human-ABHD15

Homo sapiens (Human) ABH15 Abhydrolase domain-containing protein 15

Comment

ABHD15 does not have a serine in the position of the catalytic triad. TAMRA-FP probe does not interact with ABHD15. ABHD15 has no hydrolase activity. ABHD15 is highly expressed in adipose tissues and is required for adipogenesis

Relationship

Family : abh_upf0017

Block : X

Position in NCBI Life Tree : Homo sapiens

(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)

> cellular organisms N E > Eukaryota N E > Opisthokonta N E > Metazoa N E > Eumetazoa N E > Bilateria N E > Deuterostomia N E > Chordata N E > Craniata N E > Vertebrata N E > Gnathostomata N E > Teleostomi N E > Euteleostomi N E > Sarcopterygii N E > Dipnotetrapodomorpha N E > Tetrapoda N E > Amniota N E > Mammalia N E > Theria N E > Eutheria N E > Boreoeutheria N E > Euarchontoglires N E > Primates N E > Haplorrhini N E > Simiiformes N E > Catarrhini N E > Hominoidea N E > Hominidae N E > Homininae N E > Homo N E > Homo sapiens N E

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Database

Sequence

Peptide

MPPWGAALAL ILAVLALLGL LGPRLRGPWG RAVGERTLPG AQDRDDGEEA DGGGPADQFS DGREPLPGGC SLVCKPSALA QCLLRALRRS EALEAGPRSW FSGPHLQTLC HFVLPVAPGP ELAREYLQLA DDGLVALDWV VGPCVRGRRI TSAGGLPAVL LVIPNAWGRL TRNVLGLCLL ALERGYYPVI FHRRGHHGCP LVSPRLQPFG DPSDLKEAVT YIRFRHPAAP LFAVSEGSGS ALLLSYLGEC GSSSYVTGAA CISPVLRCRE WFEAGLPWPY ERGFLLYQKI ALSRYATALE DTVDTSRLFR SRSLREFEEA LFCHTKSFPI SWDAYWDRND PLRDVDEAAV PVLCICSADD PVCGPPDHTL TTELFHSNPY FFLLLSRHGG HCGFLRQEPL PAWSHEVILE SFRALTEFFR TEERIKGLSR HRASFLGGRR RGGALQRREV SSSSNLEEIF NWKRSYTR

References (5)

Title : ABHD15 regulates adipose tissue lipolysis and hepatic lipid accumulation - Stockli_2019_Mol.Metab_25_83
Author(s) : Stockli J , Zadoorian A , Cooke KC , Deshpande V , Yau B , Herrmann G , Kebede MA , Humphrey SJ , James DE
Ref : Mol Metab , 25 :83 , 2019
PubMedID: 31105056
Gene_locus related to this paper: human-ABHD15 , mouse-ABH15

Title : Loss of ABHD15 Impairs the Anti-lipolytic Action of Insulin by Altering PDE3B Stability and Contributes to Insulin Resistance - Xia_2018_Cell.Rep_23_1948
Author(s) : Xia W , Pessentheiner AR , Hofer DC , Amor M , Schreiber R , Schoiswohl G , Eichmann TO , Walenta E , Itariu B , Prager G , Hackl H , Stulnig T , Kratky D , Rulicke T , Bogner-Strauss JG
Ref : Cell Rep , 23 :1948 , 2018
PubMedID: 29768196
Gene_locus related to this paper: human-ABHD15 , mouse-ABH15

Title : alpha\/beta-Hydrolase Domain Containing Protein 15 (ABHD15) - an Adipogenic Protein Protecting from Apoptosis - Walenta_2013_PLoS.One_8_e79134
Author(s) : Walenta E , Pessentheiner AR , Pelzmann HJ , Deutsch A , Goeritzer M , Kratky D , Hackl H , Oh da Y , Prokesch A , Bogner-Strauss JG
Ref : PLoS ONE , 8 :e79134 , 2013
PubMedID: 24236098
Gene_locus related to this paper: human-ABHD15

Title : The 47kDa Akt substrate associates with phosphodiesterase 3B and regulates its level in adipocytes - Chavez_2006_Biochem.Biophys.Res.Commun_342_1218
Author(s) : Chavez JA , Gridley S , Sano H , Lane WS , Lienhard GE
Ref : Biochemical & Biophysical Research Communications , 342 :1218 , 2006
PubMedID: 16516160
Gene_locus related to this paper: human-ABHD15

Title : Novel insulin-elicited phosphoproteins in adipocytes - Gridley_2005_Cell.Signal_17_59
Author(s) : Gridley S , Lane WS , Garner CW , Lienhard GE
Ref : Cell Signal , 17 :59 , 2005
PubMedID: 15451025
Gene_locus related to this paper: human-ABHD15