Carb_B_Platyhelminthe

Relationship

Family: Carb_B_Platyhelminthe

Block: C

Parent Family: Carboxylesterase

Comment

These proteins have a cytoplasmic domain and a transmembrane domain N-terminal similar to neurotactine. Carboxylesterase type B (CestB) increased expression in flukes exposed to triclabendazole (TCBZ). Three mutations in TCBZ-resistant parasites allow binding of TCBZ-SX. TCBZ is metabolized into TCBZSO by the host liver but also by the parasites. This enzyme hydrolyses p-nitrophenyl acetate. Other Platyhelmithe CO esterase belong to neurotactin, gliotactin, neuroligin Cholinesterase or OtherNon-catalytic_C families

Database

Interpro : IPR002018 Carboxylesterase, type B

PIRSF : No PIRSF

Pdoc : No Pdoc

Pfam : PF00135 COesterase

Prints : No Print

EC Number : No EC Number

Sequences

Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

No structure scheme yet for this family

Genes Proteins in Carb_B_Platyhelminthe family (9)

Fragments of genes in Carb_B_Platyhelminthe family (1)

No fragment of genes

No substrate

No Inhibitor

References (3)

Title : Single Amino Acid Polymorphisms in the Fasciola hepatica Carboxylesterase Type B Gene and Their Potential Role in Anthelmintic Resistance - Miranda-Miranda_2023_Pathogens_12_1255
Author(s) : Miranda-Miranda E , Cossio-Bayugar R , Trejo-Castro L , Aguilar-Diaz H
Ref : Pathogens , 12 :1255 , 2023
PubMedID: 37887771
Gene_locus related to this paper: fashe-a0a4e0s0j7

Title : A Single Nucleotide Polymorphism Translates into a Radical Amino Acid Substitution at the Ligand-Binding Site in Fasciola hepatica Carboxylesterase B - Miranda-Miranda_2022_Genes.(Basel)_13_
Author(s) : Miranda-Miranda E , Scarcella S , Reynaud E , Narvaez-Padilla V , Neira G , Mera YSR , Aguilar-Diaz H , Cossio-Bayugar R
Ref : Genes (Basel) , 13 : , 2022
PubMedID: 36292784
Gene_locus related to this paper: fashe-a0a4e0s0j7

Title : Transcriptome-Based Identification of a Functional Fasciola hepatica Carboxylesterase B - Pedroza-Gomez_2021_Pathogens_10_1454
Author(s) : Pedroza-Gomez YJ , Cossio-Bayugar R , Aguilar-Diaz H , Scarcella S , Reynaud E , Sanchez-Carbente MDR , Narvaez-Padilla V , Miranda-Miranda E
Ref : Pathogens , 10 :1454 , 2021
PubMedID: 34832612
Gene_locus related to this paper: fashe-a0a4e0s0j7 , fashe-a0a2h1cec8 , fashe-a0a2h1cpf2 , fashe-a0a4e0s092 , fashe-a0a4e0rpg5 , fashe-a0a4e0rjz9 , fashe-a0a2h1cvt6