| Title : FumDSB can alleviate the inflammatory response induced by fumonisin B(1) in growing pigs - Liu_2022_Food.Addit.Contam.Part.A.Chem.Anal.Control.Expo.Risk.Assess__ |
| Author(s) : Liu Q , Huang L , Cui Z , Qiao B , Li F , Wang C |
| Ref : Food Additives & Contaminants Part A Chem Anal Control Expo Risk Assess , :1 , 2022 |
| Abstract : Fumonisin B(1) (FB(1)) has the highest natural contamination rate among all fumonisin analogs and can inhibit food intake and weight gain of pigs. Under laboratory conditions, carboxylesterase FumDSB has a high FB(1) degradation rate and excellent pH and thermal stability. The present study sought to estimate the effects of FumDSB on growing pigs from the perspective of a brain-intestinal axis. Twenty-four growing pigs of similar weight were divided into Control, FB(1) (5mg FB(1)/kg feed), and FumDSB (5mg FB(1)/kg and 0.1% FumDSB in the feed) groups. After 42 days of feeding, hypothalamus and jejunum samples were collected for quantitative real-time fluorescence, western blotting, and immunohistochemistry. The results showed that FB(1) consumption can destruct the tissue structure of hypothalamus and jejunum, affect the expression and distribution of several appetite-related neuropeptides and inflammatory cytokines, thereby inducing neuroinflammatory responses and affecting food intake and weight gain. However, these anorexia effects and inflammatory responses are alleviated when FumDSB is added to the feed. In short, FumDSB can alleviate the inflammatory response induced by FB(1) in growing pigs. |
| ESTHER : Liu_2022_Food.Addit.Contam.Part.A.Chem.Anal.Control.Expo.Risk.Assess__ |
| PubMedSearch : Liu_2022_Food.Addit.Contam.Part.A.Chem.Anal.Control.Expo.Risk.Assess__ |
| PubMedID: 35858108 |
| Gene_locus related to this paper: sphmc-FumD , 9sphn-a0a101vlk1 |
| Gene_locus related to this paper: sphmc-FumD , 9sphn-a0a101vlk1 |
Liu Q, Huang L, Cui Z, Qiao B, Li F, Wang C (2022)
FumDSB can alleviate the inflammatory response induced by fumonisin B(1) in growing pigs
Food Additives & Contaminants Part A Chem Anal Control Expo Risk Assess
:1
Liu Q, Huang L, Cui Z, Qiao B, Li F, Wang C (2022)
Food Additives & Contaminants Part A Chem Anal Control Expo Risk Assess
:1