Amino-ebselen
Ebselen and derivatives are effective inhibitors of the Ag85 complex through covalent modification of a cysteine residue proximal to the Ag85 active site and are therefore covalent, allosteric inhibitors
General
Type : Organoselenium, Thiol-reactive
Chemical_Nomenclature : N-(4-aminophenyl)-2-$l^{1}-selanylbenzamide
Canonical SMILES : C1=CC=C(C(=C1)C(=O)NC2=CC=C(C=C2)N)[Se]
InChI : InChI=1S\/C13H11N2OSe\/c14-9-5-7-10(8-6-9)15-13(16)11-3-1-2-4-12(11)17\/h1-8H,14H2,(H,15,16)
InChIKey : RAJFYOZBFJFJIV-UHFFFAOYSA-N || MAEAMJWLVXANNO-UHFFFAOYSA-N
Other name(s) : Amino ebselen || 6Y3 || N-(4-Aminophenyl)-2-selanylbenzamide || Benzamide, N-(4-aminophenyl)-2-selenyl-
MW : 290.21
Formula : C13H11N2OSe
CAS_number :
PubChem : 124222732
UniChem : RAJFYOZBFJFJIV-UHFFFAOYSA-N, MAEAMJWLVXANNO-UHFFFAOYSA-N
Target
Families : Amino-ebselen ligand of proteins in family
A85-Mycolyl-transferase
Structure :
5KWJ
Protein :
myctu-a85c
References (1)
| Title : Exploring Covalent Allosteric Inhibition of Antigen 85C from Mycobacterium tuberculosis by Ebselen Derivatives - Goins_2017_ACS.Infect.Dis_3_378 |
| Author(s) : Goins CM , Dajnowicz S , Thanna S , Sucheck SJ , Parks JM , Ronning DR |
| Ref : ACS Infect Dis , 3 :378 , 2017 |
| Abstract : |
| PubMedSearch : Goins_2017_ACS.Infect.Dis_3_378 |
| PubMedID: 28285521 |
| Gene_locus related to this paper: myctu-a85c |