Streptomyces sp. (dauP) Rhodomycin D methylesterase DauP
Involved in the biosynthesis of the anthracyclines carminomycin and daunorubicin (daunomycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. Catalyzes the removal of methyl group from the carbomethoxy group of rhodomycin D ( giving product 10-carbomethoxy-13-deoxycarminomycin CID: 126779)
Family : Aclacinomycin-methylesterase_RdmC
Block : X
Position in NCBI Life Tree : Streptomyces sp.
(Below N is a link to NCBI taxonomic web page and E link to ESTHER at designed phylum.)
> cellular organisms N E > Bacteria N E > Terrabacteria group N E > Actinobacteria [phylum] N E > Actinobacteria [class] N E > Streptomycetales N E > Streptomycetaceae N E > Streptomyces N E > Streptomyces sp. N E > cellular organisms N E > Bacteria N E > Terrabacteria group N E > Actinobacteria [phylum] N E > Actinobacteria [class] N E > Streptomycetales N E > Streptomycetaceae N E > Streptomyces N E > Streptomyces sp. N E > cellular organisms N E > Bacteria N E > Terrabacteria group N E > Actinobacteria [phylum] N E > Actinobacteria [class] N E > Streptomycetales N E > Streptomycetaceae N E > Streptomyces N E > Streptomyces sp. N EMPTRMITKDE VTLWSEGIGD PADAPLLLIA GGNLSARSWP DEFVERLAAA GHFVIRYDHR DTGRSSRYDF ALHPYGFDEL ATDALAVLDA WQVRAAHVVG MSLGNTIGQL LALDAPERLL TLTVMLGGAL DVDFDADLEA ALKGEPSVSG LPVPSRRFLD MMMLLQQPAG TDEELLERRV EKWRLLNGEG VPFDSDEFRR RELLAAGHAG TFDEPIVHHM IPQPPVSRGA ELARITTPVL AIQAMCDPAA PPPHARHLAD RIPGARVVEI ENMGHALPLA VHEPLAAAIC AHTRAATV
| Title : In vivo and in vitro bioconversion of epsilon-rhodomycinone glycoside to doxorubicin: functions of DauP, DauK, and DoxA - Dickens_1997_J.Bacteriol_179_2641 |
| Author(s) : Dickens ML , Priestley ND , Strohl WR |
| Ref : Journal of Bacteriology , 179 :2641 , 1997 |
| Abstract : |
| PubMedSearch : Dickens_1997_J.Bacteriol_179_2641 |
| PubMedID: 9098063 |
| Gene_locus related to this paper: strsp-dauP |
| Title : In vivo and in vitro bioconversion of epsilon-rhodomycinone glycoside to doxorubicin: functions of DauP, DauK, and DoxA - Dickens_1997_J.Bacteriol_179_2641 |
| Author(s) : Dickens ML , Priestley ND , Strohl WR |
| Ref : Journal of Bacteriology , 179 :2641 , 1997 |
| Abstract : |
| PubMedSearch : Dickens_1997_J.Bacteriol_179_2641 |
| PubMedID: 9098063 |
| Gene_locus related to this paper: strsp-dauP |
| Title : In vivo and in vitro bioconversion of epsilon-rhodomycinone glycoside to doxorubicin: functions of DauP, DauK, and DoxA - Dickens_1997_J.Bacteriol_179_2641 |
| Author(s) : Dickens ML , Priestley ND , Strohl WR |
| Ref : Journal of Bacteriology , 179 :2641 , 1997 |
| Abstract : |
| PubMedSearch : Dickens_1997_J.Bacteriol_179_2641 |
| PubMedID: 9098063 |
| Gene_locus related to this paper: strsp-dauP |
| Title : Analysis of clustered genes encoding both early and late steps in daunomycin biosynthesis by Streptomyces sp. strain C5 - Dickens_1995_J.Bacteriol_177_536 |
| Author(s) : Dickens ML , Ye J , Strohl WR |
| Ref : Journal of Bacteriology , 177 :536 , 1995 |
| Abstract : |
| PubMedSearch : Dickens_1995_J.Bacteriol_177_536 |
| PubMedID: 7836284 |
| Gene_locus related to this paper: strsp-dauP |
| Title : Analysis of clustered genes encoding both early and late steps in daunomycin biosynthesis by Streptomyces sp. strain C5 - Dickens_1995_J.Bacteriol_177_536 |
| Author(s) : Dickens ML , Ye J , Strohl WR |
| Ref : Journal of Bacteriology , 177 :536 , 1995 |
| Abstract : |
| PubMedSearch : Dickens_1995_J.Bacteriol_177_536 |
| PubMedID: 7836284 |
| Gene_locus related to this paper: strsp-dauP |
| Title : Analysis of clustered genes encoding both early and late steps in daunomycin biosynthesis by Streptomyces sp. strain C5 - Dickens_1995_J.Bacteriol_177_536 |
| Author(s) : Dickens ML , Ye J , Strohl WR |
| Ref : Journal of Bacteriology , 177 :536 , 1995 |
| Abstract : |
| PubMedSearch : Dickens_1995_J.Bacteriol_177_536 |
| PubMedID: 7836284 |
| Gene_locus related to this paper: strsp-dauP |