Carboxylesterase
Relationship
Comment
Higher eukaryotes have many distinct esterases. The different types include those that act on carboxylic esters (EC 3.1.1). Carboxyl-esterases have been classified into three categories (A, B and C) on the basis of differential patterns of inhibition by organophosphates. Here are B type. WARNING There is no Plant carboxylesterases in this family except an EST from sorgho (sorbi-cxest) which could be a contaminant. Plant carboxylesterases do not possess SEDCLYLN and are included in a specific family: Plant_carboxylesterase. This family corresponds to the Carbohydrate Esterase family CE10 in CAZy - Carbohydrate-Active enZYmes database (CE_10). For bacterial enzymes this family correspond to family VII of the classification of Arpigny and Jaeger (1999)
Database
Interpro : IPR002018 Carboxylesterase, type B
PIRSF : PIRSF005676 COesterase
Pdoc : PDOC00112
Pfam : PF00135 COesterase
Prints : No Print
EC Number : 3.1.1.1
Sequences
| Peptide in | Fasta |
| Nucleotide in | Fasta |
| Alignment with Multalin | Text only |
| Seed alignment with MAFFT | No colour / coloured with Mview |
| Alignment with MAFFT | No colour / coloured with Mview |
| Dendrogram | The dnd file |
| Substrate | Chemical Nomenclature | Proteins |
|---|---|---|
| Paranitrophenylacetate | (4-nitrophenyl) acetate | arath-AT5G62180 9psed-q0mrg5 burgl-EstC 9bace-b3cet1 9bace-b3c9d0.2 emeni-faec 9acto-h1qtl0 strco-SCO2123 human-NOTUM pseae-PA3859 pyrbr-Q9Y7G8 9baci-EstD9 9rhiz-g9i933 malgo-a8puy1 human-CIB 9actn-EstGS1 |
| Butyl-gallate | butyl 3,4,5-trihydroxybenzoate | human-CES1 human-CES2 |
| Tyr-DHA | 2-(4-hydroxyphenyl)ethyl docosa-4,7,10,13,16,19-hexaenoate | human-CES1 human-CES2 |
| Tert-pentyl-HTCF | human-CES2 | |
| NT-0796 | propan-2-yl (2R)-2-(1,2,3,5,6,7-hexahydro-s-indacen-4-ylcarbamoyloxy)-3-pyrimidin-2-ylpropanoate | human-CES1 |
| Deltamethrin | [(S)-cyano-(3-phenoxyphenyl)methyl] (1R,3R)-3-(2,2-dibromoethenyl)-2,2-dimethylcyclopropane-1-carboxylate | 9bact-i6yrg4 9actn-EstGS1 |
| DTS-108 | ||
| Remifentanil | methyl 1-(3-methoxy-3-oxopropyl)-4-(N-propanoylanilino)piperidine-4-carboxylate | |
| Meperidine | ethyl 1-methyl-4-phenylpiperidine-4-carboxylate | human-BCHE human-CES1 |
| Permethrin | (3-phenoxyphenyl)methyl 3-(2,2-dichloroethenyl)-2,2-dimethylcyclopropane-1-carboxylate | culqu-b0xfi3 culqu-b0xfi2 culqu-b0xfi1 |
| 1-Naphtylacetate | naphthalen-1-yl acetate | burgl-EstC human-BCHE lacjo-q74hk5 aspor-faec aspor-q2uf27 pseae-PA3859 aphgo-cxest |
| O-Nitrophenylacetate | (2-nitrophenyl) acetate | |
| Lidocaine | 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide | human-CES1 |
| Capecitabine | pentyl N-[1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-methyloxolan-2-yl]-5-fluoro-2-oxopyrimidin-4-yl]carbamate | human-CES1 human-CES2 |
| Cholesteryl-oleate | [(3S,8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] (Z)-octadec-9-enoate | human-NCEH1 |
| Oleoyl-CoA | S-[2-[3-[[(2R)-4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (Z)-octadec-9-enethioate | |
| Vinyl-acetate | ethenyl acetate | 9psed-q0mrg5 bovin-balip rabit-1cxes |
| Inhibitor | Chemical Nomenclature | Proteins |
|---|---|---|
| AKOS021877793 | 5-(3,4-dimethoxyphenyl)-3-[1-[(3-fluorophenyl)methyl]-5-methyltriazol-4-yl]-1,2,4-oxadiazole | human-CES2 |
| DECF | [5-hydroxy-2-(4-hydroxyphenyl)-4-oxo-2,3-dihydrochromen-7-yl] N,N-diethylcarbamate | human-CES2 |
| LK-44 | 2-[2-chloro-4-[(Z)-(3-oxo-6-propoxy-1-benzofuran-2-ylidene)methyl]phenoxy]-2-methylpropanoic acid | human-CES2 |
| Dicyclohexylethanedione | 1,2-dicyclohexylethane-1,2-dione | human-CES1 |
| DETFP | 3-dodecylsulfanyl-1,1,1-trifluoropropan-2-one | human-CES1 |
| Irinotecan | 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin) || [(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate | rabit-1cxes |
| Meperidine | 1-Methyl-4-phenyl-4-piperidinecarboxylic acid ethyl ester || ethyl 1-methyl-4-phenylpiperidine-4-carboxylate | human-BCHE |
| 9-Amino-6-chloro-2-methoxyacridine | 6-chloro-2-methoxyacridin-9-amine | |
| bis-benzene-sulfonamide | N-{4-[(Phenylsulfonyl)aminophenyl}benzenesulfonamide | |
| Tamoxifen | 2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine | human-CES1 |
| Benzil | 1,2-diphenylethane-1,2-dione | human-CES1 |
| Mevastatin | [(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate | human-CES1 |
References (3)
| Title : Carboxyl ester lipase: structure-function relationship and physiological role in lipoprotein metabolism and atherosclerosis - Hui_2002_J.Lipid.Res_43_2017 |
| Author(s) : Hui DY , Howles PN |
| Ref : J Lipid Res , 43 :2017 , 2002 |
| Abstract : |
| PubMedSearch : Hui_2002_J.Lipid.Res_43_2017 |
| PubMedID: 12454261 |
| Title : Carboxyl\/cholinesterases: a case study of the evolution of a successful multigene family - Oakeshott_1999_Bioessays_21_1031 |
| Author(s) : Oakeshott JG , Claudianos C , Russell RJ , Robin GC |
| Ref : Bioessays , 21 :1031 , 1999 |
| Abstract : |
| PubMedSearch : Oakeshott_1999_Bioessays_21_1031 |
| PubMedID: 10580988 |
| Title : The mammalian carboxylesterases: from molecules to functions - Satoh_1998_Annu.Rev.Pharmacol.Toxicol_38_257 |
| Author(s) : Satoh T , Hosokawa M |
| Ref : Annual Review of Pharmacology & Toxicology , 38 :257 , 1998 |
| Abstract : |
| PubMedSearch : Satoh_1998_Annu.Rev.Pharmacol.Toxicol_38_257 |
| PubMedID: 9597156 |