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Family Report for: HOD-cofactorfree-dioxygenase


Block X
Parent Family : Abhydrolase_6

1h-3-hydroxy-4-oxoquinaldine 2,4-dioxygenase (HOD) Oxygenases without requirement for cofactors or metal ions, catalyzing N-heterocyclic-ring cleavage and formation of carbon monoxide. Composed of a classical alpha/beta-hydrolase fold core domain with a cap domain. Organic substrates undergo selective deprotonation of their hydroxyl group by a His/Asp charge-relay system affording the generation of electron-donating species. The oxyanion hole of the alpha/beta-hydrolase fold, is utilized here to host and control oxygen chemistry involving a peroxide anion intermediate. Product release occurs by proton back transfer from the catalytic histidine.It is a non-nucleophilic general-base mechanism

PF12697 (Abhydrolase_6)
no EC number

Peptide in
Nucleotide in
Alignment with Multalin
|Text only/graphic display
Seed alignment with MAFFT
|No colour/coloured with Mview
Alignment with MAFFT
|No colour/coloured with Mview
|Graphical display, obtained with the dnd file produced by Clustalw

5 more
    Title: Definition of an alpha/beta-hydrolase fold subfamily comprising Pseudomonas quinolone signal cleaving dioxygenases
    Wullich SC, Arranz San Martin A, Fetzner S
    Ref: Applied Environmental Microbiology, :, 2020 : PubMed


    Title: Structural basis for recognition and ring-cleavage of the Pseudomonas quinolone signal (PQS) by AqdC, a mycobacterial dioxygenase of the alpha/beta-hydrolase fold family
    Wullich SC, Kobus S, Wienhold M, Hennecke U, Smits SHJ, Fetzner S
    Ref: J Struct Biol, 207:287, 2019 : PubMed


    Title: Structural basis for cofactor-independent dioxygenation of N-heteroaromatic compounds at the alpha/beta-hydrolase fold
    Steiner RA, Janssen HJ, Roversi P, Oakley AJ, Fetzner S
    Ref: Proc Natl Acad Sci U S A, 107:657, 2010 : PubMed


Other Papers

No structure scheme yet for this family

Structures in HOD-cofactorfree-dioxygenase family (15)

Genes Proteins in HOD-cofactorfree-dioxygenase family (37)

No fragments
Substrates of some enzymes in the HOD-cofactorfree-dioxygenase family (6)

Inhibitors of some enzymes in the HOD-cofactorfree-dioxygenase family (1)

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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