Family: Carboxylesterase

Block: C

Parent Family: No family


Higher eukaryotes have many distinct esterases. The different types include those that act on carboxylic esters (EC 3.1.1). Carboxyl-esterases have been classified into three categories (A, B and C) on the basis of differential patterns of inhibition by organophosphates. Here are B type. WARNING There is no Plant carboxylesterases in this family except an EST from sorgho (sorbi-cxest) which could be a contaminant. Plant carboxylesterases do not possess SEDCLYLN and are included in a specific family: Plant_carboxylesterase. This family corresponds to the Carbohydrate Esterase family CE10 in CAZy - Carbohydrate-Active enZYmes database (CE_10). For bacterial enzymes this family correspond to family VII of the classification of Arpigny and Jaeger (1999)


Interpro : IPR002018 Carboxylesterase, type B

PIRSF : PIRSF005676 COesterase

Pdoc : PDOC00112

Pfam : PF00135 COesterase

Prints : No Print

EC Number :


Peptide in Fasta
Nucleotide in Fasta
Alignment with Multalin Text only
Seed alignment with MAFFT No colour
Alignment with MAFFT No colour
Dendrogram The dnd file

No structure scheme yet for this family

No Genes Proteins

No fragment of genes

No fragment of genes

Substrates in Carboxylesterase family (17)

Inhibitors in Carboxylesterase family (12)

References (3)

Title : Carboxyl ester lipase: structure-function relationship and physiological role in lipoprotein metabolism and atherosclerosis - Hui_2002_J.Lipid.Res_43_2017
Author(s) : Hui DY , Howles PN
Ref : J Lipid Res , 43 :2017 , 2002
PubMedID: 12454261

Title : Carboxyl\/cholinesterases: a case study of the evolution of a successful multigene family - Oakeshott_1999_Bioessays_21_1031
Author(s) : Oakeshott JG , Claudianos C , Russell RJ , Robin GC
Ref : Bioessays , 21 :1031 , 1999
PubMedID: 10580988

Title : The mammalian carboxylesterases: from molecules to functions - Satoh_1998_Annu.Rev.Pharmacol.Toxicol_38_257
Author(s) : Satoh T , Hosokawa M
Ref : Annual Review of Pharmacology & Toxicology , 38 :257 , 1998
PubMedID: 9597156