Streptomyces cinnamonensis monensin cyclase
MonCII from the monensin biosynthetic gene cluster in Streptomyces cinnamonensis, which was previously thought to be an epoxide hydrolase, is a novel thioesterase. It hydrolyse several thioester substrates, including an N-acetylcysteamine thioester derivative of monensin A (strci-MONAIX and strci-MONAX are thioesterases typeII)
Family : Epoxide_hydrolase
Block : X
Position in NCBI Life Tree : Streptomyces cinnamonensis
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Bacteria N E > Terrabacteria group N E > Actinobacteria [phylum] N E > Actinobacteria [class] N E > Streptomycetales N E > Streptomycetaceae N E > Streptomyces N E > Streptomyces cinnamonensis N E > cellular organisms N E > Bacteria N E > Terrabacteria group N E > Actinobacteria [phylum] N E > Actinobacteria [class] N E > Streptomycetales N E > Streptomycetaceae N E > Streptomyces N E > Streptomyces cinnamonensis N E > cellular organisms N E > Bacteria N E > Terrabacteria group N E > Actinobacteria [phylum] N E > Actinobacteria [class] N E > Streptomycetales N E > Streptomycetaceae N E > Streptomyces N E > Streptomyces cinnamonensis N EMKNLRIPVSQ TVSLNVRYRP ADGPGAPGRP FLLLHGMLSN ARMWDEVAAR LAAAGHPAYA VDHRGHGESD TPPDGYDNAT VVTDLVAAVT ALDLSGALVA GHSWGAHLAL RLAAEHPDLV AGLALIDGGW YEFDGPVMRA FWERTADVVR RAQQGTTSAA DMRAYLRATH PDWSPTSIEA RLADYRVGPD GLLIPRLTST QVMSIVAGLQ REAPADWYPK VTVPVRLLPL IPAIPQLSDQ VRAWVAAAEA ALEQVSVRWY PGSDHDLHAG APDEIAADLL LLARSCEAMP GGKAGVRPA
| Title : Evidence that a novel thioesterase is responsible for polyketide chain release during biosynthesis of the polyether ionophore monensin - Harvey_2006_Chembiochem_7_1435 |
| Author(s) : Harvey BM , Hong H , Jones MA , Hughes-Thomas ZA , Goss RM , Heathcote ML , Bolanos-Garcia VM , Kroutil W , Staunton J , Leadlay PF , Spencer JB |
| Ref : Chembiochem , 7 :1435 , 2006 |
| Abstract : |
| PubMedSearch : Harvey_2006_Chembiochem_7_1435 |
| PubMedID: 16897798 |
| Gene_locus related to this paper: strci-MONCII |
| Title : Evidence that a novel thioesterase is responsible for polyketide chain release during biosynthesis of the polyether ionophore monensin - Harvey_2006_Chembiochem_7_1435 |
| Author(s) : Harvey BM , Hong H , Jones MA , Hughes-Thomas ZA , Goss RM , Heathcote ML , Bolanos-Garcia VM , Kroutil W , Staunton J , Leadlay PF , Spencer JB |
| Ref : Chembiochem , 7 :1435 , 2006 |
| Abstract : |
| PubMedSearch : Harvey_2006_Chembiochem_7_1435 |
| PubMedID: 16897798 |
| Gene_locus related to this paper: strci-MONCII |
| Title : Evidence that a novel thioesterase is responsible for polyketide chain release during biosynthesis of the polyether ionophore monensin - Harvey_2006_Chembiochem_7_1435 |
| Author(s) : Harvey BM , Hong H , Jones MA , Hughes-Thomas ZA , Goss RM , Heathcote ML , Bolanos-Garcia VM , Kroutil W , Staunton J , Leadlay PF , Spencer JB |
| Ref : Chembiochem , 7 :1435 , 2006 |
| Abstract : |
| PubMedSearch : Harvey_2006_Chembiochem_7_1435 |
| PubMedID: 16897798 |
| Gene_locus related to this paper: strci-MONCII |
| Title : Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization - Oliynyk_2003_Mol.Microbiol_49_1179 |
| Author(s) : Oliynyk M , Stark CB , Bhatt A , Jones MA , Hughes-Thomas ZA , Wilkinson C , Oliynyk Z , Demydchuk Y , Staunton J , Leadlay PF |
| Ref : Molecular Microbiology , 49 :1179 , 2003 |
| Abstract : |
| PubMedSearch : Oliynyk_2003_Mol.Microbiol_49_1179 |
| PubMedID: 12940979 |
| Gene_locus related to this paper: strci-MONAIX , strci-MONAX , strci-MONCII , strci-Q846W0 |
| Title : Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization - Oliynyk_2003_Mol.Microbiol_49_1179 |
| Author(s) : Oliynyk M , Stark CB , Bhatt A , Jones MA , Hughes-Thomas ZA , Wilkinson C , Oliynyk Z , Demydchuk Y , Staunton J , Leadlay PF |
| Ref : Molecular Microbiology , 49 :1179 , 2003 |
| Abstract : |
| PubMedSearch : Oliynyk_2003_Mol.Microbiol_49_1179 |
| PubMedID: 12940979 |
| Gene_locus related to this paper: strci-MONAIX , strci-MONAX , strci-MONCII , strci-Q846W0 |
| Title : Analysis of the biosynthetic gene cluster for the polyether antibiotic monensin in Streptomyces cinnamonensis and evidence for the role of monB and monC genes in oxidative cyclization - Oliynyk_2003_Mol.Microbiol_49_1179 |
| Author(s) : Oliynyk M , Stark CB , Bhatt A , Jones MA , Hughes-Thomas ZA , Wilkinson C , Oliynyk Z , Demydchuk Y , Staunton J , Leadlay PF |
| Ref : Molecular Microbiology , 49 :1179 , 2003 |
| Abstract : |
| PubMedSearch : Oliynyk_2003_Mol.Microbiol_49_1179 |
| PubMedID: 12940979 |
| Gene_locus related to this paper: strci-MONAIX , strci-MONAX , strci-MONCII , strci-Q846W0 |