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Sulfonamide

General

Sulfonamide (sulphonamide) is an organosulfur group with the structure RS(=O)2NR2. It consists of a sulfonyl group (O=S=O) connected to an amine group (NH2). Building block for many inhibitors of enzymes
Inhibitor Main targeted enzyme families Type Structure
(R)-37a BCHE Benzazepin Sulfur Compound Sulfonamide Benzamide
Fluoromethylphenyl-sulfamoyl-phenyl-morpholin-methyl-benzamide Sulfur Compound Sulfonamide Benzamide Morpholine
X20348 Thioesterase Oxadiazol Sulfur Compound Sulfonamide
N,N-diethyl-4,5-dimethoxy-2-methylbenzenesulfonamide ACHE Benzenesulfonamide Sulfur Compound Sulfonamide
Tosyl-Octyl-2-aminobenzo-thiazole-6-carboxylate-cpd6k BCHE ACHE Monoamine-oxidase-inhibitor Multitarget Urea derivative Benzothiazol Sulfur Compound Sulfonamide
SEH-48-RK4 Epoxide_hydrolase Carboxamide Sulfur Compound Sulfonamide
SEH-45-RK3 Epoxide_hydrolase Carboxamide Sulfur Compound Sulfonamide
Chlorophenyl-methylsulfonyl-indol-acryloyl-phenyl-acetamide-cpd5b BCHE ACHE Multitarget Indole Carboxamide Sulfur Compound Sulfonamide
Cofrogliptin DPP4N_Peptidase_S9 Gliptin Trifluoro Pyrazole Sulfonamide Sulfur Compound
Glimepiride Epoxide_hydrolase Sulfonamide Sulfur Compound Carboxamide Urea derivative
J8-A34 ACHE Piperidine Sulfur Compound Sulfonamide Quinoline Derivative of Donepezil
TMR-S4 Haloalkane_dehalogenase-HLD2 HaloTag-ligand Sulfur Compound Sulfonamide Xanthene
TMR-T4 Haloalkane_dehalogenase-HLD2 HaloTag-ligand Sulfur Compound Sulfonamide Xanthene
TMR-S5 Haloalkane_dehalogenase-HLD2 HaloTag-ligand Sulfur Compound Sulfonamide Xanthene
TMR-T5 Haloalkane_dehalogenase-HLD2 HaloTag-ligand Sulfur Compound Sulfonamide Xanthene
ZINC59501712 ACHE Sulfur Compound Indole Sulfonamide Phthalimido Benzenesulfonamide
AZ12756122 Thioesterase Sulfonamide Piperidine Cyanide Sulfur Compound
Chlorophenyl-sulfonyl-quinolin-piperidine-carboxamide-4d Epoxide_hydrolase Piperidine Sulfur Compound Sulfonamide Carboxamide Multitarget
Diclofenac-derivative-39 ACHE Monoamine-oxidase-inhibitor Multitarget 5-Lipoxygenase inhibitor Sulfur Compound Sulfonamide Pyrazole
Tacrine-pentylmethylene-tolylsulfonamide ACHE BCHE Alkyl linked bis-ligand Derivative of Tacrine Sulfur Compound Sulfonamide Benzenesulfonamide
3-cyano-N-cyclopropylbenzenesulfonamide PAF-Acetylhydrolase Cyanide Sulfonamide Cyclopropyl Sulfur Compound Benzenesulfonamide
SBP-7635 Thioesterase Thiazolidine Sulfonamide Sulfur Compound Benzenesulfonamide
SBP-7957 Thioesterase Morpholine Thiazolidine Sulfur Compound Sulfonamide
Sulfapyridine Pectinacetylesterase-Notum Fragment inhibitor of Notum Sulfonamide Sulfur Compound Antibiotic Pyridine Not A\/B H target Benzenesulfonamide
PTUPB Epoxide_hydrolase Multitarget Trifluoro Urea derivative Sulfur Compound Sulfonamide Pyrazole
FL217 Epoxide_hydrolase Multitarget PPARgamma ligand Cyclopropyl Sulfur Compound Sulfonamide Indole
Benzothiazole-analogue-13f Epoxide_hydrolase Benzothiazol Piperidine Sulfur Compound Sulfonamide Carboxamide
CHEMBL2313198 Epoxide_hydrolase Piperidine Sulfur Compound Sulfonamide Carboxamide Trifluoro
CHEMBL3585776 ACHE Carbamate Sulfur Compound Sulfonamide Carbonic anhydrase inhibitor Multitarget
Cpd17-Tacrine-5-HT6 ACHE BCHE Acridine Derivative of Tacrine Multitarget 5-HT-receptor-ligand Sulfur Compound Sulfonamide Indole Alkyl linked bis-ligand anti-Abeta-aggregation
Cpd54-BChEin-5-HT6 BCHE Multitarget 5-HT-receptor-ligand Sulfur Compound Sulfonamide Indole Alkyl linked bis-ligand tert-Butyloxycarbonyl tert-Butyl
Cpd27-BChEin-5-HT6 BCHE Multitarget 5-HT-receptor-ligand Sulfur Compound Sulfonamide Indole Alkyl linked bis-ligand
Cpd35-Rivastigmine-5-HT6 BCHE Derivative of Rivastigmine Multitarget 5-HT-receptor-ligand Sulfur Compound Sulfonamide Indole Carbamate Alkyl linked bis-ligand anti-Abeta-aggregation
P1-benzoxadiazole-fluorogenic-ligand Haloalkane_dehalogenase-HLD2 Fluorescent Probe Sulfur Compound Sulfonamide Benzoxadiazole
6OT-5JZB Carbon-carbon_bond_hydrolase Sulfur Compound Sulfonamide Benzenesulfonamide
ABD957 ABHD17-depalmitoylase Trifluoro Sulfur Compound Sulfonamide Piperazine Pyrazole Azabicyclo
CID155803786 ABHD17-depalmitoylase Piperazine Trifluoro Sulfur Compound Sulfonamide Morpholine Pyrazole
CID155803792 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Trifluoro Sulfur Compound Sulfonamide Morpholine Pyrazole
CID155803782 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Trifluoro Sulfur Compound Sulfonamide Morpholine Pyrazole
CID155803778 ABHD17-depalmitoylase LYsophospholipase_carboxylesterase Piperazine Sulfur Compound Sulfonamide Pyrazole
Tosyl-L-lysine-chloromethyl-ketone Carb_B_Bacteria BCHE S9N_PREPL_Peptidase_S9 Ketone Peptide Sulfur Compound Sulfonamide Benzenesulfonamide
6RUA-3a BCHE Sulfur Compound Sulfonamide Coumarin Piperidine Carboxamide Naphthalen Chromen
JUB BCHE Piperidine Piperazine NBD-nitro-benzoxadiazol-fluorescent Benzoxadiazole Sulfur Compound Sulfonamide Naphthalen
LEI-106 Lipase_3 ABHD6-Lip Sulfur Compound Phenoxyphenyl Sulfonamide Chromen
SR-3133 CGI-58_ABHD5_ABHD4 Piperazine Sulfur Compound Sulfonamide Benzofuran
SR-3134 CGI-58_ABHD5_ABHD4 Piperazine Sulfur Compound Sulfonamide Benzofuran
SR-4559 CGI-58_ABHD5_ABHD4 Piperazine Sulfur Compound Sulfonamide Benzofuran
CHEMBL4076637 PAF-Acetylhydrolase Sulfur Compound Sulfonamide
TUPS Epoxide_hydrolase Piperidine Urea derivative Trifluoro Sulfur Compound Sulfonamide
5DYT-5hb BCHE Piperidine Derivative of Donepezil Sulfonamide Sulfur Compound Naphthalen
5DYY-5hh BCHE Piperidine Derivative of Donepezil Sulfonamide Sulfur Compound Naphthalen
CHEMBL3087804 ACHE Sulfonamide Sulfur Compound Benzenesulfonamide
dansyl-PEG2-HaloTag Haloalkane_dehalogenase-HLD2 Polymer Poly-ethylene-glycol Sulfonamide Sulfur Compound HaloTag-ligand Naphthalen
CHEMBL3087808 ACHE Sulfur Compound Sulfonamide
CHEMBL3087813 ACHE Sulfur Compound Sulfonamide Sulfonyl Benzenesulfonamide
CHEMBL3087814 ACHE Sulfur Compound Sulfonamide Benzenesulfonamide
CHEMBL3087815 ACHE Trifluoro Sulfur Compound Sulfonamide Benzenesulfonamide
CHEMBL1624646 ACHE Sulfur Compound Sulfonamide Benzenesulfonamide
2-allyl-4-oxocyclobutyl-4-methylbenzenesulfonamide LYsophospholipase_carboxylesterase Sulfur Compound Sulfonamide Benzenesulfonamide
Sulfonamide-D1C DPP4N_Peptidase_S9 Sulfur Compound Sulfonamide Trifluoro Benzenesulfonamide
5ALH-4UA Epoxide_hydrolase Sulfonamide Carboxamide Sulfur Compound Piperidine Sulfonyl
5ALZ-XQ9 Epoxide_hydrolase Urea derivative Adamantyl Piperidine Sulfur Compound Sulfonyl Sulfonamide
CHEMBL4451596 Epoxide_hydrolase Sulfonamide Pyridine Trifluoro Sulfur Compound
5DYW-5hf-C11 BCHE Piperidine Derivative of Donepezil Sulfur Compound Sulfonamide PET probe Naphthalen
5DYW-5hf-F BCHE Piperidine Derivative of Donepezil Sulfur Compound Sulfonamide PET probe
5DYW-5hf BCHE Piperidine Derivative of Donepezil Sulfur Compound Sulfonamide Naphthalen
P-Toluenesulfonamide Carb_B_Chordata Sulfonamide Sulfur Compound Benzenesulfonamide
GTPL9797 PAF-Acetylhydrolase Trifluoro Piperidine Sulfur Compound Sulfonamide Benzenesulfonamide
Indolesufonamide1 DPP4N_Peptidase_S9 Sulfur Compound Indole Sulfonamide
SZC Epoxide_hydrolase Sulfur Compound Sulfonamide Trifluoro Imidazole Benzimidazole
GSK-264220A Lipoprotein_Lipase Urea derivative Sulfur Compound Sulfonamide
CHEMBL3087809 ACHE Sulfonamide Sulfur Compound Trifluoro
CHEMBL3087807 ACHE Sulfonamide Sulfur Compound
CHEMBL3087806 ACHE Sulfur Compound Sulfonamide
Bensulide BCHE Sulfur Compound Sulfonamide Organophosphate Herbicide Not A\/B H target Benzenesulfonamide
Famphur ACHE Organophosphate Sulfur Compound Sulfonamide Benzenesulfonamide Insecticide
STL118972 BCHE Sulfonamide Sulfur Compound Benzenesulfonamide
bis-benzene-sulfonamide Carboxylesterase Carb_B_Chordata Lipase inhibitor Sulfur Compound Sulfonamide Benzenesulfonamide