Carb_B_Platyhelminthe
Relationship
Comment
These proteins have a cytoplasmic domain and a transmembrane domain N-terminal similar to neurotactine. Carboxylesterase type B (CestB) increased expression in flukes exposed to triclabendazole (TCBZ). Three mutations in TCBZ-resistant parasites allow binding of TCBZ-SX. TCBZ is metabolized into TCBZSO by the host liver but also by the parasites. This enzyme hydrolyses p-nitrophenyl acetate. Other Platyhelmithe CO esterase belong to neurotactin, gliotactin, neuroligin Cholinesterase or OtherNon-catalytic_C families
Database
Interpro : IPR002018 Carboxylesterase, type B
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF00135 COesterase
Prints : No Print
EC Number : No EC Number
Sequences
| Peptide in | Fasta |
| Nucleotide in | Fasta |
| Alignment with Multalin | Text only |
| Seed alignment with MAFFT | No colour / coloured with Mview |
| Alignment with MAFFT | No colour / coloured with Mview |
| Dendrogram | The dnd file |
| Gene_locus | Name | Species |
|---|---|---|
| fashe-a0a4e0s0j7 | Fasciola hepatica (Liver fluke)\; Fasciola gigantica transcript 473 Carboxylesterase type B | Fasciola hepatica |
| 9trem-a0a075ad52 | Opisthorchis viverrini. Carboxylesterase | Opisthorchis viverrini |
| rodna-a0a0r3t4s0 | Rodentolepis nana (Dwarf tapeworm) (Hymenolepis nana). Carboxylesterase type B domain-containing protein | Rodentolepis nana |
| hydta-a0a0r3wj44 | Hydatigera taeniaeformis (Feline tapeworm) (Taenia taeniaeformis). COesterase domain-containing protein | Hydatigera taeniaeformis |
| taeas-a0a158r8q2 | Taenia asiatica (Asian tapeworm). COesterase domain-containing protein | Taenia asiatica |
| 9plat-a0a267gcx5 | Macrostomum lignano. Carboxylesterase type B domain-containing protein | Macrostomum lignano |
| 9trem-a0a8e0s582 | Fasciolopsis buski. Carboxylesterase type B domain-containing protein | Fasciolopsis buski |
| 9trem-a0a8j4wec9 | Paragonimus heterotremus. Carboxylesterase | Paragonimus heterotremus |
| closi-h2krw6 | Clonorchis sinensis (Chinese liver fluke). Neuroligin-4 Y-linked protein | Clonorchis sinensis |
| Gene_locus_frgt | Name | Species |
|---|---|---|
| echgr-a0a068w7t2 | Echinococcus granulosus (Hydatid tapeworm). Carboxylesterase 5A | Echinococcus granulosus |
References (3)
| Title : Single Amino Acid Polymorphisms in the Fasciola hepatica Carboxylesterase Type B Gene and Their Potential Role in Anthelmintic Resistance - Miranda-Miranda_2023_Pathogens_12_1255 |
| Author(s) : Miranda-Miranda E , Cossio-Bayugar R , Trejo-Castro L , Aguilar-Diaz H |
| Ref : Pathogens , 12 :1255 , 2023 |
| Abstract : |
| PubMedSearch : Miranda-Miranda_2023_Pathogens_12_1255 |
| PubMedID: 37887771 |
| Gene_locus related to this paper: fashe-a0a4e0s0j7 |
| Title : A Single Nucleotide Polymorphism Translates into a Radical Amino Acid Substitution at the Ligand-Binding Site in Fasciola hepatica Carboxylesterase B - Miranda-Miranda_2022_Genes.(Basel)_13_ |
| Author(s) : Miranda-Miranda E , Scarcella S , Reynaud E , Narvaez-Padilla V , Neira G , Mera YSR , Aguilar-Diaz H , Cossio-Bayugar R |
| Ref : Genes (Basel) , 13 : , 2022 |
| Abstract : |
| PubMedSearch : Miranda-Miranda_2022_Genes.(Basel)_13_ |
| PubMedID: 36292784 |
| Gene_locus related to this paper: fashe-a0a4e0s0j7 |
| Title : Transcriptome-Based Identification of a Functional Fasciola hepatica Carboxylesterase B - Pedroza-Gomez_2021_Pathogens_10_1454 |
| Author(s) : Pedroza-Gomez YJ , Cossio-Bayugar R , Aguilar-Diaz H , Scarcella S , Reynaud E , Sanchez-Carbente MDR , Narvaez-Padilla V , Miranda-Miranda E |
| Ref : Pathogens , 10 :1454 , 2021 |
| Abstract : |
| PubMedSearch : Pedroza-Gomez_2021_Pathogens_10_1454 |
| PubMedID: 34832612 |
| Gene_locus related to this paper: fashe-a0a4e0s0j7 , fashe-a0a2h1cec8 , fashe-a0a2h1cpf2 , fashe-a0a4e0s092 , fashe-a0a4e0rpg5 , fashe-a0a4e0rjz9 , fashe-a0a2h1cvt6 |