Thioesterase-YsfF-HD
Relationship
Comment
The gene ysfF encodes two proteins, an entire YsfF with a N-terminal alpha/beta-hydrolase domain (YsfF-HD) and a C-terminal 4-hydroxybenzoyl-CoA thioesterase (4-HBT)-like enzyme (hot-dog domain, not a/b hydrolase). The YsfFHBT (4-HBT-like enzyme) is nested in the gene (it has its own ribosome binding site). Both domains of YsfF display thioesterase activities. A new TE family, named TE36 is suggested. In ESTHER only the alpha/beta-hydrolase domain is considered (only the 4-HBT domain acts as an electrocyclase to accomplish the ring-closure reaction that give rise to cinnamoyl lipid compound youssoufene or dimerisation that produce youssoufene A1)
Database
Interpro : No interpro
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : No Pfam
Prints : No Print
EC Number : No EC Number
Sequences
| Peptide in | Fasta |
| Nucleotide in | Fasta |
| Alignment with Multalin | Text only |
| Seed alignment with MAFFT | No colour / coloured with Mview |
| Alignment with MAFFT | No colour / coloured with Mview |
| Dendrogram | The dnd file |
| Gene_locus | Name | Species |
|---|---|---|
| 9actn-YsfF | Streptomyces youssoufiensis. YsfF | Streptomyces youssoufiensis |
| 9actn-a0a1r1s6h8 | Streptomyces sparsogenes DSM 40356. AB hydrolase-1 domain-containing protein | Streptomyces sparsogenes DSM 40356 |
| 9actn-a0a229gmj4 | Streptomyces sp. NBS 14\/10. AB hydrolase-1 domain-containing protein | Streptomyces sp. NBS 14\/10 |
| 9actn-a0a6i6nea9 | Streptomyces broussonetiae. Alpha\/beta fold hydrolase | Streptomyces broussonetiae |
| 9actn-a0a7g8kep7 | Streptomyces buecherae. Alpha\/beta hydrolase | Streptomyces buecherae |
| 9actn-a0a7h8n8u9 | Streptomyces buecherae. Alpha\/beta hydrolase | Streptomyces buecherae |
| 9actn-a0a7w9qh35 | Streptomyces zagrosensis. Pimeloyl-ACP methyl ester carboxylesterase\/acyl-CoA thioesterase FadM | Streptomyces zagrosensis |
| 9actn-a0a7x1ihq2 | Streptomyces sp. TYQ1024. Alpha\/beta hydrolase | Streptomyces sp. TYQ1024 |
| 9actn-a0a918dqu8 | Wenjunlia tyrosinilytica. AB hydrolase-1 domain-containing protein | Wenjunlia tyrosinilytica |
| 9actn-a0a937eff8 | Streptomyces actinomycinicus. Alpha\/beta fold hydrolase | Streptomyces actinomycinicus |
| 9pseu-a0a5b2wr23 | Solihabitans fulvus. Alpha\/beta hydrolase | Solihabitans fulvus |
| salto-a4x8n2 | Salinispora tropica (strain ATCC BAA-916 \/ DSM 44818 \/ CNB-440) Alpha\/beta hydrolase fold | Salinispora tropica |
| straw-q93hc9 | Streptomyces avermitilis putative hydrolase | Streptomyces avermitilis |
| strbb-d7bxw8 | Streptomyces bingchenggensis (strain BCW-1). AB hydrolase-1 domain-containing protein | Streptomyces bingchenggensis |
| strgg-b1vl52 | Streptomyces griseus subsp. griseus (strain JCM 4626 \/ NBRC 13350) Putative hydrolase | Streptomyces griseus subsp. griseus |
| strsq-a0a890ctl7 | Streptomyces sp. Alpha\/beta fold hydrolase | Streptomyces sp. |
| strsq-a0a973l0c3 | Streptomyces sp. Alpha\/beta fold hydrolase | Streptomyces sp. |
| Inhibitor | Chemical Nomenclature | Proteins |
|---|---|---|
| Youssoufene-A1 | (3S)-3-[(1S,4E,5R)-4-(2-carboxyethylidene)-5-[(1Z,3E,5Z,7E)-nona-1,3,5,7-tetraenyl]cyclohex-2-en-1-yl]-3-[2-[(1Z,3E,5Z,7E)-nona-1,3,5,7-tetraenyl]phenyl]propanoic acid | 9actn-YsfF |
References (1)
| Title : A Versatile Thioesterase Involved in Dimerizationduring Cinnamoyl Lipid Biosynthesis - Deng_2024_Angew.Chem.Int.Ed.Engl__e202402010 |
| Author(s) : Deng Z , Liu C , Wang F , Song N , Liu J , Li H , Liu S , Li T , Liu Z , Xiao F , Li W |
| Ref : Angew Chem Int Ed Engl , :e202402010 , 2024 |
| Abstract : |
| PubMedSearch : Deng_2024_Angew.Chem.Int.Ed.Engl__e202402010 |
| PubMedID: 38462490 |
| Gene_locus related to this paper: 9actn-YsfF |