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Urea derivative

General

Urea, also known as carbamide, is an organic compound with chemical formula CO(NH2)2. Building block for many inhibitors of enzymes
Inhibitor Main targeted enzyme families Type Structure
sEH-HDAC6-Cpd28g Epoxide_hydrolase Urea derivative Multitarget HDAC inhibitor Piperidine Carboxamide
GL-B437 Epoxide_hydrolase Urea derivative Adamantyl Piperidine Carboxamide
MGLL-IN-Cpd239 Monoglyceridelipase_lysophospholip Urea derivative Azetidin
Adamantyl-trifluoromethoxy-phenyl-sulfonylurea-4f Epoxide_hydrolase Sulfur Compound Urea derivative Trifluoro Adamantyl
Lyplal1-IN-1 LYsophospholipase_carboxylesterase Piperidine Urea derivative Triazol Morpholine Pyrimidine
sEH-HDAC6-IN-M9 Epoxide_hydrolase Multitarget Adamantyl Urea derivative HDAC inhibitor
Tosyl-Octyl-2-aminobenzo-thiazole-6-carboxylate-cpd6k BCHE ACHE Monoamine-oxidase-inhibitor Multitarget Urea derivative Benzothiazol Sulfur Compound Sulfonamide
SCHEMBL3454366 Epoxide_hydrolase Urea derivative Piperidine
SCHEMBL3454366-Boc Epoxide_hydrolase Urea derivative tert-Butyl Piperidine
SCHEMBL3454366-Isobutyryl Epoxide_hydrolase Piperidine Urea derivative
ALT-PG2 Epoxide_hydrolase Urea derivative Trifluoro PROTAC Multitarget
Glimepiride Epoxide_hydrolase Sulfonamide Sulfur Compound Carboxamide Urea derivative
Adamantyl-urea-Cpd28 Epoxide_hydrolase Adamantyl Urea derivative Indole
AL237 ACHE Urea derivative Sulfur Compound
Dihydroindole-thiourea-73 Epoxide_hydrolase Indole Urea derivative Multitarget 5-Lipoxygenase inhibitor Sulfur Compound
JCP276 Coumarin Urea derivative Chromen
Imidocarb Urea derivative Drug
SCHEMBL22462761 Monoglyceridelipase_lysophospholip PET probe Trifluoro Urea derivative Azetidin
LF-14 ACHE Pyridine Urea derivative
Isatin-thiosemicarbazone-cpd13 ACHE BCHE Urea derivative Indole Sulfur Compound
ML225 PAF-Acetylhydrolase Triazol Urea derivative Pyrrolidine
TPPU-6-Chlorotacrine-12c Epoxide_hydrolase ACHE Multitarget Derivative of Tacrine Trifluoro Piperidine Urea derivative Alkyl linked bis-ligand
Fragment-828 Pectinacetylesterase-Notum Fragment inhibitor of Notum Urea derivative
Fragment-110 Pectinacetylesterase-Notum Fragment inhibitor of Notum Urea derivative Pyridine
(4-fluoroanilino)thiourea Pectinacetylesterase-Notum Fragment inhibitor of Notum Urea derivative Sulfur Compound
PTUPB Epoxide_hydrolase Multitarget Trifluoro Urea derivative Sulfur Compound Sulfonamide Pyrazole
KT129 A85-EsteraseD-FGH Triazol Urea derivative
KT130 A85-EsteraseD-FGH Triazol Urea derivative
ZINC395065-W9L-4C4Z Epoxide_hydrolase Urea derivative Naphthalen
ZINC1603176-7WI-4C4Y Epoxide_hydrolase Urea derivative
ZINC10109382-S0A-3WK4 Epoxide_hydrolase Urea derivative Cyclopropyl
Fragment-063-notum-screen Pectinacetylesterase-Notum Urea derivative Fragment inhibitor of Notum Benzoxadiazole
Fragment-064-notum-screen Pectinacetylesterase-Notum Urea derivative Fragment inhibitor of Notum Sulfur Compound
Fragment-049-notum-screen Pectinacetylesterase-Notum Urea derivative Fragment inhibitor of Notum
DH376 Lipase_3 Piperidine Triazol Urea derivative
UB-EV-52 Epoxide_hydrolase Adamantyl Urea derivative
SR-3420 CGI-58_ABHD5_ABHD4 Urea derivative Sulfur Compound Benzothiazepine Azepane Trifluoro
SR-4995 CGI-58_ABHD5_ABHD4 Urea derivative Sulfur Compound Benzothiazepine Azepane
TUPS Epoxide_hydrolase Piperidine Urea derivative Trifluoro Sulfur Compound Sulfonamide
Regorafenib Epoxide_hydrolase Urea derivative Not A\/B H target Trifluoro Carboxamide multi-kinase inhibitor
Sorafenib Epoxide_hydrolase Urea derivative Not A\/B H target Trifluoro Carboxamide multi-kinase inhibitor
6H12-(R)2 ACHE Derivative of Tacrine Derivative of Valmerin Urea derivative GSK-3 kinase inhibitor Multitarget Isoindole Indole Triazol
6H13-(R)3 ACHE Derivative of Tacrine Derivative of Valmerin Urea derivative GSK-3 kinase inhibitor Multitarget Isoindole Indole Triazol
6H14-(S)6 ACHE Derivative of Tacrine Derivative of Valmerin Urea derivative GSK-3 kinase inhibitor Multitarget Isoindole Indole Triazol
6N3Z-4 Epoxide_hydrolase Urea derivative Trifluoro
6N5G-2 Epoxide_hydrolase Urea derivative Carboxamide
6N3K-1 Epoxide_hydrolase Urea derivative
DO264 ABHD12-PHARC Urea derivative Sulfur Compound
sEH-LTA4H-14 Epoxide_hydrolase Urea derivative LTA4-hydrolase-inhibitor Multitarget Sulfur Compound
Talinolol Epoxide_hydrolase Urea derivative Not A\/B H target Adrenergic-Receptor-ligand tert-Butyl
Morpholino-Talinolol Epoxide_hydrolase Urea derivative Not A\/B H target Adrenergic-Receptor-ligand Morpholine tert-Butyl
KK073 RsbQ-like Urea derivative Trifluoro Triazol
KK052 RsbQ-like Urea derivative Triazol Piperazine
KK023-N1 RsbQ-like Urea derivative Strigolactone receptors ligand Triazol Indole
KK023-N2 RsbQ-like Urea derivative Strigolactone receptors ligand Triazol Indole
KK094 RsbQ-like Urea derivative Strigolactone receptors ligand Triazol Indole
LK864 Epoxide_hydrolase Azaspiro Sulfur Compound Sulfonyl Urea derivative Trifluoro
CHEMBL1818384 Epoxide_hydrolase Adamantyl Urea derivative
t-AUCB Epoxide_hydrolase Adamantyl Urea derivative
Piperidinyl-1,2,3-triazole-urea-inhibitor-11 LYsophospholipase_carboxylesterase Piperidine Urea derivative Triazol
Piperidinyl-1,2,3-triazole-urea-inhibitor-12 LYsophospholipase_carboxylesterase Piperidine Urea derivative Triazol
Piperidinyl-1,2,3-triazole-urea-inhibitor-2 LYsophospholipase_carboxylesterase Carb_B_Chordata ABHD11-Acetyl_transferase PAF-Acetylhydrolase Cholesterol_esterase Piperidine Urea derivative Triazol
Tiratricol-derivative-8c CFTR-inhibitory-factor_Cif Carboxamide Thyroid hormone analogue Urea derivative
Eprotirome CFTR-inhibitory-factor_Cif Thyroid hormone analogue Drug Urea derivative
Tiratricol-derivative-8h CFTR-inhibitory-factor_Cif Urea derivative Thyroid hormone analogue
MMU Epoxide_hydrolase Natural Urea derivative
1,3-Dibenzylurea Epoxide_hydrolase Natural Urea derivative
TPPU-methyl Epoxide_hydrolase Trifluoro Piperidine Urea derivative
SCHEMBL15272467 Epoxide_hydrolase Trifluoro Piperidine Urea derivative
TPPU Epoxide_hydrolase Trifluoro Piperidine Urea derivative
CHEMBL1615216 Epoxide_hydrolase Piperidine Urea derivative Cyclopropyl Carboxamide Oxadiazol
Z-Pro-Prolinal-IC4 S9N_PPCE_Peptidase_S9 Benzyloxycarbonyl Pyrrolidine Peptide Carboxamide Urea derivative
nbAUDA Epoxide_hydrolase Adamantyl Urea derivative Dodecanoate Laurate
CHEMBL3633668 Epoxide_hydrolase Urea derivative Adamantyl
5ALI-Q3B Epoxide_hydrolase Urea derivative Pyrimidine Imidazole Sulfur Compound
5ALU-HD2 Epoxide_hydrolase Adamantyl Urea derivative Carboxamide Pyrimidine Not A\/B H target
5ALZ-XQ9 Epoxide_hydrolase Urea derivative Adamantyl Piperidine Sulfur Compound Sulfonyl Sulfonamide
1,3-Dicyclohexylurea Epoxide_hydrolase Urea derivative
AEPU Epoxide_hydrolase Adamantyl Urea derivative
AUDA Epoxide_hydrolase Adamantyl Dodecanoate Urea derivative
N-1-adamantyl-N'-cyclohexylurea Epoxide_hydrolase Adamantyl Urea derivative
AAF DPP4N_Peptidase_S9 Pyrrolidine Benzoate Urea derivative
4-(3-cyclohexyluriedo)-ethanoic-acid Epoxide_hydrolase Urea derivative
4-(3-cyclohexyluriedo)-butyric-acid Epoxide_hydrolase Urea derivative
4-(3-cyclohexyluriedo)-hexanoic-acid Epoxide_hydrolase Urea derivative
4-(3-cyclohexyluriedo)-heptanoic-acid Epoxide_hydrolase Urea derivative
7-methoxytacrine-memantine-Cpd4 ACHE Multitarget NMDA-Ligand Adamantyl Urea derivative Alkyl linked bis-ligand Sulfur Compound Derivative of Tacrine
Diuron ACHE Epoxide_hydrolase Herbicide Not A\/B H target Urea derivative
Tr-EH-urea-13 Epoxide_hydrolase Urea derivative Trifluoro
CHEMBL3401634 Epoxide_hydrolase Cyclopropyl Urea derivative
CHEMBL3114611 Epoxide_hydrolase Cyclopropyl Piperidine Urea derivative Carboxamide
Diphenylurea Epoxide_hydrolase Urea derivative
AM6580 Monoglyceridelipase_lysophospholip Piperazine Piperidine Fluoren Triazol Urea derivative
SCHEMBL19358888 Epoxide_hydrolase Urea derivative Benzoate FAAH inhibitor Multitarget
B401 Epoxide_hydrolase Urea derivative Adamantyl Piperidine
EC5026 Epoxide_hydrolase Urea derivative Trifluoro Piperidine
GSK2256294A Epoxide_hydrolase Urea derivative Cyanide Carboxamide Triazine
Ar9281 Epoxide_hydrolase Adamantyl Urea derivative
t-AUCMB Epoxide_hydrolase Urea derivative Multitarget Adamantyl
t-MTUCB-NH Epoxide_hydrolase Urea derivative Multitarget
t-MTUCB Epoxide_hydrolase Urea derivative Multitarget
t-TUCB Epoxide_hydrolase Urea derivative Multitarget FAAH inhibitor
Atglistatin Carb_B_Chordata Urea derivative Biphenyl
GSK-264220A Lipoprotein_Lipase Urea derivative Sulfur Compound Sulfonamide
CPU Epoxide_hydrolase Urea derivative
CIU Epoxide_hydrolase Urea derivative
CDU Epoxide_hydrolase Urea derivative
BAY-59-9435 Hormone-sensitive_lipase_like Piperidine Urea derivative
AM6701 ABHD6-Lip Monoglyceridelipase_lysophospholip Biphenyl Urea derivative Cannabinoid-Receptor-ligand FAAH inhibitor Multitarget Carboxamide Tetrazol
LY2183240 Monoglyceridelipase_lysophospholip Arylacetamide_deacetylase ABHD6-Lip Cannabinoid-Receptor-ligand Biphenyl Urea derivative FAAH inhibitor Multitarget Carboxamide Tetrazol