_2021_Front.Cell.Dev.Biol_9_710864
Author(s) : Bjorkgren I , Chung DH , Mendoza S , Gabelev-Khasin L , Modzelewski A , He L , Lishko PV
Ref : Front Cell Developmental Biology , 9 :710864 , 2021
PubMedID: 34568325
Gene_locus related to this paper: human-ABHD2 , mouse-ABHD2

Title : A large-scale genome-lipid association map guides lipid identification - Linke_2020_Nat.Metab_2_1149
Author(s) : Linke V , Overmyer KA , Miller IJ , Brademan DR , Hutchins PD , Trujillo EA , Reddy TR , Russell JD , Cushing EM , Schueler KL , Stapleton DS , Rabaglia ME , Keller MP , Gatti DM , Keele GR , Pham D , Broman KW , Churchill GA , Attie AD , Coon JJ
Ref : Nat Metab , 2 :1149 , 2020
PubMedID: 32958938
Gene_locus related to this paper: human-ABHD1 , human-ABHD3

Title : miR-140-3p Inhibits Cutaneous Melanoma Progression by Disrupting AKT\/p70S6K and JNK Pathways through ABHD2 - He_2020_Mol.Ther.Oncolytics_17_83
Author(s) : He Y , Yang Y , Liao Y , Xu J , Liu L , Li C , Xiong X
Ref : Mol Ther Oncolytics , 17 :83 , 2020
PubMedID: 32322665
Gene_locus related to this paper: human-ABHD2

Title : ABHD2 Inhibitor Identified by Activity-Based Protein Profiling Reduces Acrosome Reaction - Baggelaar_2019_ACS.Chem.Biol_14_2295
Author(s) : Baggelaar MP , den Dulk H , Florea BI , Fazio D , Perruzza D , Bernabo N , Raspa M , Janssen APA , Scavizzi F , Barboni B , Overkleeft HS , Maccarrone M , van der Stelt M
Ref : ACS Chemical Biology , 14 :2295 , 2019
PubMedID: 31525885
Gene_locus related to this paper: human-ABHD2 , human-ABHD3

Title : Retinoic Acid Induces Differentiation of Mouse F9 Embryonic Carcinoma Cell by Modulating the miR-485 Targeting of Abhd2 - Yu_2019_Int.J.Mol.Sci_20_
Author(s) : Yu M , Zhang L , Liu Y , Liu D , Guo Z
Ref : Int J Mol Sci , 20 : , 2019
PubMedID: 31035455
Gene_locus related to this paper: human-ABHD2

Title : ABHD15 regulates adipose tissue lipolysis and hepatic lipid accumulation - Stockli_2019_Mol.Metab_25_83
Author(s) : Stockli J , Zadoorian A , Cooke KC , Deshpande V , Yau B , Herrmann G , Kebede MA , Humphrey SJ , James DE
Ref : Mol Metab , 25 :83 , 2019
PubMedID: 31105056
Gene_locus related to this paper: human-ABHD15 , mouse-ABH15

Title : Loss of ABHD15 Impairs the Anti-lipolytic Action of Insulin by Altering PDE3B Stability and Contributes to Insulin Resistance - Xia_2018_Cell.Rep_23_1948
Author(s) : Xia W , Pessentheiner AR , Hofer DC , Amor M , Schreiber R , Schoiswohl G , Eichmann TO , Walenta E , Itariu B , Prager G , Hackl H , Stulnig T , Kratky D , Rulicke T , Bogner-Strauss JG
Ref : Cell Rep , 23 :1948 , 2018
PubMedID: 29768196
Gene_locus related to this paper: human-ABHD15 , mouse-ABH15

Title : Novel Pharmacological Probes Reveal ABHD5 as a Locus of Lipolysis Control in White and Brown Adipocytes - Rondini_2017_J.Pharmacol.Exp.Ther_363_367
Author(s) : Rondini EA , Mladenovic-Lucas L , Roush WR , Halvorsen GT , Green AE , Granneman JG
Ref : Journal of Pharmacology & Experimental Therapeutics , 363 :367 , 2017
PubMedID: 28928121
Gene_locus related to this paper: human-ABHD5 , mouse-abhd5

Title : Regulation of the sperm calcium channel CatSper by endogenous steroids and plant triterpenoids - Mannowetz_2017_Proc.Natl.Acad.Sci.U.S.A_114_5743
Author(s) : Mannowetz N , Miller MR , Lishko PV
Ref : Proc Natl Acad Sci U S A , 114 :5743 , 2017
PubMedID: 28507119
Gene_locus related to this paper: human-ABHD2

Title : Regulation of calcium release from the endoplasmic reticulum by the serine hydrolase ABHD2 - Yun_2017_Biochem.Biophys.Res.Commun_490_1226
Author(s) : Yun B , Lee H , Powell R , Reisdorph N , Ewing H , Gelb MH , Hsu KL , Cravatt BF , Leslie CC
Ref : Biochemical & Biophysical Research Communications , 490 :1226 , 2017
PubMedID: 28684316
Gene_locus related to this paper: human-ABHD2

Title : Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone - Miller_2016_Science_352_555
Author(s) : Miller MR , Mannowetz N , Iavarone AT , Safavi R , Gracheva EO , Smith JF , Hill RZ , Bautista DM , Kirichok Y , Lishko PV
Ref : Science , 352 :555 , 2016
PubMedID: 26989199
Gene_locus related to this paper: human-ABHD2

Title : Associations of ABHD2 Genetic Variations with Risks for Chronic Obstructive Pulmonary Disease in a Chinese Han Population - Liu_2015_PLoS.One_10_e0123929
Author(s) : Liu L , Li X , Yuan R , Zhang H , Qiang L , Shen J , Jin S
Ref : PLoS ONE , 10 :e0123929 , 2015
PubMedID: 25880496
Gene_locus related to this paper: human-ABHD2

Title : The yeast enzyme Eht1 is an octanoyl-CoA:ethanol acyltransferase that also functions as a thioesterase - Knight_2014_Yeast_31_463
Author(s) : Knight MJ , Bull ID , Curnow P
Ref : Yeast , 31 :463 , 2014
PubMedID: 25308280
Gene_locus related to this paper: yeast-MCFS2

Title : alpha\/beta-Hydrolase Domain Containing Protein 15 (ABHD15) - an Adipogenic Protein Protecting from Apoptosis - Walenta_2013_PLoS.One_8_e79134
Author(s) : Walenta E , Pessentheiner AR , Pelzmann HJ , Deutsch A , Goeritzer M , Kratky D , Hackl H , Oh da Y , Prokesch A , Bogner-Strauss JG
Ref : PLoS ONE , 8 :e79134 , 2013
PubMedID: 24236098
Gene_locus related to this paper: human-ABHD15

Title : Metabolomics annotates ABHD3 as a physiologic regulator of medium-chain phospholipids - Long_2011_Nat.Chem.Biol_7_763
Author(s) : Long JZ , Cisar JS , Milliken D , Niessen S , Wang C , Trauger SA , Siuzdak G , Cravatt BF
Ref : Nat Chemical Biology , 7 :763 , 2011
PubMedID: 21926997
Gene_locus related to this paper: human-ABHD3 , mouse-abhd3

Title : Age-related pulmonary emphysema in mice lacking alpha\/beta hydrolase domain containing 2 gene - Jin_2009_Biochem.Biophys.Res.Commun_380_419
Author(s) : Jin S , Zhao G , Li Z , Nishimoto Y , Isohama Y , Shen J , Ito T , Takeya M , Araki K , He P , Yamamura K
Ref : Biochemical & Biophysical Research Communications , 380 :419 , 2009
PubMedID: 19250629
Gene_locus related to this paper: human-ABHD2 , mouse-ABHD2

Title : Elevated mature macrophage expression of human ABHD2 gene in vulnerable plaque - Miyata_2008_Biochem.Biophys.Res.Commun_365_207
Author(s) : Miyata K , Nakayama M , Mizuta S , Hokimoto S , Sugamura K , Oshima S , Oike Y , Sugiyama S , Ogawa H , Yamamura K
Ref : Biochemical & Biophysical Research Communications , 365 :207 , 2008
PubMedID: 17980156
Gene_locus related to this paper: human-ABHD2 , mouse-ABHD2

Title : The Saccharomyces cerevisiae EHT1 and EEB1 genes encode novel enzymes with medium-chain fatty acid ethyl ester synthesis and hydrolysis capacity - Saerens_2006_J.Biol.Chem_281_4446
Author(s) : Saerens SM , Verstrepen KJ , Van Laere SD , Voet AR , Van Dijck P , Delvaux FR , Thevelein JM
Ref : Journal of Biological Chemistry , 281 :4446 , 2006
PubMedID: 16361250
Gene_locus related to this paper: yeast-MCFS1 , yeast-MCFS2 , yeast-ym60

Title : Increase of smooth muscle cell migration and of intimal hyperplasia in mice lacking the alpha\/beta hydrolase domain containing 2 gene - Miyata_2005_Biochem.Biophys.Res.Commun_329_296
Author(s) : Miyata K , Oike Y , Hoshii T , Maekawa H , Ogawa H , Suda T , Araki K , Yamamura K
Ref : Biochemical & Biophysical Research Communications , 329 :296 , 2005
PubMedID: 15721306
Gene_locus related to this paper: human-ABHD2 , mouse-ABHD2

Title : Alpha\/beta hydrolase2, a predicated gene adjacent to mad in Drosophila melanogaster, belongs to a new global multigene family and is associated with obesity - Wisotzkey_2003_J.Mol.Evol_56_351
Author(s) : Wisotzkey RG , Johnson AN , Takaesu NT , Newfeld SJ
Ref : Journal of Molecular Evolution , 56 :351 , 2003
PubMedID: 12612838
Gene_locus related to this paper: drome-abhd2

Title : Cloning and characterization of six embryogenesis-associated cDNAs from somatic embryos of Picea glauca and their comparative expression during zygotic embryogenesis - Dong_1999_Plant.Mol.Biol_39_859
Author(s) : Dong JZ , Dunstan DI
Ref : Plant Mol Biol , 39 :859 , 1999
PubMedID: 10350098
Gene_locus related to this paper: picgl-emb8

Title : Functional analysis of the Escherichia coli genome for members of the alpha\/beta hydrolase family - Zhang_1998_Fold.Des_3_535
Author(s) : Zhang L , Godzik A , Skolnick J , Fetrow JS
Ref : Fold Des , 3 :535 , 1998
PubMedID: 9889164