(R)-37a

m-Sulfamoyl Benzoamide derivative of Z32439948: hBChE IC50 = 0.005 +/- 0.001 microM

General

Type : Benzazepin, Sulfur Compound, Sulfonamide, Benzamide

Chemical_Nomenclature :

Canonical SMILES : N2(NC(C[S](C1=CC(=CC=C1C)C(N(CCC)CCC)=O)(=O)=O)C)CCCCCC2

InChI : InChI=1S\/C23H39N3O3S\/c1-5-13-25(14-6-2)23(27)21-12-11-19(3)22(17-21)30(28,29)18-20(4)24-26-15-9-7-8-10-16-26\/h11-12,17,20,24H,5-10,13-16,18H2,1-4H3

InChIKey : RRNMXISIJOCPRX-UHFFFAOYSA-N

Other name(s) :

MW : 437.63

Formula : C23H39N3O3S

CAS_number :

PubChem :

UniChem : RRNMXISIJOCPRX-UHFFFAOYSA-N

Target

Families : (R)-37a ligand of proteins in family
BCHE

Protein :
human-BCHE

References (1)

Title : Discovery, Structure-Based Modification, In Vitro, In Vivo, and In Silico Exploration of m-Sulfamoyl Benzoamide Derivatives as Selective Butyrylcholinesterase Inhibitors for Treating Alzheimer's Disease - Lu_2024_ACS.Chem.Neurosci__

Author(s) : Lu X , Li Y , Guan Q , Yang H , Liu Y , Du C , Wang L , Wang Q , Pei Y , Wu L , Sun H , Chen Y

Ref : ACS Chem Neurosci , : , 2024

Abstract :

PubMedSearch : Lu_2024_ACS.Chem.Neurosci__

PubMedID: 38453668

(R)-37a

General

Target

References (1)

1. Discovery, Structure-Based Modification, In Vitro, In Vivo, and In Silico Exploration of m-Sulfamoyl Benzoamide Derivatives as Selective Butyrylcholinesterase Inhibitors for Treating Alzheimer's Disease - Lu_2024_ACS.Chem.Neurosci__