Sphingomonadales bacterium; Sphingomonadales bacterium BRH_c42, Carboxylic ester hydrolase Fumonisin B1 hydrolase FumDSB
Fumonisins are toxins produced by several species of Fusarium molds, such as Fusarium verticillioides which occur mainly in maize (corn), wheat and other cereals. Fumonisin B1 is hepatotoxic and nephrotoxic. fumonisins are able to inhibit sphingosine-sphinganin-transferases and ceramide synthases and are therefore competitive inhibitors of sphingolipid biosynthesis and metabolism. Fumonisin is hydrolysed by Sphingopyxis macrogoltabida FumD. It is used as enzyme-basedfeed additive intended to degrade fumonisin mycotoxins found as contaminants in feeds for growing pigs.
MTLASLLLLA PAVAHAGPSV VTTDAGRLRG AVEGELDVFR GVPFAAAPIG QLRWREPQRI APWTDIRDAS KFAPACMQSG VSIPGEPAPQ ISEDCLYLNI WAPRHSGRAK LPVMIFIHGG GWQNGATALP LYWGDRLAQQ GAVVVSVSYR LGALGFLAHP ELTAESPHHT SGNYGLLDQI AALNWVQRNI AAFGGDPANV TLFGQSAGSS SIAILMASPL AKGLFHRVIG QSGGFFEPLQ LAPHYELALA EKQGVAFAHS LETSTLADLR SLPPQALLTK QAASVSHPVI EPWLLPRTPF EVFSVGQQHG ADILVGYNAE EGRAFFDASS VTAANFGEQL RAELGDLPPA IMAAYPFASD VEAGQARVAL ERDLRFGWNM WTWAKLHAAT GKNAVHAYYF THKPPFPSDS VRRNWQASHF AELWYMFDHL GQEDWQWTKF DRQIARTMSR YWVNFARNGN PNGRGLPHWP AYRTDQPLVL QIGQPITPTP EPNTGSIGVI DAVFSAVRGD T
| Title : Comparison Study of Two Fumonisin-Degrading Enzymes for Detoxification in Piglets - Wang_2024_Toxins.(Basel)_16_3 |
| Author(s) : Wang Z , Lv Z , Czabany T , Nagl V , Krska R , Wang X , Han B , Tao H , Liu J , Wang J |
| Ref : Toxins (Basel) , 16 :3 , 2024 |
| Abstract : Wang_2024_Toxins.(Basel)_16_3 |
| ESTHER : Wang_2024_Toxins.(Basel)_16_3 |
| PubMedSearch : Wang_2024_Toxins.(Basel)_16_3 |
| PubMedID: 38276527 |
| Gene_locus related to this paper: sphmc-FumD , 9sphn-a0a101vlk1 |
| Title : FumDSB can alleviate the inflammatory response induced by fumonisin B(1) in growing pigs - Liu_2022_Food.Addit.Contam.Part.A.Chem.Anal.Control.Expo.Risk.Assess__ |
| Author(s) : Liu Q , Huang L , Cui Z , Qiao B , Li F , Wang C |
| Ref : Food Additives & Contaminants Part A Chem Anal Control Expo Risk Assess , :1 , 2022 |
| Abstract : Liu_2022_Food.Addit.Contam.Part.A.Chem.Anal.Control.Expo.Risk.Assess__ |
| ESTHER : Liu_2022_Food.Addit.Contam.Part.A.Chem.Anal.Control.Expo.Risk.Assess__ |
| PubMedSearch : Liu_2022_Food.Addit.Contam.Part.A.Chem.Anal.Control.Expo.Risk.Assess__ |
| PubMedID: 35858108 |
| Gene_locus related to this paper: sphmc-FumD , 9sphn-a0a101vlk1 |
| Title : FumDSB Can Reduce the Toxic Effects of Fumonisin B(1) by Regulating Several Brain-Gut Peptides in Both the Hypothalamus and Jejunum of Growing Pigs - Liu_2021_Toxins.(Basel)_13_874 |
| Author(s) : Liu Q , Li F , Huang L , Chen W , Li Z , Wang C |
| Ref : Toxins (Basel) , 13 :874 , 2021 |
| Abstract : Liu_2021_Toxins.(Basel)_13_874 |
| ESTHER : Liu_2021_Toxins.(Basel)_13_874 |
| PubMedSearch : Liu_2021_Toxins.(Basel)_13_874 |
| PubMedID: 34941712 |
| Gene_locus related to this paper: 9sphn-a0a101vlk1 |
| Title : Biological detoxification of fumonisin by a novel carboxylesterase from Sphingomonadales bacterium and its biochemical characterization - Li_2021_Int.J.Biol.Macromol_169_18 |
| Author(s) : Li Z , Wang Y , Liu Z , Jin S , Pan K , Liu H , Liu T , Li X , Zhang C , Luo X , Song Y , Zhao J , Zhang T |
| Ref : Int J Biol Macromol , 169 :18 , 2021 |
| Abstract : Li_2021_Int.J.Biol.Macromol_169_18 |
| ESTHER : Li_2021_Int.J.Biol.Macromol_169_18 |
| PubMedSearch : Li_2021_Int.J.Biol.Macromol_169_18 |
| PubMedID: 33309671 |
| Gene_locus related to this paper: 9sphn-a0a101vlk1 |