HAA-synthase-thioesterase-RhlA-PhaG
Relationship
Comment
The biosurfactant 3-(3-hydroxyalkanoyloxy)alkanoic acid (HAA) is the hydrophobic moiety of rhamnolipids and most often consists of two hydroxy fatty acids linked by an ester bond. rhlA genes encoding the acyltransferase responsible for the synthesis of the lipophilic rhamnolipid precursor 3-(3-hydroxyalkanoyloxy)alkanoic acid (HAA) (found only in Betaproteobacteria and Gammaproteobacteria or by horizontal gene transfer in Actinobacteria). Acyl-carrier protein (ACP)-activated hydroxy fatty acids are the preferred substrate for RhlA. The carbon chain lengths of HAAs determine their abilities to foam and emulsify, and their critical micelle concentration (CMC). Their chain lengths are determined by RhlA structure. The family alos contains phaG genes involved in polyhydroxyalkanoate biosynthesis. 3-hydroxyacyl-acyl carrier protein CoA transferase involved in the synthesis of polyhydroxyalkanoic acid with medium chain lengthDatabase
Interpro : No interpro
PIRSF : No PIRSF
Pdoc : No Pdoc
Pfam : No Pfam
Prints : No Print
EC Number : No EC Number
References (10)
| Title : RhlA Exhibits Dual Thioesterase and Acyltransferase Activities during Rhamnolipid Biosynthesis - Tang_2023_ACS.Catal_13_5759 |
| Author(s) : Ting Tang T , Fu L , Xie W , Luo Y , Zhang Y , Zhang J , Si T |
| Ref : ACS Catal , 13 :5759 , 2023 |
| Abstract : Tang_2023_ACS.Catal_13_5759 |
| ESTHER : Tang_2023_ACS.Catal_13_5759 |
| PubMedSearch : Tang_2023_ACS.Catal_13_5759 |
| PubMedID: |
| Gene_locus related to this paper: pseae-rhla |
| Title : Exploiting the Natural Diversity of RhlA Acyltransferases for the Synthesis of the Rhamnolipid Precursor 3-(3-Hydroxyalkanoyloxy)Alkanoic Acid - Germer_2020_Appl.Environ.Microbiol_86_e02317 |
| Author(s) : Germer A , Tiso T , Muller C , Behrens B , Vosse C , Scholz K , Froning M , Hayen H , Blank LM |
| Ref : Applied Environmental Microbiology , 86 : , 2020 |
| Abstract : Germer_2020_Appl.Environ.Microbiol_86_e02317 |
| ESTHER : Germer_2020_Appl.Environ.Microbiol_86_e02317 |
| PubMedSearch : Germer_2020_Appl.Environ.Microbiol_86_e02317 |
| PubMedID: 31924623 |
| Gene_locus related to this paper: pseae-rhla |
| Title : Oil degradation and biosurfactant production by the deep sea bacterium Dietzia maris As-13-3 - Wang_2014_Front.Microbiol_5_711 |
| Author(s) : Wang W , Cai B , Shao Z |
| Ref : Front Microbiol , 5 :711 , 2014 |
| Abstract : Wang_2014_Front.Microbiol_5_711 |
| ESTHER : Wang_2014_Front.Microbiol_5_711 |
| PubMedSearch : Wang_2014_Front.Microbiol_5_711 |
| PubMedID: 25566224 |
| Gene_locus related to this paper: burcj-b4ehi9 |
| Title : RhlA converts beta-hydroxyacyl-acyl carrier protein intermediates in fatty acid synthesis to the beta-hydroxydecanoyl-beta-hydroxydecanoate component of rhamnolipids in Pseudomonas aeruginosa - Zhu_2008_J.Bacteriol_190_3147 |
| Author(s) : Zhu K , Rock CO |
| Ref : Journal of Bacteriology , 190 :3147 , 2008 |
| Abstract : Zhu_2008_J.Bacteriol_190_3147 |
| ESTHER : Zhu_2008_J.Bacteriol_190_3147 |
| PubMedSearch : Zhu_2008_J.Bacteriol_190_3147 |
| PubMedID: 18326581 |
| Gene_locus related to this paper: pseae-rhla |
| Title : Poly(hydroxyalkanoate) synthase genotype and PHA production of Pseudomonas corrugata and P. mediterranea - Solaiman_2005_J.Ind.Microbiol.Biotechnol_32_75 |
| Author(s) : Solaiman DK , Catara V , Greco S |
| Ref : J Ind Microbiol Biotechnol , 32 :75 , 2005 |
| Abstract : Solaiman_2005_J.Ind.Microbiol.Biotechnol_32_75 |
| ESTHER : Solaiman_2005_J.Ind.Microbiol.Biotechnol_32_75 |
| PubMedSearch : Solaiman_2005_J.Ind.Microbiol.Biotechnol_32_75 |
| PubMedID: 15726440 |
| Title : Production of rhamnolipids by Pseudomonas chlororaphis, a nonpathogenic bacterium - Gunther_2005_Appl.Environ.Microbiol_71_2288 |
| Author(s) : Gunther NWt , Nunez A , Fett W , Solaiman DK |
| Ref : Applied Environmental Microbiology , 71 :2288 , 2005 |
| Abstract : Gunther_2005_Appl.Environ.Microbiol_71_2288 |
| ESTHER : Gunther_2005_Appl.Environ.Microbiol_71_2288 |
| PubMedSearch : Gunther_2005_Appl.Environ.Microbiol_71_2288 |
| PubMedID: 15870313 |
| Title : Biosynthesis of medium-chain-length poly(hydroxyalkanoates) with altered composition by mutant hybrid PHA synthases - Solaiman_2003_J.Ind.Microbiol.Biotechnol_30_322 |
| Author(s) : Solaiman DK |
| Ref : J Ind Microbiol Biotechnol , 30 :322 , 2003 |
| Abstract : Solaiman_2003_J.Ind.Microbiol.Biotechnol_30_322 |
| ESTHER : Solaiman_2003_J.Ind.Microbiol.Biotechnol_30_322 |
| PubMedSearch : Solaiman_2003_J.Ind.Microbiol.Biotechnol_30_322 |
| PubMedID: 12761653 |
| Gene_locus related to this paper: psere-PHAC1 |
| Title : The Pseudomonas aeruginosa phaG gene product is involved in the synthesis of polyhydroxyalkanoic acid consisting of medium-chain-length constituents from non-related carbon sources - Hoffmann_2000_FEMS.Microbiol.Lett_184_253 |
| Author(s) : Hoffmann N , Steinbuchel A , Rehm BH |
| Ref : FEMS Microbiology Letters , 184 :253 , 2000 |
| Abstract : Hoffmann_2000_FEMS.Microbiol.Lett_184_253 |
| ESTHER : Hoffmann_2000_FEMS.Microbiol.Lett_184_253 |
| PubMedSearch : Hoffmann_2000_FEMS.Microbiol.Lett_184_253 |
| PubMedID: 10713430 |
| Gene_locus related to this paper: pseae-phag |
| Title : A new metabolic link between fatty acid de novo synthesis and polyhydroxyalkanoic acid synthesis. The PHAG gene from Pseudomonas putida KT2440 encodes a 3-hydroxyacyl-acyl carrier protein-coenzyme a transferase - Rehm_1998_J.Biol.Chem_273_24044 |
| Author(s) : Rehm BH , Kruger N , Steinbuchel A |
| Ref : Journal of Biological Chemistry , 273 :24044 , 1998 |
| Abstract : Rehm_1998_J.Biol.Chem_273_24044 |
| ESTHER : Rehm_1998_J.Biol.Chem_273_24044 |
| PubMedSearch : Rehm_1998_J.Biol.Chem_273_24044 |
| PubMedID: 9727022 |
| Gene_locus related to this paper: psepu-PHAG |
| Title : Isolation, characterization, and expression in Escherichia coli of the Pseudomonas aeruginosa rhlAB genes encoding a rhamnosyltransferase involved in rhamnolipid biosurfactant synthesis - Ochsner_1994_J.Biol.Chem_269_19787 |
| Author(s) : Ochsner UA , Fiechter A , Reiser J |
| Ref : Journal of Biological Chemistry , 269 :19787 , 1994 |
| Abstract : Ochsner_1994_J.Biol.Chem_269_19787 |
| ESTHER : Ochsner_1994_J.Biol.Chem_269_19787 |
| PubMedSearch : Ochsner_1994_J.Biol.Chem_269_19787 |
| PubMedID: 8051059 |
| Gene_locus related to this paper: pseae-rhla |
Structures (1)
Genes Proteins in HAA-synthase-thioesterase-RhlA-PhaG family (36)
No fragment of genes
Structures in HAA-synthase-thioesterase-RhlA-PhaG family (1)Substrates in HAA-synthase-thioesterase-RhlA-PhaG family (2)
No Inhibitor