Fasciola hepatica (Liver fluke); Fasciola gigantica transcript 473 Carboxylesterase type B
Other strains: Fasciola hepatica (Liver fluke)\; Fasciola gigantica (Giant liver fluke). Carboxylesterase type B (CestB) increased expression in flukes exposed to triclabendazole (TCBZ). Three mutations in TCBZ-resistant parasites allow binding of TCBZ-SX. TCBZ is metabolized into TCBZSO by the host liver but also by the parasites. This enzyme hydrolyses: p-nitrophenyl acetate
Family : Carb_B_Platyhelminthe
Block : C
Position in NCBI Life Tree : Fasciola hepatica
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Platyhelminthes N E > Trematoda N E > Digenea N E > Plagiorchiida N E > Echinostomata N E > Echinostomatoidea N E > Fasciolidae N E > Fasciola N E > Fasciola hepatica N EMGLKEGASRA AVGQSADEPP GPSKDEENEM PLADGSDDPN VLHVRNYMSL NSLLPSPEEW DEICHRQKME RIRFLVGVSI TYLVLWVAHA PVAIWKTWSL QNNAELKRLL SDRPGLGQPL PPNCIVTKCA ALCPEPSDTK DWYTLFRIPY ATLPQQSSYF SAATYPFTFK ECYLAYWHGV AKEKRRFIDG QIRFIGREAN DDGSECAQLK NKKGKLVPVG KPQSCLTLSF HYPWFSSSHT EEKQFRGMPI VAYIGGSYLM NHRPQLPSPK MVADLRVLYV AISYRLGVFG FSDFGIDGAG PNHGVSDVRE ALIWIQEHAH RFGGDPSRVM LYGENSGATI AAALLSSSGL ENLMVGGESR SLFSHVWLAD GSVVIPDVPD SQDAFQQLVL NDPYLADECK KWVQKSAKHA HMDRSHPLAR MYECLHDMTV QQWLQKTPLA WQDSRTADTT LLPQAHEMRT SLIKRDLENS LVENPLGMLH PKATGWTHSI RDMPLVVFSS MNYAYDQFGN QNSSDHWNLE ETEQKLRNAL NSFRKPTSQL PYADAMWNAY QGYLRNLIAW RRDDQAPEEI NYRNFYDVIR GDLRGACPYN LYAKHLQLGR YIMVNPIYRI LNRIQVQPYV DADGARCDVP FFLIDEHFYC GEGTRPLYEA LEPEQKEVLV RAFVQFAYYG SILGAREMQY PLSSDMPSLE ATYNILTEMG LTTAGTREIA FLKACQMWIS EEGLFEHVMK YAQMN
| Title : Single Amino Acid Polymorphisms in the Fasciola hepatica Carboxylesterase Type B Gene and Their Potential Role in Anthelmintic Resistance - Miranda-Miranda_2023_Pathogens_12_1255 |
| Author(s) : Miranda-Miranda E , Cossio-Bayugar R , Trejo-Castro L , Aguilar-Diaz H |
| Ref : Pathogens , 12 :1255 , 2023 |
| Abstract : |
| PubMedSearch : Miranda-Miranda_2023_Pathogens_12_1255 |
| PubMedID: 37887771 |
| Gene_locus related to this paper: fashe-a0a4e0s0j7 |
| Title : A Single Nucleotide Polymorphism Translates into a Radical Amino Acid Substitution at the Ligand-Binding Site in Fasciola hepatica Carboxylesterase B - Miranda-Miranda_2022_Genes.(Basel)_13_ |
| Author(s) : Miranda-Miranda E , Scarcella S , Reynaud E , Narvaez-Padilla V , Neira G , Mera YSR , Aguilar-Diaz H , Cossio-Bayugar R |
| Ref : Genes (Basel) , 13 : , 2022 |
| Abstract : |
| PubMedSearch : Miranda-Miranda_2022_Genes.(Basel)_13_ |
| PubMedID: 36292784 |
| Gene_locus related to this paper: fashe-a0a4e0s0j7 |
| Title : Transcriptome-Based Identification of a Functional Fasciola hepatica Carboxylesterase B - Pedroza-Gomez_2021_Pathogens_10_1454 |
| Author(s) : Pedroza-Gomez YJ , Cossio-Bayugar R , Aguilar-Diaz H , Scarcella S , Reynaud E , Sanchez-Carbente MDR , Narvaez-Padilla V , Miranda-Miranda E |
| Ref : Pathogens , 10 :1454 , 2021 |
| Abstract : |
| PubMedSearch : Pedroza-Gomez_2021_Pathogens_10_1454 |
| PubMedID: 34832612 |
| Gene_locus related to this paper: fashe-a0a4e0s0j7 , fashe-a0a2h1cec8 , fashe-a0a2h1cpf2 , fashe-a0a4e0s092 , fashe-a0a4e0rpg5 , fashe-a0a4e0rjz9 , fashe-a0a2h1cvt6 |