(The family Pha_synthase was split in four families (PHA_synth_I, PHA_synth_II, PHA_synth_III, PhaC_cen_dom ) according to Interpro and Tigrpfam. PhaC_cen_dom groups enzyme with the central domain but not the class I,II,III domains)This entry represents the central domain of the bacterial poly-beta-hydroxybutyrate polymerase (PhaC). Polyhydroxyalkanoic acids (PHAs) are carbon and energy reserve polymers produced in some bacteria when carbon sources are plentiful and another nutrient, such as nitrogen, phosphate, oxygen, or sulphur, becomes limiting. PHAs composed of monomeric units ranging from 3 to 14 carbons exist in nature. When the carbon source is exhausted, PHA is utilised by the bacterium. PhaC links D-(-)-3-hydroxybutyrl-CoA to an existing PHA molecule by the formation of an ester bond. Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus. This entry represents the central domain of the bacterial poly-beta-hydroxybutyrate polymerase (PhaC). Polyhydroxyalkanoic acids (PHAs) are carbon and energy reserve polymers produced in some bacteria when carbon sources are plentiful and another nutrient, such as nitrogen, phosphate, oxygen, or sulphur, becomes limiting. PHAs composed of monomeric units ranging from 3 to 14 carbons exist in nature. When the carbon source is exhausted, PHA is utilised by the bacterium. PhaC links D-(-)-3-hydroxybutyrl-CoA to an existing PHA molecule by the formation of an ester bond PHA_synth_I TIGR01838 PHA_synth_II TIGR01839. The nucleophilic residue of the catalytic triad is a cysteine (with exceptions)
Interpro : IPR010941 PhaC_cen_dom Poly-beta-hydroxybutyrate polymerase, central domain
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : PF07167 PhaC_N
Prints : No Print
EC Number : No EC Number
No structure scheme yet for this family
Genes Proteins in PhaC_cen_dom family (35)
Fragments of genes in PhaC_cen_dom family (3)
No fragment of genesNo substrate
No Inhibitor
Title : Polyhydroxyalkanoate synthase (PhaC): The key enzyme for biopolyester synthesis - Neoh_2022_Curr.Res.Biotechnol_4_87 |
Author(s) : Neoh SZ , Chek MF , Tan HT , Linares-Pasten JA , Nandakumar A , Hakoshima T , Sudesh K |
Ref : Current Research in Biotechnology , 4 :87 , 2022 |
Abstract : Neoh_2022_Curr.Res.Biotechnol_4_87 |
ESTHER : Neoh_2022_Curr.Res.Biotechnol_4_87 |
PubMedSearch : Neoh_2022_Curr.Res.Biotechnol_4_87 |
PubMedID: |
Title : Polyester synthases: natural catalysts for plastics - Rehm_2003_Biochem.J_376_15 |
Author(s) : Rehm BH |
Ref : Biochemical Journal , 376 :15 , 2003 |
Abstract : Rehm_2003_Biochem.J_376_15 |
ESTHER : Rehm_2003_Biochem.J_376_15 |
PubMedSearch : Rehm_2003_Biochem.J_376_15 |
PubMedID: 12954080 |
Title : Cloning, molecular analysis, and expression of the polyhydroxyalkanoic acid synthase (phaC) gene from Chromobacterium violaceum - Kolibachuk_1999_Appl.Environ.Microbiol_65_3561 |
Author(s) : Kolibachuk D , Miller A , Dennis D |
Ref : Applied Environmental Microbiology , 65 :3561 , 1999 |
Abstract : Kolibachuk_1999_Appl.Environ.Microbiol_65_3561 |
ESTHER : Kolibachuk_1999_Appl.Environ.Microbiol_65_3561 |
PubMedSearch : Kolibachuk_1999_Appl.Environ.Microbiol_65_3561 |
PubMedID: 10427049 |
Gene_locus related to this paper: chrvi-PHAC , vibpa-PHAC |