8-HUDE
Similar to EET but urea derivative || 8-HUDE appears to modulate contractions of vascular smooth muscle cells (VAMCs) through effects on multiple ion channels. Difficult to decipher if these effects are attributable to direct actions of 8-HUDE on ion channels or through enhanced local concentrations of endogenous EETs due to sEH properties of this agent
General
Type : Urea derivative
Chemical_Nomenclature : 12-(hexylcarbamoylamino)dodec-8-enoic acid
Canonical SMILES : CCCCCCNC(=O)NCCCC=CCCCCCCC(=O)O
InChI : InChI=1S\/C19H36N2O3\/c1-2-3-4-13-16-20-19(24)21-17-14-11-9-7-5-6-8-10-12-15-18(22)23\/h7,9H,2-6,8,10-17H2,1H3,(H,22,23)(H2,20,21,24)
InChIKey : CQPDPYBIHJYCBO-UHFFFAOYSA-N
Other name(s) :
MW : 340.5
Formula : C19H36N2O3
CAS_number :
PubChem : 74959936
UniChem : CQPDPYBIHJYCBO-UHFFFAOYSA-N
Target
Families : 8-HUDE ligand of proteins in family
Epoxide_hydrolase
Protein :
human-EPHX2
References (2)
| Title : A soluble epoxide hydrolase inhibitor--8-HUDE increases pulmonary vasoconstriction through inhibition of K(ATP) channels - Liu_2012_Pulm.Pharmacol.Ther_25_69 |
| Author(s) : Liu Y , Zhang J , Yu L , Cao F , Rao J , Li J , Jiang C , Falck JR , Jacobs ER , Zhu D |
| Ref : Pulm Pharmacol Ther , 25 :69 , 2012 |
| Abstract : |
| PubMedSearch : Liu_2012_Pulm.Pharmacol.Ther_25_69 |
| PubMedID: 22155000 |
| Title : Stable EET urea agonist and soluble epoxide hydrolase inhibitor regulate rat pulmonary arteries through TRPCs - Liu_2011_Hypertens.Res_34_630 |
| Author(s) : Liu Y , Wang R , Li J , Rao J , Li W , Falck JR , Manthati VL , Medhora M , Jacobs ER , Zhu D |
| Ref : Hypertens Res , 34 :630 , 2011 |
| Abstract : |
| PubMedSearch : Liu_2011_Hypertens.Res_34_630 |
| PubMedID: 21307870 |