Dihydroprecondylocarpine-acetate

Dihydroprecondylocarpine acetate is an organic cation which is an intermediate in the biosynthetic pathway leading to the synthesis of the monoterpenoid indole alkaloids, catharanthine and tabersonine. Leads to the formation of Dehydrosecodine an instable intermediate in the biosynthesis of aspidosperma and iboga alkaloids. It is a terpenoid indole alkaloid, a methyl ester, a dihydropyridine, a member of indoles, an alkaloid ester and an enamine. Three carboxylesterase (CXE)-like enzymes from Catharanthus roseus and Tabernanthe iboga catalyze regio- and enantiodivergent cycloaddition reactions to generate the aspidosperma (tabersonine synthase, TS) and iboga (coronaridine synthase, CorS; catharanthine synthase, CS) scaffolds from a common biosynthetic intermediate. Dehydrosecodine(1+) (CID 135398075) is a tertiary ammonium ion result from the protonation of the tertiary amino group of dehydrosecodine (the enamine form). Dehydrosecodine is the substrate and tabersonine catharanthine and carbomehtoxycleaviminium are the products of these enzyme. These later compound are substrate for aditional enzymes to give vinblastine coronaridine and ibogaine