2-Isopropyl-6-methyl-4-pyrimidinol
Not an inhibitor of Cholinesterases. Major metabolite of diazinon. sometimes called IMPY but confusing with another unrelated compound
General
Type : Pyrimidine
Chemical_Nomenclature : 4-methyl-2-propan-2-yl-1H-pyrimidin-6-one
Canonical SMILES : CC1=CC(=O)NC(=N1)C(C)C
InChI : InChI=1S\/C8H12N2O\/c1-5(2)8-9-6(3)4-7(11)10-8\/h4-5H,1-3H3,(H,9,10,11)
InChIKey : AJPIUNPJBFBUKK-UHFFFAOYSA-N
Other name(s) : 2-Isopropyl-6-methyl-4-pyrimidone || IMHP || 2-Isopropyl-4-methyl-6-hydroxypyrimidine || 6-Pyrimidinol, 2-isopropyl-4-methyl || 4(3H)-Pyrimidinone, 2-isopropyl-6-methyl- || 0JET159MZQ || SCHEMBL190354 || SCHEMBL3030918 || SCHEMBL7053977 || SCHEMBL8169002 || CHEMBL3183282 || SCHEMBL10715964 || SCHEMBL11548127 || SCHEMBL30228949 || CHEBI:83445
MW : 152.19
Formula : C8H12N2O
CAS_number : 2814-20-2
PubChem : 135444498
UniChem : AJPIUNPJBFBUKK-UHFFFAOYSA-N
Target
References (8)
| Title : Systemic organophosphate poisoning in child following anti-lice lotion application - Aknouche_2025_J.Anal.Toxicol__bkaf096 |
| Author(s) : Aknouche F , Magny R , Maruejouls C , Trebuchet C , Fargeot K , Thion L , Valancony C , Scherrer F , Djebrani Oussedik N , Kintz P , Labat L , Houze P |
| Ref : J Anal Toxicol , : , 2025 |
| Abstract : |
| PubMedSearch : Aknouche_2025_J.Anal.Toxicol__bkaf096 |
| PubMedID: 41128598 |
| Title : Physiologically based kinetic modelling based prediction of in vivo rat and human acetylcholinesterase (AChE) inhibition upon exposure to diazinon - Zhao_2021_Arch.Toxicol__ |
| Author(s) : Zhao S , Wesseling S , Spenkelink B , Rietjens I |
| Ref : Archives of Toxicology , : , 2021 |
| Abstract : |
| PubMedSearch : Zhao_2021_Arch.Toxicol__ |
| PubMedID: 33715020 |
| Title : Toxicological Investigations in a Death Involving 2,5-Dimethoxy-4-Chloamphetamine (DOC) Performed on an Exhumed Body - Aknouche_2021_J.Anal.Toxicol_45_e1 |
| Author(s) : Aknouche F , Ameline A , Kernalleguen A , Arbouche N , Maruejouls C , Kintz P |
| Ref : J Anal Toxicol , 45 :e1 , 2021 |
| Abstract : |
| PubMedSearch : Aknouche_2021_J.Anal.Toxicol_45_e1 |
| PubMedID: 32860677 |
| Title : Toxicokinetic and toxicodynamic model for diazinon toxicity-mechanistic explanation of differences in the sensitivity of Daphnia magna and Gammarus pulex - Kretschmann_2012_Environ.Toxicol.Chem_31_2014 |
| Author(s) : Kretschmann A , Ashauer R , Hollender J , Escher BI |
| Ref : Environ Toxicol Chem , 31 :2014 , 2012 |
| Abstract : |
| PubMedSearch : Kretschmann_2012_Environ.Toxicol.Chem_31_2014 |
| PubMedID: 22653849 |
| Title : Toxicokinetic model describing bioconcentration and biotransformation of diazinon in Daphnia magna - Kretschmann_2011_Environ.Sci.Technol_45_4995 |
| Author(s) : Kretschmann A , Ashauer R , Preuss TG , Spaak P , Escher BI , Hollender J |
| Ref : Environ Sci Technol , 45 :4995 , 2011 |
| Abstract : |
| PubMedSearch : Kretschmann_2011_Environ.Sci.Technol_45_4995 |
| PubMedID: 21561125 |
| Title : Toxic effects of diazinon and its photodegradation products - Colovic_2010_Toxicol.Lett_193_9 |
| Author(s) : Colovic M , Krstic D , Petrovic S , Leskovac A , Joksic G , Savic J , Franko M , Trebse P , Vasic V |
| Ref : Toxicol Lett , 193 :9 , 2010 |
| Abstract : |
| PubMedSearch : Colovic_2010_Toxicol.Lett_193_9 |
| PubMedID: 19948211 |
| Title : Pharmacokinetic and pharmacodynamic interaction for a binary mixture of chlorpyrifos and diazinon in the rat - Timchalk_2005_Toxicol.Appl.Pharmacol_205_31 |
| Author(s) : Timchalk C , Poet TS , Hinman MN , Busby AL , Kousba AA |
| Ref : Toxicol Appl Pharmacol , 205 :31 , 2005 |
| Abstract : |
| PubMedSearch : Timchalk_2005_Toxicol.Appl.Pharmacol_205_31 |
| PubMedID: 15885262 |
| Title : Physiologically based pharmacokinetic\/pharmacodynamic model for the organophosphorus pesticide diazinon - Poet_2004_Neurotoxicol_25_1013 |
| Author(s) : Poet TS , Kousba AA , Dennison SL , Timchalk C |
| Ref : Neurotoxicology , 25 :1013 , 2004 |
| Abstract : |
| PubMedSearch : Poet_2004_Neurotoxicol_25_1013 |
| PubMedID: 15474619 |