Pyrimidine

General

Pyrimidine is an aromatic heterocyclic organic compound similar to pyridine. One of the three diazines (six-membered heterocyclics with two nitrogen atoms in the ring), it has the nitrogen atoms at positions 1 and 3 in the ring. The other diazines are pyrazine (nitrogen atoms at the 1 and 4 positions) and pyridazine (nitrogen atoms at the 1 and 2 positions). In nucleic acids, three types of nucleobases are pyrimidine derivatives: cytosine (C), thymine (T), and uracil (U) Building block for many inhibitors of enzymes
Inhibitor Main targeted enzyme familyes Type Structure
Lyplal1-IN-1 LYsophospholipase_carboxylesterase Piperidine Urea derivative Triazol Morpholine Pyrimidine
5ISM-6DG DPP4N_Peptidase_S9 Pyrimidine Pyrrolidine Pyrazole
X20419 Thioesterase Piperazine Piperidine Pyrimidine Carboxamide Indole
Amiridine-thiouracil-13c BCHE Quinoline Derivative of Tacrine Derivative of Amiridine Pyrimidine Sulfur Compound
8AEV-LWU ACHE Pyridine Pyrimidine
Aminoalkyl-tetrahydropyrimido-azocine-7c BCHE Pyrimidine
Indol-thioxotetrahydropyrimidine-Cpd7 BCHE Sulfur Compound Indole Pyrimidine
Indol-thioxotetrahydropyrimidine-Cpd5 ACHE Sulfur Compound Indole Pyrimidine
Tacrine-dihydropyrimidine-4e ACHE Multitarget Derivative of Tacrine Calcium Channel Antagonist Sulfur Compound Quinoline Pyrimidine
CHEMBL3793506 PAF-Acetylhydrolase Trifluoro Cyanide Pyrimidine Morpholine
CHEMBL351434 PAF-Acetylhydrolase Sulfur Compound Pyrimidine
Fragment-823 Fragment inhibitor of Notum Pyrimidine
Fragment-067 Pectinacetylesterase-Notum Fragment inhibitor of Notum Pyrimidine Pyrazole
ZYH-deriv-F Monoglyceridelipase_lysophospholip Azetidin Piperazine Carboxamide Pyrimidine PET probe Indole
CHEMBL3233607-S0G-3WKA Epoxide_hydrolase Piperidine Pyrimidine
M9N Pectinacetylesterase-Notum Pyrimidine Sulfur Compound
LP-914822 Pectinacetylesterase-Notum Pyrimidine Sulfur Compound
75L-5T4E DPP4N_Peptidase_S9 Piperidine Pyrimidine Quinazoline Purine
LP-922056 Pectinacetylesterase-Notum Pyrimidine Sulfur Compound Cyclopropyl
C35-CVZ Pyrimidine
5LP1-71H PAF-Acetylhydrolase Trifluoro Pyrimidine Sulfur Compound
Anagliptin DPP4N_Peptidase_S9 Drug Cyanide Pyrrolidine Gliptin Pyrimidine Carboxamide Pyrazole
CHEMBL1214943 DPP4N_Peptidase_S9 Pyrimidine Morpholine
CHEMBL1910111 DPP4N_Peptidase_S9 Pyrrolidine Pyridine Pyrimidine
24D Epoxide_hydrolase Piperidine Pyrimidine Carboxamide
Pyrimidinone-inhibitor3 DPP4N_Peptidase_S9 Pyrimidine Cyanide
Gemigliptin DPP4N_Peptidase_S9 Drug Piperidine Pyrimidine Gliptin Trifluoro
Gosogliptin DPP4N_Peptidase_S9 Drug Piperidine Pyrimidine Gliptin
Trelagliptin DPP4N_Peptidase_S9 Drug Piperidine Pyrimidine Cyanide Gliptin
5ALI-Q3B Epoxide_hydrolase Urea derivative Pyrimidine Imidazole Sulfur Compound
5ALU-HD2 Epoxide_hydrolase Adamantyl Urea derivative Carboxamide Pyrimidine Not A\/B H target
3-amino-4-phenyl-pyrrolidine-15B DPP4N_Peptidase_S9 Trifluoro Pyrrolidine Pyridine Pyrimidine
Piperidine-constrained-phenethylamine-42 DPP4N_Peptidase_S9 Trifluoro Sulfur Compound Pyrimidine Piperidine
DLI DPP4N_Peptidase_S9 Trifluoro Sulfur Compound Pyrrolidine Pyrimidine
Xanthine-inhibitor-4 DPP4N_Peptidase_S9 Pyrimidine Piperidine Cyanide Purine
CHEMBL2159182 DPP4N_Peptidase_S9 Pyrimidine
Darapladib PAF-Acetylhydrolase Trifluoro Pyrimidine Sulfur Compound
CHEMBL1215376 DPP4N_Peptidase_S9 Pyrimidine Carboxamide
Alogliptin DPP4N_Peptidase_S9 Drug Piperidine Pyrimidine Cyanide Gliptin
ZYH Monoglyceridelipase_lysophospholip Piperazine Pyrimidine Azetidin Benzoxazol
5AP DPP4N_Peptidase_S9 Pyrimidine
C-547 ACHE Bisquaternary Pyrimidine Uracil derivative
Tebupirimfos ACHE BCHE Organophosphate Insecticide Pyrimidine Sulfur Compound
Diazinon ACHE Insecticide Organophosphate Sulfur Compound Organothiophosphate Pyrimidine
Diazinon-oxon ACHE Insecticide Organophosphate Pyrimidine
Pirimicarb ACHE Carbamate Insecticide Pyrimidine
Pirimiphos-methyl ACHE Organophosphate Insecticide Pyrimidine Sulfur Compound