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psesp-llipa

Pseudomonas species (strain 109) gene for lactonizing lipase

Comment

efficiently catalyzes intramolecular transesterification of omega-hydroxyesters to form macrocyclic lactones. The production of the enzymatically active LipL requires a specific molecular chaperon (LimL protein) together with a low-M(r) lipase-activation-factor (LAF) (reduced form of glutathione) for formation of intermolecular disulfide bound

Relationship

Family : Bacterial_lip_FamI.1

Block : L

Position in NCBI Life Tree : Pseudomonas sp.

Molecular evidence

No mutation

No structure

No kinetic

No disease

No substrate

No inhibitor

Database

Sequence

Peptide

MKKKSLLPLG LAIGLASLAA SPLIQASTYT QTKYPIVLAH GMLGFDNILG VDYWFGIPSA LRRDGAQVYV TEVSQLDTSE VRGEQLLQQV EEIVALSGQP KVNLIGHSHG GPTIRYVAAV RPDLMPSATS VGAPHKGSDT ADFLRQIPPG SAGEAVLSGL VNSLGALISF LSSGSAGTQN SLGSLESLNS EGAARFNAKY PQGIPTSACG EGAYKVNGVS YYSWSGSSPL TNFLDPSDAF LGASSLTFKN GTANDGLVGT CSSHLGMVIR DNYRMNHLDE VNQVFGLTSL FETSPVSVYR QHANRLKNAS L

References

Title : Glutathione as an essential factor for chaperon-mediated activation of lactonizing lipase (LipL) from Pseudomonas sp. 109 - Tanaka_2000_J.Biochem_127_597
Author(s) : Tanaka J , Nihira T , Yamada Y
Ref : J Biochem , 127 :597 , 2000
Abstract : Tanaka_2000_J.Biochem_127_597
ESTHER : Tanaka_2000_J.Biochem_127_597
PubMedSearch : Tanaka_2000_J.Biochem_127_597
PubMedID: 10739951
Gene_locus related to this paper: psesp-llipa

Title : Purification, characterization, and molecular cloning of lactonizing lipase from Pseudomonas species - Ihara_1991_J.Biol.Chem_266_18135
Author(s) : Ihara F , Kageyama Y , Hirata M , Nihira T , Yamada Y
Ref : Journal of Biological Chemistry , 266 :18135 , 1991
Abstract : Ihara_1991_J.Biol.Chem_266_18135
ESTHER : Ihara_1991_J.Biol.Chem_266_18135
PubMedSearch : Ihara_1991_J.Biol.Chem_266_18135
PubMedID: 1917947
Gene_locus related to this paper: psesp-llipa