(R)-BEL

inhibitor of patatin like phospholipase domain containing 8, calcium-independent phospholipase A (iPLA2), ATGL; haloenol lactone suicide substrate (HELSS)

General

Type : Not A\/B H target

Chemical_Nomenclature : (3R,6E)-6-(bromomethylidene)-3-naphthalen-1-yloxan-2-one

Canonical SMILES : C1CC(=CBr)OC(=O)C1C2=CC=CC3=CC=CC=C32

InChI : InChI=1S\/C16H13BrO2\/c17-10-12-8-9-15(16(18)19-12)14-7-3-5-11-4-1-2-6-13(11)14\/h1-7,10,15H,8-9H2\/b12-10+\/t15-\/m1\/s1

InChIKey : BYUCSFWXCMTYOI-HBIYDYFMSA-N

Other name(s) : (R)-Bromoenol lactone  ||  (E)-6-(bromomethylene)-3-(1-naphthalenyl)-2H-tetrahydropyran-2-one  ||  (R,E)-6-(Bromomethylene)-3-(naphthalen-1-yl)tetrahydro-2H-pyran-2-one  ||  (3R,6E)-6-(Bromomethylidene)-3-naphthalen-1-yloxan-2-one


MW : 317.18

Formula : C16H13BrO2

CAS_number : 478288-90-3

PubChem : 40486928

UniChem : BYUCSFWXCMTYOI-HBIYDYFMSA-N

Target

References (2)

Title : Lysosomal acid lipase is the major acid retinyl ester hydrolase in cultured human hepatic stellate cells but not essential for retinyl ester degradation - Wagner_2020_Biochim.Biophys.Acta.Mol.Cell.Biol.Lipids_1865_158730
Author(s) : Wagner C , Hois V , Pajed L , Pusch LM , Wolinski H , Trauner M , Zimmermann R , Taschler U , Lass A
Ref : Biochimica & Biophysica Acta Molecular & Cellular Biology Lipids , 1865 :158730 , 2020
Abstract :
PubMedSearch : Wagner_2020_Biochim.Biophys.Acta.Mol.Cell.Biol.Lipids_1865_158730
PubMedID: 32361002
Gene_locus related to this paper: human-LIPA

Title : Anti-angiogenic pigment epithelium-derived factor regulates hepatocyte triglyceride content through adipose triglyceride lipase (ATGL) - Chung_2008_J.Hepatol_48_471
Author(s) : Chung C , Doll JA , Gattu AK , Shugrue C , Cornwell M , Fitchev P , Crawford SE
Ref : Journal of Hepatology , 48 :471 , 2008
Abstract :
PubMedSearch : Chung_2008_J.Hepatol_48_471
PubMedID: 18191271