catro-CS
Catharanthus roseus (Madagascar periwinkle) hydrolase 1, Tabersonine Synthase TS
Comment
Component of iboga and aspidosperma monoterpenoid indole alkaloids (MIAs, e.g. tabersonine and catharanthine) biosynthesis pathway from 19E-geissoschizine. Catalyzes the conversion of O-acetylstemmadenine (OAS) to catharanthine.
Relationship
Molecular evidence
No mutation
No kinetic
No disease
Sequence
Peptide
MNSSTDPTSD ETIWDLSPYI KIFKDGRVER LHNSPYVPPS LNDPETGVSW KDVPISSQVS ARVYIPKISD HEKLPIFVYV HGAGFCLESA FRSFFHTFVK HFVAETKVIG VSIEYRLAPE HLLPAAYEDC WEALQWVASH VGLDNSGLKT AIDKDPWIIN YGDFDRLYLA GDSPGANIVH NTLIRAGKEK LKGGVKILGA ILYYPYFIIP TSTKLSDDFE YNYTCYWKLA YPNAPGGMNN PMINPIAENA PDLAGYGCSR LLVTLVSMIS TTPDETKDIN AVYIEALEKS GWKGELEVAD FDADYFELFT LETEMGKNMF RRLASFIKHE
References
| Title : Evolution and diversification of carboxylesterase-like [4+2] cyclases in aspidosperma and iboga alkaloid biosynthesis - DeMars_2024_Proc.Natl.Acad.Sci.U.S.A_121_e2318586121 |
| Author(s) : DeMars MD, 2nd , O'Connor SE |
| Ref : Proc Natl Acad Sci U S A , 121 :e2318586121 , 2024 |
| Abstract : DeMars_2024_Proc.Natl.Acad.Sci.U.S.A_121_e2318586121 |
| ESTHER : DeMars_2024_Proc.Natl.Acad.Sci.U.S.A_121_e2318586121 |
| PubMedSearch : DeMars_2024_Proc.Natl.Acad.Sci.U.S.A_121_e2318586121 |
| PubMedID: 38319969 |
| Gene_locus related to this paper: catro-CS , catro-TS , tabib-a0a5b8x6s2 , tabib-CorS |
| Title : Structural basis of cycloaddition in biosynthesis of iboga and aspidosperma alkaloids - Caputi_2020_Nat.Chem.Biol_16_383 |
| Author(s) : Caputi L , Franke J , Bussey K , Farrow SC , Vieira IJC , Stevenson CEM , Lawson DM , O'Connor SE |
| Ref : Nat Chemical Biology , 16 :383 , 2020 |
| Abstract : Caputi_2020_Nat.Chem.Biol_16_383 |
| ESTHER : Caputi_2020_Nat.Chem.Biol_16_383 |
| PubMedSearch : Caputi_2020_Nat.Chem.Biol_16_383 |
| PubMedID: 32066966 |
| Gene_locus related to this paper: catro-CS , catro-TS , tabib-a0a5b8x6s2 , tabib-CorS |
| Title : Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle - Caputi_2018_Science_360_1235 |
| Author(s) : Caputi L , Franke J , Farrow SC , Chung K , Payne RME , Nguyen TD , Dang TT , Soares Teto Carqueijeiro I , Koudounas K , Duge de Bernonville T , Ameyaw B , Jones DM , Vieira IJC , Courdavault V , O'Connor SE |
| Ref : Science , 360 :1235 , 2018 |
| Abstract : Caputi_2018_Science_360_1235 |
| ESTHER : Caputi_2018_Science_360_1235 |
| PubMedSearch : Caputi_2018_Science_360_1235 |
| PubMedID: 29724909 |
| Gene_locus related to this paper: catro-CS , catro-TS |
| Title : Solution of the multistep pathway for assembly of corynanthean, strychnos, iboga, and aspidosperma monoterpenoid indole alkaloids from 19E-geissoschizine - Qu_2018_Proc.Natl.Acad.Sci.U.S.A_115_3180 |
| Author(s) : Qu Y , Easson M , Simionescu R , Hajicek J , Thamm AMK , Salim V , De Luca V |
| Ref : Proc Natl Acad Sci U S A , 115 :3180 , 2018 |
| Abstract : Qu_2018_Proc.Natl.Acad.Sci.U.S.A_115_3180 |
| ESTHER : Qu_2018_Proc.Natl.Acad.Sci.U.S.A_115_3180 |
| PubMedSearch : Qu_2018_Proc.Natl.Acad.Sci.U.S.A_115_3180 |
| PubMedID: 29511102 |
| Gene_locus related to this paper: catro-CS , catro-TS , catro-hl3 , catro-hl4 |